Skip to main content
Erschienen in: Intensive Care Medicine 5/2007

01.05.2007 | Editorial

Targeting caspase-1 in sepsis: a novel approach to an old problem

verfasst von: Gustavo Matute-Bello

Erschienen in: Intensive Care Medicine | Ausgabe 5/2007

Einloggen, um Zugang zu erhalten

Excerpt

More than 500,000 people develop sepsis each year in the USA alone, and approximately 175,000 of them die [1, 2]. Moreover, the incidence of sepsis has been increasing at an annualized rate of 8.7% [1]. Sepsis is one of the most common risk factors for acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS), accounting for 89% of all ALI/ARDS cases [3]. Approximately 30–50% of patients with ALI/ARDS who die have sepsis [4]. Understandably, the identification of small molecules that can be used as therapeutic agents in the treatment of sepsis has been a major research priority for the past several years. …
Literatur
1.
Zurück zum Zitat Martin GS, Mannino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348:1546–1554CrossRefPubMed Martin GS, Mannino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348:1546–1554CrossRefPubMed
2.
Zurück zum Zitat Sarkar A, Hall MW, Exline M, Hart J, Knatz N, Gatson NT, Wewers MD (2006) Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am J Respir Crit Care Med 174:1003–1010CrossRefPubMedPubMedCentral Sarkar A, Hall MW, Exline M, Hart J, Knatz N, Gatson NT, Wewers MD (2006) Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am J Respir Crit Care Med 174:1003–1010CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353:1685–1693CrossRefPubMed Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353:1685–1693CrossRefPubMed
4.
Zurück zum Zitat Stapleton RD, Wang BM, Hudson LD, Rubenfeld GD, Caldwell ES, Steinberg KP (2005) Causes and timing of death in patients with ARDS. Chest 128:525–532CrossRefPubMed Stapleton RD, Wang BM, Hudson LD, Rubenfeld GD, Caldwell ES, Steinberg KP (2005) Causes and timing of death in patients with ARDS. Chest 128:525–532CrossRefPubMed
5.
Zurück zum Zitat Cannon JG, Tompkins RG, Gelfand JA, Michie HR, Stanford GG, van der Meer JW, Endres S, Lonnemann G, Corsetti J, Chernow B, et al. (1990) Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J Infect Dis 161:79–84CrossRefPubMed Cannon JG, Tompkins RG, Gelfand JA, Michie HR, Stanford GG, van der Meer JW, Endres S, Lonnemann G, Corsetti J, Chernow B, et al. (1990) Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J Infect Dis 161:79–84CrossRefPubMed
6.
Zurück zum Zitat Wakabayashi G, Cannon JG, Gelfand JA, Clark BD, Aiura K, Burke JF, Wolff SM, Dinarello CA (1994) Altered interleukin-1 and tumor necrosis factor production and secretion during pyrogenic tolerance to LPS in rabbits. Am J Physiol Regul Integr Comp Physiol 267:R329–R336CrossRef Wakabayashi G, Cannon JG, Gelfand JA, Clark BD, Aiura K, Burke JF, Wolff SM, Dinarello CA (1994) Altered interleukin-1 and tumor necrosis factor production and secretion during pyrogenic tolerance to LPS in rabbits. Am J Physiol Regul Integr Comp Physiol 267:R329–R336CrossRef
7.
Zurück zum Zitat Ikejima T, Okusawa S, Ghezzi P, van der Meer JW, Dinarello CA (1990) Interleukin-1 induces tumor necrosis factor (TNF) in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits. J Infect Dis 162:215–223CrossRefPubMed Ikejima T, Okusawa S, Ghezzi P, van der Meer JW, Dinarello CA (1990) Interleukin-1 induces tumor necrosis factor (TNF) in human peripheral blood mononuclear cells in vitro and a circulating TNF-like activity in rabbits. J Infect Dis 162:215–223CrossRefPubMed
8.
Zurück zum Zitat Shalaby MR, Waage A, Aarden L, Espevik T (1989) Endotoxin, tumor necrosis factor-alpha and interleukin 1 induce interleukin 6 production in vivo. Clin Immunol Immunopathol 53:488–498CrossRefPubMed Shalaby MR, Waage A, Aarden L, Espevik T (1989) Endotoxin, tumor necrosis factor-alpha and interleukin 1 induce interleukin 6 production in vivo. Clin Immunol Immunopathol 53:488–498CrossRefPubMed
9.
Zurück zum Zitat Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, Elliston KO, Ayala JM, Casano FJ, Chin J, Ding GJ-F, Egger LA, Gaffney EP, Limjuco G, Palyha OC, Raju SM, Rolando AM, Salley JP, Yamin T-T, Lee TD, Shively JE, MacCross M, Mumford RA, Schmidt JA, Tocci MJ (1992) A novel heterodimeric cysteine protease is required for interleukin-1[beta]processing in monocytes. Nature 356:768–774CrossRefPubMed Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, Elliston KO, Ayala JM, Casano FJ, Chin J, Ding GJ-F, Egger LA, Gaffney EP, Limjuco G, Palyha OC, Raju SM, Rolando AM, Salley JP, Yamin T-T, Lee TD, Shively JE, MacCross M, Mumford RA, Schmidt JA, Tocci MJ (1992) A novel heterodimeric cysteine protease is required for interleukin-1[beta]processing in monocytes. Nature 356:768–774CrossRefPubMed
10.
Zurück zum Zitat Cerretti D, Kozlosky C, Mosley B, Nelson N, Van Ness K, Greenstreet T, March C, Kronheim SR, Druck T, Cannizzaro L, et al (1992) Molecular cloning of the interleukin-1 beta converting enzyme. Science 256:97–100CrossRefPubMed Cerretti D, Kozlosky C, Mosley B, Nelson N, Van Ness K, Greenstreet T, March C, Kronheim SR, Druck T, Cannizzaro L, et al (1992) Molecular cloning of the interleukin-1 beta converting enzyme. Science 256:97–100CrossRefPubMed
11.
Zurück zum Zitat Boost K, Hoegl S, Hofstetter C, Flondor M, Stegewerth K, Platacis I, Pfeilschifter J, Muhl H, Zwissler B (2007) Targeting caspase-1 by inhalation-therapy: Effects of Ac-YVAD-CHO on IL-1, IL-18 and downstream proinflammatory parameters in rat endotoxemia. Intensive Care Med DOI http://dx.doi.org/10.1007/s00134-007-0588-0 Boost K, Hoegl S, Hofstetter C, Flondor M, Stegewerth K, Platacis I, Pfeilschifter J, Muhl H, Zwissler B (2007) Targeting caspase-1 by inhalation-therapy: Effects of Ac-YVAD-CHO on IL-1, IL-18 and downstream proinflammatory parameters in rat endotoxemia. Intensive Care Med DOI http://​dx.​doi.​org/​10.​1007/​s00134-007-0588-0
12.
Zurück zum Zitat Garcia-Calvo M, Peterson EP, Leiting B, Ruel R, Nicholson DW, Thornberry NA (1998) Inhibition of Human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 273:32608–32613CrossRefPubMed Garcia-Calvo M, Peterson EP, Leiting B, Ruel R, Nicholson DW, Thornberry NA (1998) Inhibition of Human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 273:32608–32613CrossRefPubMed
13.
Zurück zum Zitat Opal SM, Fisher CJJ, Dhainaut JF, Vincent JL, Brase R, Lowry SF, Sadoff JC, Slotman GJ, Levy H, Balk RA, Shelly MP, Pribble JP, LaBrecque JF, Lookabaugh J, Donovan H, Dubin H, Baughman R, Norman J, DeMaria E, Matzel K, Abraham E, Seneff M (1997) Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double blind, placebo controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med 25:1115–1124CrossRefPubMed Opal SM, Fisher CJJ, Dhainaut JF, Vincent JL, Brase R, Lowry SF, Sadoff JC, Slotman GJ, Levy H, Balk RA, Shelly MP, Pribble JP, LaBrecque JF, Lookabaugh J, Donovan H, Dubin H, Baughman R, Norman J, DeMaria E, Matzel K, Abraham E, Seneff M (1997) Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double blind, placebo controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med 25:1115–1124CrossRefPubMed
14.
Zurück zum Zitat Fantuzzi G, Zheng H, Faggioni R, Benigni F, Ghezzi P, Sipe J, Shaw A, Dinarello C (1996) Effect of endotoxin in IL-1 beta-deficient mice. J Immunol 157:291–296PubMed Fantuzzi G, Zheng H, Faggioni R, Benigni F, Ghezzi P, Sipe J, Shaw A, Dinarello C (1996) Effect of endotoxin in IL-1 beta-deficient mice. J Immunol 157:291–296PubMed
15.
Zurück zum Zitat Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, et al. (1995) Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80:401–411CrossRefPubMed Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, et al. (1995) Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80:401–411CrossRefPubMed
17.
Zurück zum Zitat Martinon F, Tschopp J (2004) Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117:561–574CrossRefPubMed Martinon F, Tschopp J (2004) Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117:561–574CrossRefPubMed
18.
Zurück zum Zitat Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J (1993) Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75:653–660CrossRefPubMed Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J (1993) Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75:653–660CrossRefPubMed
19.
Zurück zum Zitat Mariathasan S, Weiss DS, Dixit VM, Monack DM (2005) Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J Exp Med 202:1043–1049CrossRefPubMedPubMedCentral Mariathasan S, Weiss DS, Dixit VM, Monack DM (2005) Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J Exp Med 202:1043–1049CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Wesche H, Henzel WJ, Shillinglaw W, Li S, Cao Z (1997) MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7:837–847CrossRefPubMed Wesche H, Henzel WJ, Shillinglaw W, Li S, Cao Z (1997) MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7:837–847CrossRefPubMed
21.
Zurück zum Zitat Faouzi S, Burckhardt BE, Hanson JC, Campe CB, Schrum LW, Rippe RA, Maher JJ (2001) Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway. J Biol Chem 276:49077–49082CrossRefPubMed Faouzi S, Burckhardt BE, Hanson JC, Campe CB, Schrum LW, Rippe RA, Maher JJ (2001) Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway. J Biol Chem 276:49077–49082CrossRefPubMed
22.
Zurück zum Zitat Hotchkiss RS, Nicholson DW (2006) Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 6:813–822CrossRefPubMed Hotchkiss RS, Nicholson DW (2006) Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 6:813–822CrossRefPubMed
23.
Zurück zum Zitat Hotchkiss RS, Chang KC, Swanson PE, Tinsley KW, Hui JJ, Klender P, Xanthoudakis S, Roy S, Black C, Grimm E, Aspiotis R, Han Y, Nicholson DW, Karl IE (2000) Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat Immunol 1:496–501CrossRefPubMed Hotchkiss RS, Chang KC, Swanson PE, Tinsley KW, Hui JJ, Klender P, Xanthoudakis S, Roy S, Black C, Grimm E, Aspiotis R, Han Y, Nicholson DW, Karl IE (2000) Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat Immunol 1:496–501CrossRefPubMed
24.
Zurück zum Zitat Hotchkiss RS, Chang KC, Grayson MH, Tinsley KW, Dunne BS, Davis CG, Osborne DF, Karl IE (2003) Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. PNAS 100:6724–6729CrossRefPubMedPubMedCentral Hotchkiss RS, Chang KC, Grayson MH, Tinsley KW, Dunne BS, Davis CG, Osborne DF, Karl IE (2003) Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. PNAS 100:6724–6729CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE (1997) Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med 25:1298–1307CrossRefPubMed Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE (1997) Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med 25:1298–1307CrossRefPubMed
26.
Zurück zum Zitat Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213–218CrossRefPubMed Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213–218CrossRefPubMed
27.
Zurück zum Zitat Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-[beta]. Molecular Cell 10:417–426CrossRefPubMed Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-[beta]. Molecular Cell 10:417–426CrossRefPubMed
28.
Zurück zum Zitat Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD (2001) Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome. Nat Genet 29:301–305CrossRefPubMedPubMedCentral Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD (2001) Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome. Nat Genet 29:301–305CrossRefPubMedPubMedCentral
Metadaten
Titel
Targeting caspase-1 in sepsis: a novel approach to an old problem
verfasst von
Gustavo Matute-Bello
Publikationsdatum
01.05.2007
Verlag
Springer Berlin Heidelberg
Erschienen in
Intensive Care Medicine / Ausgabe 5/2007
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-007-0589-z

Weitere Artikel der Ausgabe 5/2007

Intensive Care Medicine 5/2007 Zur Ausgabe

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.