nach oben

Erschienen in:

13.10.2022 | Original Article

Targeting Oxidative Stress Markers, Xanthine Oxidase, TNFRSF11A and Cathepsin L in Curcumin-Treated Collagen-Induced Arthritis: A Physiological and COSMO-RS Study

verfasst von: Seghira Bisset, Widad Sobhi, Ayoub Attoui, Tarek Lamaoui, Yousef A. Bin Jardan, Shobhan Das, Manawwer Alam, Khalil Errahmane Kanouni, Abdelmalek Rezgui, Siham Ferdjioui, Yacine Derradji, Abdelhalim Khenchouche, Yacine Benguerba

Erschienen in: Inflammation | Ausgabe 1/2023

Einloggen, um Zugang zu erhalten

Abstract

The effectiveness of curcumin in preventing and treating collagen-induced inflammatory arthritis (CIA) in rats and oxidative stress in rats was investigated. We investigated curcumin’s curative and preventive effects on paw edema, arthritic size, body weight, and radiologic and histological joint abnormalities. It has been shown that curcumin may dramatically lower the risk of developing arthritis. In addition, the number of white blood cells (WBCs) in the body has dropped, which is a strong indication that curcumin has anti-inflammatory characteristics. A follow-up theoretical investigation of curcumin molecular docking on xanthine oxidase (XO) was carried out after the properties of curcumin were determined using the conductor-like screening model for real solvents (COSMO-RS) theory. Because of the interaction between curcumin and the residues on XO named Ile264, Val259, Asn351, and Leu404, XO may be suppressed by this molecule. Curcumin’s anti-inflammatory and antioxidant properties may be responsible for the anti-arthritic effects that have been seen on oxidative stress markers and XO. On the other hand, more research is being conducted to understand its function better in the early stages of rheumatoid arthritis (RA). To determine whether or not curcumin interacts with AR targets, a molecular docking study was conducted using MVD software against TNFRSF11A and cathepsin L.

Nur mit Berechtigung zugänglich

Scherlinger, M., P. Mertz, F. Sagez, A. Meyer, R. Felten, E. Chatelus, R.-M. Javier, C. Sordet, T. Martin, A.-S. Korganow, A. Guffroy, V. Poindron, C. Richez, M.-E. Truchetet, P. Blanco, T. Schaeverbeke, J. Sibilia, H. Devillers, and L. Arnaud. 2020. Worldwide trends in all-cause mortality of auto-immune systemic diseases between 2001 and 2014. Autoimmunity Reviews 19 (6): 102531. https://doi.org/10.1016/j.autrev.2020.102531.CrossRefPubMed

Burgos-Vargas, R., L.J. Catoggio, C. Galarza-Maldonado, K. Ostojich, and M.H. Cardiel. 2013. Current therapies in rheumatoid arthritis: A Latin American perspective. Reumatología Clínica 9 (2): 106–112. https://doi.org/10.1016/j.reuma.2012.09.001.CrossRefPubMed

Paleolog, E.M. 2002. Angiogenesis in rheumatoid arthritis. Arthritis Research 4: S81-90. https://doi.org/10.1007/978-3-7091-1428-5_16.CrossRefPubMedPubMedCentral

Pincus, T., and L.F. Callahan. 1993. What is the natural history of rheumatoid arthritis? Rheumatic Diseases Clinics of North America 19 (1): 123–151. https://doi.org/10.1016/S0889-857X(21)00171-X.CrossRefPubMed

Imboden, J.B. 2009. The immunopathogenesis of rheumatoid arthritis. Annual Review of Pathology: Mechanisms of Disease 4 (1): 417–434. https://doi.org/10.1146/annurev.pathol.4.110807.092254.CrossRef

Dewar, C.L., and M. Harth. 1994. Superoxide production from cytokine-treated adherent rheumatoid neutrophils. Clinical and Investigative Medicine 17 (1): 52–60.PubMed

Hanachi, N., N. Charef, A. Baghiani, S. Khennouf, Y. Derradji, S. Boumerfeg, D. Harzallah, and L. Arrar. 2009. Comparison of xanthine oxidase levels in synovial fluid from patients with rheumatoid arthritis and other joint inflammations. Saudi Medical Journal 30 (11): 1422–1425.PubMed

Scott, D.L., M. Shipley, A. Dawson, S. Edwards, D.P. Symmons, and A.D. Woolf. 1998. The clinical management of rheumatoid arthritis and osteoarthritis: Strategies for improving clinical effectiveness. Rheumatology 37 (5): 546–554. https://doi.org/10.1093/rheumatology/37.5.546.CrossRef

Rooney, B.K., and A.J. Silman. 1999. Epidemiology of the rheumatic diseases. Current Opinion in Rheumatology 11 (2): 91–97. https://doi.org/10.1097/00002281-199903000-00002.CrossRefPubMed

10.

Payne, R. 2000. Limitations of NSAIDs for pain management: Toxicity or lack of efficacy? The Journal of Pain 1 (3): 14–18. https://doi.org/10.1054/jpai.2000.16611.CrossRefPubMed

11.

Ramadan, G., M.A. Al-Kahtani, and W.M. El-Sayed. 2011. Anti-inflammatory and antioxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation 34 (4): 291–301. https://doi.org/10.1007/s10753-010-9278-0.CrossRefPubMed

12.

Kremers, H.M., P. Nicola, C.S. Crowson, W.M. O’Fallon, and S.E. Gabriel. 2004. Therapeutic strategies in rheumatoid arthritis over a 40-year period. Journal of Rheumatology 31 (12): 2366–2373.PubMed

13.

Goel, A., A.B. Kunnumakkara, and B.B. Aggarwal. 2008. Curcumin as “curecumin”: From kitchen to clinic. Biochemical Pharmacology 75 (4): 787–809. https://doi.org/10.1016/j.bcp.2007.08.016.CrossRefPubMed

14.

Strimpakos, A.S., and R.A. Sharma. 2008. Curcumin: Preventive and therapeutic properties in laboratory studies and clinical trials. Antioxidants & Redox Signaling 10 (3): 511–546. https://doi.org/10.1089/ars.2007.1769.CrossRef

15.

Khopde, S.M., K.I., Priyadarsini, P., Venkatesan, and M.N.A, Rao. 1999. Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue. Biophysical Chemistry 80(2): 85–91. https://doi.org/10.1016/S0301-4622(99)00070-8.

16.

Gupta, S.C., S. Prasad, J.H. Kim, S. Patchva, L.J. Webb, I.K. Priyadarsini, and B.B. Aggarwal. 2011. Multitargeting by curcumin as revealed by molecular interaction studies. Natural Products Reports 28 (12): 1937. https://doi.org/10.1039/c1np00051a.CrossRef

17.

Aggarwal, B.B., and K.B. Harikumar. 2009. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. International Journal of Biochemistry & Cell Biology 41 (1): 40–59. https://doi.org/10.1016/j.biocel.2008.06.010.CrossRef

18.

Kannan, K., R.A. Ortmann, and D. Kimpel. 2005. Animal models of rheumatoid arthritis and their relevance to human disease. Pathophysiology 12 (3): 167–181. https://doi.org/10.1016/j.pathophys.2005.07.011.CrossRefPubMed

19.

Tong, B., X. Yuan, Y. Dou, X. Wu, Y. Wang, Y. Xia, and Y. Dai. 2016. Sinomenine induces the generation of intestinal Treg cells and attenuates arthritis via activation of aryl hydrocarbon receptor. Laboratory Investigation 96 (10): 1076–1086. https://doi.org/10.1038/labinvest.2016.86.CrossRefPubMed

20.

Du, F., L. Lü, Q. Fu, M. Dai, J. Teng, W. Fan, S. Chen, P. Ye, N. Shen, X. Huang, J. Qian, and C. Bao. 2008. T-614, a Novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis. Arthritis Research & Therapy 10 (6): R136. https://doi.org/10.1186/ar2554.CrossRef

21.

Shealy, D.J., P.H. Wooley, E. Emmell, A. Volk, A. Rosenberg, G. Treacy, C.L. Wagner, L. Mayton, D.E. Griswold, and X.-Y.R. Song. 2002. Anti-TNF-alpha antibody allows healing of joint damage in polyarthritic transgenic mice. Arthritis Research 4 (5): R7. https://doi.org/10.1186/ar430.CrossRefPubMedPubMedCentral

22.

Zhu, L., W. Wei, Y.-Q. Zheng, and X.-Y. Jia. 2005. Effects and mechanisms of total glucosides of paeony on joint damage in rat collagen-induced arthritis. Inflammation Research 54 (5): 211–220. https://doi.org/10.1007/s00011-005-1345-x.CrossRefPubMed

23.

Bai, S., and B. Lu. 2014. VCMM: A visual tool for continuum molecular modeling. Journal of Molecular Graphics and Modelling 50: 44–49. https://doi.org/10.1016/j.jmgm.2014.03.006.CrossRefPubMed

24.

Ellman, G.L. 1959. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics 82 (1): 70–77. https://doi.org/10.1016/0003-9861(59)90090-6.CrossRefPubMed

25.

Ohkawa, H., N. Ohishi, and K. Yagi. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 95 (2): 351–358. https://doi.org/10.1016/0003-2697(79)90738-3.CrossRefPubMed

26.

Aebi, H. 1984. Catalase in vitro. pp 121–126. https://doi.org/10.1016/S0076-6879(84)05016-3.

27.

Nandy, S., H.S. Paul, and N.R. Barman. 2012. In vitro evaluation of antioxidant activity of Leucas plukenetii ( Roth ) Spreng. Asian Journal of Plant Science and Research 2 (3): 254–262.

28.

Zheng, L., and D. Dong. 2011. Development and validation of an HPLC method for simultaneous determination of nine active components in “Da-Chai-Hu-Tang.” Chinese Medicine 02 (01): 20–28. https://doi.org/10.4236/cm.2011.21004.CrossRef

29.

Gornall, A.G., C.J. Bardawill, and M.M. David. 1949. Determination of serum proteins by means of the biuret reaction. Journal of Biological Chemistry 177 (2): 751–766.CrossRefPubMed

30.

Song, Z., Q. Zeng, J. Zhang, H. Cheng, L. Chen, and Z. Qi. 2016. Solubility of imidazolium-based ionic liquids in model fuel hydrocarbons: A COSMO-RS and Experimental Study. Journal of Molecular Liquids 224: 544–550. https://doi.org/10.1016/j.molliq.2016.10.026.CrossRef

31.

Evers, F., F. Weigend, and M. Koentopp. 2003. Coherent transport through a molecular wire: DFT calculation. Phys. E Low-dimensional Syst. Nanostructures 18 (1–3): 255–257. https://doi.org/10.1016/S1386-9477(02)01006-8.CrossRef

32.

Delley, B. 1990. An all-electron numerical method for solving the local density functional for polyatomic molecules. The Journal of Chemical Physics 92 (1): 508–517. https://doi.org/10.1063/1.458452.CrossRef

33.

Kanouni, K.E., Y. Benguerba, and A. Erto. 2019. Theoretical investigation of the solubility of some antiemetic drugs. Journal of Molecular Liquids 282: 626–632. https://doi.org/10.1016/j.molliq.2019.03.028.CrossRef

34.

Alioui, O., Y. Benguerba, and I.M. Alnashef. 2020. Investigation of the CO2-solubility in deep eutectic solvents using COSMO-RS and molecular dynamics methods. Journal of Molecular Liquids 307: 113005. https://doi.org/10.1016/j.molliq.2020.113005.CrossRef

35.

Benabid, S., N. Haddaoui, T. Lemaoui, A.S. Darwish, Y. Benguerba, and I.M. Alnashef. 2021. Computational modeling of polydecanediol-co-citrate using benzalkonium chloride-based hydrophobic eutectic solvents: COSMO-RS, reactivity, and compatibility insights. Journal of Molecular Liquids 339: 116674. https://doi.org/10.1016/j.molliq.2021.116674.CrossRef

36.

Bououden, W., Y. Benguerba, A.S. Darwish, A. Attoui, T. Lemaoui, M. Balsamo, A. Erto, and I.M. Alnashef. 2021. Surface adsorption of crizotinib on carbon and boron nitride nanotubes as anti-cancer drug carriers: COSMO-RS and DFT molecular insights. Journal of Molecular Liquids 338: 116666. https://doi.org/10.1016/j.molliq.2021.116666.CrossRef

37.

Benabid, S., Y. Benguerba, I.M. AlNashef, and N. Haddaoui. 2019. Theoretical study of physicochemical properties of selected ammonium salt-based deep eutectic solvents. Journal of Molecular Liquids 285: 38–46. https://doi.org/10.1016/j.molliq.2019.04.052.CrossRef

38.

Pérez, P., L.R., Domingo, M., Duque-Noreña, and E.A., Chamorro. 2009. condensed-to-atom nucleophilicity index. An application to the director effects on the electrophilic aromatic substitutions. Journal of Molecular Structure: THEOCHEM 895(1–3): 86–91. https://doi.org/10.1016/j.theochem.2008.10.014.

39.

Parr, R.G., and W. Yang. 1984. Density functional approach to the frontier-electron theory of chemical reactivity. Journal of the American Chemical Society 106 (14): 4049–4050. https://doi.org/10.1021/ja00326a036.CrossRef

40.

Tarek, L., H.N. El Houda, B. Yacine, and A. Ayoub. 2019. Molecular docking of new active compounds towards the acetylcholinesterase enzyme. Current Research Bioinformatics 8 (1): 18–20. https://doi.org/10.3844/ajbsp.2019.18.20.CrossRef

41.

Kanouni, K.E., and Y. Benguerba. 2020. Theoretical investigation of two antiemetic drugs at DFT level. Current Research Bioinformatics 9 (1): 17–25. https://doi.org/10.3844/ajbsp.2020.17.25.CrossRef

42.

Lemaoui, T., A.S. Darwish, N.E.H. Hammoudi, F. Abu Hatab, A. Attoui, I.M. Alnashef, and Y. Benguerba. 2020. Prediction of electrical conductivity of deep eutectic solvents using COSMO-RS sigma profiles as molecular descriptors: A quantitative structure-property relationship study. Industrial and Engineering Chemistry Research 59 (29): 13343–13354. https://doi.org/10.1021/acs.iecr.0c02542.CrossRef

43.

Lemaoui, T., N.E.H. Hammoudi, I.M. Alnashef, M. Balsamo, A. Erto, B. Ernst, and Y. Benguerba. 2020. Quantitative structure properties relationship for deep eutectic solvents using Sσ-profile as molecular descriptors. Journal of Molecular Liquids 309: 113165. https://doi.org/10.1016/j.molliq.2020.113165.CrossRef

44.

Lemaoui, T., A.S. Darwish, A. Attoui, F. Abu Hatab, N.E.H. Hammoudi, Y. Benguerba, L.F. Vega, and I.M. Alnashef. 2020. Predicting the density and viscosity of hydrophobic eutectic solvents: Towards the development of sustainable solvents. Green Chemistry 22 (23): 8511–8530. https://doi.org/10.1039/d0gc03077e.CrossRef

45.

Lemaoui, T., F. Abu Hatab, A.S. Darwish, A. Attoui, N.E.H. Hammoudi, G. Almustafa, M. Benaicha, Y. Benguerba, and I.M. Alnashef. 2021. Molecular-based guide to predict the pH of eutectic solvents: Promoting an efficient design approach for new green solvents. ACS Sustainable Chemistry & Engineering 9 (17): 5783–5808. https://doi.org/10.1021/acssuschemeng.0c07367.CrossRef

46.

Darwish, A.S., F., Abu Hatab, T., Lemaoui, O.A.Z., Ibrahim, G, Almustafa, B., Zhuman, S.E.E., Warrag, M.K., Hadj-Kali, Y., Benguerba, and I.M., Alnashef. 2021. Multicomponent extraction of aromatics and heteroaromatics from diesel using acidic eutectic solvents: experimental and COSMO-RS predictions. Journal of Molecular Liquid 336: 116575. https://doi.org/10.1016/j.molliq.2021.116575.

47.

McInnes, I.B., and G. Schett. 2011. The pathogenesis of rheumatoid arthritis. New England Journal of Medicine 365 (23): 2205–2219. https://doi.org/10.1056/NEJMra1004965.CrossRefPubMed

48.

García-González, A., R., Gaxiola-Robles, and T., Zenteno-Savín. 2015. Oxidative stress in patients with rheumatoid arthritis. Revista de Investigacion Clinica 67 (1): 46–53.

49.

Sobhi, W. 2020. Involvement of oxidative stress in type 1 diabetes. American Journal of Biomedical Science Research 6 (6): 538–543. https://doi.org/10.34297/ajbsr.2020.06.001100.

50.

Stevens, C.R., M. Benboubetra, R. Harrison, T. Sahinoglu, E.C. Smith, and D.R. Blake. 1991. Localisation of xanthine oxidase to synovial endothelium. Annals of the Rheumatic Diseases 50 (11): 760–762. https://doi.org/10.1136/ard.50.11.760.CrossRefPubMedPubMedCentral

51.

Henrotin, Y., A.L. Clutterbuck, D. Allaway, E.M. Lodwig, P. Harris, M. Mathy-Hartert, M. Shakibaei, and A. Mobasheri. 2010. Biological actions of curcumin on articular chondrocytes. Osteoarthritis and Cartilage 18 (2): 141–149. https://doi.org/10.1016/j.joca.2009.10.002.CrossRefPubMed

52.

Banerjee, M., L.M. Tripathi, V.M.L. Srivastava, A. Puri, and R. Shukla. 2003. Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat. Immunopharmacology and Immunotoxicology 25 (2): 213–224. https://doi.org/10.1081/IPH-120020471.CrossRefPubMed

53.

Anand, P., A.B. Kunnumakkara, R.A. Newman, and B.B. Aggarwal. 2007. Bioavailability of Curcumin: Problems and Promises. Molecular Pharmaceutics 4 (6): 807–818. https://doi.org/10.1021/mp700113r.CrossRefPubMed

54.

Bisset, S., W. Sobhi, C. Bensouici, and A. Khenchouche. 2020. Chain-Breaking/Preventive Antioxidant, Urate-Lowering, and Anti-Inflammatory Effects of Pure Curcumin. Current Nutrition & Food Science 17 (1): 66–74. https://doi.org/10.2174/1573401316999200421095134.CrossRef

55.

Naik, S.R., V.N. Thakare, and S.R. Patil. 2011. Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: Evidence of its antioxidant property. Experimental and Toxicologic Pathology 63 (5): 419–431. https://doi.org/10.1016/j.etp.2010.03.001.CrossRefPubMed

56.

Srivastava, R.M., S. Singh, S.K. Dubey, K. Misra, and A. Khar. 2011. Immunomodulatory and therapeutic activity of curcumin. International Immunopharmacology 11 (3): 331–341. https://doi.org/10.1016/j.intimp.2010.08.014.CrossRefPubMed

57.

Bresnihan, B., J.M. Alvaro-Gracia, M. Cobby, M. Doherty, Z. Domljan, P. Emery, G. Nuki, K. Pavelka, R. Rau, B. Rozman, I. Watt, B. Williams, R. Aitchison, D. McCabe, and P. Musikic. 1998. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis and Rheumatism 41 (12): 2196–2204. https://doi.org/10.1002/1529-0131(199812)41:12%3c2196::AID-ART15%3e3.0.CO;2-2.CrossRefPubMed

58.

Smeets, T.J.M., M.C. Kraan, M.E. van Loon, and P.-P. Tak. 2003. Tumor necrosis factor ? Blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue. Arthritis and Rheumatism 48 (8): 2155–2162. https://doi.org/10.1002/art.11098.CrossRefPubMed

59.

Ranjan, D., C. Chen, T.D. Johnston, H. Jeon, and M. Nagabhushan. 2004. Curcumin Inhibits Mitogen Stimulated lymphocyte proliferation, NFκB activation, and IL-2 signaling. Journal of Surgical Research 121 (2): 171–177. https://doi.org/10.1016/j.jss.2004.04.004.CrossRefPubMed

60.

Abe, Y., S. Hashimoto, and T. Horie. 1999. Curcumin inhibition of inflammation cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacological Research 39 (1): 41–47. https://doi.org/10.1006/phrs.1998.0404.CrossRefPubMed

61.

Epstein, F.H., and E.D. Harris. 1990. Rheumatoid arthritis: Pathophysiology and implications for therapy. New England Journal of Medicine 322 (18): 1277–1289. https://doi.org/10.1056/NEJM199005033221805.CrossRef

62.

Teitelbaum, S.L. 2000. Bone resorption by osteoclasts. Science (80-.) 289(5484): 1504–1508. https://doi.org/10.1126/science.289.5484.1504.

63.

Redlich, K., E.F., Wagner, G., Schett, K., Redlich, S., Hayer, R., Ricci, J., David, M., Tohidast-akrad, G., Kollias, G., Steiner, J.S., Smolen, E.F., Wagner, and G., Schett. 2002 Osteoclasts are essential for TNF- a – mediated joint destruction Find the Latest Version : Joint Destruction 110(10): 1419–1427. https://doi.org/10.1172/JCI200215582.Introduction.

64.

Zahidah, A.F., O. Faizah, K. Nur Aqilah, and K. Anna Taty. 2012. Curcumin as an anti-arthritic agent in collagen-induced arthritic Sprague-Dawley rats. Sains Malaysiana 41 (5): 591–595.

65.

Youssef, P.P., T.J. Smeets, B. Bresnihan, G. Cunnane, O. Fitzgerald, F. Breedveld, and P.P. Tak. 1998. Microscopic Measurement of cellular infiltration in the rheumatoid arthritis synovial membrane: A comparison of semiquantitative and quantitative analysis. British Journal of Rheumatology 37 (9): 1003–1007. https://doi.org/10.1093/rheumatology/37.9.1003.CrossRefPubMed

66.

Abou-Seif, M.A., and A.-A. Youssef. 2004. Evaluation of some biochemical changes in diabetic patients. Clinica Chimica Acta 346 (2): 161–170. https://doi.org/10.1016/j.cccn.2004.03.030.CrossRef

67.

Olayinka, E., A. Ore, O. Adeyemo, O. Ola, O. Olotu, and R. Echebiri. 2015. Quercetin, a Flavonoid antioxidant, ameliorated procarbazine-induced oxidative damage to murine tissues. Antioxidants 4 (2): 304–321. https://doi.org/10.3390/antiox4020304.CrossRefPubMedPubMedCentral

68.

Gottschalk, T.A., E., Tsantikos, and M.L., Hibbs. 2015. Pathogenic inflammation and its therapeutic targeting in systemic lupus erythematosus. Frontier in Immunology. 6. https://doi.org/10.3389/fimmu.2015.00550.

69.

Kalpana, C., and V.P., Menon. 2004. Modulatory effects of curcumin on lipid peroxidation and antioxidant status during nicotine-induced toxicity. Polish Journal of Pharmacology 56(5): 581–586.

70.

Menon, V.P., and A.R, Sudheer. 2007. Antioxidant and anti-inflammatory properties of curcumin. in The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease; Springer US: Boston, MA; pp 105–125. https://doi.org/10.1007/978-0-387-46401-5_3.

71.

Samarghandian, S., M. Azimi-Nezhad, T. Farkhondeh, and F. Samini. 2017. Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney. Biomedicine & Pharmacotherapy 87: 223–229. https://doi.org/10.1016/j.biopha.2016.12.105.CrossRef

72.

Momeni, H.R., and N. Eskandari. 2017. Effect of curcumin on kidney histopathological changes, lipid peroxidation and total antioxidant capacity of serum in sodium arsenite-treated mice. Experimental and Toxicologic Pathology 69 (2): 93–97. https://doi.org/10.1016/j.etp.2016.08.006.CrossRefPubMed

73.

Boudiaf, K., Z. Houcher, W. Sobhi, and M. Benboubetra. 2010. Evaluation of antioxidant and anti-xanthine oxidoreductase activities of Nigella sativa Linn seeds’ extracts. Journal of Applied Biological Sciences 4 (1): 7–16.

74.

Khither, H., S., Madoui, K., Mokhnache, and W., Sobhi. 2020. Evaluation of in vitro and in vivo anti-arthritic and xanthine oxidase inhibitory activities of thymoquinone: applied to collagen-induced rheumatoid arthritis in male rats. No. November.

75.

Allen, R.E., J.M. Outhwaite, C.J. Morris, and D.R. Blake. 1987. Xanthine oxidoreductase is present in human synovium. Annals of the Rheumatic Diseases 46 (11): 843–845. https://doi.org/10.1136/ard.46.11.843.CrossRefPubMedPubMedCentral

76.

Miesel, R., and M. Zuber. 1993. Elevated levels of xanthine oxidase in serum of patients with inflammatory and autoimmune rheumatic diseases. Inflammation 17 (5): 551–561. https://doi.org/10.1007/BF00914193.CrossRefPubMed

77.

Sarmiento, C., A., Chiou, M.J., Duryee, J., Tian, G.M., Thiele, D.R., Anderson, T.R., Mikuls, and M.C., Zimmerman. 2017. Methotrexate scavenges xanthine oxidase-derived superoxide without inhibiting xanthine oxidase activity. The FASEB Journal 31(S1): lb689–lb689. https://doi.org/10.1096/fasebj.31.1_supplement.lb689.

78.

Hughes, A.E., S.H. Ralston, J. Marken, C. Bell, H. MacPherson, R.G. Wallace, W. van Hul, M.P. Whyte, K. Nakatsuka, L. Hovy, and D.M. Anderson. 2000. Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Nature Genetics 24 (1): 45–48. https://doi.org/10.1038/71667.CrossRefPubMed

79.

Adán, N. J., Guzmán-Morales, M.G., Ledesma-Colunga, S.I., Perales-Canales, A., Quintanar-Stéphano, F., López-Barrera, I., Méndez, B., Moreno-Carranza, J., Triebel, N., Binart, G., Martínez de la Escalera, S., Thebault, and C., Clapp. 2013. Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis. The Journal of Clinical Investigation 123(9): 3902–3913. https://doi.org/10.1172/JCI69485.

80.

Ledesma-Colunga, M.G., N., Adán, G., Ortiz, M., Solís-Gutiérrez, F., López-Barrera, G., Martínez de la Escalera, and C., Clapp. 2017. Prolactin Blocks the expression of receptor activator of nuclear factor ΚB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis. Arthritis Research & Therapy. 19(1): 93. https://doi.org/10.1186/s13075-017-1290-4.

81.

Vasiljeva, O., T. Reinheckel, C. Peters, D. Turk, V. Turk, and B. Turk. 2007. Emerging roles of cysteine cathepsins in disease and their potential as drug targets. Current Pharmaceutical Design 13 (4): 387–403. https://doi.org/10.2174/138161207780162962.CrossRefPubMed

82.

Bethel, P.A., S. Gerhardt, E.V. Jones, P.W. Kenny, G.I. Karoutchi, A.D. Morley, K. Oldham, N. Rankine, M. Augustin, S. Krapp, H. Simader, and S. Steinbacher. 2009. Design of selective cathepsin inhibitors. Bioorganic & Medicinal Chemistry Letters 19 (16): 4622–4625. https://doi.org/10.1016/j.bmcl.2009.06.090.CrossRef

Titel: Targeting Oxidative Stress Markers, Xanthine Oxidase, TNFRSF11A and Cathepsin L in Curcumin-Treated Collagen-Induced Arthritis: A Physiological and COSMO-RS Study
verfasst von: Seghira Bisset
Widad Sobhi
Ayoub Attoui
Tarek Lamaoui
Yousef A. Bin Jardan
Shobhan Das
Manawwer Alam
Khalil Errahmane Kanouni
Abdelmalek Rezgui
Siham Ferdjioui
Yacine Derradji
Abdelhalim Khenchouche
Yacine Benguerba
Publikationsdatum: 13.10.2022
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 1/2023
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-022-01745-7

SARS-CoV-2 Variants Show a Gradual Declining Pathogenicity and Pro-Inflammatory Cytokine Stimulation, an Increasing Antigenic and Anti-Inflammatory Cytokine Induction, and Rising Structural Protein Instability: A Minimal Number Genome-Based Approach

Original Article

Role of T Cells in the Pathogenesis of Rheumatoid Arthritis: Focus on Immunometabolism Dysfunctions

Review

MicroRNA-19a Inhibition Directly and Indirectly Ameliorates Th2 Airway Inflammation in Asthma by Targeting RUNX3

Original Article

Silence of S1PR4 Represses the Activation of Fibroblast-like Synoviocytes by Regulating IL-17/STAT3 Signaling Pathway

Original Article

Circ_0088194 Regulates Proliferation, Migration, Apoptosis, and Inflammation by miR-30a-3p/ADAM10 Axis in Rheumatoid Arthritis Fibroblastic Synovial Cells

Original Article

Role of NLRP3 Inflammasome and Its Inhibitors as Emerging Therapeutic Drug Candidate for Alzheimer’s Disease: a Review of Mechanism of Activation, Regulation, and Inhibition

Review

Kompaktes Leitlinien-Wissen Innere Medizin (Link öffnet in neuem Fenster)

Mit medbee Pocketcards schnell und sicher entscheiden.
Leitlinien-Wissen kostenlos und immer griffbereit auf ihrem Desktop, Handy oder Tablet.

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Mit Lidocain kommt der Darm nicht schneller in Schwung

13.01.2025
Kolektomie
Nachrichten

Verzögertes Wiederanspringen der Darmfunktion ist ein Hauptfaktor dafür, wenn Patientinnen und Patienten nach einer Kolonresektion länger als geplant im Krankenhaus bleiben müssen. Ob man diesem Problem mit Lidocain vorbeugen kann, war Thema einer Studie.

Koronare Herzkrankheit: Das waren die Top-Studien in 2024

12.01.2025
Koronare Herzerkrankung
Nachrichten

Zum Thema Koronare Herzkrankheit gab es 2024 wichtige neue Studien. Beleuchtet wurden darin unter anderem der Stellenwert von Betablockern nach Herzinfarkt, neue Optionen für eine Lipidsenkung sowie die Therapie bei infarktbedingtem kardiogenem Schock.

CDK4/6-Inhibitoren bei Brustkrebs in die Zweitlinie aufschieben?

10.01.2025
Mammakarzinom
Nachrichten

Ergebnisse einer Phase-III-Studie sprechen dafür, dass die Behandlung mit CDK4/6-Inhibitoren bei fortgeschrittenem HR-positivem, HER2-negativem Brustkrebs auch auf die Zweitlinie verschoben werden könnte, ohne die onkologischen Ergebnisse zu kompromittieren.

Inhalative Steroide bei COPD nicht kardioprotektiv

10.01.2025
COPD
Nachrichten

Ob inhalative Kortikosteroide (ICS) COPD-Kranke außer vor akuten Exazerbationen auch vor kardiovaskulären Komplikationen schützen können, ist unklar. Eine bevölkerungsbasierte Studie aus England spricht nicht dafür.

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

In diesem CME-Kurs können Sie Ihr Wissen zur EKG-Befundung anhand von zwölf Video-Tutorials auffrischen und 10 CME-Punkte sammeln.
Praxisnah, relevant und mit vielen Tipps & Tricks vom Profi.

Jetzt 10 CME-Punkte sammeln

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Targeting Oxidative Stress Markers, Xanthine Oxidase, TNFRSF11A and Cathepsin L in Curcumin-Treated Collagen-Induced Arthritis: A Physiological and COSMO-RS Study

Abstract

Weitere Artikel der Ausgabe 1/2023

SARS-CoV-2 Variants Show a Gradual Declining Pathogenicity and Pro-Inflammatory Cytokine Stimulation, an Increasing Antigenic and Anti-Inflammatory Cytokine Induction, and Rising Structural Protein Instability: A Minimal Number Genome-Based Approach

Role of T Cells in the Pathogenesis of Rheumatoid Arthritis: Focus on Immunometabolism Dysfunctions

MicroRNA-19a Inhibition Directly and Indirectly Ameliorates Th2 Airway Inflammation in Asthma by Targeting RUNX3

Silence of S1PR4 Represses the Activation of Fibroblast-like Synoviocytes by Regulating IL-17/STAT3 Signaling Pathway

Circ_0088194 Regulates Proliferation, Migration, Apoptosis, and Inflammation by miR-30a-3p/ADAM10 Axis in Rheumatoid Arthritis Fibroblastic Synovial Cells

Role of NLRP3 Inflammasome and Its Inhibitors as Emerging Therapeutic Drug Candidate for Alzheimer’s Disease: a Review of Mechanism of Activation, Regulation, and Inhibition

Kompaktes Leitlinien-Wissen Innere Medizin (Link öffnet in neuem Fenster)

Neu im Fachgebiet Innere Medizin

Mit Lidocain kommt der Darm nicht schneller in Schwung

Koronare Herzkrankheit: Das waren die Top-Studien in 2024

CDK4/6-Inhibitoren bei Brustkrebs in die Zweitlinie aufschieben?

Inhalative Steroide bei COPD nicht kardioprotektiv

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten