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Cellular Oncology

Erschienen in:

30.09.2023 | Review

Targeting the lipid metabolic reprogramming of tumor-associated macrophages: A novel insight into cancer immunotherapy

verfasst von: Liang Li, Si-Rui Ma, Zi-Li Yu

Erschienen in: Cellular Oncology | Ausgabe 2/2024

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Abstract

Background

Tumor-associated macrophages, as the major immunocytes in solid tumors, show divided loyalty and remarkable plasticity in tumorigenesis. Once the M2-to-M1 repolarization is achieved, they could be switched from the supporters for tumor development into the guardians for host immunity. Meanwhile, Lipid metabolic reprogramming is demonstrated to be one of the most important hallmarks of tumor-associated macrophages, which plays a decisive role in regulating their phenotypes and functions to promote tumorigenesis and immunotherapy resistance. Therefore, targeting the lipid metabolism of TAMs may provide a new direction for anti-tumor strategies.

Conclusion

In this review, we first summarized the origins, classifications and general lipid metabolic process of TAMs. Then we discussed the currently available drugs and interventions that target lipid metabolic disorders of TAMs, including those targeting lipid uptake, efflux, lipolysis, FAO and lipid peroxidation. Besides, based on the recent research status, we summarized the present challenges for this cancer immunotherapy, including the precise drug delivery system, the lipid metabolic heterogeneity, and the intricate lipid metabolic interactions in the TME, and we also proposed corresponding possible solutions. Collectively, we hope this review will give researchers a better understanding of the lipid metabolism of TAMs and lead to the development of corresponding anti-tumor therapies in the future.

B. Faubert, A. Solmonson and R.J. DeBerardinis, Science 368, eaaw5473 (2020). https://doi.org/10.1126/science.aaw5473

A.C. Gonçalves, E. Richiardone, J. Jorge, B. Polónia, C.P.R. Xavier, I.C. Salaroglio, C. Riganti, M.H. Vasconcelos, C. Corbet, A.B. Sarmento-Ribeiro, Drug Resist Updat 59, 100797 (2021). https://doi.org/10.1016/j.drup.2021.100797CrossRefPubMed

J.E. Bader, K. Voss, J.C. Rathmell, Mol Cell 78, 1019–1033 (2020). https://doi.org/10.1016/j.molcel.2020.05.034CrossRefPubMedPubMedCentral

O. Warburg, S. Minami, Klinische Wochenschrift 2, 776–777 (1923). https://doi.org/10.1007/BF01712130CrossRef

O. Warburg, Naturwissenschaften 12, 1131–1137 (1924). https://doi.org/10.1007/BF01504608CrossRef

I. Vitale, G. Manic, L.M. Coussens, G. Kroemer, L. Galluzzi, Cell Metab 30, 36–50 (2019). https://doi.org/10.1016/j.cmet.2019.06.001CrossRefPubMed

K.E. Beckermann, S.O. Dudzinski, J.C. Rathmell, Cytokine Growth Factor Rev 35, 7–14 (2017). https://doi.org/10.1016/j.cytogfr.2017.04.003CrossRefPubMedPubMedCentral

K. Yang, X. Wang, C. Song, Z. He, R. Wang, Y. Xu, G. Jiang, Y. Wan, J. Mei, W. Mao, Theranostics 13, 1774–1808 (2023). https://doi.org/10.7150/thno.82920CrossRefPubMedPubMedCentral

S. Vinogradov, G. Warren, X. Wei, Nanomedicine (Lond) 9, 695–707 (2014). https://doi.org/10.2217/nnm.14.13CrossRefPubMed

10.

D.A. Chistiakov, A.A. Melnichenko, V.A. Myasoedova, A.V. Grechko, A.N. Orekhov, J Mol Med (Berl) 95, 1153–1165 (2017). https://doi.org/10.1007/s00109-017-1575-8CrossRefPubMed

11.

P. Su, Q. Wang, E. Bi, X. Ma, L. Liu, M. Yang, J. Qian, Q. Yi, Cancer Res 80, 1438–1450 (2020). https://doi.org/10.1158/0008-5472.Can-19-2994CrossRefPubMedPubMedCentral

12.

A. Bleve, B. Durante, A. Sica and F.M. Consonni, Int J Mol Sci 21, 5845 (2020). https://doi.org/10.3390/ijms21165845

13.

Y. Pan, Y. Yu, X. Wang, T. Zhang, Front Immunol 11, 583084 (2020). https://doi.org/10.3389/fimmu.2020.583084CrossRefPubMedPubMedCentral

14.

J. Korbecki, K. Kojder, D. Simińska, R. Bohatyrewicz, I. Gutowska, D. Chlubek and I. Baranowska-Bosiacka, Int J Mol Sci 21, 8412 (2020). https://doi.org/10.3390/ijms21218412

15.

Y. Zhu, J.M. Herndon, D.K. Sojka, K.W. Kim, B.L. Knolhoff, C. Zuo, D.R. Cullinan, J. Luo, A.R. Bearden, K.J. Lavine, W.M. Yokoyama, W.G. Hawkins, R.C. Fields, G.J. Randolph, D.G. DeNardo, Immunity 47, 323-338.e326 (2017). https://doi.org/10.1016/j.immuni.2017.07.014CrossRefPubMedPubMedCentral

16.

K. Wu, K. Lin, X. Li, X. Yuan, P. Xu, P. Ni, D. Xu, Front Immunol 11, 1731 (2020). https://doi.org/10.3389/fimmu.2020.01731CrossRefPubMedPubMedCentral

17.

C. Tripathi, B.N. Tewari, R.K. Kanchan, K.S. Baghel, N. Nautiyal, R. Shrivastava, H. Kaur, M.L. Bhatt, S. Bhadauria, Oncotarget 5, 5350–5368 (2014). https://doi.org/10.18632/oncotarget.2110CrossRefPubMedPubMedCentral

18.

L. Cassetta, J.W. Pollard, Curr. Biol. 30, R246-r248 (2020). https://doi.org/10.1016/j.cub.2020.01.031CrossRefPubMed

19.

A.J. Boutilier and S.F. Elsawa, Int J Mol Sci 22, 6995 (2021). https://doi.org/10.3390/ijms22136995

20.

H. Bruns, M. Büttner, M. Fabri, D. Mougiakakos, J.T. Bittenbring, M.H. Hoffmann, F. Beier, S. Pasemann, R. Jitschin, A.D. Hofmann, F. Neumann, C. Daniel, A. Maurberger, B. Kempkes, K. Amann, A. Mackensen, A. Gerbitz, Sci Transl Med 7, 282247 (2015). https://doi.org/10.1126/scitranslmed.aaa3230CrossRef

21.

S. Wang, M. Cheng, P. Peng, Y. Lou, A. Zhang and P. Liu, Int J Mol Sci 22, 7010 (2021). https://doi.org/10.3390/ijms22137010

22.

J. Wu, Z. Chen, S.L. Wickström, J. Gao, X. He, X. Jing, J. Wu, Q. Du, M. Yang, Y. Chen, D. Zhang, X. Yin, Z. Guo, L. Jensen, Y. Yang, W. Tao, A. Lundqvist, R. Kiessling, Y. Cao, Adv Sci (Weinh) 8, e2101029 (2021). https://doi.org/10.1002/advs.202101029CrossRefPubMed

23.

K. Movahedi, D. Laoui, C. Gysemans, M. Baeten, G. Stangé, J. Van den Bossche, M. Mack, D. Pipeleers, P. In't Veld, P. De Baetselier and J.A. Van Ginderachter, Cancer Res 70, 5728–5739 (2010). https://doi.org/10.1158/0008-5472.Can-09-4672

24.

W. Fang, T. Zhou, H. Shi, M. Yao, D. Zhang, H. Qian, Q. Zeng, Y. Wang, F. Jin, C. Chai, T. Chen, J Exp Clin Cancer Res 40, 4 (2021). https://doi.org/10.1186/s13046-020-01786-6CrossRefPubMedPubMedCentral

25.

D.N. Huggins, R.S. LaRue, Y. Wang, T.P. Knutson, Y. Xu, J.W. Williams, K.L. Schwertfeger, Cancer Res 81, 5284–5295 (2021). https://doi.org/10.1158/0008-5472.Can-21-0101CrossRefPubMedPubMedCentral

26.

E. Timperi, P. Gueguen, M. Molgora, I. Magagna, Y. Kieffer, S. Lopez-Lastra, P. Sirven, L.G. Baudrin, S. Baulande, A. Nicolas, G. Champenois, D. Meseure, A. Vincent-Salomon, A. Tardivon, E. Laas, V. Soumelis, M. Colonna, F. Mechta-Grigoriou, S. Amigorena, E. Romano, Cancer Res 82, 3291–3306 (2022). https://doi.org/10.1158/0008-5472.Can-22-1427CrossRefPubMed

27.

A. Shapouri-Moghaddam, S. Mohammadian, H. Vazini, M. Taghadosi, S.A. Esmaeili, F. Mardani, B. Seifi, A. Mohammadi, J.T. Afshari, A. Sahebkar, J Cell Physiol 233, 6425–6440 (2018). https://doi.org/10.1002/jcp.26429CrossRefPubMed

28.

G. van Meer, D.R. Voelker, G.W. Feigenson, Nat Rev Mol Cell Biol 9, 112–124 (2008). https://doi.org/10.1038/nrm2330CrossRefPubMedPubMedCentral

29.

R.A. DeBose-Boyd, Semin Cell Dev Biol 81, 97 (2018). https://doi.org/10.1016/j.semcdb.2017.12.003

30.

V.V. Kunjathoor, M. Febbraio, E.A. Podrez, K.J. Moore, L. Andersson, S. Koehn, J.S. Rhee, R. Silverstein, H.F. Hoff, M.W. Freeman, J Biol Chem 277, 49982–49988 (2002). https://doi.org/10.1074/jbc.M209649200CrossRefPubMed

31.

M.Y. Pepino, O. Kuda, D. Samovski, N.A. Abumrad, Annu Rev Nutr 34, 281–303 (2014). https://doi.org/10.1146/annurev-nutr-071812-161220CrossRefPubMedPubMedCentral

32.

C. Cheng, F. Geng, X. Cheng, D. Guo, Cancer Commun (Lond) 38, 27 (2018). https://doi.org/10.1186/s40880-018-0301-4CrossRefPubMed

33.

J. Luo, H. Yang, B.L. Song, Nat Rev Mol Cell Biol 21, 225–245 (2020). https://doi.org/10.1038/s41580-019-0190-7CrossRefPubMed

34.

X. Bian, R. Liu, Y. Meng, D. Xing, D. Xu and Z. Lu, J Exp Med 218, e20201606 (2021). https://doi.org/10.1084/jem.20201606

35.

Y. Xiang, H. Miao, Adv Exp Med Biol 1316, 87–101 (2021). https://doi.org/10.1007/978-981-33-6785-2_6CrossRefPubMed

36.

T. Wang, X. Fu, Q. Chen, J.K. Patra, D. Wang, Z. Wang and Z. Gai, Int J Mol Sci 20, 3683 (2019). https://doi.org/10.3390/ijms20153683

37.

L. Yvan-Charvet, N. Wang, A.R. Tall, Arterioscler Thromb Vasc Biol 30, 139–143 (2010). https://doi.org/10.1161/atvbaha.108.179283CrossRefPubMed

38.

S. Junankar, G. Shay, J. Jurczyluk, N. Ali, J. Down, N. Pocock, A. Parker, A. Nguyen, S. Sun, B. Kashemirov, C.E. McKenna, P.I. Croucher, A. Swarbrick, K. Weilbaecher, T.G. Phan, M.J. Rogers, Cancer Discov 5, 35–42 (2015). https://doi.org/10.1158/2159-8290.Cd-14-0621CrossRefPubMed

39.

G. Germano, R. Frapolli, C. Belgiovine, A. Anselmo, S. Pesce, M. Liguori, E. Erba, S. Uboldi, M. Zucchetti, F. Pasqualini, M. Nebuloni, N. van Rooijen, R. Mortarini, L. Beltrame, S. Marchini, I. Fuso Nerini, R. Sanfilippo, P.G. Casali, S. Pilotti, C.M. Galmarini, A. Anichini, A. Mantovani, M. D'Incalci and P. Allavena, Cancer Cell 23, 249–262 (2013). https://doi.org/10.1016/j.ccr.2013.01.008

40.

D.E. Sanford, B.A. Belt, R.Z. Panni, A. Mayer, A.D. Deshpande, D. Carpenter, J.B. Mitchem, S.M. Plambeck-Suess, L.A. Worley, B.D. Goetz, A. Wang-Gillam, T.J. Eberlein, D.G. Denardo, S.P. Goedegebuure, D.C. Linehan, Clin Cancer Res 19, 3404–3415 (2013). https://doi.org/10.1158/1078-0432.Ccr-13-0525CrossRefPubMedPubMedCentral

41.

Y. Chen, Y. Huang, T. Reiberger, A.M. Duyverman, P. Huang, R. Samuel, L. Hiddingh, S. Roberge, C. Koppel, G.Y. Lauwers, A.X. Zhu, R.K. Jain, D.G. Duda, Hepatology 59, 1435–1447 (2014). https://doi.org/10.1002/hep.26790CrossRefPubMed

42.

S.B. Willingham, J.P. Volkmer, A.J. Gentles, D. Sahoo, P. Dalerba, S.S. Mitra, J. Wang, H. Contreras-Trujillo, R. Martin, J.D. Cohen, P. Lovelace, F.A. Scheeren, M.P. Chao, K. Weiskopf, C. Tang, A.K. Volkmer, T.J. Naik, T.A. Storm, A.R. Mosley, B. Edris, S.M. Schmid, C.K. Sun, M.S. Chua, O. Murillo, P. Rajendran, A.C. Cha, R.K. Chin, D. Kim, M. Adorno, T. Raveh, D. Tseng, S. Jaiswal, P. Enger, G.K. Steinberg, G. Li, S.K. So, R. Majeti, G.R. Harsh, M. van de Rijn, N.N. Teng, J.B. Sunwoo, A.A. Alizadeh, M.F. Clarke, I.L. Weissman, Proc Natl Acad Sci U S A 109, 6662–6667 (2012). https://doi.org/10.1073/pnas.1121623109CrossRefPubMedPubMedCentral

43.

S. Hoves, C.H. Ooi, C. Wolter, H. Sade, S. Bissinger, M. Schmittnaegel, O. Ast, A.M. Giusti, K. Wartha, V. Runza, W. Xu, Y. Kienast, M.A. Cannarile, H. Levitsky, S. Romagnoli, M. De Palma, D. Rüttinger, C.H. Ries, J Exp Med 215, 859–876 (2018). https://doi.org/10.1084/jem.20171440CrossRefPubMedPubMedCentral

44.

S.R. Gordon, R.L. Maute, B.W. Dulken, G. Hutter, B.M. George, M.N. McCracken, R. Gupta, J.M. Tsai, R. Sinha, D. Corey, A.M. Ring, A.J. Connolly, I.L. Weissman, Nature 545, 495–499 (2017). https://doi.org/10.1038/nature22396CrossRefPubMedPubMedCentral

45.

L. Bonapace, M.M. Coissieux, J. Wyckoff, K.D. Mertz, Z. Varga, T. Junt, M. Bentires-Alj, Nature 515, 130–133 (2014). https://doi.org/10.1038/nature13862CrossRefPubMed

46.

K. Mortezaee, J. Majidpoor, Int Rev Immunol 42, 287–303 (2023). https://doi.org/10.1080/08830185.2022.2095374CrossRefPubMed

47.

K. Ohnishi, Y. Komohara, Y. Saito, Y. Miyamoto, M. Watanabe, H. Baba, M. Takeya, Cancer Sci 104, 1237–1244 (2013). https://doi.org/10.1111/cas.12212CrossRefPubMedPubMedCentral

48.

Z. Liu, Z. Gao, B. Li, J. Li, Y. Ou, X. Yu, Z. Zhang, S. Liu, X. Fu, H. Jin, J. Wu, S. Sun, S. Sun, Q. Wu, Oncoimmunology 11, 2085432 (2022). https://doi.org/10.1080/2162402x.2022.2085432CrossRefPubMedPubMedCentral

49.

M. Masetti, R. Carriero, F. Portale, G. Marelli, N. Morina, M. Pandini, M. Iovino, B. Partini, M. Erreni, A. Ponzetta, E. Magrini, P. Colombo, G. Elefante, F.S. Colombo, J.M.M. den Haan, C. Peano, J. Cibella, A. Termanini, P. Kunderfranco, J. Brummelman, M.W.H. Chung, M. Lazzeri, R. Hurle, P. Casale, E. Lugli, R.A. DePinho, S. Mukhopadhyay, S. Gordon and D. Di Mitri, J Exp Med 219, e20210564 (2022). https://doi.org/10.1084/jem.20210564

50.

C. Neyen, A. Plüddemann, S. Mukhopadhyay, E. Maniati, M. Bossard, S. Gordon, T. Hagemann, J Immunol 190, 3798–3805 (2013). https://doi.org/10.4049/jimmunol.1203194CrossRefPubMed

51.

D. Sag, C. Cekic, R. Wu, J. Linden, C.C. Hedrick, Nat Commun 6, 6354 (2015). https://doi.org/10.1038/ncomms7354CrossRefPubMed

52.

P. Goossens, J. Rodriguez-Vita, A. Etzerodt, M. Masse, O. Rastoin, V. Gouirand, T. Ulas, O. Papantonopoulou, M. Van Eck, N. Auphan-Anezin, M. Bebien, C. Verthuy, T.P. Vu Manh, M. Turner, M. Dalod, J.L. Schultze and T. Lawrence 2019 Cell Metab 29, 1376–1389.e4 (2019). https://doi.org/10.1016/j.cmet.2019.02.016

53.

R. Shi, K. Zhao, T. Wang, J. Yuan, D. Zhang, W. Xiang, J. Qian, N. Luo, Y. Zhou, B. Tang, C. Li, H. Miao, Theranostics 12, 875–890 (2022). https://doi.org/10.7150/thno.66420CrossRefPubMedPubMedCentral

54.

P. Costet, Y. Luo, N. Wang, A.R. Tall, J Biol Chem 275, 28240–28245 (2000). https://doi.org/10.1074/jbc.M003337200CrossRefPubMed

55.

H. Jin, Y. He, P. Zhao, Y. Hu, J. Tao, J. Chen, Y. Huang, Theranostics 9, 265–278 (2019). https://doi.org/10.7150/thno.27246CrossRefPubMedPubMedCentral

56.

C.A. Corzo, T. Condamine, L. Lu, M.J. Cotter, J.I. Youn, P. Cheng, H.I. Cho, E. Celis, D.G. Quiceno, T. Padhya, T.V. McCaffrey, J.C. McCaffrey, D.I. Gabrilovich, J Exp Med 207, 2439–2453 (2010). https://doi.org/10.1084/jem.20100587CrossRefPubMedPubMedCentral

57.

M.F. Tavazoie, I. Pollack, R. Tanqueco, B.N. Ostendorf, B.S. Reis, F.C. Gonsalves, I. Kurth, C. Andreu-Agullo, M.L. Derbyshire, J. Posada, S. Takeda, K.N. Tafreshian, E. Rowinsky, M. Szarek, R.J. Waltzman, E.A. McMillan, C. Zhao, M. Mita, A. Mita, B. Chmielowski, M.A. Postow, A. Ribas, D. Mucida, S.F. Tavazoie, Cell 172, 825-840 e818 (2018). https://doi.org/10.1016/j.cell.2017.12.026CrossRefPubMedPubMedCentral

58.

L.S. Simon, Am. J. Med. 106, 37s–42s (1999). https://doi.org/10.1016/s0002-9343(99)00115-1CrossRefPubMed

59.

S. Narumiya, Y. Sugimoto, F. Ushikubi, Physiol Rev 79, 1193–1226 (1999). https://doi.org/10.1152/physrev.1999.79.4.1193CrossRefPubMed

60.

S. Lang, S. Tiwari, M. Andratschke, I. Loehr, L. Lauffer, C. Bergmann, B. Mack, A. Lebeau, A. Moosmann, T.L. Whiteside, R. Zeidler, Cancer Immunol Immunother 56, 1645–1652 (2007). https://doi.org/10.1007/s00262-007-0312-5CrossRefPubMedPubMedCentral

61.

E. Eruslanov, I. Daurkin, J. Ortiz, J. Vieweg, S. Kusmartsev, J Leukoc Biol 88, 839–848 (2010). https://doi.org/10.1189/jlb.1209821CrossRefPubMedPubMedCentral

62.

E. Eruslanov, S. Kaliberov, I. Daurkin, L. Kaliberova, D. Buchsbaum, J. Vieweg, S. Kusmartsev, J Immunol 182, 7548–7557 (2009). https://doi.org/10.4049/jimmunol.0802358CrossRefPubMed

63.

D.I. Albu, Z. Wang, K.C. Huang, J. Wu, N. Twine, S. Leacu, C. Ingersoll, L. Parent, W. Lee, D. Liu, R. Wright-Michaud, N. Kumar, G. Kuznetsov, Q. Chen, W. Zheng, K. Nomoto, M. Woodall-Jappe, X. Bao, Oncoimmunology 6, e1338239 (2017). https://doi.org/10.1080/2162402x.2017.1338239CrossRefPubMedPubMedCentral

64.

L. Zhu, Q. Zhao, T. Yang, W. Ding, Y. Zhao, Int Rev Immunol 34, 82–100 (2015). https://doi.org/10.3109/08830185.2014.969421CrossRefPubMed

65.

Q. Yang, Y. Li, J Mol Med (Berl) 85, 697–706 (2007). https://doi.org/10.1007/s00109-007-0170-9CrossRefPubMed

66.

S. Liu, H. Zhang, Y. Li, Y. Zhang, Y. Bian, Y. Zeng, X. Yao, J. Wan, X. Chen, J. Li, Z. Wang and Z. Qin, J Immunother Cancer 9, e002548 (2021). https://doi.org/10.1136/jitc-2021-002548

67.

Q. Zhang, H. Wang, C. Mao, M. Sun, G. Dominah, L. Chen, Z. Zhuang, Mol Immunol 94, 27–35 (2018). https://doi.org/10.1016/j.molimm.2017.12.011CrossRefPubMed

68.

L. Wu, X. Zhang, L. Zheng, H. Zhao, G. Yan, Q. Zhang, Y. Zhou, J. Lei, J. Zhang, J. Wang, R. Xin, L. Jiang, J. Peng, Q. Chen, S.M. Lam, G. Shui, H. Miao, Y. Li, Cancer Immunol Res 8, 710–721 (2020). https://doi.org/10.1158/2326-6066.Cir-19-0261CrossRefPubMed

69.

Z. Niu, Q. Shi, W. Zhang, Y. Shu, N. Yang, B. Chen, Q. Wang, X. Zhao, J. Chen, N. Cheng, X. Feng, Z. Hua, J. Ji, P. Shen, Nat Commun 8, 766 (2017). https://doi.org/10.1038/s41467-017-00523-6CrossRefPubMedPubMedCentral

70.

G. Gionfriddo, P. Plastina, G. Augimeri, S. Catalano, C. Giordano, I. Barone, C. Morelli, F. Giordano, L. Gelsomino, D. Sisci, R. Witkamp, S. Andò, K. van Norren and D. Bonofiglio, Cells 9, 174 (2020). https://doi.org/10.3390/cells9010174

71.

S. Qiao, C. Lv, Y. Tao, Y. Miao, Y. Zhu, W. Zhang, D. Sun, X. Yun, Y. Xia, Z. Wei, Y. Dai, Cancer Lett 491, 162–179 (2020). https://doi.org/10.1016/j.canlet.2020.08.033CrossRefPubMed

72.

Z. Chi, S. Chen, T. Xu, W. Zhen, W. Yu, D. Jiang, X. Guo, Z. Wang, K. Zhang, M. Li, J. Zhang, H. Fang, D. Yang, Q. Ye, X. Yang, H. Lin, F. Yang, X. Zhang, D. Wang, Mol Cell 80, 43-58.e47 (2020). https://doi.org/10.1016/j.molcel.2020.08.015CrossRefPubMed

73.

Y. Yang, Y. Wang, L. Guo, W. Gao, T.L. Tang, M. Yan, Cell Death Dis 13, 355 (2022). https://doi.org/10.1038/s41419-022-04775-zCrossRefPubMedPubMedCentral

74.

C. Zhang, X. Liu, S. Jin, Y. Chen, R. Guo, Mol Cancer 21, 47 (2022). https://doi.org/10.1186/s12943-022-01530-yCrossRefPubMedPubMedCentral

75.

L.G. Li, X.C. Peng, T.T. Yu, H.Z. Xu, N. Han, X.X. Yang, Q.R. Li, J. Hu, B. Liu, Z.Y. Yang, X. Xu, X. Chen, M.F. Wang, T.F. Li, Front Pharmacol 13, 949835 (2022). https://doi.org/10.3389/fphar.2022.949835CrossRefPubMedPubMedCentral

76.

Z. Gu, T. Liu, C. Liu, Y. Yang, J. Tang, H. Song, Y. Wang, Y. Yang, C. Yu, Nano Lett 21, 6471–6479 (2021). https://doi.org/10.1021/acs.nanolett.1c01401CrossRefPubMed

77.

X. Hao, Z. Zheng, H. Liu, Y. Zhang, J. Kang, X. Kong, D. Rong, G. Sun, G. Sun, L. Liu, H. Yu, W. Tang, X. Wang, Redox Biol 56, 102463 (2022). https://doi.org/10.1016/j.redox.2022.102463CrossRefPubMedPubMedCentral

78.

T. Liu, C. Zhu, X. Chen, G. Guan, C. Zou, S. Shen, J. Wu, Y. Wang, Z. Lin, L. Chen, P. Cheng, W. Cheng, A. Wu, Neuro Oncol 24, 1113–1125 (2022). https://doi.org/10.1093/neuonc/noac033CrossRefPubMedPubMedCentral

79.

V. Ejigah, O. Owoseni, P. Bataille-Backer, O.D. Ogundipe, F.A. Fisusi and S.K. Adesina, Polymers (Basel) 14, 2601 (2022). https://doi.org/10.3390/polym14132601

80.

N. Kumari, S.H. Choi, J Exp Clin Cancer Res 41, 68 (2022). https://doi.org/10.1186/s13046-022-02272-xCrossRefPubMedPubMedCentral

81.

B. Dalzon, M. Guidetti, D. Testemale, S. Reymond, O. Proux, J. Vollaire, V. Collin-Faure, I. Testard, D. Fenel, G. Schoehn, J. Arnaud, M. Carrière, V. Josserand, T. Rabilloud, C. Aude-Garcia, Nanoscale 11, 9341–9352 (2019). https://doi.org/10.1039/c8nr03364aCrossRefPubMed

82.

E. Blanco, H. Shen, M. Ferrari, Nat Biotechnol 33, 941–951 (2015). https://doi.org/10.1038/nbt.3330CrossRefPubMedPubMedCentral

83.

X. Sun, D. Gao, L. Gao, C. Zhang, X. Yu, B. Jia, F. Wang, Z. Liu, Theranostics 5, 597–608 (2015). https://doi.org/10.7150/thno.11546CrossRefPubMedPubMedCentral

84.

Y. Hattori, J. Yamashita, C. Sakaida, K. Kawano, E. Yonemochi, J Liposome Res 25, 131–140 (2015). https://doi.org/10.3109/08982104.2014.954128CrossRefPubMed

85.

Y. Qian, S. Qiao, Y. Dai, G. Xu, B. Dai, L. Lu, X. Yu, Q. Luo, Z. Zhang, ACS Nano 11, 9536–9549 (2017). https://doi.org/10.1021/acsnano.7b05465CrossRefPubMed

86.

Y.W. Choo, M. Kang, H.Y. Kim, J. Han, S. Kang, J.R. Lee, G.J. Jeong, S.P. Kwon, S.Y. Song, S. Go, M. Jung, J. Hong, B.S. Kim, Acta Biomater 154, 478–496 (2022). https://doi.org/10.1016/j.actbio.2022.10.032CrossRef

87.

W.J. Xu, J.X. Cai, Y.J. Li, J.Y. Wu, D. Xiang, Drug Deliv Transl Res 12, 2287–2302 (2022). https://doi.org/10.1007/s13346-021-01110-5CrossRefPubMed

88.

M.S. Kim, M.J. Haney, Y. Zhao, D. Yuan, I. Deygen, N.L. Klyachko, A.V. Kabanov, E.V. Batrakova, Nanomedicine 14, 195–204 (2018). https://doi.org/10.1016/j.nano.2017.09.011CrossRefPubMed

89.

W. Nie, G. Wu, J. Zhang, L.L. Huang, J. Ding, A. Jiang, Y. Zhang, Y. Liu, J. Li, K. Pu, H.Y. Xie, Angew Chem Int Ed Engl 59, 2018–2022 (2020). https://doi.org/10.1002/anie.201912524CrossRefPubMed

90.

N. Khatoon, Z. Zhang, C. Zhou, M. Chu, Biomater Sci 10, 1193–1208 (2022). https://doi.org/10.1039/d1bm01664dCrossRefPubMed

91.

Y. Xia, L. Rao, H. Yao, Z. Wang, P. Ning, X. Chen, Adv Mater 32, e2002054 (2020). https://doi.org/10.1002/adma.202002054CrossRefPubMed

92.

Y.W. Choo, M. Kang, H.Y. Kim, J. Han, S. Kang, J.R. Lee, G.J. Jeong, S.P. Kwon, S.Y. Song, S. Go, M. Jung, J. Hong, B.S. Kim, ACS Nano 12, 8977–8993 (2018). https://doi.org/10.1021/acsnano.8b02446CrossRefPubMed

93.

N.R. Fuentes, E. Kim, Y.Y. Fan, R.S. Chapkin, Mol Aspects Med 64, 79–91 (2018). https://doi.org/10.1016/j.mam.2018.04.001CrossRefPubMedPubMedCentral

94.

A. Remmerie, C.L. Scott, Cell Immunol 330, 27–42 (2018). https://doi.org/10.1016/j.cellimm.2018.01.020CrossRefPubMedPubMedCentral

95.

J.K. Kao, S.C. Wang, L.W. Ho, S.W. Huang, C.H. Lee, M.S. Lee, R.C. Yang, J.J. Shieh, Ann Hematol 99, 431–441 (2020). https://doi.org/10.1007/s00277-020-03916-8CrossRefPubMed

96.

D.G. Hardie, D.A. Pan, Biochem Soc Trans 30, 1064–1070 (2002). https://doi.org/10.1042/bst0301064CrossRefPubMed

97.

K.J. Hiam-Galvez, B.M. Allen, M.H. Spitzer, Nat Rev Cancer 21, 345–359 (2021). https://doi.org/10.1038/s41568-021-00347-zCrossRefPubMedPubMedCentral

98.

H. Wu, Y. Han, Y. Rodriguez Sillke, H. Deng, S. Siddiqui, C. Treese, F. Schmidt, M. Friedrich, J. Keye, J. Wan, Y. Qin, A.A. Kühl, Z. Qin, B. Siegmund and R. Glauben, EMBO Mol Med 11, e10698 (2019). https://doi.org/10.15252/emmm.201910698

99.

L. Sun, T. Kees, A.S. Almeida, B. Liu, X.Y. He, D. Ng, X. Han, D.L. Spector, I.A. McNeish, P. Gimotty, S. Adams, M. Egeblad, Cancer Cell 39, 1361–13741369 (2021). https://doi.org/10.1016/j.ccell.2021.08.005CrossRefPubMedPubMedCentral

100.

S. Ogino, J.A. Nowak, T. Hamada, A.I. Phipps, U. Peters, D.A. Milner Jr., E.L. Giovannucci, R. Nishihara, M. Giannakis, W.S. Garrett, M. Song, Gut 67, 1168–1180 (2018). https://doi.org/10.1136/gutjnl-2017-315537CrossRefPubMed

101.

H. Miao, J. Ou, Y. Peng, X. Zhang, Y. Chen, L. Hao, G. Xie, Z. Wang, X. Pang, Z. Ruan, J. Li, L. Yu, B. Xue, H. Shi, C. Shi, H. Liang, Nat Commun 7, 11716 (2016). https://doi.org/10.1038/ncomms11716CrossRefPubMedPubMedCentral

102.

Z. Li, C. Sun, Z. Qin, Theranostics 11, 8322–8336 (2021). https://doi.org/10.7150/thno.62378CrossRefPubMedPubMedCentral

Titel: Targeting the lipid metabolic reprogramming of tumor-associated macrophages: A novel insight into cancer immunotherapy
verfasst von: Liang Li
Si-Rui Ma
Zi-Li Yu
Publikationsdatum: 30.09.2023
Verlag: Springer Netherlands
Erschienen in: Cellular Oncology / Ausgabe 2/2024
Print ISSN: 2211-3428
Elektronische ISSN: 2211-3436
DOI: https://doi.org/10.1007/s13402-023-00881-y

Inhibition of thioredoxin-1 enhances the toxicity of glycolysis inhibitor 2-deoxyglucose by downregulating SLC1A5 expression in colorectal cancer cells

Research

Identifying cancer subtypes based on embryonic and hematopoietic stem cell signatures in pan-cancer

Research

Exploration of molecular markers related to chemotherapy efficacy of hepatoid adenocarcinoma of the stomach

Research

Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer

Open Access
Research

The microbiota and renal cell carcinoma

Review

From basic research to clinical application: targeting fibroblast activation protein for cancer diagnosis and treatment

Review

Neu im Fachgebiet Pathologie

Overview of a comparative analysis of microsatellite instability and standard mismatch repair protein-deficiency tests in a large cancer cohort

Hauptreferate: Hauptprogramm der DGP

A retrospective analysis was carried out based on a large cancer patient cohort of our institute ( n  = 1306; collected from 2018 to 2023). dMMR was tested by four IHC reactions (MLH1 and PMS2 or MSH2 and MSH 6). Further, parallel pentaplex …

Molekulare Testung bei mesenchymalen Neoplasien: Was, wann und wie testen?

Sarkome
Übersichtsartikel

Mit dem weit verbreiteten Einsatz diverser molekularer Methoden in der histopathologischen Routinediagnostik hat die Tumorklassifikation in den letzten beiden Jahrzehnten signifikante Fortschritte gemacht. Dabei wurden zum einen zahlreiche …

Reconstructing 3D histological structures using machine learning (artificial intelligence) algorithms

Hauptreferate: Hauptprogramm der DGP

Artificial intelligence (AI) has recently been applied to pathological and medical image analysis with high sensitivity and specificity [ 1 , 2 ], aiding in various dental diagnostic techniques. The use of AI in image annotation has enhanced the …

Key considerations when implementing new diagnostic technologies in routine practice

Hauptreferate: Arbeitsgemeinschaften der DGP

This review explores several key considerations that are critical for implementing new diagnostic technologies into routine practice. These elements will provide a comprehensive guide for navigating the complexities of integrating cutting-edge …

Springer Medizin

Targeting the lipid metabolic reprogramming of tumor-associated macrophages: A novel insight into cancer immunotherapy

Abstract

Background

Conclusion

Weitere Artikel der Ausgabe 2/2024

Inhibition of thioredoxin-1 enhances the toxicity of glycolysis inhibitor 2-deoxyglucose by downregulating SLC1A5 expression in colorectal cancer cells

Identifying cancer subtypes based on embryonic and hematopoietic stem cell signatures in pan-cancer

Exploration of molecular markers related to chemotherapy efficacy of hepatoid adenocarcinoma of the stomach

Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer

The microbiota and renal cell carcinoma

From basic research to clinical application: targeting fibroblast activation protein for cancer diagnosis and treatment

Neu im Fachgebiet Pathologie

Overview of a comparative analysis of microsatellite instability and standard mismatch repair protein-deficiency tests in a large cancer cohort

Molekulare Testung bei mesenchymalen Neoplasien: Was, wann und wie testen?

Reconstructing 3D histological structures using machine learning (artificial intelligence) algorithms

Key considerations when implementing new diagnostic technologies in routine practice

Springer Medizin

Abstract

Background

Conclusion

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