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Current Treatment Options in Oncology

Erschienen in:

01.03.2018 | Genitourinary Cancers (N Agarwal, Section Editor)

Targeting the Tumor Microenvironment with Immunotherapy for Genitourinary Malignancies

verfasst von: Ariel E. Marciscano, MD, Ravi A. Madan, MD

Erschienen in: Current Treatment Options in Oncology | Ausgabe 3/2018

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Opinion statement

Bacillus Calmette-Guérin in urothelial carcinoma, high-dose interleukin-2 in renal cell carcinoma, and sipuleucel-T in prostate cancer serve as enduring examples that the host immune response can be harnessed to promote effective anti-tumor immunity in genitourinary malignancies. Recently, cancer immunotherapy with immune checkpoint inhibitors has transformed the prognostic landscape leading to durable responses in a subset of urothelial carcinoma and renal cell carcinoma patients with traditionally poor prognosis. Despite this success, many patients fail to respond to immune checkpoint inhibitors and progression/relapse remains common. Furthermore, modest clinical activity has been observed with ICIs as a monotherapy in advanced PCa. As such, novel treatment approaches are warranted and improved biomarkers for patient selection and treatment response are desperately needed. Future efforts should focus on exploring synergistic and rational combinations that safely and effectively boost response rates and survival in genitourinary malignancies. Specific areas of interest include (1) evaluating the optimal sequencing, disease burden, and timing of immuno-oncology agents with other anti-cancer therapeutics and (2) validating novel biomarkers of response to immunotherapy to optimize patient selection and to identify individuals most likely to benefit from immunotherapy across the heterogenous spectrum of genitourinary malignancies.

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Titel: Targeting the Tumor Microenvironment with Immunotherapy for Genitourinary Malignancies
verfasst von: Ariel E. Marciscano, MD
Ravi A. Madan, MD
Publikationsdatum: 01.03.2018
Verlag: Springer US
Erschienen in: Current Treatment Options in Oncology / Ausgabe 3/2018
Print ISSN: 1527-2729
Elektronische ISSN: 1534-6277
DOI: https://doi.org/10.1007/s11864-018-0523-3

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Targeting the Tumor Microenvironment with Immunotherapy for Genitourinary Malignancies

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie