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The Cerebellum
Erschienen in:

01.06.2019 | Review

Task Force Paper On Cerebellar Transplantation: Are We Ready to Treat Cerebellar Disorders with Cell Therapy?

verfasst von: Jan Cendelin, Annalisa Buffo, Hirokazu Hirai, Lorenzo Magrassi, Hiroshi Mitoma, Rachel Sherrard, Frantisek Vozeh, Mario Manto

Erschienen in: The Cerebellum | Ausgabe 3/2019

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Abstract

Restoration of damaged central nervous system structures, functional recovery, and prevention of neuronal loss during neurodegenerative diseases are major objectives in cerebellar research. The highly organized anatomical structure of the cerebellum with numerous inputs/outputs, the complexity of cerebellar functions, and the large spectrum of cerebellar ataxias render therapies of cerebellar disorders highly challenging. There are currently several therapeutic approaches including motor rehabilitation, neuroprotective drugs, non-invasive cerebellar stimulation, molecularly based therapy targeting pathogenesis of the disease, and neurotransplantation. We discuss the goals and possible beneficial mechanisms of transplantation therapy for cerebellar damage and its limitations and factors determining outcome.
Literatur
1.
Rossi F, Cattaneo E. Opinion: neural stem cell therapy for neurological diseases: dreams and reality. Nat Rev Neurosci. 2002;3:401–9.CrossRefPubMed
2.
Carletti B, Piemonte F, Rossi F. Neuroprotection: the emerging concept of restorative neural stem cell biology for the treatment of neurodegenerative diseases. Curr Neuropharmacol. 2011;9:313–7.CrossRefPubMedPubMedCentral
3.
4.
Cendelin J. Transplantation and stem cell therapy for cerebellar degenerations. Cerebellum. 2016b;15:48–50.CrossRefPubMed
5.
Kumar A, Narayanan K, Chaudhary RK, Mishra S, Kumar S, Vinoth KJ, et al. Current perspective of stem cell therapy in neurodegenerative and metabolic diseases. Mol Neurobiol. 2017;54(9):7276–96.CrossRefPubMed
6.
Cendelin J, Mitoma H, Manto M. Neurotransplantation therapy and cerebellar reserve. CNS Neurol Disord Drug Targets. 2018a;17(3):172–83.CrossRefPubMed
7.
Grade S, Gotz M. Neuronal replacement therapy: previous achievements and challenges ahead. NPJ Regener Med. 2017;2:29.CrossRef
8.
9.
Barker RA, Barrett J, Mason SL, Bjorklund A. Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson’s disease. Lancet Neurol. 2013;12:84–91.CrossRefPubMed
10.
Barker RA, Studer L, Cattaneo E, Takahashi J. G-Force PD: a global initiative in coordinating stem cell-based dopamine treatments for Parkinson’s disease. NPJ Park Dis. 2015;1:15017.CrossRef
11.
Sotelo C, Alvarado-Mallart RM. Embryonic and adult neurons interact to allow Purkinje cell replacement in mutant cerebellum. Nature. 1987;327:421–3.CrossRefPubMed
12.
Triarhou LC, Low WC, Ghetti B. Transplantation of cerebellar anlagen to hosts with genetic cerebellocortical atrophy. Anat Embryol. 1987;176:145–54.CrossRefPubMed
13.
Kohsaka S, Takayama H, Ueda T, Toya S, Tsukada Y. Reorganization of cerebellar cell suspension transplanted into the weaver mutant cerebellum and immunohistochemical detection of synaptic formation. Neurosci Res. 1988;6:162–6.CrossRefPubMed
14.
Dumesnil-Bousez N, Sotelo C. Partial reconstruction of the adult Lurcher cerebellar circuitry by neural grafting. Neuroscience. 1993;55:1–21.CrossRefPubMed
15.
Tomey DA, Heckroth JA. Transplantation of normal embryonic cerebellar cell suspensions into the cerebellum of lurcher mutant mice. Exp Neurol. 1993;122:165–70.CrossRefPubMed
16.
Heckroth JA, Hobart NJ, Summers D. Transplanted neurons alter the course of neurodegenerative disease in Lurcher mutant mice. Exp Neurol. 1998;154:336–52.CrossRefPubMed
17.
Cendelin J, Korelusova I, Vozeh F. A preliminary study of solid embryonic cerebellar graft survival in adult B6CBA Lurcher mutant and wild type mice. Anat Rec (Hoboken). 2009;292:1986–92.CrossRef
18.
Cendelin J, Babuska V, Korelusova I, Houdek Z, Vozeh F. Long-term survival of solid embryonic cerebellar grafts in Lurcher mice. Neurosci Lett. 2012;515:23–7.CrossRefPubMed
19.
Purkartova Z, Tuma J, Pesta M, Kulda V, Hajkova L, Sebesta O, et al. Morphological analysis of embryonic cerebellar grafts in SCA2 mice. Neurosci Lett. 2014;558:154–8.CrossRefPubMed
20.
Cendelin J, Purkartova Z, Kubik J, Ulbricht E, Tichanek F, Kolinko Y. Long-term development of embryonic cerebellar grafts in two strains of lurcher mice. Cerebellum. 2018b;17(4):428–37.CrossRefPubMed
21.
Li J, Imitola J, Snyder EY, Sidman RL. Neural stem cells rescue nervous Purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets. J Neurosci. 2006;26:7839–48.CrossRefPubMedPubMedCentral
22.
Roybon L, Ma Z, Asztely F, Fosum A, Jacobsen SE, Brundin P, et al. Failure of transdifferentiation of adult hematopoietic stem cells into neurons. Stem Cells. 2006;24:1594–604.CrossRefPubMed
23.
Sidman RL, Li J, Stewart GR, Clarke J, Yang W, Snyder EY, et al. Injection of mouse and human neural stem cells into neonatal Niemann-Pick A model mice. Brain Res. 2007;1140:195–204.CrossRefPubMed
24.
Chen KA, Lanuto D, Zheng T, Steindler DA. Transplantation of embryonic and adult neural stem cells in the granuloprival cerebellum of the weaver mutant mouse. Stem Cells. 2009;27:1625–34.CrossRefPubMedPubMedCentral
25.
Chintawar S, Hourez R, Ravella A, Gall D, Orduz D, Rai M, et al. Grafting neural precursor cells promotes functional recovery in an SCA1 mouse model. J Neurosci. 2009;29:13126–35.CrossRefPubMedPubMedCentral
26.
Jaderstad J, Jaderstad LM, Li J, Chintawar S, Salto C, Pandolfo M, et al. Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and the host. Proc Natl Acad Sci U S A. 2010;107:5184–9.CrossRefPubMedPubMedCentral
27.
Takayama H, Kohsaka S, Shinozaki T, Inoue H, Toya S, Ueda T, et al. Immunohistochemical studies on synapse formation by embryonic cerebellar tissue transplanted into the cerebellum of the weaver mutant mouse. Neurosci Lett. 1987;79:246–50.CrossRefPubMed
28.
Takayama H, Toya S, Shinozaki T, Inoue H, Otani M, Kohsaka S, et al. Possible synapse formation by embryonic cerebellar tissue grafted into the cerebellum of the weaver mutant mouse. Acta Neurochir Suppl. 1988;43:154–8.PubMed
29.
Gardette R, Alvarado-Mallart RM, Crepel F, Sotelo C. Electrophysiological demonstration of a synaptic integration of transplanted Purkinje cells into the cerebellum of the adult Purkinje cell degeneration mutant mouse. Neuroscience. 1988;24:777–89.CrossRefPubMed
30.
Sotelo C, Alvarado-Mallart RM. The reconstruction of cerebellar circuits. Trends Neurosci. 1991;14:350–5.CrossRefPubMed
31.
Triarhou LC, Zhang W, Lee WH. Graft-induced restoration of function in hereditary cerebellar ataxia. Neuroreport. 1995;6:1827–32.CrossRefPubMed
32.
Triarhou LC, Zhang W, Lee WH. Amelioration of the behavioral phenotype in genetically ataxic mice through bilateral intracerebellar grafting of fetal Purkinje cells. Cell Transplant. 1996;5:269–77.CrossRefPubMed
33.
Kaemmerer WF, Low WC. Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1. Exp Neurol. 1999;158:301–11.CrossRefPubMed
34.
Babuska V, Houdek Z, Tuma J, Purkartova Z, Tumova J, Kralickova M, et al. Transplantation of embryonic cerebellar grafts improves gait parameters in ataxic lurcher mice. Cerebellum. 2015;14:632–41.CrossRefPubMed
35.
Fuca E, Guglielmotto M, Boda E, Rossi F, Leto K, Buffo A. Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice. Neurobiol Dis. 2017;102:49–59.CrossRefPubMed
36.
Bae JS, Furuya S, Ahn SJ, Yi SJ, Hirabayashi Y, Jin HK. Neuroglial activation in Niemann-Pick type C mice is suppressed by intracerebral transplantation of bone marrow-derived mesenchymal stem cells. Neurosci Lett. 2005;381:234–6.CrossRefPubMed
37.
Jones J, Jaramillo-Merchan J, Bueno C, Pastor D, Viso-Leon M, Martinez S. Mesenchymal stem cells rescue Purkinje cells and improve motor functions in a mouse model of cerebellar ataxia. Neurobiol Dis. 2010;40:415–23.CrossRefPubMed
38.
Lee H, Lee JK, Min WK, Bae JH, He X, Schuchman EH, et al. Bone marrow-derived mesenchymal stem cells prevent the loss of Niemann-Pick type C mouse Purkinje neurons by correcting sphingolipid metabolism and increasing sphingosine-1-phosphate. Stem Cells. 2010;28:821–31.CrossRefPubMed
39.
Matsuura S, Shuvaev AN, Iizuka A, Nakamura K, Hirai H. Mesenchymal stem cells ameliorate cerebellar pathology in a mouse model of spinocerebellar ataxia type 1. Cerebellum. 2014;13:323–30.CrossRefPubMed
40.
Mendonca LS, Nobrega C, Hirai H, Kaspar BK, Pereira de Almeida L. Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice. Brain. 2015;138:320–35.CrossRefPubMed
41.
42.
Bae JS, Carter JE, Jin HK. Adipose tissue-derived stem cells rescue Purkinje neurons and alleviate inflammatory responses in Niemann-Pick disease type C mice. Cell Tissue Res. 2010;340:357–69.CrossRefPubMed
43.
Martins LF, Costa RO, Pedro JR, Aguiar P, Serra SC, Teixeira FG, et al. Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF. Sci Rep. 2017;7:4153.CrossRefPubMedPubMedCentral
44.
Reidling JC, Relano-Gines A, Holley SM, Ochaba J, Moore C, Fury B, et al. Human neural stem cell transplantation rescues functional deficits in R6/2 and Q140 Huntington’s disease mice. Stem Cell Rep. 2018;10:58–72.CrossRef
45.
Carter AR, Chen C, Schwartz PM, Segal RA. Brain-derived neurotrophic factor modulates cerebellar plasticity and synaptic ultrastructure. J Neurosci. 2002;22:1316–27.CrossRefPubMed
46.
Huang Y, Ko H, Cheung ZH, Yung KK, Yao T, Wang JJ, et al. Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Exp Neurol. 2012;233:791–8.CrossRefPubMed
47.
Watson LM, Wong MM, Becker EB. Induced pluripotent stem cell technology for modelling and therapy of cerebellar ataxia. Open Biol. 2015;5:150056.CrossRefPubMedPubMedCentral
48.
Wong MMK, Watson LM, Becker EBE. Recent advances in modelling of cerebellar ataxia using induced pluripotent stem cells. J Neurol Neuromedicine. 2017;2:11–5.CrossRefPubMedPubMedCentral
49.
Su HL, Muguruma K, Matsuo-Takasaki M, Kengaku M, Watanabe K, Sasai Y. Generation of cerebellar neuron precursors from embryonic stem cells. Dev Biol. 2006;290:287–96.CrossRefPubMed
50.
51.
Tao O, Shimazaki T, Okada Y, Naka H, Kohda K, Yuzaki M, et al. Efficient generation of mature cerebellar Purkinje cells from mouse embryonic stem cells. J Neurosci Res. 2010;88:234–47.CrossRefPubMed
52.
Muguruma K, Nishiyama A, Ono Y, Miyawaki H, Mizuhara E, Hori S, et al. Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells. Nat Neurosci. 2010;13:1171–80.CrossRefPubMed
53.
Higuera GA, Iaffaldano G, Bedar M, Shpak G, Broersen R, Munshi ST, et al. An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum. Sci Rep. 2017;7:8863.CrossRefPubMedPubMedCentral
54.
Wang S, Wang B, Pan N, Fu L, Wang C, Song G, et al. Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons. Sci Rep. 2015;5:9232.CrossRefPubMedPubMedCentral
55.
Ishida Y, Kawakami H, Kitajima H, Nishiyama A, Sasai Y, Inoue H, et al. Vulnerability of Purkinje cells generated from spinocerebellar ataxia type 6 patient-derived iPSCs. Cell Rep. 2016;17:1482–90.CrossRefPubMed
56.
Sundberg M, Tochitsky I, Buchholz DE, Winden K, Kujala V, Kapur K, et al. Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin. Mol Psychiatry. 2018;23:2167–83.CrossRefPubMedPubMedCentral
57.
Muguruma K, Nishiyama A, Kawakami H, Hashimoto K, Sasai Y. Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells. Cell Rep. 2015;10:537–50.CrossRefPubMed
58.
Watson LM, Wong MMK, Vowles J, Cowley SA, Becker EBE. A simplified method for generating Purkinje cells from human-induced pluripotent stem cells. Cerebellum. 2018;17:419–27.CrossRefPubMedPubMedCentral
59.
Carletti B, Grimaldi P, Magrassi L, Rossi F. Specification of cerebellar progenitors after heterotopic-heterochronic transplantation to the embryonic CNS in vivo and in vitro. J Neurosci. 2002;22:7132–46.CrossRefPubMed
60.
Zhang W, Lee WH, Triarhou LC. Grafted cerebellar cells in a mouse model of hereditary ataxia express IGF-I system genes and partially restore behavioral function. Nat Med. 1996;2:65–71.CrossRefPubMed
61.
62.
Carletti B, Williams IM, Leto K, Nakajima K, Magrassi L, Rossi F. Time constraints and positional cues in the developing cerebellum regulate Purkinje cell placement in the cortical architecture. Dev Biol. 2008;317:147–60.CrossRefPubMed
63.
Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. Nature. 2011;480:547–51.CrossRefPubMedPubMedCentral
64.
Grealish S, Diguet E, Kirkeby A, Mattsson B, Heuer A, Bramoulle Y, et al. Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson’s disease. Cell Stem Cells. 2014;15:653–65.CrossRef
65.
Michelsen KA, Acosta-Verdugo S, Benoit-Marand M, Espuny-Camacho I, Gaspard N, Saha B, et al. Area-specific reestablishment of damaged circuits in the adult cerebral cortex by cortical neurons derived from mouse embryonic stem cells. Neuron. 2015;85:982–97.CrossRefPubMed
66.
Steinbeck JA, Choi SJ, Mrejeru A, Ganat Y, Deisseroth K, Sulzer D, et al. Optogenetics enables functional analysis of human embryonic stem cell-derived grafts in a Parkinson’s disease model. Nat Biotechnol. 2015;33:204–9.CrossRefPubMedPubMedCentral
67.
Falkner S, Grade S, Dimou L, Conzelmann KK, Bonhoeffer T, Gotz M, et al. Transplanted embryonic neurons integrate into adult neocortical circuits. Nature. 2016;539:248–53.CrossRefPubMed
68.
Faedo A, Laporta A, Segnali A, Galimberti M, Besusso D, Cesana E, et al. Differentiation of human telencephalic progenitor cells into MSNs by inducible expression of Gsx2 and Ebf1. Proc Natl Acad Sci U S A. 2017;114:E1234–e42.CrossRefPubMedPubMedCentral
69.
Kikuchi T, Morizane A, Doi D, Magotani H, Onoe H, Hayashi T, et al. Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model. Nature. 2017;548:592–6.CrossRefPubMed
70.
Sotelo C, Alvarado-Mallart RM, Frain M, Vernet M. Molecular plasticity of adult Bergmann fibers is associated with radial migration of grafted Purkinje cells. J Neurosci. 1994;14:124–33.CrossRefPubMed
71.
Miyata T, Nakajima K, Aruga J, Takahashi S, Ikenaka K, Mikoshiba K, et al. Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice. J Comp Neurol. 1996;372:215–28.CrossRefPubMed
72.
Miyata T, Nakajima K, Mikoshiba K, Ogawa M. Regulation of Purkinje cell alignment by reelin as revealed with CR-50 antibody. J Neurosci. 1997;17:3599–609.CrossRefPubMed
73.
Rosenfeld JV, Richards LJ, Bartlett PF. Mutant mouse cerebellum does not provide specific signals for the selective migration and development of transplanted Purkinje cells. Neurosci Lett. 1993;155:19–23.CrossRefPubMed
74.
de Luca A, Vassallo S, Benitez-Temino B, Menichetti G, Rossi F, Buffo A. Distinct modes of neuritic growth in Purkinje neurons at different developmental stages: axonal morphogenesis and cellular regulatory mechanisms. PLoS One. 2009;4:e6848.CrossRefPubMedPubMedCentral
75.
Kordower JH, Goetz CG, Chu Y, Halliday GM, Nicholson DA, Musial TF, et al. Robust graft survival and normalized dopaminergic innervation do not obligate recovery in a Parkinson disease patient. Ann Neurol. 2017;81:46–57.CrossRefPubMedPubMedCentral
76.
Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341:738–46.CrossRef
77.
Krampera M, Franchini M, Pizzolo G, Aprili G. Mesenchymal stem cells: from biology to clinical use. Blood Transfus. 2007;5:120–9.PubMedPubMedCentral
78.
Johnson TV, DeKorver NW, Levasseur VA, Osborne A, Tassoni A, Lorber B, et al. Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome. Brain. 2014;137:503–19.CrossRefPubMed
79.
Yang Y, Ye Y, Su X, He J, Bai W, He X. MSCs-derived exosomes and neuroinflammation, neurogenesis and therapy of traumatic brain injury. Front Cell Neurosci. 2017;11:55.PubMedPubMedCentral
80.
Lo Furno D, Mannino G, Giuffrida R. Functional role of mesenchymal stem cells in the treatment of chronic neurodegenerative diseases. J Cell Physiol. 2018;233:3982–99.CrossRefPubMed
81.
Chang YK, Chen MH, Chiang YH, Chen YF, Ma WH, Tseng CY, et al. Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells. J Biomed Sci. 2011;18:54.CrossRefPubMedPubMedCentral
82.
Mieda T, Suto N, Iizuka A, Matsuura S, Iizuka H, Takagishi K, et al. Mesenchymal stem cells attenuate peripheral neuronal degeneration in spinocerebellar ataxia type 1 knockin mice. J Neurosci Res. 2016;94:246–52.CrossRefPubMed
83.
Chen KA, Cruz PE, Lanuto DJ, Flotte TR, Borchelt DR, Srivastava A, et al. Cellular fusion for gene delivery to SCA1 affected Purkinje neurons. Mol Cell Neurosci. 2011;47:61–70.CrossRefPubMedPubMedCentral
84.
Bae JS, Han HS, Youn DH, Carter JE, Modo M, Schuchman EH, et al. Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with neurodegeneration. Stem Cells. 2007;25:1307–16.CrossRefPubMed
85.
Huda F, Fan Y, Suzuki M, Konno A, Matsuzaki Y, Takahashi N, et al. Fusion of human fetal mesenchymal stem cells with “degenerating” cerebellar neurons in spinocerebellar ataxia type 1 model mice. PLoS One. 2016;11:e0164202.CrossRefPubMedPubMedCentral
86.
Weimann JM, Johansson CB, Trejo A, Blau HM. Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat Cell Biol. 2003;5:959–66.CrossRefPubMed
87.
Johansson CB, Youssef S, Koleckar K, Holbrook C, Doyonnas R, Corbel SY, et al. Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation. Nat Cell Biol. 2008;10:575–83.CrossRefPubMedPubMedCentral
88.
Magrassi L, Grimaldi P, Ibatici A, Corselli M, Ciardelli L, Castello S, et al. Induction and survival of binucleated Purkinje neurons by selective damage and aging. J Neurosci. 2007;27:9885–92.CrossRefPubMedPubMedCentral
89.
Park HW, Chang JW, Yang YS, Oh W, Hwang JH, Kim DG, et al. The effect of donor-dependent administration of human umbilical cord blood-derived mesenchymal stem cells following focal cerebral ischemia in rats. Exp Neurol. 2015;24:358–65.
90.
Sherrard RM, Bower AJ. Climbing fiber development: do neurotrophins have a part to play? Cerebellum. 2002;1:265–75.CrossRefPubMed
91.
Wilkins A, Kemp K, Ginty M, Hares K, Mallam E, Scolding N. Human bone marrow-derived mesenchymal stem cells secrete brain-derived neurotrophic factor which promotes neuronal survival in vitro. Stem Cell Res. 2009;3:63–70.CrossRefPubMed
92.
Dusart I, Airaksinen MS, Sotelo C. Purkinje cell survival and axonal regeneration are age dependent: an in vitro study. J Neurosci. 1997;17:3710–26.CrossRefPubMed
93.
Eisenman LM, Schalekamp MP, Voogd J. Development of the cerebellar cortical efferent projection: an in-vitro anterograde tracing study in rat brain slices. Brain Res Dev Brain Res. 1991;60:261–6.CrossRefPubMed
94.
Goffinet AM. The embryonic development of the cerebellum in normal and reeler mutant mice. Anat Embryol. 1983;168:73–86.CrossRefPubMed
95.
96.
Kapfhammer JP. Cellular and molecular control of dendritic growth and development of cerebellar Purkinje cells. Prog Histochem Cytochem. 2004;39:131–82.CrossRefPubMed
97.
Sotelo C, Dusart I. Intrinsic versus extrinsic determinants during the development of Purkinje cell dendrites. Neuroscience. 2009;162:589–600.CrossRefPubMed
98.
Torres-Aleman I, Pons S, Arevalo MA. The insulin-like growth factor I system in the rat cerebellum: developmental regulation and role in neuronal survival and differentiation. J Neurosci Res. 1994;39:117–26.CrossRefPubMed
99.
Nieto-Bona MP, Garcia-Segura LM, Torres-Aleman I. Transynaptic modulation by insulin-like growth factor I of dendritic spines in Purkinje cells. Int J Dev Neurosci. 1997;15:749–54.CrossRefPubMed
100.
Sadakata T, Kakegawa W, Mizoguchi A, Washida M, Katoh-Semba R, Shutoh F, et al. Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. J Neurosci. 2007;27:2472–82.CrossRefPubMedPubMedCentral
101.
Borghesani PR, Peyrin JM, Klein R, Rubin J, Carter AR, Schwartz PM, et al. BDNF stimulates migration of cerebellar granule cells. Development. 2002;129:1435–42.PubMed
102.
Tsutsui K, Ukena K, Sakamoto H, Okuyama S, Haraguchi S. Biosynthesis, mode of action, and functional significance of neurosteroids in the Purkinje cell. Front Endocrinol. 2011;2:61.
103.
Chen S, Hillman DE. Marked reorganization of Purkinje cell dendrites and spines in adult rat following vacating of synapses due to deafferentation. Brain Res. 1982;245:131–5.CrossRefPubMed
104.
Shimada A, Mason CA, Morrison ME. TrkB signaling modulates spine density and morphology independent of dendrite structure in cultured neonatal Purkinje cells. J Neurosci. 1998;18:8559–70.CrossRefPubMed
105.
Ohira K, Funatsu N, Nakamura S, Hayashi M. Expression of BDNF and TrkB receptor subtypes in the postnatal developing Purkinje cells of monkey cerebellum. Gene Expr Patterns. 2004;4:257–61.CrossRefPubMed
106.
Lei L, Parada LF. Transcriptional regulation of Trk family neurotrophin receptors. Cell Mol Life Sci. 2007;64:522–32.CrossRefPubMed
107.
Rossi F, Wiklund L, van der Want JJ, Strata P. Reinnervation of cerebellar Purkinje cells by climbing fibres surviving a subtotal lesion of the inferior olive in the adult rat. I. Development of new collateral branches and terminal plexuses. J Comp Neurol. 1991;308:513–35.CrossRefPubMed
108.
Dhar M, Brenner JM, Sakimura K, Kano M, Nishiyama H. Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum. Nat Commun. 2016;7:12938.CrossRefPubMedPubMedCentral
109.
Dixon KJ, Sherrard RM. Brain-derived neurotrophic factor induces post-lesion transcommissural growth of olivary axons that develop normal climbing fibers on mature Purkinje cells. Exp Neurol. 2006;202:44–56.CrossRefPubMed
110.
Sherrard RM, Bower AJ. IGF-1 induces neonatal climbing-fibre plasticity in the mature rat cerebellum. Neuroreport. 2003;14:1713–6.CrossRefPubMed
111.
Willson ML, McElnea C, Mariani J, Lohof AM, Sherrard RM. BDNF increases homotypic olivocerebellar reinnervation and associated fine motor and cognitive skill. Brain. 2008;131:1099–112.CrossRefPubMed
112.
Sherrard RM, Dixon KJ, Bakouche J, Rodger J, Lemaigre-Dubreuil Y, Mariani J. Differential expression of TrkB isoforms switches climbing fiber-Purkinje cell synaptogenesis to selective synapse elimination. Dev Neurobiol. 2009;69:647–62.CrossRefPubMed
113.
Letellier M, Bailly Y, Demais V, Sherrard RM, Mariani J, Lohof AM. Reinnervation of late postnatal Purkinje cells by climbing fibers: neosynaptogenesis without transient multi-innervation. J Neurosci. 2007;27:5373–83.CrossRefPubMedPubMedCentral
114.
Ribar TJ, Rodriguiz RM, Khiroug L, Wetsel WC, Augustine GJ, Means AR. Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice. J Neurosci. 2000;20:Rc107.CrossRefPubMed
115.
Bosman LW, Hartmann J, Barski JJ, Lepier A, Noll-Hussong M, Reichardt LF, et al. Requirement of TrkB for synapse elimination in developing cerebellar Purkinje cells. Brain Cell Biol. 2006;35:87–101.CrossRefPubMed
116.
Choo M, Miyazaki T, Yamazaki M, Kawamura M, Nakazawa T, Zhang J, et al. Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum. Nat Commun. 2017;8:195.CrossRefPubMedPubMedCentral
117.
Lindvall O. Treatment of Parkinson’s disease using cell transplantation. Philos Trans R Soc Lond Ser B Biol Sci. 2015;370:20140370.CrossRef
118.
Kordower JH, Freeman TB, Snow BJ, Vingerhoets FJ, Mufson EJ, Sanberg PR, et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson’s disease. N Engl J Med. 1995;332:1118–24.CrossRefPubMed
119.
120.
Piccini P, Lindvall O, Bjorklund A, Brundin P, Hagell P, Ceravolo R, et al. Delayed recovery of movement-related cortical function in Parkinson’s disease after striatal dopaminergic grafts. Ann Neurol. 2000;48:689–95.CrossRefPubMed
121.
Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, Kao R, et al. Transplantation of embryonic dopamine neurons for severe Parkinson’s disease. N Engl J Med. 2001;344:710–9.CrossRefPubMed
122.
Olanow CW, Goetz CG, Kordower JH, Stoessl AJ, Sossi V, Brin MF, et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson’s disease. Ann Neurol. 2003;54:403–14.CrossRefPubMed
123.
Piccini P, Pavese N, Hagell P, Reimer J, Bjorklund A, Oertel WH, et al. Factors affecting the clinical outcome after neural transplantation in Parkinson’s disease. Brain. 2005;128:2977–86.CrossRefPubMed
124.
Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med. 2006;12:1259–68.CrossRefPubMed
125.
Bjorklund LM, Sanchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A. 2002;99:2344–9.CrossRefPubMedPubMedCentral
126.
Fukuda H, Takahashi J, Watanabe K, Hayashi H, Morizane A, Koyanagi M, et al. Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation. Stem Cells. 2006;24:763–71.CrossRefPubMed
127.
Bieberich E, Silva J, Wang G, Krishnamurthy K, Condie BG. Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants. J Cell Biol. 2004;167:723–34.CrossRefPubMedPubMedCentral
128.
Parish CL, Parisi S, Persico MG, Arenas E, Minchiotti G. Cripto as a target for improving embryonic stem cell-based therapy in Parkinson’s disease. Stem Cells. 2005;23:471–6.CrossRefPubMed
129.
Xiao B, Ng HH, Takahashi R, Tan EK. Induced pluripotent stem cells in Parkinson’s disease: scientific and clinical challenges. J Neurol Neurosurg Psychiatry. 2016;87:697–702.CrossRefPubMedPubMedCentral
130.
Krystkowiak P, Gaura V, Labalette M, Rialland A, Remy P, Peschanski M, et al. Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington’s disease. PLoS One. 2007;2:e166.CrossRefPubMedPubMedCentral
131.
Morizane A, Li JY, Brundin P. From bench to bed: the potential of stem cells for the treatment of Parkinson’s disease. Cell Tissue Res. 2008;331:323–36.CrossRefPubMed
132.
Ma Y, Feigin A, Dhawan V, Fukuda M, Shi Q, Greene P, et al. Dyskinesia after fetal cell transplantation for parkinsonism: a PET study. Ann Neurol. 2002;52:628–34.CrossRefPubMed
133.
Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson’s disease. Nat Med. 2008a;14:504–6.CrossRefPubMed
134.
Kordower JH, Chu Y, Hauser RA, Olanow CW, Freeman TB. Transplanted dopaminergic neurons develop PD pathologic changes: a second case report. Mov Disord. 2008b;23:2303–6.CrossRefPubMed
135.
136.
Chen X, Tang TS, Tu H, Nelson O, Pook M, Hammer R, et al. Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. J Neurosci. 2008;28:12713–24.CrossRefPubMedPubMedCentral
137.
Boy J, Schmidt T, Wolburg H, Mack A, Nuber S, Bottcher M, et al. Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3. Hum Mol Genet. 2009;18:4282–95.CrossRefPubMed
138.
Liu J, Tang TS, Tu H, Nelson O, Herndon E, Huynh DP, et al. Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. J Neurosci. 2009;29:9148–62.CrossRefPubMedPubMedCentral
139.
Furrer SA, Waldherr SM, Mohanachandran MS, Baughn TD, Nguyen KT, Sopher BL, et al. Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7. Hum Mol Genet. 2013;22:890–903.CrossRefPubMed
140.
Chort A, Alves S, Marinello M, Dufresnois B, Dornbierer JG, Tesson C, et al. Interferon beta induces clearance of mutant ataxin 7 and improves locomotion in SCA7 knock-in mice. Brain. 2013;136:1732–45.CrossRefPubMed
141.
Nobrega C, Nascimento-Ferreira I, Onofre I, Albuquerque D, Hirai H, Deglon N, et al. Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice. PLoS One. 2013;8:e52396.CrossRefPubMedPubMedCentral
142.
Rodriguez-Lebron E, Costa Mdo C, Luna-Cancalon K, Peron TM, Fischer S, Boudreau RL, et al. Silencing mutant ATXN3 expression resolves molecular phenotypes in SCA3 transgenic mice. Mol Ther. 2013;21:1909–18.CrossRefPubMedPubMedCentral
143.
Wang HL, Hu SH, Chou AH, Wang SS, Weng YH, Yeh TH. H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse. Neuropharmacology. 2013;70:1–11.CrossRefPubMed
144.
Ramachandran PS, Bhattarai S, Singh P, Boudreau RL, Thompson S, Laspada AR, et al. RNA interference-based therapy for spinocerebellar ataxia type 7 retinal degeneration. PLoS One. 2014;9:e95362.CrossRefPubMedPubMedCentral
145.
Ilg W, Bastian AJ, Boesch S, Burciu RG, Celnik P, Claassen J, et al. Consensus paper: management of degenerative cerebellar disorders. Cerebellum. 2014;13:248–68.CrossRefPubMedPubMedCentral
146.
147.
Benussi A, Koch G, Cotelli M, Padovani A, Borroni B. Cerebellar transcranial direct current stimulation in patients with ataxia: a double-blind, randomized, sham-controlled study. Mov Disord. 2015;30:1701–5.CrossRefPubMed
148.
Benussi A, Dell’Era V, Cotelli MS, Turla M, Casali C, Padovani A, et al. Long term clinical and neurophysiological effects of cerebellar transcranial direct current stimulation in patients with neurodegenerative ataxia. Brain Stimul. 2017;10:242–50.CrossRefPubMed
Metadaten
Titel
Task Force Paper On Cerebellar Transplantation: Are We Ready to Treat Cerebellar Disorders with Cell Therapy?
verfasst von
Jan Cendelin
Annalisa Buffo
Hirokazu Hirai
Lorenzo Magrassi
Hiroshi Mitoma
Rachel Sherrard
Frantisek Vozeh
Mario Manto
Publikationsdatum
01.06.2019
Verlag
Springer US
Erschienen in
The Cerebellum / Ausgabe 3/2019
Print ISSN: 1473-4222
Elektronische ISSN: 1473-4230
DOI
https://doi.org/10.1007/s12311-018-0999-1

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