Skip to main content
Erschienen in: DNP - Der Neurologe & Psychiater 10/2015

06.10.2015 | Zertifizierte Fortbildung

Neurodegenerative Erkrankungen

Tau (τ)-orientierte Therapien der Alzheimer-Demenz

verfasst von: Prof. Dr. Georg Adler, Prof. Dr. Angelika Mautes

Erschienen in: DNP – Die Neurologie & Psychiatrie | Ausgabe 10/2015

Einloggen, um Zugang zu erhalten

Zusammenfassung

Die τ-(tau)-Protein-orientierten Therapiestrategien bei Alzheimer-Demenz stehen noch am Anfang. Dies liegt wohl vor allem daran, dass die Entwicklung durch die primär intrazelluläre und daher pharmakologisch schlecht zugängliche Lokalisation der τ-Pathologie erschwert ist. Nach bislang eher enttäuschenden Ergebnissen β-Amyloid-orientierter Studien, ist zu erwarten, dass die τ-Protein-orientierten Therapiestrategien in Zukunft mehr Aufmerksamkeit finden werden.
Literatur
1.
Zurück zum Zitat Wimo A, Jonsson L, Bond J, et al. (2013) Alzheimer Disease International. The worldwide economic impact of dementia 2010. Alzheimers Dement 9:1–11CrossRefPubMed Wimo A, Jonsson L, Bond J, et al. (2013) Alzheimer Disease International. The worldwide economic impact of dementia 2010. Alzheimers Dement 9:1–11CrossRefPubMed
2.
Zurück zum Zitat Jack Jr CR, Knopman DS, Jagust WJ et al. (2013) Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 12:207–216PubMedCentralCrossRefPubMed Jack Jr CR, Knopman DS, Jagust WJ et al. (2013) Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 12:207–216PubMedCentralCrossRefPubMed
3.
Zurück zum Zitat Hardy J, Selkoe DJ (2002) The amyoid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 297:353–356CrossRefPubMed Hardy J, Selkoe DJ (2002) The amyoid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 297:353–356CrossRefPubMed
4.
Zurück zum Zitat Ballatore C, Lee VM, Trojanowski JQ (2007) Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders. Nat Rev Neurosci 8:663–672CrossRefPubMed Ballatore C, Lee VM, Trojanowski JQ (2007) Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders. Nat Rev Neurosci 8:663–672CrossRefPubMed
5.
Zurück zum Zitat Bettens K, Sleegers K, Van BC (2013) Genetic insights in Alzheimer’s disease. Lancet Neurol 12:92–104CrossRefPubMed Bettens K, Sleegers K, Van BC (2013) Genetic insights in Alzheimer’s disease. Lancet Neurol 12:92–104CrossRefPubMed
6.
Zurück zum Zitat Bayer AJ, Bullock R, Jones RW, et al. (2005) Evaluation of the safety and immunogenicity of synthetic Aβ (AN1792) in patients with AD. Neurol 64:94–101CrossRef Bayer AJ, Bullock R, Jones RW, et al. (2005) Evaluation of the safety and immunogenicity of synthetic Aβ (AN1792) in patients with AD. Neurol 64:94–101CrossRef
7.
Zurück zum Zitat Holmes C, Boche D, Wilkinson D, et al. (2008) Long-term effects of A 42 immunization in Alzheimer’s disease: immune response, plaque removal and clinical function. Lancet 372: 216–223CrossRefPubMed Holmes C, Boche D, Wilkinson D, et al. (2008) Long-term effects of A 42 immunization in Alzheimer’s disease: immune response, plaque removal and clinical function. Lancet 372: 216–223CrossRefPubMed
9.
Zurück zum Zitat Nelson PT, Alafuzoff I, Bigio EH, et al. (2012) Correlation of Alzheimer’s disease neuropathologic changes with cognitive status: a review of the literature. J Neuropath Exp Neurol 71: 362–381PubMedCentralCrossRefPubMed Nelson PT, Alafuzoff I, Bigio EH, et al. (2012) Correlation of Alzheimer’s disease neuropathologic changes with cognitive status: a review of the literature. J Neuropath Exp Neurol 71: 362–381PubMedCentralCrossRefPubMed
10.
Zurück zum Zitat Kolarova M, García-Sierra F, Bartos A et al. (2012) Structure and pathology of tau protein in Alzheimer’s disease. Int J Alzheimers Dis. Doi:10.1155/2012/731526 Kolarova M, García-Sierra F, Bartos A et al. (2012) Structure and pathology of tau protein in Alzheimer’s disease. Int J Alzheimers Dis. Doi:10.​1155/​2012/​731526
11.
Zurück zum Zitat Frost B, Götz J, Feany MB (2015) Connecting the dots between tau dysfunction and neurodegeneration. Trends Cell Biol 25:46–53CrossRefPubMed Frost B, Götz J, Feany MB (2015) Connecting the dots between tau dysfunction and neurodegeneration. Trends Cell Biol 25:46–53CrossRefPubMed
12.
Zurück zum Zitat Clavaguerra F, Hench J, Goedert M et al. (2015) Invited review: Prion-like transmission and spreading of tau pathology. Neuropathol Appl Neurobiol 41:47–58CrossRef Clavaguerra F, Hench J, Goedert M et al. (2015) Invited review: Prion-like transmission and spreading of tau pathology. Neuropathol Appl Neurobiol 41:47–58CrossRef
14.
Zurück zum Zitat Anand R, Gill KD, Mahdi AA (2014) Therapeutics of Alzheimer’s disease: past, present and future. Neuropharmacology 76:27–50CrossRefPubMed Anand R, Gill KD, Mahdi AA (2014) Therapeutics of Alzheimer’s disease: past, present and future. Neuropharmacology 76:27–50CrossRefPubMed
15.
Zurück zum Zitat Tariot PN, Aisen PS (2009) Can lithium or valproate untie tangles in Alzheimer’s disease? J Clin Psychiatry 70:919–921CrossRefPubMed Tariot PN, Aisen PS (2009) Can lithium or valproate untie tangles in Alzheimer’s disease? J Clin Psychiatry 70:919–921CrossRefPubMed
16.
Zurück zum Zitat Blair LJ, Sabbagh JJ, Dickey CA (2014) Targeting Hsp90 and its co-chaperones to treat Alzheimer’s disease. Expert Opin Ther Targets 18:1219–1232CrossRefPubMed Blair LJ, Sabbagh JJ, Dickey CA (2014) Targeting Hsp90 and its co-chaperones to treat Alzheimer’s disease. Expert Opin Ther Targets 18:1219–1232CrossRefPubMed
18.
Zurück zum Zitat Castillo-Carranza DL, Guerrero-Muñoz MJ, Kayed R (2014) Immunotherapy for the treatment of Alzheimer’s disease: amyloid-β or tau, which is the right target? ImmunoTargets and Therapy 3:19–28 Castillo-Carranza DL, Guerrero-Muñoz MJ, Kayed R (2014) Immunotherapy for the treatment of Alzheimer’s disease: amyloid-β or tau, which is the right target? ImmunoTargets and Therapy 3:19–28
19.
Zurück zum Zitat Mori T, Koyama N, Segawa T et al. (2014) Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice. J Biol Chem 289:30303–30317CrossRefPubMed Mori T, Koyama N, Segawa T et al. (2014) Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice. J Biol Chem 289:30303–30317CrossRefPubMed
20.
Zurück zum Zitat del Ser T, Steinwachs KC, Gertz HJ et al. (2013) Treatment of Alzheimer’s disease with the GSK-3 inhibitor tideglusib: a pilot study. J Alzheimers Dis 33:205–215PubMed del Ser T, Steinwachs KC, Gertz HJ et al. (2013) Treatment of Alzheimer’s disease with the GSK-3 inhibitor tideglusib: a pilot study. J Alzheimers Dis 33:205–215PubMed
21.
Zurück zum Zitat Wischik CM, Staff RT, Wischik DJ et al. (2015) Tau aggregation inhibitor therapy: an exploratory phase 2 study in mild or moderate Alzheimer’s disease. J Alzheimers Dis 44: 705–720PubMed Wischik CM, Staff RT, Wischik DJ et al. (2015) Tau aggregation inhibitor therapy: an exploratory phase 2 study in mild or moderate Alzheimer’s disease. J Alzheimers Dis 44: 705–720PubMed
22.
Zurück zum Zitat Adler G, Mautes AEM (2014) Improvement in behavioral symptoms, motor impairment and activities of daily living in a patient with the behavioral variant of frontotemporal dementia under treatment with methylene blue. Geriatr Ment Health Care 2:1–2CrossRef Adler G, Mautes AEM (2014) Improvement in behavioral symptoms, motor impairment and activities of daily living in a patient with the behavioral variant of frontotemporal dementia under treatment with methylene blue. Geriatr Ment Health Care 2:1–2CrossRef
Metadaten
Titel
Neurodegenerative Erkrankungen
Tau (τ)-orientierte Therapien der Alzheimer-Demenz
verfasst von
Prof. Dr. Georg Adler
Prof. Dr. Angelika Mautes
Publikationsdatum
06.10.2015
Verlag
Urban & Vogel
Erschienen in
DNP – Die Neurologie & Psychiatrie / Ausgabe 10/2015
Print ISSN: 2731-8168
Elektronische ISSN: 2731-8176
DOI
https://doi.org/10.1007/s15202-015-0841-2

Weitere Artikel der Ausgabe 10/2015

DNP - Der Neurologe & Psychiater 10/2015 Zur Ausgabe

Praxis konkret_Berufspolitik

Krankenhaus-MVZ weiter im Aufwind