Background
Methods
Preparation of taurine and tea polyphenols (TPs) combination
Animal experiments
Serum biochemical analysis
Determinations of oxidative stress levels
Histological assessment
Steatosis | Grade 1 | Up to 25% steatosis |
2 | 26% to 50% steatosis | |
3 | 51% to 75% steatosis | |
4 | More than 76% steatosis | |
Inflammation | Grade 1 | Focal collection of mononuclear cells |
2 | Diffuse infiltrates of mononuclear cells | |
3 | Focal collection of polymorphonuclear cells | |
4 | Diffuse infiltrates of polymorphonuclear |
Statistical analysis
Results
Taurine and TPs combination reduces the liver index in NASH rats but not body weights
Nor | Mod | Mod cont | Tau | wsTP | lsTP | Tau + wsTP | Tau + lsTP | |
---|---|---|---|---|---|---|---|---|
Liver index (Mean ± SD) | 0.0269 ± 0.0008 | 0.0331 ± 0.0011a
| 0.0335 ± 0.0014a
| 0.0285 ± 0.0010b
| 0.0291 ± 0.0012b
| 0.0302 ± 0.0007 | 0.0290 ± 0.0011b
| 0.0288 ± 0.0015c
|
n | 13 | 12 | 12 | 12 | 12 | 12 | 12 | 12 |
Taurine and TPs combination improves serum biochemical parameters
Effects of taurine and TPs combination on hepatic oxidative stress
Taurine and TPs combination diminished LPS level in NASH rats
Taurine and TPs combination alleviated steatosis and inflammation in the NASH liver
Group | 1 | 2 | 3 | 4 | χ 2 | Group | 1 | 2 | 3 | 4 | χ 2 | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Steatosis | Nor | 13 | 0 | 0 | 0 | Inflammation | Nor | 13 | 0 | 0 | 0 | ||
Mod | 0 | 0 | 3 | 9 | 49.48a
| Mod | 0 | 0 | 0 | 12 | 53.42a
| ||
Mod cont | 0 | 0 | 1 | 11 | 0.11 | Mod cont | 0 | 0 | 0 | 12 | 0.00 | ||
Tau | 0 | 6 | 6 | 0 | 14.73c
| Tau | 0 | 4 | 8 | 0 | 15.06c
| ||
wsTP | 0 | 6 | 6 | 0 | 10.73 | wsTP | 0 | 4 | 8 | 0 | 9.06 | ||
lsTP | 0 | 8 | 4 | 0 | 14.17c
| lsTP | 0 | 10 | 2 | 0 | 21.55b
| ||
Tau + wsTP | 0 | 9 | 3 | 0 | 16.08c
| Tau + wsTP | 0 | 8 | 4 | 0 | 15.39c
| ||
Tau + lsTP | 0 | 12 | 0 | 0 | 22.50b
| Tau + lsTP | 0 | 12 | 0 | 0 | 23.38b
|
Tau treatment | wsTP treatment | lsTP treatment | Tau + wsTP treatment | ||
---|---|---|---|---|---|
Steatosis | Tau + wsTP treatment | 14.54a
| 14.54a
| / | / |
Tau + lsTP treatment | 2.77a
| / | 2.14b
| 1.81 | |
Inflammation | Tau + wsTP treatment | 1.60 | 1.60 | / | / |
Tau + lsTP treatment | 3.19a
| / | 1.44 | 2.14b
|