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Breast Cancer Research

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01.06.2001 | Commentary

Telomerase and breast cancer

verfasst von: Brittney-Shea Herbert, Woodring E Wright, Jerry W Shay

Erschienen in: Breast Cancer Research | Ausgabe 3/2001

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Abstract

Current therapies for breast cancer include treatments that are toxic and often result in drug resistance. Telomerase, a cellular reverse transcriptase that maintains the ends of chromosomes (telomeres), is activated in the vast majority of breast cancers (over 90% of breast carcinomas) but not in normal adjacent tissues. Telomerase is thus an attractive target for both diagnosis and therapy because of its distinct pattern of expression. We address the use of telomerase in the diagnostics of breast pathology, as well as the use of telomerase inhibitors in the treatment and prevention of breast cancer.

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Titel: Telomerase and breast cancer
verfasst von: Brittney-Shea Herbert
Woodring E Wright
Jerry W Shay
Publikationsdatum: 01.06.2001
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 3/2001
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr288

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