Skip to main content
Erschienen in:

24.09.2021 | Original Article

Telomere lengths in Barrett’s esophagus as a precancerous lesion

verfasst von: Junko Aida, Kaiyo Takubo, Michael Vieth, Horst Neuhaus, Mutsunori Fujiwara, Tomio Arai, Toshiyuki Ishiwata

Erschienen in: Esophagus | Ausgabe 2/2022

Einloggen, um Zugang zu erhalten

Abstract

Background

We have reported that precancerous conditions and lesions invariably have shorter telomeres and associated chromosomal instability relative to normal tissue.

Methods

Using the Q-FISH method and our original software, Tissue Telo, we estimated telomere lengths in cardiac- and intestinal-type mucosae in 48 cases of Barrett’s esophagus (short-segment (SS) n = 18; long-segment (LS) n = 30).

Results

There were no significant differences in telomere length between the cardiac and intestinal types in any of the 48 cases, suggesting that the presence or absence of goblet cells in the columnar segments is unrelated to telomere-dependent chromosomal instability in Barrett’s esophagus. In LS Barrett’s esophagus, telomeres were shorter in cardiac-type than in intestinal-type mucosa, suggesting that the former may play a more important role than the latter as a precancerous lesion in LS. Telomeres in cardiac-type mucosa were longer in SS than in LS, supporting the possibility that cardiac-type LS may pose a higher risk as a precancerous lesion than cardiac-type SS.

Conclusions

Although it has been considered that Barrett’s carcinoma arises only from intestinal-type mucosa, our present findings support previous histogenetic studies suggesting that cardiac-type mucosa is more important as a precancerous condition in Barrett’s esophagus than anticipated.
Literatur
1.
Zurück zum Zitat Blackburn EH. Switching and signaling at the telomere. Cell. 2001;106:661–73.CrossRef Blackburn EH. Switching and signaling at the telomere. Cell. 2001;106:661–73.CrossRef
2.
Zurück zum Zitat de Lange TS. The protein complex that shapes and safeguards human telomeres. Genes Dev. 2005;19:2100–10.CrossRef de Lange TS. The protein complex that shapes and safeguards human telomeres. Genes Dev. 2005;19:2100–10.CrossRef
4.
Zurück zum Zitat Londono-Vallejo JA. Telomere instability and cancer. Biochimie. 2008;90:73–82.CrossRef Londono-Vallejo JA. Telomere instability and cancer. Biochimie. 2008;90:73–82.CrossRef
5.
Zurück zum Zitat Ikeda H, Aida J, Hatamochi A, et al. Quantitative fluorescence in situ hybridization measurement of telomere length in skin with/without sun exposure or actinic keratosis. Hum Pathol. 2014;45:473–80.CrossRef Ikeda H, Aida J, Hatamochi A, et al. Quantitative fluorescence in situ hybridization measurement of telomere length in skin with/without sun exposure or actinic keratosis. Hum Pathol. 2014;45:473–80.CrossRef
6.
Zurück zum Zitat Aida J, Kobayashi T, Saku T, et al. Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia. J Oral Pathol Med. 2012;41:372–8.CrossRef Aida J, Kobayashi T, Saku T, et al. Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia. J Oral Pathol Med. 2012;41:372–8.CrossRef
7.
Zurück zum Zitat Shiraishi H, Mikami T, Aida J, et al. Telomere shortening in Barrett’s mucosa and esophageal adenocarcinoma and its association with loss of heterozygosity. Scand J Gastroenterol. 2009;44:538–44.CrossRef Shiraishi H, Mikami T, Aida J, et al. Telomere shortening in Barrett’s mucosa and esophageal adenocarcinoma and its association with loss of heterozygosity. Scand J Gastroenterol. 2009;44:538–44.CrossRef
8.
Zurück zum Zitat Izumiyama-Shimomura N, Nakamura K, Aida J, et al. Short telomeres and chromosome instability prior to histologic malignant progression and cytogenetic aneuploidy in papillary urothelial neoplasms. Urol Oncol. 2014;32:135–45.CrossRef Izumiyama-Shimomura N, Nakamura K, Aida J, et al. Short telomeres and chromosome instability prior to histologic malignant progression and cytogenetic aneuploidy in papillary urothelial neoplasms. Urol Oncol. 2014;32:135–45.CrossRef
9.
Zurück zum Zitat Aida J, Izumo T, Shimomura N, et al. Telomere lengths in the oral epithelia with and without carcinoma. Eur J Cancer. 2010;46:430–8.CrossRef Aida J, Izumo T, Shimomura N, et al. Telomere lengths in the oral epithelia with and without carcinoma. Eur J Cancer. 2010;46:430–8.CrossRef
10.
Zurück zum Zitat Takubo K, Fujita M, Izumiyama N, et al. Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ. J Pathol. 2010;221:201–9.CrossRef Takubo K, Fujita M, Izumiyama N, et al. Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ. J Pathol. 2010;221:201–9.CrossRef
11.
Zurück zum Zitat Aida J, Yokoyama A, Izumiyama N, et al. Alcoholics show reduced telomere length in the oesophagus. J Pathol. 2011;223:410–6.CrossRef Aida J, Yokoyama A, Izumiyama N, et al. Alcoholics show reduced telomere length in the oesophagus. J Pathol. 2011;223:410–6.CrossRef
12.
Zurück zum Zitat Aida J, Yokoyama A, Shimomura N, et al. Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history. PLoS ONE. 2013;8:e63860.CrossRef Aida J, Yokoyama A, Shimomura N, et al. Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history. PLoS ONE. 2013;8:e63860.CrossRef
13.
Zurück zum Zitat Matsuda Y, Ishiwata T, Izumiyama-Shimomura N, et al. Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas. PLoS ONE. 2015;10:e0117575.CrossRef Matsuda Y, Ishiwata T, Izumiyama-Shimomura N, et al. Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas. PLoS ONE. 2015;10:e0117575.CrossRef
14.
Zurück zum Zitat Aoki Y, Aida J, Kawano Y, et al. Telomere length of gallbladder epithelium is shortened in patients with congenital biliary dilatation: measurement by quantitative fluorescence in situ hybridization. J Gastroenterol. 2018;53:291–301.CrossRef Aoki Y, Aida J, Kawano Y, et al. Telomere length of gallbladder epithelium is shortened in patients with congenital biliary dilatation: measurement by quantitative fluorescence in situ hybridization. J Gastroenterol. 2018;53:291–301.CrossRef
15.
Zurück zum Zitat O’Sullivan JN, Bronner MP, Brentnall TA, et al. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat Genet. 2002;32:280–4.CrossRef O’Sullivan JN, Bronner MP, Brentnall TA, et al. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat Genet. 2002;32:280–4.CrossRef
16.
Zurück zum Zitat Meeker AK, Hicks JL, Iacobuzio-Donahue CA, et al. Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin Cancer Res. 2004;10:3317–26.CrossRef Meeker AK, Hicks JL, Iacobuzio-Donahue CA, et al. Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin Cancer Res. 2004;10:3317–26.CrossRef
17.
Zurück zum Zitat Kim H, Oh BK, Roncalli M, et al. Large liver cell change in hepatitis B virus-related liver cirrhosis. Hepatology (Baltimore, MD). 2009;50:752–62.CrossRef Kim H, Oh BK, Roncalli M, et al. Large liver cell change in hepatitis B virus-related liver cirrhosis. Hepatology (Baltimore, MD). 2009;50:752–62.CrossRef
18.
Zurück zum Zitat Spechler SJ, Goyal RK. The columnar-lined esophagus, intestinal metaplasia, and norman barrett. Gastroenterology. 1996;110:614–21.CrossRef Spechler SJ, Goyal RK. The columnar-lined esophagus, intestinal metaplasia, and norman barrett. Gastroenterology. 1996;110:614–21.CrossRef
19.
Zurück zum Zitat Ruol A, Parenti A, Zaninotto G, et al. Intestinal metaplasia is the probable common precursor of adenocarcinoma in barrett esophagus and adenocarcinoma of the gastric cardia. Cancer. 2000;88:2520–8.CrossRef Ruol A, Parenti A, Zaninotto G, et al. Intestinal metaplasia is the probable common precursor of adenocarcinoma in barrett esophagus and adenocarcinoma of the gastric cardia. Cancer. 2000;88:2520–8.CrossRef
20.
Zurück zum Zitat Takubo K, Aida J, Naomoto Y, et al. Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma. Hum Pathol. 2009;40:65–74.CrossRef Takubo K, Aida J, Naomoto Y, et al. Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma. Hum Pathol. 2009;40:65–74.CrossRef
21.
Zurück zum Zitat Aida J, Vieth M, Shepherd NA, et al. Is Carcinoma in columnar-lined esophagus always located adjacent to intestinal metaplasia?: A histopathologic assessment. Am J Surg Pathol. 2015;39:188–96.CrossRef Aida J, Vieth M, Shepherd NA, et al. Is Carcinoma in columnar-lined esophagus always located adjacent to intestinal metaplasia?: A histopathologic assessment. Am J Surg Pathol. 2015;39:188–96.CrossRef
22.
Zurück zum Zitat Coleman HG, Bhat SK, Murray LJ, et al. Symptoms and endoscopic features at barrett’s esophagus diagnosis: implications for neoplastic progression risk. Am J Gastroenterol. 2014;109:527–34.CrossRef Coleman HG, Bhat SK, Murray LJ, et al. Symptoms and endoscopic features at barrett’s esophagus diagnosis: implications for neoplastic progression risk. Am J Gastroenterol. 2014;109:527–34.CrossRef
23.
Zurück zum Zitat Aida J, Izumiyama-Shimomura N, Nakamura K, et al. Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method. Hum Pathol. 2007;38:1192–200.CrossRef Aida J, Izumiyama-Shimomura N, Nakamura K, et al. Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method. Hum Pathol. 2007;38:1192–200.CrossRef
24.
Zurück zum Zitat Kurabayashi R, Takubo K, Aida J, et al. Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts. Hum Pathol. 2008;39:1647–55.CrossRef Kurabayashi R, Takubo K, Aida J, et al. Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts. Hum Pathol. 2008;39:1647–55.CrossRef
25.
Zurück zum Zitat Aida J, Izumiyama-Shimomura N, Nakamura K, et al. Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium. Exp Gerontol. 2008;43:833–9.CrossRef Aida J, Izumiyama-Shimomura N, Nakamura K, et al. Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium. Exp Gerontol. 2008;43:833–9.CrossRef
26.
Zurück zum Zitat O’Sullivan JN, Finley JC, Risques RA, et al. Telomere length assessment in tissue sections by quantitative FISH: image analysis algorithms. Cytometry A. 2004;58:120–31.CrossRef O’Sullivan JN, Finley JC, Risques RA, et al. Telomere length assessment in tissue sections by quantitative FISH: image analysis algorithms. Cytometry A. 2004;58:120–31.CrossRef
27.
Zurück zum Zitat Ohashi M, Aizawa S, Ooka H, et al. A new human diploid cell strain, TIG-1, for the research on cellular aging. Expl Gerontol. 1980;15:121–33.CrossRef Ohashi M, Aizawa S, Ooka H, et al. A new human diploid cell strain, TIG-1, for the research on cellular aging. Expl Gerontol. 1980;15:121–33.CrossRef
28.
Zurück zum Zitat Takubo K, Aida J, Izumiyama N, et al. Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence. Mech Ageing Dev. 2010;131:614–24.CrossRef Takubo K, Aida J, Izumiyama N, et al. Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence. Mech Ageing Dev. 2010;131:614–24.CrossRef
Metadaten
Titel
Telomere lengths in Barrett’s esophagus as a precancerous lesion
verfasst von
Junko Aida
Kaiyo Takubo
Michael Vieth
Horst Neuhaus
Mutsunori Fujiwara
Tomio Arai
Toshiyuki Ishiwata
Publikationsdatum
24.09.2021
Verlag
Springer Singapore
Erschienen in
Esophagus / Ausgabe 2/2022
Print ISSN: 1612-9059
Elektronische ISSN: 1612-9067
DOI
https://doi.org/10.1007/s10388-021-00884-4

Kompaktes Leitlinien-Wissen Innere Medizin (Link öffnet in neuem Fenster)

Mit medbee Pocketcards schnell und sicher entscheiden.
Leitlinien-Wissen kostenlos und immer griffbereit auf ihrem Desktop, Handy oder Tablet.

Neu im Fachgebiet Innere Medizin

Podcast

Magendarminfekte: Dos and Don'ts bei Kleinkindern

Die Leitlinie zur akuten infektiösen Gastroenteritis wurde 2024 umfassend überarbeitet. Cola und Saft zur oralen Hydratation und einige Antidiarrhoika sollten vermieden werden. Von einem standardmäßigen Erregerpanel wird abgeraten. Die Hintergründe zu diesen und weiteren Empfehlungen erläutert Leitlinienkoordinator Prof. Carsten Posovszky.

Körperlich fitte Krebskranke leben länger

Krebspatienten, auch und vor allem solche in fortgeschrittenen Stadien, profitieren offenbar von guter körperlicher Verfassung. Hohe Muskelkraft und kardiorespiratorische Fitness sind laut Ergebnissen einer Metaanalyse mit geringerer Mortalität assoziiert.

Vorhofflimmern: Antikoagulation vor Schlaganfall von Vorteil

Erleiden Menschen mit Vorhofflimmern einen ischämischen Schlaganfall, ist dieser weniger schwer, auch sind Infarktgröße und Blutungsrisiko geringer, wenn sie zuvor orale Antikoagulanzien erhalten haben. Die Art der Antikoagulation spielt dabei keine Rolle.

HCL-Systeme bei Typ-1-Diabetes: Blutzuckerkontrolle besser, Risiko für Ketoazidose aber höher

Eine bessere Blutzuckerkontrolle und weniger Fälle von hypoglykämischem Koma, dafür mehr diabetische Ketoazidosen. Dieses HCL-Insulin-Therapie-Profil zeigte sich in einem Vergleich von Hybrid-Closed-Loop(HCL)- und Open-Loop-Systemen bei Typ-I-Diabetes im DPV-Register.

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

In diesem CME-Kurs können Sie Ihr Wissen zur EKG-Befundung anhand von zwölf Video-Tutorials auffrischen und 10 CME-Punkte sammeln.
Praxisnah, relevant und mit vielen Tipps & Tricks vom Profi.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.