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03.04.2018 | Original Article

Temporal trajectory of quality of life and its predictors in recipients of hematopoietic stem cell transplantation

verfasst von: Ryul Kim, Kyung-Lak Son, Kwang-Min Lee, Younak Choi, Junshik Hong, Dong-Yeop Shin, Youngil Koh, Bong-Jin Hahm, Inho Kim

Erschienen in: Annals of Hematology | Ausgabe 8/2018

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Abstract

This prospective longitudinal study evaluated the temporal trajectory of health-related quality of life (HRQOL) and its associated factors in patients who received hematopoietic stem cell transplantation (SCT) 6 months after transplantation. Eighty-nine adult patients who were admitted to Seoul National University Hospital for SCT were consecutively included in the study. The participants completed three standardized questionnaires: Insomnia Severity Index, Hospital Anxiety and Depression Scale, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. The participants completed the study questionnaires at three time points: before SCT (T1), immediately after SCT (T1), and 6 months after SCT (T3). Immediately after SCT, HRQOL decreased significantly (p < 0.001), followed by recovery over 6 months. The conditioning regimen for SCT showed no correlation with HRQOL at T2 (p = 0.283) or T3 (p = 0.799), with no significant difference in HRQOL between allogeneic and autologous SCT recipients at T2 (p = 0.829) or T3 (p = 0.824). Depression (p = 0.042), pain (p = 0.023), and appetite loss (p = 0.004) negatively influenced HRQOL at T1, whereas only pain (p = 0.048) remained an important factor at T2. Six months after SCT, the two most frequent symptoms, fatigue and financial problems, became major factors (p = 0.004 and p = 0.005, respectively). Depression began to play an important role in HRQOL again at T3 (p = 0.040). These findings demonstrate that SCT recipients need both psychological and medical support to achieve a better HRQOL after SCT.

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Fuji S, Loffler J, Savani BN, Einsele H, Kapp M (2016) Hyperglycemia as a possible risk factor for mold infections-the potential preventative role of intensified glucose control in allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 52:657–662. https://doi.org/10.1038/bmt.2016.306 CrossRefPubMed

Bellm LA, Epstein JB, Rose-Ped A, Martin P, Fuchs HJ (2000) Patient reports of complications of bone marrow transplantation. Support Care Cancer 8(1):33–39PubMed

(1995) The World Health Organization Quality of Life assessment (WHOQOL): position paper from the World Health Organization. Soc Sci Med (1982) 41(10):1403–1409

Worel N, Biener D, Kalhs P, Mitterbauer M, Keil F, Schulenburg A, Hocker P, Dieckmann K, Fischer G, Rosenmayr A, Linkesch W, Hinterberger W, Lechner K, Greinix HT (2002) Long-term outcome and quality of life of patients who are alive and in complete remission more than two years after allogeneic and syngeneic stem cell transplantation. Bone Marrow Transplant 30(9):619–626. https://doi.org/10.1038/sj.bmt.1703677 CrossRefPubMed

Hjermstad MJ, Kaasa S (1995) Quality of life in adult cancer patients treated with bone marrow transplantation--a review of the literature. Eur J Cancer (Oxford, England : 1990) 31a(2):163–173CrossRef

Neitzert CS, Ritvo P, Dancey J, Weiser K, Murray C, Avery J (1998) The psychosocial impact of bone marrow transplantation: a review of the literature. Bone Marrow Transplant 22(5):409–422. https://doi.org/10.1038/sj.bmt.1701358 CrossRefPubMed

Wingard JR (1998) Quality of life following bone marrow transplantation. Curr Opin Oncol 10(2):108–111CrossRefPubMed

Fashoyin-Aje LA, Martinez KA, Dy SM (2012) New patient-centered care standards from the commission on cancer: opportunities and challenges. J Support Oncol 10(3):107–111. https://doi.org/10.1016/j.suponc.2011.12.002 CrossRefPubMed

Pandey M, Sarita GP, Devi N, Thomas BC, Hussain BM, Krishnan R (2006) Distress, anxiety, and depression in cancer patients undergoing chemotherapy. World J Surg Oncol 4:68–68. https://doi.org/10.1186/1477-7819-4-68 CrossRefPubMedPubMedCentral

10.

Massie MJ (2004) Prevalence of depression in patients with cancer. JNCI Monographs 2004(32):57–71. https://doi.org/10.1093/jncimonographs/lgh014 CrossRef

11.

Pillay B, Lee SJ, Katona L, Burney S, Avery S (2014) Psychosocial factors predicting survival after allogeneic stem cell transplant. Support Care Cancer 22(9):2547–2555. https://doi.org/10.1007/s00520-014-2239-7 CrossRefPubMed

12.

Trask PC, Paterson A, Riba M, Brines B, Griffith K, Parker P, Weick J, Steele P, Kyro K, Ferrara J (2002) Assessment of psychological distress in prospective bone marrow transplant patients. Bone Marrow Transplant 29(11):917–925. https://doi.org/10.1038/sj.bmt.1703557 CrossRefPubMed

13.

Howell D, Olsen K (2011) Distress-the 6th vital sign. Curr Oncol (Toronto, Ont) 18(5):208–210

14.

Larsen J, Nordstrom G, Ljungman P, Gardulf A (2007) Factors associated with poor general health after stem-cell transplantation. Support Care Cancer 15(7):849–857. https://doi.org/10.1007/s00520-006-0200-0 CrossRefPubMed

15.

Bevans MF, Marden S, Leidy NK, Soeken K, Cusack G, Rivera P, Mayberry H, Bishop MR, Childs R, Barrett AJ (2006) Health-related quality of life in patients receiving reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 38(2):101–109. https://doi.org/10.1038/sj.bmt.1705406 CrossRefPubMed

16.

Hjermstad MJ, Knobel H, Brinch L, Fayers PM, Loge JH, Holte H, Kaasa S (2004) A prospective study of health-related quality of life, fatigue, anxiety and depression 3-5 years after stem cell transplantation. Bone Marrow Transplant 34(3):257–266. https://doi.org/10.1038/sj.bmt.1704561 CrossRefPubMed

17.

Hacker ED, Ferrans CE (2003) Quality of life immediately after peripheral blood stem cell transplantation. Cancer Nurs 26(4):312–322CrossRefPubMed

18.

Braamse AM, Gerrits MM, van Meijel B, Visser O, van Oppen P, Boenink AD, Cuijpers P, Huijgens PC, Beekman AT, Dekker J (2012) Predictors of health-related quality of life in patients treated with auto- and allo-SCT for hematological malignancies. Bone Marrow Transplant 47(6):757–769. https://doi.org/10.1038/bmt.2011.130 CrossRefPubMed

19.

Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365–376CrossRefPubMed

20.

AN FPM, Bjordal K, Groenvold M, Curran D, Bottomley A, on, Group botEQoL (2001) The EORTC QLQ-C30 scoring manual, 3rd edn. European Organisation for Research and Treatment of Cancer, Brussels

21.

Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67(6):361–370CrossRefPubMed

22.

Bjelland I, Dahl AA, Haug TT, Neckelmann D (2002) The validity of the hospital anxiety and depression scale. An updated literature review. J Psychosom Res 52(2):69–77CrossRefPubMed

23.

Savard MH, Savard J, Simard S, Ivers H (2005) Empirical validation of the insomnia severity index in cancer patients. Psycho-Oncology 14(6):429–441. https://doi.org/10.1002/pon.860 CrossRefPubMed

24.

Rosch PJ (1994) Insomnia, psychological assessment and management, Charles M. Morin, Guilford Press, New York, 1993. No. of pages: 238. Price: $26.95. Stress Med 10(1):69–70. https://doi.org/10.1002/smi.2460100113 CrossRef

25.

Sorror ML, Maris MB, Storb R, Baron F, Sandmaier BM, Maloney DG, Storer B (2005) Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood 106(8):2912–2919. https://doi.org/10.1182/blood-2005-05-2004 CrossRefPubMedPubMedCentral

26.

Broers S, Kaptein AA, Le Cessie S, Fibbe W, Hengeveld MW (2000) Psychological functioning and quality of life following bone marrow transplantation: a 3-year follow-up study. J Psychosom Res 48(1):11–21CrossRefPubMed

27.

Fife BL, Huster GA, Cornetta KG, Kennedy VN, Akard LP, Broun ER (2000) Longitudinal study of adaptation to the stress of bone marrow transplantation. J Clin Oncol 18(7):1539–1549. https://doi.org/10.1200/jco.2000.18.7.1539 CrossRefPubMed

28.

Lee SJ, Fairclough D, Parsons SK, Soiffer RJ, Fisher DC, Schlossman RL, Antin JH, Weeks JC (2001) Recovery after stem-cell transplantation for hematologic diseases. J Clin Oncol Off J Am Soc Clin Oncol 19(1):242–252. https://doi.org/10.1200/jco.2001.19.1.242 CrossRef

29.

Mumby PB, Hurley C, Samsi M, Thilges S, Parthasarathy M, Stiff PJ (2012) Predictors of non-compliance in autologous hematopoietic SCT patients undergoing out-patient transplants. Bone Marrow Transplant 47(4):556–561. https://doi.org/10.1038/bmt.2011.129 CrossRefPubMed

30.

Fawzy FI, Fawzy NW, Arndt LA, Pasnau RO (1995) Critical review of psychosocial interventions in cancer care. Arch Gen Psychiatry 52(2):100–113CrossRefPubMed

31.

Trijsburg RW, van Knippenberg FC, Rijpma SE (1992) Effects of psychological treatment on cancer patients: a critical review. Psychosom Med 54(4):489–517CrossRefPubMed

32.

Smith EM, Pang H, Cirrincione C, Fleishman S, Paskett ED, Ahles T, Bressler LR, Fadul CE, Knox C, Le-Lindqwister N, Gilman PB, Shapiro CL (2013) Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA 309(13):1359–1367. https://doi.org/10.1001/jama.2013.2813 CrossRefPubMedPubMedCentral

33.

Kerr CW, Drake J, Milch RA, Brazeau DA, Skretny JA, Brazeau GA, Donnelly JP (2012) Effects of methylphenidate on fatigue and depression: a randomized, double-blind, placebo-controlled trial. J Pain Symptom Manag 43(1):68–77. https://doi.org/10.1016/j.jpainsymman.2011.03.026 CrossRef

34.

Association AP (2013) Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5). American Psychiatric Publishing, ArlingtonCrossRef

35.

Larsen J, Nordstrom G, Ljungman P, Gardulf A (2004) Symptom occurrence, symptom intensity, and symptom distress in patients undergoing high-dose chemotherapy with stem-cell transplantation. Cancer Nurs 27(1):55–64CrossRefPubMed

36.

Hendriks MG, Schouten HC (2002) Quality of life after stem cell transplantation: a patient, partner and physician perspective. Eur J Int Med 13(1):52–56CrossRef

37.

Larsen J, Gardulf A, Nordstrom G, Bjorkstrand B, Ljungman P (1996) Health-related quality of life in women with breast cancer undergoing autologous stem-cell transplantation. Cancer Nurs 19(5):368–375CrossRefPubMed

38.

McQuellon RP, Russell GB, Cella DF, Craven BL, Brady M, Bonomi A, Hurd DD (1997) Quality of life measurement in bone marrow transplantation: development of the functional assessment of cancer therapy-bone marrow transplant (FACT-BMT) scale. Bone Marrow Transplant 19(4):357–368. https://doi.org/10.1038/sj.bmt.1700672 CrossRefPubMed

39.

McQuellon RP, Russell GB, Rambo TD, Craven BL, Radford J, Perry JJ, Cruz J, Hurd DD (1998) Quality of life and psychological distress of bone marrow transplant recipients: the 'time trajectory' to recovery over the first year. Bone Marrow Transplant 21(5):477–486. https://doi.org/10.1038/sj.bmt.1701115 CrossRefPubMed

40.

Fiuza-Luces C, Simpson RJ, Ramírez M, Lucia A, Berger NA (2016) Physical function and quality of life in patients with chronic graft-versus-host-disease: a summary of preclinical and clinical studies and a call for exercise intervention trials in patients. Bone Marrow Transplant 51(1):13–26. https://doi.org/10.1038/bmt.2015.195 CrossRefPubMed

41.

Schwartz CE, Andresen EM, Nosek MA, Krahn GL (2007) Response shift theory: important implications for measuring quality of life in people with disability. Arch Phys Med Rehabil 88(4):529–536. https://doi.org/10.1016/j.apmr.2006.12.032 CrossRefPubMed

42.

Loge JH, Abrahamsen AF, Ekeberg O, Kaasa S (1999) Hodgkin’s disease survivors more fatigued than the general population. J Clin Oncol Off J Am Soc Clin Oncol 17(1):253–261. https://doi.org/10.1200/jco.1999.17.1.253 CrossRef

43.

Leigh S, Wilson KC, Burns R, Clark RE (1995) Psychosocial morbidity in bone marrow transplant recipients: a prospective study. Bone Marrow Transplant 16(5):635–640PubMed

44.

Molassiotis A, van den Akker OB, Milligan DW, Goldman JM, Boughton BJ, Holmes JA, Thomas S (1996) Quality of life in long-term survivors of marrow transplantation: comparison with a matched group receiving maintenance chemotherapy. Bone Marrow Transplant 17(2):249–258PubMed

45.

Prieto JM, Saez R, Carreras E, Atala J, Sierra J, Rovira M, Batlle M, Blanch J, Escobar R, Vieta E, Gomez E, Rozman C, Cirera E (1996) Physical and psychosocial functioning of 117 survivors of bone marrow transplantation. Bone Marrow Transplant 17(6):1133–1142PubMed

Titel: Temporal trajectory of quality of life and its predictors in recipients of hematopoietic stem cell transplantation
verfasst von: Ryul Kim
Kyung-Lak Son
Kwang-Min Lee
Younak Choi
Junshik Hong
Dong-Yeop Shin
Youngil Koh
Bong-Jin Hahm
Inho Kim
Publikationsdatum: 03.04.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Annals of Hematology / Ausgabe 8/2018
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-018-3319-4

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