Skip to main content
Erschienen in: Acta Diabetologica 7/2018

20.04.2018 | Original Article

Ten-year comparative analysis of incidence, prognosis, and associated factors for dialysis and renal transplantation in type 1 and type 2 diabetes versus non-diabetes

verfasst von: Carlo Bruno Giorda, Paolo Carnà, Mario Salomone, Roberta Picariello, Giuseppe Costa, Barbara Tartaglino, Roberto Gnavi

Erschienen in: Acta Diabetologica | Ausgabe 7/2018

Einloggen, um Zugang zu erhalten

Abstract

Aims

To study the incidence of and the factors associated with renal dialysis and transplantation in type 1 (T1DM) and type 2 diabetes (T2DM).

Methods

Data on individuals who had received dialysis treatment or renal transplant between 1 January 2004 and 31 December 2013 were extracted from the regional administrative database (Piedmont, Italy), and the crude (cumulative) incidence of dialysis was calculated. Overall cumulative survival was estimated using the Kaplan–Meier method and compared using the log-rank test. Poisson regression was used to estimate adjusted rate ratios for potential predictors of renal transplant or death.

Results

A total of 7401 persons started dialysis treatment during the decade, with a 10-year cumulative crude incidence of 16.8/100,000. Incidence was stable and consistently eightfold higher in persons with T2DM (tenfold higher in T1DM) compared to those without diabetes. The risk of dialysis in T1DM was about double that of T2DM. The mortality rate was significantly higher in diabetics than in non-diabetes (241.4/1000 vs. 153.99/1000 person-years). During the decade 2004–2013, 893 patients underwent a kidney transplant. Transplantation rates were significantly lower for diabetics than non-diabetics (16.5/1000 vs. 42.9/1000 person-years).

Conclusions

In the past decade, the incidence of dialysis has stabilized in both the general population and in diabetics in whom it remains far higher by comparison. Also mortality rates are higher, with a worse prognosis for T1DM. Diabetes poses a barrier to allotransplantation, and efforts should be made to overcome this limitation.
Literatur
1.
Zurück zum Zitat The Emerging Risk Factors Collaboration (2011) Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 364:829–841CrossRefPubMedCentral The Emerging Risk Factors Collaboration (2011) Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 364:829–841CrossRefPubMedCentral
2.
Zurück zum Zitat D’Errico MM, Mangiacotti A, Graziano D et al (2017) Kidney disease measures are associated with the burden of coronary atherosclerosis, independently of diabetes. Acta Diabetol 54(11):1065–1068CrossRefPubMed D’Errico MM, Mangiacotti A, Graziano D et al (2017) Kidney disease measures are associated with the burden of coronary atherosclerosis, independently of diabetes. Acta Diabetol 54(11):1065–1068CrossRefPubMed
3.
Zurück zum Zitat Bacci S, Gargano A, di Lorenzo A et al (2016) Urinary albumin excretion correlates with carotid intima-media thickness in offspring of patients with type 2 diabetes and albuminuria. Acta Diabetol 53(6):1045–1048CrossRefPubMed Bacci S, Gargano A, di Lorenzo A et al (2016) Urinary albumin excretion correlates with carotid intima-media thickness in offspring of patients with type 2 diabetes and albuminuria. Acta Diabetol 53(6):1045–1048CrossRefPubMed
5.
Zurück zum Zitat Foley RN, Collins AJ (2007) End-stage renal disease in the United States: an update from the United States Renal Data System. J Am Soc Nephrol 18:2644–2648CrossRefPubMed Foley RN, Collins AJ (2007) End-stage renal disease in the United States: an update from the United States Renal Data System. J Am Soc Nephrol 18:2644–2648CrossRefPubMed
6.
Zurück zum Zitat De Matthaeis A, Di Lorenzo A, Gargano A et al (2016) Chronic inflammation in offspring of patients with type 2 diabetes and albuminuria. Acta Diabetol 53(1):125–126CrossRefPubMed De Matthaeis A, Di Lorenzo A, Gargano A et al (2016) Chronic inflammation in offspring of patients with type 2 diabetes and albuminuria. Acta Diabetol 53(1):125–126CrossRefPubMed
7.
Zurück zum Zitat Hayashino Y, Okamura S, Tsujii S et al (2016) Association of serum uric acid levels with the risk of development or progression of albuminuria among Japanese patients with type 2 diabetes: a prospective cohort study [Diabetes Distress and Care Registry at Tenri (DDCRT 10)]. Acta Diabetol 53(4):599–607CrossRefPubMed Hayashino Y, Okamura S, Tsujii S et al (2016) Association of serum uric acid levels with the risk of development or progression of albuminuria among Japanese patients with type 2 diabetes: a prospective cohort study [Diabetes Distress and Care Registry at Tenri (DDCRT 10)]. Acta Diabetol 53(4):599–607CrossRefPubMed
8.
Zurück zum Zitat Gnavi R, Karaghiosoff L, Dalmasso M, Bruno G (2006) The Piedmont Diabetes Register: opportunities and limits for epidemiological purposes. Epidemiol Prev 30(1):59–64PubMed Gnavi R, Karaghiosoff L, Dalmasso M, Bruno G (2006) The Piedmont Diabetes Register: opportunities and limits for epidemiological purposes. Epidemiol Prev 30(1):59–64PubMed
10.
Zurück zum Zitat Nordio M, Limido A, Conte F et al (2016) Italian Registry Dialysis and Transplant 2011–2013. 33(3) (Article in Italian) Nordio M, Limido A, Conte F et al (2016) Italian Registry Dialysis and Transplant 2011–2013. 33(3) (Article in Italian)
14.
Zurück zum Zitat Villar E, Chang SH, McDonald SP (2007) Incidences, treatments, outcomes, and sex effect on survival in patients with end-stage renal disease by diabetes status in Australia and New Zealand (1991–2005). Diabetes Care 30(12):3070–3076CrossRefPubMed Villar E, Chang SH, McDonald SP (2007) Incidences, treatments, outcomes, and sex effect on survival in patients with end-stage renal disease by diabetes status in Australia and New Zealand (1991–2005). Diabetes Care 30(12):3070–3076CrossRefPubMed
16.
Metadaten
Titel
Ten-year comparative analysis of incidence, prognosis, and associated factors for dialysis and renal transplantation in type 1 and type 2 diabetes versus non-diabetes
verfasst von
Carlo Bruno Giorda
Paolo Carnà
Mario Salomone
Roberta Picariello
Giuseppe Costa
Barbara Tartaglino
Roberto Gnavi
Publikationsdatum
20.04.2018
Verlag
Springer Milan
Erschienen in
Acta Diabetologica / Ausgabe 7/2018
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-018-1142-y

Weitere Artikel der Ausgabe 7/2018

Acta Diabetologica 7/2018 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.