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01.12.2014 | Original Article – Clinical Oncology | Ausgabe 12/2014

Journal of Cancer Research and Clinical Oncology 12/2014

TFAP2E hypermethylation was associated with survival advantage in patients with colorectal cancer

Zeitschrift:
Journal of Cancer Research and Clinical Oncology > Ausgabe 12/2014
Autoren:
Zuo-Ming Zhang, Yibaina Wang, Rong Huang, Yu-Peng Liu, Xia Li, Fu-Lan Hu, Lin Zhu, Fan Wang, Bin-Bin Cui, Xin-Shu Dong, Ya-Shuang Zhao
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00432-014-1766-4) contains supplementary material, which is available to authorized users.

Abstract

Purpose

Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly remain unknown. This study was aimed to investigate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of prognosis.

Methods

We detected the methylation status of AP-2E in tumor and adjacent non-tumor tissues from 311 sporadic CRC patients by methylation-sensitive high-resolution melting analysis. Log-rank tests and multivariate Cox analyses were performed to evaluate the role of AP-2E methylation status and other clinicopathologic parameters as predictors of prognosis.

Results

Hypermethylation of AP-2E was detected in 61 % (190/311) tumor tissues. It occurred more frequently in tumors in earlier stages (I/II; P = 0.02), lower levels of tumor invasion (T1–T3; P = 0.04), fewer lymph nodes involved (N0; P < 0.01), and higher histologic grades (G1/G2; P < 0.01). The overall 5-year survival rates in hypermethylation and hypomethylation group were 76.91 and 47.17 % (P < 0.0001), respectively. AP-2E hypermethylation was significantly associated with a favorable clinical outcome with a hazard ratio of 0.486 (95 % CI 0.342–0.692, P < 0.0001) after controlling for age, gender, tumor location, histologic type, TNM staging, and histologic grade.

Conclusions

AP-2E was frequently hypermethylated in tumors from patients with CRC. Aberrant hypermethylation of AP-2E occurred more frequently in tumors with earlier stages, lower levels of tumor invasion, fewer lymph nodes involved, and higher histologic grades. AP-2E hypermethylation might be an independent predictor of survival advantage in patients with CRC.

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Zusatzmaterial
Supplementary material 1 (DOC 392 kb)
432_2014_1766_MOESM1_ESM.doc
Literatur
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