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Current Allergy and Asthma Reports

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01.04.2020 | Asthma (V Ortega, Section Editor)

Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma

verfasst von: Dan Liu, Yurong Tan, Ousman Bajinka, Lili Wang, Zhongxiang Tang

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 4/2020

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Abstract

Purpose of Review

Bronchial asthma is a common respiratory disease induced by immune imbalance, characterized by chronic non-specific airway inflammation and airway hyperresponsiveness (AHR). Many factors induce asthma, among which respiratory infection is the important cause. In this review, we discuss how respiratory microbes participate in the occurrence and progression of asthma via Th17/IL-17 axis.

Recent Findings

Pathogenesis of asthma has been considered as closely related to the imbalance in number and function of Th1/Th2 in the CD4⁺ T lymphocyte subsets. Recent studies have shown that Th17 cell and its secretory IL-17 also play an important role in AHR. Respiratory virus, bacteria, fungi, and other respiratory microbial infections can directly or indirectly induce the differentiation of Th17 cell and the production of related cytokines to induce AHR.

Summary

Respiratory microbial infection can affect the TH17/IL-17A axis through a variety of mechanisms, thereby promoting the occurrence and development of asthma, and these specific mechanisms may provide new effective therapeutic ideas for asthma.

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Titel: Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma
verfasst von: Dan Liu
Yurong Tan
Ousman Bajinka
Lili Wang
Zhongxiang Tang
Publikationsdatum: 01.04.2020
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 4/2020
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-020-00903-x

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Springer Medizin

Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma

Abstract

Purpose of Review

Recent Findings

Summary

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Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

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