Skip to main content
Erschienen in: European Radiology 10/2011

01.10.2011 | Hepatobiliary-Pancreas

The added value of contrast-enhanced ultrasound in patients with colorectal cancer undergoing preoperative evaluation with extensive gadobenate dimeglumine liver MRI

verfasst von: Nikolaos Kartalis, Torkel B. Brismar, Laszlo Mihocsa, Bengt Isaksson, Nils Albiin

Erschienen in: European Radiology | Ausgabe 10/2011

Einloggen, um Zugang zu erhalten

Abstract

Objectives

To evaluate the added value of pre- and intraoperative contrast-enhanced ultrasound (transabdominal, or TCEUS and intraoperative, or ICEUS, respectively) in patients with known or highly suspected colorectal cancer liver metastases (CRLM) who have previously undergone extensive gadobenate dimeglumine (Gd-BOPTA) liver MRI.

Methods

Fifteen patients with a total of 31 lesions were included in the comparison of TCEUS vs. MRI and nine patients with a total of 19 lesions were included in the comparison of ICEUS vs. MRI. MRI examinations were performed before TCEUS and ICEUS. The analysis was performed lesion by lesion. Sensitivity, positive predictive value (PPV) and accuracy were calculated and compared.

Results

On comparing TCEUS with MRI, sensitivity differed significantly, with values of 87% and 100%, respectively (p value < 0.05), but there was no significant difference in PPV and accuracy. The comparison of ICEUS with MRI, however, showed no significant difference in sensitivity, PPV or accuracy.

Conclusions

Transabdominal and intraoperative contrast-enhanced ultrasound have no added value in the preoperative evaluation of patients with CRLM undergoing extensive gadobenate dimeglumine liver MRI.
Literatur
1.
Zurück zum Zitat Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics, 2009. CA Cancer J Clin 59:225–249PubMedCrossRef Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics, 2009. CA Cancer J Clin 59:225–249PubMedCrossRef
2.
Zurück zum Zitat Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P (2007) Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 18:581–592PubMedCrossRef Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P (2007) Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 18:581–592PubMedCrossRef
3.
Zurück zum Zitat Abdalla EK, Adam R, Bilchik AJ, Jaeck D, Vauthey JN, Mahvi D (2006) Improving resectability of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol 13:1271–1280PubMedCrossRef Abdalla EK, Adam R, Bilchik AJ, Jaeck D, Vauthey JN, Mahvi D (2006) Improving resectability of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol 13:1271–1280PubMedCrossRef
4.
Zurück zum Zitat Stangl R, Altendorf-Hofmann A, Charnley RM, Scheele J (1994) Factors influencing the natural history of colorectal liver metastases. Lancet 343:1405–1410PubMedCrossRef Stangl R, Altendorf-Hofmann A, Charnley RM, Scheele J (1994) Factors influencing the natural history of colorectal liver metastases. Lancet 343:1405–1410PubMedCrossRef
5.
Zurück zum Zitat Giacchetti S, Itzhaki M, Gruia G, Adam R, Zidani R, Kunstlinger F, Brienza S, Alafaci E, Bertheault-Cvitkovic F, Jasmin C, Reynes M, Bismuth H, Misset JL, Lévi F (1999) Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol 10:663–669PubMedCrossRef Giacchetti S, Itzhaki M, Gruia G, Adam R, Zidani R, Kunstlinger F, Brienza S, Alafaci E, Bertheault-Cvitkovic F, Jasmin C, Reynes M, Bismuth H, Misset JL, Lévi F (1999) Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol 10:663–669PubMedCrossRef
6.
Zurück zum Zitat Choti MA, Sitzmann JV, Tiburi MF, Sumetchotimetha W, Rangsin R, Schulick RD, Lillemoe KD, Yeo CJ, Cameron JL (2002) Trends in long-term survival following liver resection for hepatic colorectal metastases. Ann Surg 235:759–766PubMedCrossRef Choti MA, Sitzmann JV, Tiburi MF, Sumetchotimetha W, Rangsin R, Schulick RD, Lillemoe KD, Yeo CJ, Cameron JL (2002) Trends in long-term survival following liver resection for hepatic colorectal metastases. Ann Surg 235:759–766PubMedCrossRef
7.
Zurück zum Zitat Zorzi D, Mullen JT, Abdalla EK, Pawlik TM, Andres A, Muratore A et al (2006) Comparison between hepatic wedge resection and anatomic resection for colorectal liver metastases. J Gastrointest Surg 10:86–94PubMedCrossRef Zorzi D, Mullen JT, Abdalla EK, Pawlik TM, Andres A, Muratore A et al (2006) Comparison between hepatic wedge resection and anatomic resection for colorectal liver metastases. J Gastrointest Surg 10:86–94PubMedCrossRef
9.
Zurück zum Zitat Floriani I, Torri V, Rulli E, Garavaglia D, Compagnoni A, Salvolini L, Giovagnoni A (2010) Performance of imaging modalities in diagnosis of liver metastases from colorectal cancer: a systematic review and meta-analysis. J Magn Reson Imaging 31:19–31PubMedCrossRef Floriani I, Torri V, Rulli E, Garavaglia D, Compagnoni A, Salvolini L, Giovagnoni A (2010) Performance of imaging modalities in diagnosis of liver metastases from colorectal cancer: a systematic review and meta-analysis. J Magn Reson Imaging 31:19–31PubMedCrossRef
10.
Zurück zum Zitat Ward J (2006) New MR techniques for the detection of liver metastases. Cancer Imaging 6:33–42PubMedCrossRef Ward J (2006) New MR techniques for the detection of liver metastases. Cancer Imaging 6:33–42PubMedCrossRef
11.
Zurück zum Zitat Niekel MC, Bipat S, Stoker J (2010) Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT: a meta-analysis of prospective studies including patients who have not previously undergone treatment. Radiology 257:674–684PubMedCrossRef Niekel MC, Bipat S, Stoker J (2010) Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT: a meta-analysis of prospective studies including patients who have not previously undergone treatment. Radiology 257:674–684PubMedCrossRef
12.
Zurück zum Zitat Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D’Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M (2010) Detection of colo-rectal liver metastases: prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1.5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents. Abdom Imaging 35:511–521PubMedCrossRef Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D’Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M (2010) Detection of colo-rectal liver metastases: prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1.5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents. Abdom Imaging 35:511–521PubMedCrossRef
13.
Zurück zum Zitat Dietrich CF, Kratzer W, Strobe D, Danse E, Fessl R, Bunk A, Vossas U, Hauenstein K, Koch W, Blank W, Oudkerk M, Hahn D, Greis C (2006) Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI. World J Gastroenterol 12:1699–1705PubMed Dietrich CF, Kratzer W, Strobe D, Danse E, Fessl R, Bunk A, Vossas U, Hauenstein K, Koch W, Blank W, Oudkerk M, Hahn D, Greis C (2006) Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI. World J Gastroenterol 12:1699–1705PubMed
14.
Zurück zum Zitat Konopke R, Bunk A, Kersting S (2007) The role of contrast-enhanced ultrasound for focal liver lesion detection: an overview. Ultrasound Med Biol 33:1515–1526PubMedCrossRef Konopke R, Bunk A, Kersting S (2007) The role of contrast-enhanced ultrasound for focal liver lesion detection: an overview. Ultrasound Med Biol 33:1515–1526PubMedCrossRef
15.
Zurück zum Zitat Larsen LP, Rosenkilde M, Christensen H, Bang N, Bolvig L, Christiansen T, Laurberg S (2007) The value of contrast enhanced ultrasonography in detection of liver metastases from colorectal cancer: a prospective double-blinded study. Eur J Radiol 62:302–307PubMedCrossRef Larsen LP, Rosenkilde M, Christensen H, Bang N, Bolvig L, Christiansen T, Laurberg S (2007) The value of contrast enhanced ultrasonography in detection of liver metastases from colorectal cancer: a prospective double-blinded study. Eur J Radiol 62:302–307PubMedCrossRef
16.
Zurück zum Zitat Hoeffel C, Job L, Ladam-Marcus V, Vitry F, Cadiot G, Marcus C (2009) Detection of hepatic metastases from carcinoid tumor: prospective evaluation of contrast-enhanced ultrasonography. Dig Dis Sci 54:2040–2046PubMedCrossRef Hoeffel C, Job L, Ladam-Marcus V, Vitry F, Cadiot G, Marcus C (2009) Detection of hepatic metastases from carcinoid tumor: prospective evaluation of contrast-enhanced ultrasonography. Dig Dis Sci 54:2040–2046PubMedCrossRef
17.
Zurück zum Zitat Fleiss JL (1981) Statistical methods for rates and proportions. John Wiley & Sons, New York Fleiss JL (1981) Statistical methods for rates and proportions. John Wiley & Sons, New York
18.
Zurück zum Zitat Kim YK, Lee JM, Kim CS, Chung GH, Kim CY, Kim IH (2005) Detection of liver metastases: gadobenate dimeglumine-enhanced three-dimensional dynamic phases and one-hour delayed phase MR imaging versus superparamagnetic iron oxide-enhanced MR imaging. Eur Radiol 15:220–228PubMedCrossRef Kim YK, Lee JM, Kim CS, Chung GH, Kim CY, Kim IH (2005) Detection of liver metastases: gadobenate dimeglumine-enhanced three-dimensional dynamic phases and one-hour delayed phase MR imaging versus superparamagnetic iron oxide-enhanced MR imaging. Eur Radiol 15:220–228PubMedCrossRef
19.
Zurück zum Zitat Konopke R, Kersting S, Bergert H, Bloomenthal A, Gastmeier J, Saeger HD, Bunk A (2007) Contrast-enhanced ultrasonography to detect liver metastases: a prospective trial to compare transcutaneous unenhanced and contrast-enhanced ultrasonography in patients undergoing laparotomy. Int J Colorectal Dis 22:201–207PubMedCrossRef Konopke R, Kersting S, Bergert H, Bloomenthal A, Gastmeier J, Saeger HD, Bunk A (2007) Contrast-enhanced ultrasonography to detect liver metastases: a prospective trial to compare transcutaneous unenhanced and contrast-enhanced ultrasonography in patients undergoing laparotomy. Int J Colorectal Dis 22:201–207PubMedCrossRef
20.
Zurück zum Zitat Leen E, Ceccotti P, Moug SJ, Glen P, MacQuarrie J, Angerson WJ, Albrecht T, Hohmann J, Oldenburg A, Ritz JP, Horgan PG (2006) Potential value of contrast-enhanced intraoperative ultrasonography during partial hepatectomy for metastases: an essential investigation before resection? Ann Surg 243:236–240PubMedCrossRef Leen E, Ceccotti P, Moug SJ, Glen P, MacQuarrie J, Angerson WJ, Albrecht T, Hohmann J, Oldenburg A, Ritz JP, Horgan PG (2006) Potential value of contrast-enhanced intraoperative ultrasonography during partial hepatectomy for metastases: an essential investigation before resection? Ann Surg 243:236–240PubMedCrossRef
21.
Zurück zum Zitat Tamandl D, Herberger B, Gruenberger B, Schoppmann SF, Puhalla H, Schindl M, Schima W, Jakesz R, Gruenberger T (2008) Adequate preoperative staging rarely leads to a change of intraoperative strategy in patients undergoing surgery for colorectal cancer liver metastases. Surgery 143:648–657PubMedCrossRef Tamandl D, Herberger B, Gruenberger B, Schoppmann SF, Puhalla H, Schindl M, Schima W, Jakesz R, Gruenberger T (2008) Adequate preoperative staging rarely leads to a change of intraoperative strategy in patients undergoing surgery for colorectal cancer liver metastases. Surgery 143:648–657PubMedCrossRef
22.
Zurück zum Zitat Cerwenka H, Raith J, Bacher H, Werkgartner G, El-Shabrawi A, Kornprat P, Mischinger HJ (2003) Is intraoperative ultrasonography during partial hepatectomy still necessary in the age of magnetic resonance imaging? Hepatogastroenterology 50:1539–1541PubMed Cerwenka H, Raith J, Bacher H, Werkgartner G, El-Shabrawi A, Kornprat P, Mischinger HJ (2003) Is intraoperative ultrasonography during partial hepatectomy still necessary in the age of magnetic resonance imaging? Hepatogastroenterology 50:1539–1541PubMed
23.
Zurück zum Zitat Caseiro-Alves F, Brito J, Araujo AE, Belo-Soares P, Rodrigues H, Cipriano A, Sousa D, Mathieu D (2007) Liver haemangioma: common and uncommon findings and how to improve the differential diagnosis. Eur Radiol 17:1544–1554PubMedCrossRef Caseiro-Alves F, Brito J, Araujo AE, Belo-Soares P, Rodrigues H, Cipriano A, Sousa D, Mathieu D (2007) Liver haemangioma: common and uncommon findings and how to improve the differential diagnosis. Eur Radiol 17:1544–1554PubMedCrossRef
24.
Zurück zum Zitat Dietrich CF, Mertens JC, Braden B, Schuessler G, Ott M, Ignee A (2007) Contrast-enhanced ultrasound of histologically proven liver hemangiomas. Hepatology 45:1139–1145PubMedCrossRef Dietrich CF, Mertens JC, Braden B, Schuessler G, Ott M, Ignee A (2007) Contrast-enhanced ultrasound of histologically proven liver hemangiomas. Hepatology 45:1139–1145PubMedCrossRef
25.
Zurück zum Zitat Vilgrain V, Boulos L, Vullierme MP, Denys A, Terris B, Menu Y (2000) Imaging of atypical hemangiomas of the liver with pathologic correlation. Radiographics 20:379–397PubMed Vilgrain V, Boulos L, Vullierme MP, Denys A, Terris B, Menu Y (2000) Imaging of atypical hemangiomas of the liver with pathologic correlation. Radiographics 20:379–397PubMed
Metadaten
Titel
The added value of contrast-enhanced ultrasound in patients with colorectal cancer undergoing preoperative evaluation with extensive gadobenate dimeglumine liver MRI
verfasst von
Nikolaos Kartalis
Torkel B. Brismar
Laszlo Mihocsa
Bengt Isaksson
Nils Albiin
Publikationsdatum
01.10.2011
Verlag
Springer-Verlag
Erschienen in
European Radiology / Ausgabe 10/2011
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-011-2156-9

Weitere Artikel der Ausgabe 10/2011

European Radiology 10/2011 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.