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Current Treatment Options in Pediatrics

Erschienen in:

01.12.2023 | Cardiology/CT Surgery (K Gist, Section Editor)

The Advent of Spatial Omics in Congenital Heart Disease

verfasst von: Geoffrey R. Traeger, BS, Kevin J. Jaatinen, MS, Mark W. Majesky, PhD, Christina L. Greene, MD

Erschienen in: Current Treatment Options in Pediatrics | Ausgabe 4/2023

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Abstract

Purpose of Review

Spatial omics is a transformative technology which will impact multiple areas of clinical medicine over the next decade. The goal of this review is to acquaint the pediatric clinician with the emerging field of Spatial omics by discussing the impact of this technology on the prototypical congenital heart defect: coarctation of the aorta. We will discuss how current methodologies have struggled to adequately elucidate the mechanism of this lesion and how Spatial omics may allow for better delineation of the pathobiology of this quintessential congenital heart defect.

Recent Findings

Several genes are implicated in the development of coarctation of the aorta including NOTCH1, FOXC1, and MYH6. Despite being first described nearly 200 years ago and first surgically repaired nearly 90 years ago, there is no known unifying mechanism for the development of this common congenital heart defect. The advent of Spatial omics has the potential to help clinical scientists understand the causal pathway for this lesion and many other congenital heart defects.

Summary

Spatial omics is a transformative technology that will have broad impact across multiple sub-specialties. The coming flood of information has promise to change how we view the origin, progression, and treatment of many diseases and disorders whose pathology remains enigmatic.

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Titel: The Advent of Spatial Omics in Congenital Heart Disease
verfasst von: Geoffrey R. Traeger, BS
Kevin J. Jaatinen, MS
Mark W. Majesky, PhD
Christina L. Greene, MD
Publikationsdatum: 01.12.2023
Verlag: Springer International Publishing
Erschienen in: Current Treatment Options in Pediatrics / Ausgabe 4/2023
Elektronische ISSN: 2198-6088
DOI: https://doi.org/10.1007/s40746-023-00282-1

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The Advent of Spatial Omics in Congenital Heart Disease