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Erschienen in: Journal of Neural Transmission 8/2016

Open Access 22.04.2016 | Psychiatry and Preclinical Psychiatric Studies - Original Article

The aetiological association between the dynamics of cortisol productivity and ADHD

verfasst von: Rebecca Pinto, Fruhling Rijsdijk, Isabelle Ouellet-Morin, Philip Asherson, Grainne McLoughlin, Jonna Kuntsi

Erschienen in: Journal of Neural Transmission | Ausgabe 8/2016

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Abstract

Attention-deficit/hyperactivity disorder (ADHD) has been linked to dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, indexed by salivary cortisol. The phenotypic and aetiological association of cortisol productivity with ADHD was investigated. A selected twin design using 68 male twin-pairs aged 12–15, concordant or discordant for high ADHD symptom scores, or control twin-pairs with low ADHD symptoms, based on developmentally stable parental ADHD ratings. A genetic growth curve model was applied to cortisol samples obtained across three points during a cognitive-electroencephalography assessment, to examine the aetiological overlap of ADHD affection status (high versus low ADHD symptom scores) with latent intercept and slope factors. A significant phenotypic correlation emerged between ADHD and the slope factor, with cortisol levels dropping faster for the group with high ADHD symptom scores. The analyses further suggested this overlap was mostly driven by correlated genetic effects. We identified change in cortisol activity over time as significantly associated with ADHD affection status, primarily explained by shared genetic effects, suggesting that blunted cortisol productivity can be a marker of genetic risk in ADHD.
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Metadaten
Titel
The aetiological association between the dynamics of cortisol productivity and ADHD
verfasst von
Rebecca Pinto
Fruhling Rijsdijk
Isabelle Ouellet-Morin
Philip Asherson
Grainne McLoughlin
Jonna Kuntsi
Publikationsdatum
22.04.2016
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 8/2016
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-016-1534-5

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