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Erschienen in: Journal of Bone and Mineral Metabolism 6/2019

20.04.2019 | Original Article

The age modification to leukocyte telomere length effect on bone mineral density and osteoporosis among Chinese elderly women

verfasst von: Lailin Tao, Qin Huang, Rui Yang, Yu Dai, Yun Zeng, Can Li, Xiaolong Li, Junchao Zeng, Qi Wang

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 6/2019

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Abstract

Critically short telomeres indicate cellular senescence. Leukocyte telomere length (LTL) is regarded as an aging predictor. Osteoporosis is an age-related disease. The purpose of our study is to examine the association between LTL, and BMD and osteoporosis among an elderly Chinese population. A total of 1017 participants (584 postmenopausal women) with a mean age of 66.4 years were recruited from April 2016 to August 2017. Dual-energy X-ray absorptiometry was used for BMD measurement at skeleton sites of lumbar spine (LS), femoral neck (FN), and total hip (TH). LTL was measured using quantitative real-time polymerase chain reaction. Among women, age significantly modified the effect of LTL on BMD at FN. Additionally, significant age modification was observed for the association between LTL and LS BMD category (indicative of control or osteopenia or osteoporosis), and the number of osteoporotic sites at LS or TH. The corresponding estimates (95% CI) for the relative excess risk due to interaction (RERI) were − 0.07 (− 0.11, − 0.01) and − 0.11 (− 0.16, − 0.03) sequentially in ordinal logistic regression models. The estimated RERIs (95% CI) were − 0.11 (− 0.25, − 0.02) and − 0.23 (− 0.39, − 0.10) in multinomial logistic regression models for LS/FN/TH BMD category, and − 0.20 (− 0.31, − 0.09) and − 0.34 (− 0.49, − 0.21) for FN BMD category. However, similar findings did not show in men. The effect of LTL on BMD and osteoporosis risk is modified by age in elderly women but not in men, suggesting that the predictive role of LTL in bone loss differs by sex.
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Metadaten
Titel
The age modification to leukocyte telomere length effect on bone mineral density and osteoporosis among Chinese elderly women
verfasst von
Lailin Tao
Qin Huang
Rui Yang
Yu Dai
Yun Zeng
Can Li
Xiaolong Li
Junchao Zeng
Qi Wang
Publikationsdatum
20.04.2019
Verlag
Springer Japan
Erschienen in
Journal of Bone and Mineral Metabolism / Ausgabe 6/2019
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-019-01004-0

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