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Osteoporosis International

Erschienen in:

01.09.2003 | Original Article

The aging cortex: to crack or not to crack

verfasst von: Karl J. Jepsen

Erschienen in: Osteoporosis International | Sonderheft 5/2003

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Excerpt

This article presents a general overview of age-related changes in the cortex of the human skeleton. Existing data from the literature are examined in the context of how changes in bone structure and bone quality contribute to age-related increases in fracture risk. We postulate that fragility fractures are preventable. Novel targets for diagnosis and treatment will benefit directly by solving both the engineering problem ("Why does bone become brittle with age and disease?") and the biological problem ("Why does bone become brittle with age and disease?"). This review addresses primarily the engineering problem. …

Genant HK, Cooper C, Poor G, et al (1999) Interim report and recommendations of the World Health Organization Task-Force for Osteoporosis. Osteoporos Int 10:259–264CrossRefPubMed

Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312:1254–1259PubMed

Hui SL, Slemenda CW, Johnston CC Jr (1988) Age and bone mass as predictors of fracture in a prospective study. J Clin Invest 81:1804–1809PubMed

Schaffler MB, Choi K, Milgrom C (1995) Aging and matrix microdamage accumulation in human compact bone. Bone 17:521–525CrossRefPubMed

Jepsen KJ, Schaffler MB, Kuhn JL, et al (1997) Type I collagen mutation alters the strength and fatigue behavior of Mov13 cortical tissue. J Biomech 30:1141–1147CrossRefPubMed

Zioupos P, Currey JD (1998) Changes in the stiffness, strength, and toughness of human cortical bone with age. Bone 22:57–66CrossRefPubMed

Brown CU, Yeni YN, Norman TL (2000) Fracture toughness is dependent on bone location—a study of the femoral neck, femoral shaft, and the tibial shaft. J Biomed Mater Res 49:380–389CrossRefPubMed

Evans F (1976) Changes in mechanical properties and histology of human compact bone. Yearbook of Physical Anthropology. AAPA: Columbus, vol 20, pp 57–72

Vincentelli R (1978) Relation between collagen fiber orientation and age of osteon formation in human tibial compact bone. Acta Anat (Basel) 100:120–128

10.

Atkinson P (1965) Changes in resorption spaces in femoral cortical bone with age. J Path Bacteriol 89:173–178

11.

McCalden RW, McGeough JA, Barker MB, Court-Brown CM (1993) Age-related changes in the tensile properties of cortical bone. The relative importance of changes in porosity, mineralization, and microstructure. J Bone Joint Surg [Am] 75:1193–1205

12.

Simmons ED Jr, Pritzker KP, Grynpas MD (1991) Age-related changes in the human femoral cortex. J Orthop Res 9:155–167PubMed

13.

Currey JD, Brear K, Zioupos P (1996) The effects of ageing and changes in mineral content in degrading the toughness of human femora. J Biomech 29:257–260CrossRefPubMed

14.

Wang X, Shen X, Li X, Mauli Agrawal C (2002) Age-related changes in the collagen network and toughness of bone. Bone 31:1–7CrossRefPubMed

15.

Bailey AJ, Wotton SF, Sims TJ, Thompson PW (1992) Post-translational modifications in the collagen of human osteoporotic femoral head. Biochem Biophys Res Commun 185:801–805PubMed

16.

Oxlund H, Mosekilde L, Ortoft G (1996) Reduced concentration of collagen reducible cross links in human trabecular bone with respect to age and osteoporosis. Bone 19:479–484CrossRefPubMed

17.

Vajda EG, Bloebaum RD (1999) Age-related hypermineralization in the female proximal human femur. Anat Rec 255:202–211CrossRefPubMed

18.

Cook J, Gordon J (1964) A mechanism for the control of crack propagation in all-brittle systems. Proc R Soc A-282:508–520

19.

Yeni YN, Norman TL (2000) Calculation of porosity and osteonal cement line effects on the effective fracture toughness of cortical bone in longitudinal crack growth. J Biomed Mater Res 51:504–509CrossRefPubMed

20.

Guo XE, Liang LC, Goldstein SA (1998) Micromechanics of osteonal cortical bone fracture. J Biomech Eng 120:112–117PubMed

21.

Phelps JB, Hubbard GB, Wang X, Agrawal CM (2000) Microstructural heterogeneity and the fracture toughness of bone. J Biomed Mater Res 51:735–741CrossRefPubMed

22.

Martin RB, Atkinson PJ (1977) Age- and sex-related changes in the structure and strength of the human femoral shaft. J Biomech 10:223–231PubMed

23.

Beck TJ, Ruff CB, Scott WW Jr, et al (1992) Sex differences in geometry of the femoral neck with aging: a structural analysis of bone mineral data. Calcif Tissue Int 50:24–29PubMed

24.

Flora L, Hassing G, Cloyd G, et al (1981) The long-term skeletal effects of EHDP in dogs. Metab Bone Dis Relat Res 3:289–300PubMed

25.

Forwood MR, Burr DB, Takano Y, et al (1995) Risedronate treatment does not increase microdamage in the canine femoral neck. Bone 16:643–650

26.

Mashiba T, Hirano T, Turner CH, et al (2000) Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib. J Bone Miner Res 15:613–620PubMed

27.

Hirano T, Turner CH, Forwood MR, Johnston CC, Burr DB (2000) Does suppression of bone turnover impair mechanical properties by allowing microdamage accumulation? Bone 27:13–20CrossRefPubMed

28.

Mashiba T, Turner CH, Hirano T et al (2001) Effects of high-dose etidronate treatment on microdamage accumulation and biomechanical properties in beagle bone before occurrence of spontaneous fractures. Bone 29:271–278CrossRefPubMed

29.

Delmas PD (2002) Treatment of postmenopausal osteoporosis. Lancet 359:2018–2026CrossRefPubMed

30.

Reilly DT, Burstein AH (1975) The elastic and ultimate properties of compact bone tissue. J Biomech 8:393–405PubMed

31.

McElhaney JH (1966) Dynamic response of bone and muscle tissue. J Appl Physiol 21:1231–1236

32.

Pattin CA, Caler WE, Carter DR (1996) Cyclic mechanical property degradation during fatigue loading of cortical bone. J Biomech 29:69–79CrossRefPubMed

33.

Carter DR, Caler WE (1985) A cumulative damage model for bone fracture. J Orthop Res 3:84–90PubMed

34.

Burstein AH, Reilly DT, Martens M (1976) Aging of bone tissue: mechanical properties. J Bone Joint Surg [Am] 58:82–86

35.

Currey JD (1979) Changes in the impact energy absorption of bone with age. J Biomech 12:459–469PubMed

36.

Zioupos P, Wang XT, Currey JD (1996) The accumulation of fatigue microdamage in human cortical bone of two different ages in vitro. Clin Biomech 11:365–375

Titel: The aging cortex: to crack or not to crack
verfasst von: Karl J. Jepsen
Publikationsdatum: 01.09.2003
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe Sonderheft 5/2003
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-003-1475-3

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