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01.08.2011 | Viewpoint | Ausgabe 4/2011

Breast Cancer Research 4/2011

The 'alternative' EMT switch

Zeitschrift:
Breast Cancer Research > Ausgabe 4/2011
Autoren:
Pamela Klingbeil, Clare M Isacke
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Abstract

Epithelial to mesenchymal transition (EMT) is an essential process in embryonic development and is aberrantly induced in many disease settings. Work carried out by Chonghui Cheng's laboratory addressed the involvement of alternative RNA splicing in EMT and its link to tumour progression. They describe a switch in CD44 expression from variant isoform(s) to the standard isoform and showed, for the first time, that this is required for normal epithelial cells to undergo EMT. In addition, they link expression of the CD44 standard isoform with high-grade breast cancer and to activation of the phosphoinositide 3-kinase/Akt pathway and apoptosis resistance in a mouse model of recurrent disease.

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