Skip to main content
Erschienen in:

30.01.2022 | Original Article

The analgesic effect and safety of preoperative versus postoperative administration of celecoxib in patients who underwent arthroscopic rotator cuff repair: a randomized, controlled study

verfasst von: Junfeng Yang, Shanfu Wang, Lei Liu, Yang Shao, Jianwei Wang

Erschienen in: Inflammopharmacology | Ausgabe 1/2022

Einloggen, um Zugang zu erhalten

Abstract

Aims

Celecoxib presents a good analgesic effect in patients who undergo arthroscopic rotator cuff repair (ARCR) surgery, while few studies investigate the optimal timing of celecoxib administration. This study aimed to explore the analgesic effect of preoperative versus postoperative administration of celecoxib in ARCR-treated patients.

Methods

A total of 106 ARCR-treated patients were enrolled and randomized at a 1:1 ratio into preoperative analgesia group (N = 53) and postoperative analgesia group (N = 53). The pain visual analog scale (VAS) score at rest or flexion, salvage consumption of pethidine, patient’s satisfaction score, modified University of California at Los Angeles (UCLA) score and adverse events were evaluated.

Results

Pain VAS scores at rest at 12 h and D1 (but not D2, D3 or D7) and pain VAS scores at flexion at 12 h, D1 and D2 (but not D3 or D7) were decreased in preoperative analgesia group compared to postoperative analgesia group. Meanwhile, rescue analgesia rate and 7-day pethidine consumption in preoperative analgesia group were lower than that in postoperative analgesia group. Besides, the overall satisfaction scores at D1 and D3 (but not at D7 or M3) were elevated in preoperative analgesia group compared to postoperative analgesia group. However, no difference of modified UCLA scores at D7 or M3, or the occurrences of adverse events were found between the two groups.

Conclusions

Celecoxib preoperative administration remits acute pain and facilitates satisfaction but does not improve long-term shoulder joint function recovery compared to its postoperative administration in patients who undergo ARCR surgery.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
Zurück zum Zitat Arora M, Choudhary S, Singh PK, Sapra B, Silakari O (2020) Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: a review. Life Sci 251:117631CrossRef Arora M, Choudhary S, Singh PK, Sapra B, Silakari O (2020) Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: a review. Life Sci 251:117631CrossRef
Zurück zum Zitat Burns KA, Robbins LM, LeMarr AR, Childress AL, Morton DJ, Schroer WC, Wilson ML (2021) Celecoxib significantly reduces opioid use after shoulder arthroplasty. J Shoulder Elbow Surg 30:1–8CrossRef Burns KA, Robbins LM, LeMarr AR, Childress AL, Morton DJ, Schroer WC, Wilson ML (2021) Celecoxib significantly reduces opioid use after shoulder arthroplasty. J Shoulder Elbow Surg 30:1–8CrossRef
Zurück zum Zitat Canovas F, Dagneaux L (2018) Quality of life after total knee arthroplasty. Orthop Traumatol Surg Res 104:S41–S46CrossRef Canovas F, Dagneaux L (2018) Quality of life after total knee arthroplasty. Orthop Traumatol Surg Res 104:S41–S46CrossRef
Zurück zum Zitat Dang A, Davies M (2018) Rotator cuff disease: treatment options and considerations. Sports Med Arthrosc Rev 26:129–133CrossRef Dang A, Davies M (2018) Rotator cuff disease: treatment options and considerations. Sports Med Arthrosc Rev 26:129–133CrossRef
Zurück zum Zitat Gilotra M, O’Brien MJ, Savoie FH 3rd (2016) Arthroscopic rotator cuff repair: indication and technique. Instr Course Lect 65:83–92PubMed Gilotra M, O’Brien MJ, Savoie FH 3rd (2016) Arthroscopic rotator cuff repair: indication and technique. Instr Course Lect 65:83–92PubMed
Zurück zum Zitat Han L, Fang WL, Jin B, Xu SC, Zheng X, Hu YG (2019) Enhancement of tendon-bone healing after rotator cuff injuries using combined therapy with mesenchymal stem cells and platelet rich plasma. Eur Rev Med Pharmacol Sci 23:9075–9084PubMed Han L, Fang WL, Jin B, Xu SC, Zheng X, Hu YG (2019) Enhancement of tendon-bone healing after rotator cuff injuries using combined therapy with mesenchymal stem cells and platelet rich plasma. Eur Rev Med Pharmacol Sci 23:9075–9084PubMed
Zurück zum Zitat Harirforoosh S, Asghar W, Jamali F (2013) Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci 16:821–847CrossRef Harirforoosh S, Asghar W, Jamali F (2013) Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci 16:821–847CrossRef
Zurück zum Zitat Lee BG, Cho NS, Rhee YG (2012) Effect of two rehabilitation protocols on range of motion and healing rates after arthroscopic rotator cuff repair: aggressive versus limited early passive exercises. Arthroscopy 28:34–42CrossRef Lee BG, Cho NS, Rhee YG (2012) Effect of two rehabilitation protocols on range of motion and healing rates after arthroscopic rotator cuff repair: aggressive versus limited early passive exercises. Arthroscopy 28:34–42CrossRef
Zurück zum Zitat Liu J, Wang F (2018) Preoperative celecoxib analgesia is more efficient and equally tolerated compared to postoperative celecoxib analgesia in knee osteoarthritis patients undergoing total knee arthroplasty: a randomized, controlled study. Medicine (baltimore) 97:e13663CrossRef Liu J, Wang F (2018) Preoperative celecoxib analgesia is more efficient and equally tolerated compared to postoperative celecoxib analgesia in knee osteoarthritis patients undergoing total knee arthroplasty: a randomized, controlled study. Medicine (baltimore) 97:e13663CrossRef
Zurück zum Zitat Mammoto T, Fujie K, Taguchi N, Ma E, Shimizu T, Hashimoto K (2021) Short-term effects of early postoperative celecoxib administration for pain, sleep quality, and range of motion after total knee arthroplasty: a randomized controlled trial. J Arthroplasty 36:526–531CrossRef Mammoto T, Fujie K, Taguchi N, Ma E, Shimizu T, Hashimoto K (2021) Short-term effects of early postoperative celecoxib administration for pain, sleep quality, and range of motion after total knee arthroplasty: a randomized controlled trial. J Arthroplasty 36:526–531CrossRef
Zurück zum Zitat Mardani-Kivi M, Karimi Mobarakeh M, Haghighi M, Naderi-Nabi B, Sedighi-Nejad A, Hashemi-Motlagh K, Saheb-Ekhtiari K (2013) Celecoxib as a pre-emptive analgesia after arthroscopic knee surgery; a triple-blinded randomized controlled trial. Arch Orthop Trauma Surg 133:1561–1566CrossRef Mardani-Kivi M, Karimi Mobarakeh M, Haghighi M, Naderi-Nabi B, Sedighi-Nejad A, Hashemi-Motlagh K, Saheb-Ekhtiari K (2013) Celecoxib as a pre-emptive analgesia after arthroscopic knee surgery; a triple-blinded randomized controlled trial. Arch Orthop Trauma Surg 133:1561–1566CrossRef
Zurück zum Zitat May T, Garmel GM (2021) Rotator cuff injury. In: StatPearls. Treasure Island (FL) May T, Garmel GM (2021) Rotator cuff injury. In: StatPearls. Treasure Island (FL)
Zurück zum Zitat Oh JH, Seo HJ, Lee YH, Choi HY, Joung HY, Kim SH (2018) Do selective COX-2 inhibitors affect pain control and healing after arthroscopic rotator cuff repair? A preliminary study. Am J Sports Med 46:679–686CrossRef Oh JH, Seo HJ, Lee YH, Choi HY, Joung HY, Kim SH (2018) Do selective COX-2 inhibitors affect pain control and healing after arthroscopic rotator cuff repair? A preliminary study. Am J Sports Med 46:679–686CrossRef
Zurück zum Zitat Puljak L, Marin A, Vrdoljak D, Markotic F, Utrobicic A, Tugwell P (2017) Celecoxib for osteoarthritis. Cochrane Database Syst Rev 5:CD009865PubMed Puljak L, Marin A, Vrdoljak D, Markotic F, Utrobicic A, Tugwell P (2017) Celecoxib for osteoarthritis. Cochrane Database Syst Rev 5:CD009865PubMed
Zurück zum Zitat Rodriguez-Santiago B, Castillo B, Baerga-Varela L, Micheo WF (2019) Rehabilitation management of rotator cuff injuries in the master athlete. Curr Sports Med Rep 18:330–337CrossRef Rodriguez-Santiago B, Castillo B, Baerga-Varela L, Micheo WF (2019) Rehabilitation management of rotator cuff injuries in the master athlete. Curr Sports Med Rep 18:330–337CrossRef
Zurück zum Zitat Rouhani A, Tabrizi A, Elmi A, Abedini N, Mirza Tolouei F (2014) Effects of preoperative non-steroidal anti-inflammatory drugs on pain mitigation and patients’ shoulder performance following rotator cuff repair. Adv Pharm Bull 4:363–367PubMedPubMedCentral Rouhani A, Tabrizi A, Elmi A, Abedini N, Mirza Tolouei F (2014) Effects of preoperative non-steroidal anti-inflammatory drugs on pain mitigation and patients’ shoulder performance following rotator cuff repair. Adv Pharm Bull 4:363–367PubMedPubMedCentral
Zurück zum Zitat Sivaganesan A, Chotai S, White-Dzuro G, McGirt MJ, Devin CJ (2017) The effect of NSAIDs on spinal fusion: a cross-disciplinary review of biochemical, animal, and human studies. Eur Spine J 26:2719–2728CrossRef Sivaganesan A, Chotai S, White-Dzuro G, McGirt MJ, Devin CJ (2017) The effect of NSAIDs on spinal fusion: a cross-disciplinary review of biochemical, animal, and human studies. Eur Spine J 26:2719–2728CrossRef
Zurück zum Zitat Tumialan LM, Ponton R, Riccio AI (2011) Arthroscopic techniques in minimally invasive spine surgery: closure of the lumbar fascia: surgical technique. Neurosurgery 68:1092–1094 (discussion 1095)CrossRef Tumialan LM, Ponton R, Riccio AI (2011) Arthroscopic techniques in minimally invasive spine surgery: closure of the lumbar fascia: surgical technique. Neurosurgery 68:1092–1094 (discussion 1095)CrossRef
Zurück zum Zitat Uquillas CA, Capogna BM, Rossy WH, Mahure SA, Rokito AS (2016) Postoperative pain control after arthroscopic rotator cuff repair. J Shoulder Elbow Surg 25:1204–1213CrossRef Uquillas CA, Capogna BM, Rossy WH, Mahure SA, Rokito AS (2016) Postoperative pain control after arthroscopic rotator cuff repair. J Shoulder Elbow Surg 25:1204–1213CrossRef
Zurück zum Zitat Zhang Z, Zhu W, Zhu L, Du Y (2014) Efficacy of celecoxib for pain management after arthroscopic surgery of hip: a prospective randomized placebo-controlled study. Eur J Orthop Surg Traumatol 24:919–923CrossRef Zhang Z, Zhu W, Zhu L, Du Y (2014) Efficacy of celecoxib for pain management after arthroscopic surgery of hip: a prospective randomized placebo-controlled study. Eur J Orthop Surg Traumatol 24:919–923CrossRef
Zurück zum Zitat Zhu X (2020) Efficacy of preemptive analgesia versus postoperative analgesia of celecoxib on postoperative pain, patients’ global assessment and hip function recovery in femoroacetabular impingement patients underwent hip arthroscopy surgery. Inflammopharmacology 28:131–137CrossRef Zhu X (2020) Efficacy of preemptive analgesia versus postoperative analgesia of celecoxib on postoperative pain, patients’ global assessment and hip function recovery in femoroacetabular impingement patients underwent hip arthroscopy surgery. Inflammopharmacology 28:131–137CrossRef
Metadaten
Titel
The analgesic effect and safety of preoperative versus postoperative administration of celecoxib in patients who underwent arthroscopic rotator cuff repair: a randomized, controlled study
verfasst von
Junfeng Yang
Shanfu Wang
Lei Liu
Yang Shao
Jianwei Wang
Publikationsdatum
30.01.2022
Verlag
Springer International Publishing
Erschienen in
Inflammopharmacology / Ausgabe 1/2022
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-021-00893-w