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Endocrine
Erschienen in: Endocrine 3/2021

02.10.2021 | Review

The AP-1 family of transcription factors are important regulators of gene expression within Leydig cells

verfasst von: Ha Tuyen Nguyen, Mustapha Najih, Luc J. Martin

Erschienen in: Endocrine | Ausgabe 3/2021

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Abstract

Purpose

Members of the AP-1 family of transcription factors are immediate early genes being modulated by different extracellular signals. The aim of this review is to highlight the important roles of AP-1 members in transcriptional regulation of genes important for testicular Leydig cell function and male testosterone production.

Methods

A search of the relevant literature was performed in Google Scholar and NCBI Pubmed for AP-1 members and Leydig cells. Additional information was accessed from references of relevant articles. Only primary data from original peer-reviewed articles was considered for this review.

Results

Different signaling pathways important for Leydig cells’ functions are involved in the regulation of the activity of AP-1 members. These transcription factors participate in the regulation of genes related to different biological processes important for Leydig cells.

Conclusions

We conclude that members of the AP-1 family of transcription factors play critical roles in the regulation of Leydig cell proliferation, steroidogenesis, and cell-to-cell communication.
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Metadaten
Titel
The AP-1 family of transcription factors are important regulators of gene expression within Leydig cells
verfasst von
Ha Tuyen Nguyen
Mustapha Najih
Luc J. Martin
Publikationsdatum
02.10.2021
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 3/2021
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-021-02888-7

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