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30.11.2022 | Sleep Breathing Physiology and Disorders • Original Article

The association between biomarker angiopoietin-like protein five and obstructive sleep apnea in patients undergoing bariatric surgery

verfasst von: M. Leentjens, P. F. N. Bosschieter, Abdulmohsen Al-Terki, C. A. L. de Raaff, C. E. E. de Vries, Maha Hammad, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Mohamed Abu-Farha, N. de Vries, Jehad Abubaker

Erschienen in: Sleep and Breathing

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Abstract

Purpose

Obstructive sleep apnea (OSA) is prevalent in the bariatric population. OSA should be recognized in patients undergoing bariatric surgery preoperatively to prevent peri- and post-operative complications. Lipid metabolism-related biomarkers are associated with OSA. Triglyceride metabolism is, among others, regulated by angiopoietin-like protein five (ANGPTL5). We aimed to evaluate the level of ANGPTL5 in patients with OSA of different severity levels before and after bariatric surgery.

Methods

We performed a single-center prospective cohort study including a consecutive series of patients who underwent bariatric surgery. We collected the clinical data, polysomnography (PSG) or polygraphy (PG) parameters, and plasma derived via venipuncture before and 6 to 12 months after surgery. Lipid profile, glucose levels, and ANGPTL5 levels were assessed. ANGPTL5 levels were measured using an enzyme-linked immunosorbent assay (ELISA).

Results

The study included 88 patients for analysis. The patients were divided into two subgroups: no or mild OSA (apnea–hypopnea index (AHI) < 15 events/hour, n = 57) and moderate-to-severe OSA (AHI ≥ 15 events/hour, n = 31). The ANGPTL5 level was higher in the moderate-to-severe OSA group (20.5 [15.6, 26.5] ng/mL) compared to the no or mild OSA group (16.3 [12.5, 19.4] ng/mL) (p = 0.008). A significant positive correlation was observed between ANGPTL5 and AHI (ρ = 0.256, p = 0.017), apnea index (AI) (ρ = 0.318, p = 0.003), and triglyceride levels (ρ = 0.240, p = 0.025). ANGPTL5 levels were reduced significantly after bariatric surgery in both moderate-to-severe OSA (15.6 [10.3, 18.7] ng/mL) and no or mild OSA (13.4 [9.2, 15.8] ng/mL) groups, though to a lower level in the group without or mild OSA. Post-surgery, the significant positive correlation between ANGPTL5 and AHI (ρ = 0.210, p = 0.047), AI (ρ = 0.230, p = 0.034), and triglyceride (ρ = 0.397, p < 0.001) remained.

Conclusion

The data showed increased levels of ANGPTL5 in patients with moderate-to-severe OSA. Both AHI and ANGPTL5 levels decreased significantly after bariatric surgery. We also report an association between ANGPTL5 levels and OSA severity.
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Metadaten
Titel
The association between biomarker angiopoietin-like protein five and obstructive sleep apnea in patients undergoing bariatric surgery
verfasst von
M. Leentjens
P. F. N. Bosschieter
Abdulmohsen Al-Terki
C. A. L. de Raaff
C. E. E. de Vries
Maha Hammad
Thangavel Alphonse Thanaraj
Irina Al-Khairi
Preethi Cherian
Arshad Channanath
Mohamed Abu-Farha
N. de Vries
Jehad Abubaker
Publikationsdatum
30.11.2022
Verlag
Springer International Publishing
Erschienen in
Sleep and Breathing
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-022-02736-6

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