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International Urology and Nephrology

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28.03.2018 | Nephrology - Original Paper

The association between high-density lipoproteins and estimated glomerular filtration rate in patients without severe kidney disease

verfasst von: Domagoj Markovic, Gorana Trgo, Ingrid Prkacin, Damir Fabijanic, Vedran Kovacic

Erschienen in: International Urology and Nephrology | Ausgabe 6/2018

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Abstract

Purpose

Several studies investigated the association between the estimated glomerular filtration rate (eGFR) and the concentration of high-density lipoproteins (HDL) in patients without severely damaged kidney function. As results of those studies were inconclusive and contradictory, we wanted to investigate this association in multiple cardiovascular disease (CVD) risk patients without severe kidney disease or renal failure.

Methods

We enrolled a cohort of 187 patients with intermediate and high CVD risk without severe renal disease. We grouped them based on their eGFR into: group 1 (≥ 30 < 60 ml/min/1.73 m²), group 2 (≥ 60 < 90 ml/min/1.73 m²) and group 3 (≥ 90 ml/min/1.73 m²). We analyzed the difference between their HDL levels and assessed the association of HDL and eGFR in three regression models with the following predictors: model 1 (age and gender), model 2 (model 1 plus smoking status, hs-CRP and diabetes mellitus) and model 3 (model 2 plus excessive weight and obesity, hypertension, hypercholesterolemia, hypertriglyceridemia, family history of CVD and medications they used).

Results

Patients with the lowest eGFR had the lowest HDL values (P = 0.013). In multiple linear regression, HDL was an independent predictor of eGFR (β = 0.189, P = 0.025) which was also shown in multinomial regression for all three models: model 1 [odds ratio (OR) 0.05; 95% confidence interval (CI) 0.007–0.331; P = 0.002], model 2 (OR 0.052; 95% CI 0.006–0.428; P = 0.006) and model 3 (OR 0.2; 95% CI 0.001–0.309; P = 0.005).

Conclusions

Low HDL is an independent predictor of lower eGFR in intermediate and high CVD risk patients without severe kidney disease. In such patients, low HDL could be one of the early indicators of renal failure.

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Titel: The association between high-density lipoproteins and estimated glomerular filtration rate in patients without severe kidney disease
verfasst von: Domagoj Markovic
Gorana Trgo
Ingrid Prkacin
Damir Fabijanic
Vedran Kovacic
Publikationsdatum: 28.03.2018
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 6/2018
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-018-1851-8

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The association between high-density lipoproteins and estimated glomerular filtration rate in patients without severe kidney disease

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

Purpose

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