The association between low skeletal muscle mass and immunoinflammatory markers in middle-aged and elderly patients with type 2 diabetes mellitus
- 06.04.2026
- Original Article
- Verfasst von
- Xinyuan Guo
- Binjing Pan
- Xiaoyu Lv
- Jingfang Liu
- Erschienen in
- Irish Journal of Medical Science (1971 -)
Abstract
Aims
To investigate the relationship between low skeletal muscle mass and specific immunoinflammatory markers in middle-aged and elderly patients with type 2 diabetes mellitus (T2DM).
Methods
978 hospitalized middle-aged and elderly patients with type 2 diabetes mellitus (T2DM), all with a confirmed diagnosis and disease duration ≥ 1 year, were enrolled in this study from the Department of Endocrinology. Patients were divided into a low and a normal skeletal muscle mass group using the appendicular skeletal muscle mass index (ASMI). Differences in clinical indicators between the two groups were compared. Six inflammatory markers, including the neutrophil-to-albumin ratio (NAR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate inflammation systemic index (AISI) were grouped by quartile levels. The prevalence of low skeletal muscle mass was compared between the quartile groups and logistic regression analyses used to explore the independent association between each marker and risk of low skeletal muscle mass.
Results
Levels of all six immunoinflammatory markers were significantly higher in the low skeletal muscle mass group (all P < 0.05) than in the normal group. The prevalence of low skeletal muscle mass increased with increasing quartile levels of each marker. After adjusting for confounding factors (age, gender, body mass index (BMI), and blood lipid levels), all immunoinflammatory markers were independently and positively correlated with the risk of low skeletal muscle mass. NAR×10 (OR = 2.146, 95%CI 1.224 ~ 3.762, P = 0.008), NLR (OR = 1.207, 95%CI 1.036 ~ 1.407, P = 0.016), MLR×10 (OR = 1.281, 95%CI 1.068 ~ 1.537, P = 0.008), SII (OR = 1.001, 95%CI 1.000 ~ 1.002, P = 0.009), SIRI (OR = 1.824, 95%CI 1.269 ~ 2.623, P = 0.001), AISI (OR = 1.003, 95%CI 1.001 ~ 1.004, P = 0.001).
Conclusions
Monitoring the inflammatory markers indicated has clinical value for early screening and intervention of low skeletal muscle mass in this population.
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- Titel
- The association between low skeletal muscle mass and immunoinflammatory markers in middle-aged and elderly patients with type 2 diabetes mellitus
- Verfasst von
-
Xinyuan Guo
Binjing Pan
Xiaoyu Lv
Jingfang Liu
- Publikationsdatum
- 06.04.2026
- Verlag
- Springer International Publishing
- Erschienen in
-
Irish Journal of Medical Science (1971 -)
Print ISSN: 0021-1265
Elektronische ISSN: 1863-4362 - DOI
- https://doi.org/10.1007/s11845-026-04348-5
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