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19.03.2020 | Original Article

The association between serum serotonin levels and overactive bladder: results from a community-based cross-sectional study in Japan

verfasst von: Teppei Okamoto, Shingo Hatakeyama, Atsushi Imai, Hayato Yamamoto, Tohru Yoneyama, Kazuyuki Mori, Takahiro Yoneyama, Yasuhiro Hashimoto, Shigeyuki Nakaji, Chikara Ohyama

Erschienen in: World Journal of Urology | Ausgabe 1/2021

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Abstract

Purpose

To investigate the association between serum serotonin (5-HT) levels and overactive bladder (OAB) in a community-dwelling population.

Methods

This cross-sectional study analyzed 1024 subjects who participated in the Iwaki Health Promotion Project in 2015 in Hirosaki, Japan. OAB was assessed using the Overactive Bladder Symptom Score (OABSS). OAB was defined as an occurrence of urinary urgency at least once a week and an OABSS of ≥ 3. We assessed serum 5-HT levels, laboratory data, and comorbidities of each participants. Participants’ mental health status was evaluated using the Center for Epidemiologic Studies Depression (CES-D) scale. The association of serum 5-HT levels and OAB was analyzed by multivariable logistic regression analysis.

Results

This study included 394 men and 630 women. Of those, 118 (44 male and 74 female) were OAB sufferers. There were significant group differences in age, history of cardiovascular disease, chronic kidney disease, hypertension, diabetes mellitus, and CES-D score. Participants’ serum 5-HT levels in the OAB group were significantly lower than those in the non-OAB group (100 vs. 127 ng/mL, P < 0.001). Multivariable analysis showed that age (odds ratio [OR]; 1.06, 95% confidence interval [CI]; 1.04–1.08, P < 0.001) and log serum 5-HT level (OR; 0.25, 95% CI; 0.10–0.68, P = 0.006) were independently associated with OAB.

Conclusions

Lower serum 5-HT levels could independently be associated with the presence of OAB. Further study is necessary to elucidate a possible causal relationship between serum 5-HT levels and OAB.

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Titel: The association between serum serotonin levels and overactive bladder: results from a community-based cross-sectional study in Japan
verfasst von: Teppei Okamoto
Shingo Hatakeyama
Atsushi Imai
Hayato Yamamoto
Tohru Yoneyama
Kazuyuki Mori
Takahiro Yoneyama
Yasuhiro Hashimoto
Shigeyuki Nakaji
Chikara Ohyama
Publikationsdatum: 19.03.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: World Journal of Urology / Ausgabe 1/2021
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-020-03167-2

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The association between serum serotonin levels and overactive bladder: results from a community-based cross-sectional study in Japan