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11.04.2016 | Nephrology - Original Paper

The association of endothelial progenitor cell markers with arteriovenous fistula maturation in hemodialysis patients

verfasst von: Eray Eroglu, Ismail Kocyigit, Berkay Saraymen, Aydin Tuncay, Ertugrul Mavili, Aydin Unal, Huseyin Avcilar, Mustafa Yavuz Koker, Oktay Oymak

Erschienen in: International Urology and Nephrology | Ausgabe 6/2016

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Abstract

Aims

Arteriovenous fistula (AVF) failure is one of the most important clinical problems in end-stage renal disease. Endothelial progenitor cells (EPCs) have a role on vascular angiogenesis and endothelialization. We aimed to investigate the association markers of EPCs on AVF maturation by measuring the surface expressions of CD34, CD309 and CD133 on the monocytes.

Methods

This prospective observational study was conducted in 54 voluntary patients with end-stage renal disease who were admitted for their first renal replacement therapy and were available for AVF creation. Venography was performed in all patients before AVF creation. Six patients were excluded due to inadequate veins after venographic imaging, and also seven patients were excluded due to postoperative thrombosis. The blood samples were analyzed a day before the fistula operation, and the expressions of CD34, CD133 and CD309 on the surface of monocytes were measured.

Results

Patients were divided into two groups after the evaluation of AVF maturation, as the mature group and the failure group. The CD309 expression level on the monocytes was 338.00 (35.00–479.00) in the mature group; however, it was 36.00 (5.50–237.00) (p 0.031) in the failure group. Multiple logistic regression analyses showed that both BMI and the mean fluorescence intensity level of CD309 expression on monocytes independently predicted AVF maturation.

Conclusions

The presence of DM and increased BMI negatively correlated with AVF maturation. High intensity of CD309 expression on monocytes was observed in patients with successful AVF maturation.

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Titel: The association of endothelial progenitor cell markers with arteriovenous fistula maturation in hemodialysis patients
verfasst von: Eray Eroglu
Ismail Kocyigit
Berkay Saraymen
Aydin Tuncay
Ertugrul Mavili
Aydin Unal
Huseyin Avcilar
Mustafa Yavuz Koker
Oktay Oymak
Publikationsdatum: 11.04.2016
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 6/2016
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-016-1282-3

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The association of endothelial progenitor cell markers with arteriovenous fistula maturation in hemodialysis patients

Abstract

Aims

Methods

Results

Conclusions

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Conclusions

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