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01.12.2012 | Original investigation | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

The association of insulin resistance and carotid atherosclerosis with thigh and calf circumference in patients with type 2 diabetes

Zeitschrift:
Cardiovascular Diabetology > Ausgabe 1/2012
Autoren:
Jong Suk Park, Min Ho Cho, Chul Woo Ahn, Kyung Rae Kim, Kap Bum Huh
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-62) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

Study design, data analysis and manuscript writing: JSP; data collection and analysis: MHC; study design and conduct: CWA; Manuscript revision: KRK, KBH. All authors read and approved the manuscript.

Abstract

Background

The relationship between body composition parameters such as thigh and calf circumference and insulin resistance or atherosclerosis in type 2 diabetes is poorly understood. The aim of this study was to investigate the relationship between insulin resistance, atherosclerosis, and thigh and calf circumference in patients with type 2 diabetes.

Methods

A total of 4,427 subjects with type 2 diabetes were enrolled in this study. Insulin sensitivity was assessed according the rate constant for plasma glucose disappearance (Kitt) determined via the short insulin tolerance test. Biochemical and anthropometric profiles were measured according to a standardized protocol. Visceral fat thickness and carotid intima media thickness (IMT) were measured by ultrasonography.

Results

Insulin sensitivity index (Kitt) was significantly correlated with weight adjusted thigh and calf circumference. Thigh circumference was inversely associated with IMT in men and women and calf circumference was negatively correlated with IMT in women. Multiple stepwise regression analysis revealed that thigh circumference was independently correlated with insulin sensitivity index (Kitt) and IMT. Furthermore, in multivariate logistic regression analysis, thigh circumference was an independent determinant factor for carotid atherosclerosis in patients with type 2 diabetes even after adjusting for other cardiovascular risk factors.

Conclusions

Thigh and calf circumference were correlated with insulin resistance and carotid atherosclerosis, and thigh circumference was independently associated with insulin resistance and carotid atherosclerosis in patients with type 2 diabetes.
Zusatzmaterial
Additional file 1: Figure S1. The relationship between height, body weight, and thigh and calf circumference in men; P <0.01. Figure S2. The relationship between height, body weight, and thigh and calf circumference in women; P <0.01. (DOCX 198 KB)
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Authors’ original file for figure 1
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Authors’ original file for figure 2
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Literatur
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