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Erschienen in: BMC Musculoskeletal Disorders 1/2012

Open Access 01.12.2012 | Research article

The association of sleep difficulties with health-related quality of life among patients with fibromyalgia

verfasst von: Jan-Samuel Wagner, Marco D DiBonaventura, Arthi B Chandran, Joseph C Cappelleri

Erschienen in: BMC Musculoskeletal Disorders | Ausgabe 1/2012

Abstract

Background

Difficulty sleeping is common among patients with fibromyalgia (FM); however, its impact on health-related quality of life (HRQoL) is not well understood. The aim of the current study was to assess the burden of sleep difficulty symptoms on HRQoL among patients with FM.

Methods

The current study included data from the 2009 National Health and Wellness Survey (N=75,000), which is a cross-sectional, Internet-based survey representative of the adult US population. The prevalence of sleep difficulty symptoms among patients with FM (n=2,196) were compared with matched controls (n=2,194), identified using propensity-score matching. Additionally, the relationship between the number of sleep difficulty symptoms (none, one, or two or more) and HRQoL (using the SF-12v2) was assessed using regression modeling, controlling for demographic and health history variables.

Results

Of the 2,196 patients with FM, 11.2% reported no sleep difficulty symptoms, 25.7% reported one sleep difficulty symptom, and 63.05% reported two or more sleep difficulty symptoms. The prevalence of sleep difficulty symptoms was significantly higher than matched controls. Patients with one and two sleep difficulty symptoms both reported significantly worse HRQoL summary and domain scores relative to those with no sleep difficulty symptoms (all p<.05). Further, the relationship between sleep difficulty symptoms and HRQoL was significantly different between those with FM than matched controls, suggesting a uniqueness of the burden of sleep difficulties within the FM population.

Conclusions

Among the FM population, sleep difficulty symptoms were independently associated with clinically-meaningful decrements in mental and physical HRQoL. These results suggest that greater emphasis in the treatment of sleep difficulty symptoms among the FM population may be warranted.
Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1471-2474-13-199) contains supplementary material, which is available to authorized users.

Competing interests

This study was conducted by Kantar Health on behalf of Pfizer Inc, which funded the study. JSW and MD are full-time employees of Kantar Health who were paid consultants to Pfizer in connection with the analysis and the development of this manuscript. AC and JCC are full-time employees of Pfizer, Inc.

Authors’ contributions

JSW participated in the design, coordination, and analysis of the study, and drafted the manuscript. MD was engaged in the conception and design of the study and participated in the manuscript’s drafting and editing. AC was involved in the conception, design, and coordination, of the study, and critically evaluated and provided input to the manuscript. JCC was involved in the design of the study, provided oversight on the analyses, critically evaluated and provided input to the manuscript. All authors read and approved the final manuscript.
Abkürzungen
FM
Fibromyalgia
SD
Standard deviation
HRQoL
Health-related quality of life
US
United States
NHWS
National Health and Wellness Survey
IRB
Institutional review board
BMI
Body mass index
CCI
Charlson comorbidity index
SF
Short Form
MCS
Mental component summary
PCS
Physical component summary.

Background

Fibromyalgia (FM) is a chronic disorder characterized by widespread pain of the muscle and connective tissues, and pain in response to touch or pressure[1]. Often accompanied by non-specific symptoms, such as fatigue, depressive mood, and sleep difficulties[2], FM affects approximately 5 million Americans[3]. As it largely affects a working-age population, and is associated with increased resource use and disability, FM is responsible for substantial societal costs. Indeed, prior research on managed care patients with FM found an average of $10,911 (standard deviation = $16,860) in healthcare expenses per patient per year during 2001–2004[4]. Moreover, patients with FM reported short-term disability at a greater rate than patients with rheumatoid arthritis (20% vs. 15% reported any short-term leave)[4]. Costs also increase with severity, with patients with severe symptoms reporting more than three times the costs of patients with mild symptoms[5].
The societal impact of FM is not limited to economic costs, however. Patients report that FM symptoms substantially impact their quality of life by disrupting relationships, causing social isolation, reducing productivity in activities of daily living, and complicating physical activity[6]. In a recent review of 37 studies, Hoffman & Dukes found patients with FM report mental health-related quality of life (HRQoL) scores 1 standard deviation below the United States (US) population mean and physical HRQoL scores 2 standard deviations below the US population mean[7]. In fact, HRQoL among patients with FM have been found to be similar to or worse than patients with rheumatoid arthritis[8] and other pain conditions[7].
Patients with FM have been found to be significantly more likely to experience difficulties initiating or maintaining sleep than controls (OR=4.56, 95% CI: 4.10-5.06)[9]. In particular, previous studies have identified difficulty falling asleep, staying asleep and waking up too early in the morning as the most common sleep-related symptoms among the FM population[912]. Such sleep difficulties have been associated with negative affect and mood, and pain, which, in turn, have been associated with decrements in physical functioning[1316]. Moreover, in qualitative interviews, patients with FM have reported that sleep disturbances substantially affect their quality of life[5, 17]. However, few studies have assessed the direct association of sleep difficulties with decrements in HRQoL among this patient population.
There were several aims of the current study. One aim was to determine the prevalence of sleep difficulty symptoms among those with FM in comparison with those without FM. The second aim was to examine which demographic and health history variables were significantly associated with the presence of these sleep difficulty symptoms. Lastly, the third aim was to examine the relationship between these sleep difficulty symptoms and HRQoL among patients with FM and determine whether these relationships differed from a non-FM control sample.

Methods

Data source

Data were obtained from the 2009 wave (N = 75,000) of the US National Health and Wellness Survey. The NHWS is an annual, cross-sectional, Internet-based survey administered to a sample of adults (18 years and older) identified through a web-based panel. Members of the panel are recruited through emails, Internet newsletter campaigns, website banner placements, and registration with panel partners. All panel members agreed to become panel members and registered through unique email addresses. Of 501,239 persons contacted to participate in the 2009 NHWS, 92,759 responded (an 18.5% response rate). Of those who responded, 75,000 gave their informed consent, met the inclusion criteria (aged 18 or over), and completed the survey instrument. To mimic the demographic composition of the US general population, a stratified random sampling procedure was implemented when recruiting participants for the NHWS. The NHWS sample, US census, and other national surveys have been compared elsewhere[18]. Institutional review board approval for the 2009 US NHWS was granted by Essex IRB (Lebanon, NJ).

Sample

All respondents to the 2009 US NHWS were included in the analysis (N=75,000).

Measures

Sleep difficulties

Although no sleep scale was included in the NHWS, all respondents were asked whether they experienced difficulty falling asleep, difficulty staying asleep, or waking up too early (the response options for each item were either yes or no). These items, which have been shown to be the most common characteristics of sleep difficulties among patients with FM[912], were used to operationally define the presence of sleep difficulties. Severity of sleep difficulties was established based on the number of sleep difficulty symptoms reported (see Table 1). Similar operationalizations have been used elsewhere[9, 19]. The primary independent variable was a three-level mutually exclusive group variable: no sleep difficulty symptoms, one sleep difficulty symptom, and two or more sleep difficulty symptoms.
Table 1
Criteria for establishing the presence of sleep difficulties in patients
No sleep difficulty symptoms
One sleep difficulty symptom
Two or more sleep difficulty symptoms
Reporting none of the following:
Reporting one of the following:
Reporting two or more of the following:
 · Difficulty falling asleep
 · Difficulty falling asleep
 · Difficulty falling asleep
 · Difficulty staying asleep
 · Difficulty staying asleep
 · Difficulty staying asleep
 · Waking too early
 · Waking too early
 · Waking too early
 · Insomnia
  
 · Sleep difficulties (any)
  

FM

All respondents in the NHWS were presented with a list of medical conditions and asked to select which ones they had ever experienced (“which of the following conditions have you ever experienced?”). FM (presented as “fibromyalgia” to respondents) was included in this list. All respondents who selected FM were subsequently asked “has your fibromyalgia been diagnosed by a physician?”, with yes/no response options. Only respondents who reported a diagnosis of FM were considered to have FM for the purposes of this study and the remaining respondents were considered controls.

Demographic and health history variables

Age, race/ethnicity (non-Hispanic white, non-Hispanic black, Hispanic, or other race/ethnicity), marital status (married/living with partner versus all else), education (high school graduate or less versus some college or higher), annual household income ($25K or less, $25K to <$50K, $50K to <$75K, $75K or more, or decline to answer), employment (full-time, part-time, self-employed, not employed and not looking for work, not employed but looking for work, on disability, retired, student, or homemaker), health insurance (yes versus no), exercise (no days with 20 minutes or more of exercise in the past month, 1–9 days, or 10 or more days), smoking habits (current smoker versus non-smoker), alcohol consumption (consume alcohol versus abstain from alcohol), body mass index (BMI; underweight, normal weight, overweight, obese, or decline to provide weight), and comorbidity burden (using the Charlson Comorbidity Index; CCI[20]) were assessed.
Pain severity (no pain, mild pain, moderate pain, and severe pain) and frequency (no pain, daily pain, 4–6 days of pain per week, 2–3 days of pain per week, weekly pain, 2–3 days of pain per month, 1 day of pain a month or less) information were also measured for each respondent.
HRQoL was assessed using the the Medical Outcomes Study Short Form-12 questionnaire (SF-12), version 2, which has a four-week recall period[21]. The SF-12 was developed to replicate the mental (MCS) and physical component summary (PCS) scores and domain scores of the SF-36. The eight health domains include: physical functioning, physical role limitations, emotional role limitations, bodily pain, general health, vitality, social functioning, and mental health. The PCS and MCS are normed to the US population (Mean = 50, SD = 10), with higher scores indicating greater quality of life. Differences of 3 points in MCS and PCS were considered clinically meaningful, in accordance with previous findings[22].

Analyses

There were four components to the analysis. In the first, the prevalence of sleep difficulty symptoms among patients with FM were reported and compared with those without FM (both unmatched and matched controls) using chi-square tests. Unmatched controls were defined as those who did not report a diagnosis of FM. Matched controls were created using a propensity score matching method[23].
A logistic model was conducted using age, gender, race/ethnicity, and comorbidities (using the CCI) to predict a diagnosis of FM. Propensity score values were saved from this regression and used in a greedy-matching algorithm to assign each patient diagnosed with FM with a single control, whose propensity score was identical. Although there were 2,196 patients diagnosed with FM, only 2,194 patients were able to be matched (the remaining two patients had a pattern of covariates which was too unique to find a suitable control). Therefore, there were 2,194 matched controls.
The second component of the analysis compared the different symptom groups (no sleep difficulty symptoms versus one sleep difficulty symptom versus two or more sleep difficulty symptoms) among those with FM with respect to demographics and health history variables noted above. Comparisons were made with chi-square tests and one-way ANOVAs.
The third component of the analysis consisted of regressing summary and domain scores of the SF-12 onto the number of sleep difficulty symptoms (none, one, or two or more) among patients with FM. These models were conducted using linear regression for complex survey designs (PROC SURVEYREG in SAS v9.1). For the sake of parsimony, only covariates which differed among the groups were included in the model: age, smoking status (non-smoker served as the reference category), pain severity (no pain served as the reference category), and pain frequency (no pain served as the reference category).
The fourth component of the analysis was a comparison of the relationship of sleep difficulty symptoms and HRQoL between those with FM and matched controls. This was accomplished by entering the case variable (diagnosed FM versus matched control), number of sleep symptoms (none, one, and two or more), and the interaction term into a linear regression model (PROC SURVEYREG) for each summary and domain score. Effects coding was used for all variables. This model tested the main effect (i.e., whether HRQoL was different between those with FM and matched controls) as well as the interaction (i.e., whether the relationship between the number of sleep symptoms and HRQoL differed between patients with FM and matched controls).
All analyses applied sampling weights from the NHWS. Although raw sample sizes are provided in many cases, all other statistical information (unless otherwise specified) were weighted to project to the population. Analyses were conducted using SAS v9.1 (Cary, NC) and statistical significance was set at p<.05.

Results

Frequency of sleep difficulty symptoms

A total of 2,196 patients in the NHWS reported diagnosis of FM (2.81%). Of these, 269 (11.2%) reported no sleep difficulty symptoms, 574 (25.7%) reported one sleep difficulty symptom, and 1353 (63.05%) reported two or more sleep difficulty symptoms. The prevalence of sleep difficulty symptoms was significantly higher when compared with those without FM (none: 40.7%; one: 29.0%; two or more: 30.3%; p<.0001). Indeed, even when comparing patients with FM with matched controls (those matched on age, sex, ethnicity, and comorbidities), the prevalence of sleep difficulty symptoms was significantly higher (none: 11.2% vs. 32.9% for FM and matched control patients, respectively; one: 25.7% vs. 28.22%, respectively; two or more: 63.1% vs. 38.9%, respectively; p<.0001).

Demographic and health history comparisons

Among patients with FM, few demographic and health history variables were related to the number of sleep symptoms experienced (see Table 2). Patients with FM who reported sleep difficulties were younger, less likely to be retired and possess health insurance, and more likely to be on disability and to currently smoke. Levels of severe pain increased concomitantly with the number of sleep symptoms (19.08% vs. 30.77% vs. 43.26% for those with none, one, and two sleep difficulty symptoms, respectively). Similarly, reports of daily pain also increased along with the number of sleep difficulty symptoms (49.21% vs. 59.67% vs. 70.88%).
Table 2
Demographic and health history differences associated with the number of sleep difficulty symptoms among patients with fibromyalgia
 
No sleep symptoms (n=269)
One sleep symptom (n=574)
Two or more sleep symptoms (n=1353)
 
Variable
n
Weighted n
Weighted %
SE
n
Weighted n
Weighted %
SE
n
Weighted n
Weighted %
SE
p
Male
42
100791
14.27%
2.24%
109
291061
17.96%
1.71%
204
595728
15.01%
1.08%
0.2813
Race/ethnicity
            
0.0701
 Non-Hispanic white
231
579865
82.11%
2.72%
480
1297016
80.03%
1.93%
1096
3060560
77.12%
1.34%
 
 Non-Hispanic black
16
44654
6.32%
1.55%
36
95814
5.91%
0.97%
80
207978
5.24%
0.58%
 
 Hispanic
12
51952
7.36%
2.08%
34
160905
9.93%
1.63%
82
396647
9.99%
1.06%
 
 Other
10
29762
4.21%
1.34%
24
66882
4.13%
0.86%
95
303503
7.65%
0.86%
 
Greater than high school education
205
548338
77.64%
2.86%
445
1254870
77.43%
1.89%
1041
3115084
78.49%
1.17%
0.8776
Annual household income
     
0.0906
 <$25K
67
164262
23.26%
2.91%
157
453920
28.01%
2.06%
405
1194941
30.11%
1.35%
 
 $25K to <$50K
75
209604
29.68%
3.2%
162
450214
27.78%
2.04%
431
1254027
31.60%
1.37%
 
 $50K to <$75K
59
161650
22.89%
2.87%
125
329591
20.34%
1.75%
234
691354
17.42%
1.08%
 
 $75K or more
47
128776
18.23%
2.65%
100
294962
18.20%
1.74%
228
687512
17.32%
1.1%
 
 Decline to answer
21
41942
5.94%
1.4%
30
91929
5.67%
1.09%
55
140853
3.55%
0.51%
 
Employment
            
<.0001
 Full-time
40
129881
18.39%
2.69%
96
302795
18.68%
1.78%
204
637364
16.06%
1.06%
 
 Part-time
21
56486
8.00%
1.76%
58
161415
9.96%
1.31%
132
379165
9.55%
0.83%
 
 Self-employed
17
46951
6.65%
1.62%
30
85771
5.29%
0.99%
81
248640
6.27%
0.69%
 
 Unemployed, looking for work
12
32426
4.59%
1.35%
22
59646
3.68%
0.8%
75
231083
5.82%
0.68%
 
 Unemployed, not looking
2
4421
0.63%
0.48%
15
43845
2.71%
0.7%
63
186145
4.69%
0.59%
 
 Retired
114
258239
36.57%
3.39%
160
391288
24.14%
2.02%
283
715123
18.02%
1.22%
 
 Disability
40
116650
16.52%
2.46%
133
394200
24.32%
1.89%
379
1154974
29.10%
1.31%
 
 Student
1
2271
0.32%
0.32%
6
21302
1.31%
0.56%
15
47148
1.19%
0.31%
 
 Homemaker
22
58909
8.34%
1.81%
54
160354
9.89%
1.34%
121
369046
9.30%
0.83%
 
Married/living with partner
162
420899
59.60%
3.41%
353
968068
59.73%
2.26%
816
2426243
61.13%
1.43%
0.8299
Possess health insurance
252
651206
92.21%
1.84%
517
1448371
89.37%
1.38%
1181
3433135
86.51%
0.98%
0.0153
Exercise behavior
            
0.0624
 None in past month
118
297414
42.11%
3.38%
265
709114
43.76%
2.24%
674
1954071
49.24%
1.46%
 
 1-9 days exercise in past month
59
167526
23.72%
2.97%
157
456390
28.16%
2.05%
306
938221
23.64%
1.29%
 
 10+ days exercise in past month
92
241295
34.17%
3.25%
152
455112
28.08%
2.06%
373
1076395
27.12%
1.28%
 
Alcohol use
140
367023
51.97%
3.44%
299
835869
51.58%
2.27%
672
1991970
50.19%
1.46%
0.8168
Current smoker
58
163896
23.21%
2.95%
171
515809
31.83%
2.11%
405
1227589
30.93%
1.34%
0.0405
Body mass index
            
0.1211
 Underweight
5
9180
1.30%
0.67%
11
35633
2.20%
0.68%
16
42536
1.07%
0.28%
 
 Normal
53
144538
20.47%
2.87%
128
397673
24.54%
2.01%
277
811375
20.44%
1.17%
 
 Overweight
80
208488
29.52%
3.13%
168
462626
28.55%
2.04%
346
1061443
26.75%
1.34%
 
 Obese
120
309173
43.78%
3.39%
257
696615
42.98%
2.23%
682
1956748
49.30%
1.46%
 
 Decline to answer weight
11
34856
4.94%
1.6%
10
28070
1.73%
0.55%
32
96584
2.43%
0.44%
 
Pain severity
            
<.0001
 No pain
79
217295
30.77%
3.16%
129
373430
23.04%
1.94%
217
611959
15.42%
1.03%
 
 Mild pain
10
32456
4.60%
1.7%
34
87366
5.39%
0.97%
29
83328
2.10%
0.41%
 
 Moderate pain
113
295400
41.83%
3.42%
217
593646
36.63%
2.16%
514
1503698
37.89%
1.42%
 
 Severe pain
57
134783
19.08%
2.5%
175
498641
30.77%
2.08%
574
1716877
43.26%
1.46%
 
 Missing severity
10
26300
3.72%
1.23%
19
67533
4.17%
1%
19
52824
1.33%
0.31%
 
Pain frequency
            
<.0001
 No pain
79
217295
30.77%
3.16%
129
373430
23.04%
1.94%
217
611959
15.42%
1.03%
 
 Daily pain
140
347542
49.21%
3.43%
347
966989
59.67%
2.23%
955
2813110
70.88%
1.31%
 
 4-6 days per week
18
44232
6.26%
1.55%
40
107597
6.64%
1.07%
105
320622
8.08%
0.8%
 
 2-3 days per week
11
37374
5.29%
1.9%
28
74165
4.58%
0.91%
43
128377
3.23%
0.51%
 
 Weekly pain
2
6227
0.88%
0.64%
6
19050
1.18%
0.48%
7
19631
0.49%
0.19%
 
 2-3 days per month or less
9
27264
3.86%
1.45%
5
11852
0.73%
0.35%
7
22164
0.56%
0.21%
 
Missing frequency
10
26300
3.72%
1.23%
19
67533
4.17%
1%
19
52824
1.33%
0.31%
 
 
Mean
Weighted Mean
SE
 
Mean
Weighted Mean
SE
 
Mean
Weighted Mean
SE
p
Age
57.56
56.04
1.07
 
53.36
51.90
0.7
 
52.47
51.63
0.39
0.0006
Charlson comorbidity index
1.1
1.11
0.11
 
1.3
1.34
0.13
 
1.18
1.17
0.05
0.3475

Association of sleep difficulty symptoms and health-related quality of life

The distributions of all HRQoL summary and domain scores for those with FM are presented in Table 3. Linear regressions were conducted to determine the relationship between the number of sleep difficulty symptoms and HRQoL among those with FM (see Table 4). For all summary and domain scores, the experience of sleep difficulty symptoms was associated with a significant decrement relative to those without any sleep difficulty symptoms. In the case of the normed mental and physical component summary scores, the effects of both one (b’s: -2.79 and −2.42, respectively) and two sleep difficulty symptoms (b’s: -3.91 and −2.84, respectively) approached or exceeded clinically-relevant thresholds (i.e., 3 points).
Table 3
Descriptive statistics of summary and domain scores of the SF-12 among patients with fibromyalgia
 
Min
% at Min
Q1
Median
Mean
Q3
Max
% at Max
Summary scores
 Mental component summary
3.57
0.05%
31.98
41.07
41.49
51.22
71.53
0.05%
 Physical component summary
7.25
0.05%
23.99
31.29
31.29
39.88
63.16
0.05%
 Health utilities
0.35
1.50%
0.49
0.57
0.57
0.64
1.00
0.23%
Domain scores
 Bodily pain*
0.00
20.49%
25.00
25.00
25.00
50.00
100.00
2.41%
 General health*
0.00
13.34%
25.00
25.00
25.00
60.00
100.00
1.55%
 Vitality*
0.00
30.78%
0.00
25.00
25.00
50.00
100.00
1.14%
 Social functioning*
0.00
12.66%
25.00
50.00
50.00
75.00
100.00
13.93%
 Mental health**
0.00
2.73%
37.50
50.00
50.00
75.00
100.00
1.82%
 Emotional role limitations**
0.00
8.24%
37.50
50.00
50.00
87.50
100.00
21.36%
 Physical role limitations**
0.00
21.04%
12.50
25.00
25.00
50.00
100.00
4.74%
 Physical functioning*
0.00
29.96%
0.00
25.00
25.00
50.00
100.00
10.75%
*Note these domains scores from the SF-12 are based only on a five-point range (0, 25, 50, 75, 100).
**Note these domains scores from the SF-12 are based only on a 9-point range (0, 12.5, 25, 37.5, 50, 62.5, 75, 87.5, 100).
Table 4
Regression estimates for the number of sleep difficulty symptoms when predicting health-related quality of life
Dependent variable
 
No symptoms (reference)
One symptom
Two or more symptoms
Mental component summary
b
--
−2.786
−3.905
 
95% CL
--
(−4.448, -1.124)
(−5.461, -2.35)
R2
 
0.174
Physical component summary
b
--
−2.415
−2.835
 
95% CL
--
(−4.144, -0.686)
(−4.467, -1.202)
 
R2
 
0.241
Health utilities
b
--
−0.041
−0.054
 
95% CL
--
(−0.06, -0.022)
(−0.072, -0.035)
R2
 
0.284
Bodily pain
b
--
−5.770
−8.555
 
95% CL
--
(−9.729, -1.811)
(−12.239, -4.87)
R2
 
0.312
General health
b
--
−6.349
−8.441
 
95% CL
--
(−10.358, -2.34)
(−12.222, -4.66)
Vitality
R2
 
0.153
 
b
--
−5.943
−6.637
 
95% CL
--
(−9.994, -1.893)
(−10.447, -2.827)
R2
 
0.097
Social functioning
b
--
−7.327
−10.838
 
95% CL
--
(−11.741, -2.913)
(−14.906, -6.771)
R2
 
0.205
Mental health
b
--
−4.366
−8.658
 
95% CL
--
(−7.71, -1.021)
(−11.805, -5.511)
R2
 
0.184
Emotional role limitations
b
--
−8.094
−7.546
 
95% CL
--
(−12.802, -3.387)
(−11.847, -3.245)
R2
 
0.120
Physical role limitations
b
--
−9.485
−10.416
 
95% CL
--
(−14.043, -4.928)
(−14.683, -6.148)
R2
 
0.194
Physical functioning
b
--
−6.015
−6.915
 
95% CL
--
(−11.315, -0.715)
(−11.867, -1.963)
 
R2
 
0.177
Regression coefficients represent the difference in HRQoL for those with one and two symptoms relative to those without any (e.g., those with one symptom and two or more symptoms reported mental component summary scores 2.786 and 3.905 points less, respectively, than those without symptoms). All models controlled for age, smoking status, pain severity, and pain frequency.
Similarly, decrements in health utility values (b = −0.04 and −0.05 for one and two sleep difficulty symptoms, respectively) were also above clinically-relevant thresholds (i.e., 0.03 points). The SF-12 domain scores for those with one sleep difficulty symptom were equally affected (generally speaking) compared with those with no sleep difficulty symptoms (b’s ranged from −4.37 to −9.49); similarly, the SF-12 domain scores for those with two sleep difficulty symptoms were also equally affected compared with those with no sleep difficulty symptoms (b’s ranged from −6.64 to −10.84).
Additional models were then conducted to determine whether the relationship between sleep difficulty symptoms and HRQoL was different among those with FM than a similar cohort without FM. When compared with matched controls, patients with FM reported significantly worse HRQoL across all summary and domain scores of the SF-12 (i.e., “main effects”; see Table 5; all p<.0001).
Table 5
Mean levels of health-related quality of life for patients with fibromyalgia and matched controls as a function of sleep difficulty symptoms
 
Matched control
Patients with FM
No symptoms (n=717)
One symptom (n=636)
Two or more symptoms (n=841)
No symptoms (n=269)
One symptom (n=572)
Two or more symptoms (n=1353)
p (Main effect)
p (Interaction)
Mental component summary
51.20
47.65
43.51
47.26
42.34
40.00
<.0001
<.0001
Physical component summary
46.56
43.51
41.68
35.91
33.24
31.57
<.0001
0.0445
Health utilities
0.77
0.71
0.66
0.64
0.59
0.55
<.0001
<.0001
Bodily pain
75.45
66.86
59.69
46.00
37.94
31.04
<.0001
0.0028
General health
67.34
59.82
54.99
52.86
43.75
39.49
<.0001
0.0097
Vitality
53.66
46.74
37.57
36.52
28.54
25.67
<.0001
<.0001
Social functioning
83.05
73.86
63.59
63.66
52.01
44.92
<.0001
0.0003
Mental health
74.01
64.94
56.79
64.73
55.75
49.06
<.0001
<.0001
Emotional role limitations
83.26
76.47
69.59
69.80
58.26
55.14
<.0001
0.0545
Physical role limitations
73.34
63.38
56.45
48.19
36.39
31.88
<.0001
0.0069
Physical functioning
74.23
64.98
58.95
46.47
39.51
34.59
<.0001
0.0151
The p-value for the main effect represents the significance of the HRQoL differences between patients with FM and matched controls across all levels of symptoms. The p-value for the interaction represents the significance of whether the change from no symptoms to one symptom to two or more symptoms was different between patients with FM and matched controls.
However, the relationships between the number of sleep difficulty symptoms and HRQoL was significantly stronger among those with FM. In other words, significant interactions were observed for all summary and domain scores (with the exception of emotional role limitations). In most cases, the decrement between no sleep difficulty symptoms and one sleep difficulty symptom was larger among those patients with FM; conversely, the quality of life decrement between one and two or more sleep difficulty symptoms was larger among matched controls.

Discussion

The objective of the current study was to assess the impact of sleep difficulties on HRQoL among patients with FM. Despite the research on the sleep-related symptoms experienced by those with FM, no study to our knowledge has examined the relationship of these symptoms with HRQoL, especially in comparison with a matched control group. Our results suggest sleep difficulties are pervasive among the FM population, as over 88% of patients reported some level of sleep difficulties, as defined by experiencing either difficulty falling asleep, difficulty staying asleep, or waking up too early. Nearly 63% of patients with FM reported experiencing at least two of the above symptoms. These figures were significantly higher than those without FM, even those matched with FM patients.
Replicating past literature, our sample of patients with FM reported significant decrements in both MCS (41.49) and PCS (31.29) scores relative to population norms (50 and 50, respectively). Indeed, the one and two standard deviation differences, respectively, in MCS and PCS compared with the population mean is nearly identical to the results reported by previous literature[6, 7]. On an absolute level, these levels of HRQoL are worse than reported in the same survey for patients with severe osteoarthritis, chronic obstructive pulmonary disease, atrial fibrillation, hepatitis C, arthritis, and back pain, among others[2428], However, our findings suggest that the presence of sleep difficulties poses an additional burden on patients with FM. Our results suggest that sleep difficulty symptoms has an independent, and significant, clinically-meaningful effect on HRQoL among the FM population. Past research has suggested a three-point between-groups difference in MCS and PCS is often associated with a clinically-meaningful difference[21]. The comparison between one sleep difficulty symptom and no sleep difficulty symptoms approached this threshold while the comparison between two sleep difficulty symptoms and no sleep difficulty symptoms exceeded it, even after adjusting for confounding variables.
It is particularly important to note that these models controlled for pain severity and frequency. Naturally, severe pain and frequent pain (as confirmed in Table 2) would be expected to have a significant effect on sleep symptoms, as also demonstrated in prior research[14, 16, 20, 22]. Yet, even accounting for the higher prevalence of pain severity and frequency among those with more sleep difficulty symptoms, worse HRQoL summary and domain scores were observed. This suggests that sleep difficulties have an independent effect on HRQoL among those with FM, beyond any potential effect of the pain experience.
Also noteworthy was that the relationship between sleep difficulties and HRQoL varied between those with FM and matched controls. In many cases, the introduction of a single sleep difficulty symptom was associated with a larger decrement in HRQoL among patients with FM, however, the introduction in a second sleep difficulty symptom was associated with larger decrement in HRQoL among matched controls. Further research may be necessary to ascertain the cause of the discrepancy. One possibility is that sleep difficulties are generally more burdensome for patients with FM, however, given the nature of the disease, a floor effect is reached upon the introduction of the second sleep difficulty symptom. In other words, patients with FM are so burdened already by their condition that the introduction of an additional sleep difficulty symptom does not affect their HRQoL as much as it would a patient without FM. Regardless, our preliminary evidence suggests that the pattern of the relationship between sleep difficulty symptoms and HRQoL is unique among those with FM.
The effect of sleep difficulty symptoms extended beyond HRQoL. In unadjusted comparisons, patients who reported sleep difficulties showed higher rates of disability than those without sleep difficulties. Although beyond the scope of the present analysis, the effect of sleep difficulties on participation in the labor force and productivity at work may also need to be considered in future research.
In sum, the results suggest patients with FM experience considerable difficulty initiating and maintaining sleep. The presence of these sleep difficulty symptoms have a significant and clinically-meaningful impact on HRQoL, even after accounting for a range of confounding variables. The study results suggest the improved management of these sleep difficulty symptoms among patients with FM may lead to clinically-relevant improvements in HRQoL. The alleviation of pain could have an important effect of improving sleep, but more research would be necessary to establish this causal pathway. Indeed, the relationship between pain and sleep does appear bidirectional[29]. Of course, since the effect of sleep difficulty symptoms on HRQoL was observed even after controlling for pain, the management of sleep difficulties likely extends beyond the mere alleviation of pain.

Limitations

Several limitations should be noted from the results of this study. Given the cross-sectional design of the study, the causal inference cannot be determined. Although alternative explanations have been included (such as comorbidities and, demographic confounders), it is possible other unmeasured variables might explain the relationship between sleep difficulties and HRQoL. Because of the self-reported nature, recall bias may have introduced additional error into the observed associations. As described before, the sleep difficulty groups were not defined by a sleep scale but rather using three symptoms of initiating and maintaining sleep to operationalize sleep difficulty severity. It should also be emphasized that although the NHWS is demographically representative of the US population, the sample in the current study of FM patients may differ with respect to healthcare attitudes or healthcare engagement (among other variables) that could affect the size and direction of the relationships observed here.

Conclusions

Sleep difficulties were found to have significant and clinically meaningful deleterious effects on HRQoL among the FM population. Effective treatment of sleep difficulties may improve HRQoL among the FM population.

Acknowledgements

The authors would like to thank Ms. Da-In Kim for her assistance coordinating the study and editorial support which was funded by Pfizer Inc.
Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://​creativecommons.​org/​licenses/​by/​2.​0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Competing interests

This study was conducted by Kantar Health on behalf of Pfizer Inc, which funded the study. JSW and MD are full-time employees of Kantar Health who were paid consultants to Pfizer in connection with the analysis and the development of this manuscript. AC and JCC are full-time employees of Pfizer, Inc.

Authors’ contributions

JSW participated in the design, coordination, and analysis of the study, and drafted the manuscript. MD was engaged in the conception and design of the study and participated in the manuscript’s drafting and editing. AC was involved in the conception, design, and coordination, of the study, and critically evaluated and provided input to the manuscript. JCC was involved in the design of the study, provided oversight on the analyses, critically evaluated and provided input to the manuscript. All authors read and approved the final manuscript.
Anhänge

Authors’ original submitted files for images

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Metadaten
Titel
The association of sleep difficulties with health-related quality of life among patients with fibromyalgia
verfasst von
Jan-Samuel Wagner
Marco D DiBonaventura
Arthi B Chandran
Joseph C Cappelleri
Publikationsdatum
01.12.2012
Verlag
BioMed Central
Erschienen in
BMC Musculoskeletal Disorders / Ausgabe 1/2012
Elektronische ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-13-199

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