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Osteoporosis International

Erschienen in:

01.06.2018 | Original Article

The associations between the changes in serum inflammatory markers and bone mineral accrual in boys with overweight and obesity during pubertal maturation: a 3-year longitudinal study in Estonian boys

verfasst von: E. Mengel, V. Tillmann, L. Remmel, P. Kool, P. Purge, E. Lätt, J. Jürimäe

Erschienen in: Osteoporosis International | Ausgabe 9/2018

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Abstract

Summary

Adipose tissue produces different inflammatory cytokines which compromise bone mineral accrual during puberty. Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), interleukin (IL)-8, and interferon-gamma (IFN-γ) are significantly related to bone mineral accrual during pubertal maturation in boys with different BMI values.

Introduction

This longitudinal study aims to identify the inflammatory markers that most strongly associate with pubertal bone mineral density (BMD) increment in boys with overweight and obesity (OWB).

Methods

Twenty-six OWB and 29 normal-weight boys were followed yearly for 3 years to measure changes in 12 serum inflammatory markers, BMD (by DXA), and apparent volumetric BMD. The OWB group was further divided into two subgroups according to their BMI gain during the 3-year period. Data through time points presented as slopes were used to calculate correlation coefficients to explore the possible relationships between variables of interest. In the whole study group, linear mixed effects (LME) models were also used.

Results

Increment in serum VEGF concentration was inversely associated with an increase in total body (TB) BMD (r = − 0.82, P = 0.02) and TB bone mineral content (BMC)/height (r = − 0.82, P = 0.02) in those OWB whose BMI gain was higher during pubertal years. In the whole study group, the LME model confirmed the inverse association between VEGF and TB BMC/height (P < 0.05). EGF was inversely associated with LS BMD and LS BMAD (P < 0.05), whereas there was a positive association between IL-8 and TB BMAD and between IFN-γ and LS BMD (P < 0.05).

Conclusions

Lower increment in BMD in OWB with higher BMI gain is associated with increasing serum VEGF concentration during pubertal maturation. VEGF, EGF, IL-8, and IFN-γ are significantly associated with BMD during pubertal maturation in boys with different BMI values.

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Titel: The associations between the changes in serum inflammatory markers and bone mineral accrual in boys with overweight and obesity during pubertal maturation: a 3-year longitudinal study in Estonian boys
verfasst von: E. Mengel
V. Tillmann
L. Remmel
P. Kool
P. Purge
E. Lätt
J. Jürimäe
Publikationsdatum: 01.06.2018
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 9/2018
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-018-4580-z

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Springer Medizin

The associations between the changes in serum inflammatory markers and bone mineral accrual in boys with overweight and obesity during pubertal maturation: a 3-year longitudinal study in Estonian boys

Abstract

Summary

Introduction

Methods

Results

Conclusions

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Springer Medizin

Abstract

Summary

Introduction

Methods

Results

Conclusions

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