The objective of this study was to investigate the biomechanical and histological effects of the posterior cruciate ligament (PCL) on the medial tibial plateau.
A total of 12 cadaveric human knee specimens were collected and grouped as follows: the PCL intact group (n = 12), the anterolateral bundle rupture group (n = 6), the postmedial bundle rupture group (n = 6), and the PCL rupture group (n = 12). The strain on the anterior, middle, and posterior parts of the medial tibial plateau with an axial loading force at different flexion angles was measured and analyzed, respectively. Forty-eight rabbits were chosen for animal study: surgery was performed on the one side of each rabbit randomly (experimental group), while the other side was taken as control (control group). Every 12 rabbits were culled at each of the four selected time points to collect the medial tibial plateau for morphological and histological observation.
The PCL rupture, either partial or complete, may generate an abnormal load on all the parts of the medial tibial plateau with axial loading at all positions. Noticeable time-dependent degenerative histological changes of the medial tibial plateau were observed in the rabbit models of PCL rupture. Compared with the control group, all the PCL rupture groups exhibited a higher expression of the matrix metalloproteinase-7 (MMP-7) and the tissue inhibitors of metalloproteinase-1 (TIMP-1) at all the time points.
Either partial or complete PCL rupture may generate an abnormal load on all the parts of the medial tibial plateau with axial loading at all the positions and may cause cartilage degeneration on the medial tibial plateau.
Kim SJ, Jung M, Moon HK, Kim SG, Chun YM. Anterolateral transtibial posterior cruciate ligament reconstruction combined with anatomical reconstruction of posterolateral corner insufficiency: comparison of single-bundle versus double-bundle posterior cruciate ligament reconstruction over a 2- to 6-year follow-up. Am J Sports Med. 2011;39(3):481–9. CrossRefPubMed
Lei P, Sun R, Hu Y, Li K, Liao Z. Effect of posterior cruciate ligament rupture on the radial displacement of lateral meniscus. Clin Biomech (Bristol, Avon). 2015;30(5):448–53. CrossRef
Chen YT, Hou CH, Hou SM, Liu JF. The effects of amphiregulin induced MMP-13 production in human osteoarthritis synovial fibroblast. Mediators Inflamm. 2014:759028. doi: 10.1155/2014/759028. Epub 2014 Jul 24. PMID: 25147440.
Li G, Li K, Zhu Y, Li S, Zhang J. Histological changes of degenerated lateral meniscus after anterior cruciate ligament rupture in rabbits. J Clin Rehabilit Tissue Eng Res. 2009;13:3873–6.
Wang J, Ao Y. Study on the articular cartilage degeneration secondary to posterior cruciate ligament rupture in rabbit knee. Chin J Sports Med. 2004;23:476–9.
Tchetina EV, Squires G, Poole AR. Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions. J Rheumatol. 2005;32(5):876–86. PubMed
- The biomechanical and histological effects of posterior cruciate ligament rupture on the medial tibial plateau
- BioMed Central
Neu im Fachgebiet Orthopädie und Unfallchirurgie
Mail Icon II