The Bone-Vascular Axis in Chronic Kidney Disease: From Pathophysiology to Treatment
- 10.01.2024
Erschienen in:
- Verfasst von
- Clément Vachey
- Alexandre Candellier
- Soline Toutain
- Fabrice Mac-Way
- Erschienen in
- Current Osteoporosis Reports | Ausgabe 1/2024
Abstract
Purpose of Review
This review aims to describe the pathogenic factors involved in bone-vessel anomalies in CKD which are the object of numerous experimental and clinical research.
Recent Findings
Knowledge on the pathophysiological mechanisms involved in the regulation of vascular calcification and mineral-bone disorders is evolving. Specific bone turnover anomalies influence the vascular health while recent studies demonstrate that factors released by the calcified vessels also contribute to bone deterioration in CKD. Current therapies used to control mineral dysregulations will impact both the vessels and bone metabolism. Available anti-osteoporotic treatments used in non-CKD population may negatively or positively affect vascular health in the context of CKD. It is essential to study the bone effects of the new therapeutic options that are currently under investigation to reduce vascular calcification.
Summary
Our paper highlights the complexity of the bone-vascular axis and discusses how current therapies may affect both organs in CKD.
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- Titel
- The Bone-Vascular Axis in Chronic Kidney Disease: From Pathophysiology to Treatment
- Verfasst von
-
Clément Vachey
Alexandre Candellier
Soline Toutain
Fabrice Mac-Way
- Publikationsdatum
- 10.01.2024
- Verlag
- Springer US
- Erschienen in
-
Current Osteoporosis Reports / Ausgabe 1/2024
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241 - DOI
- https://doi.org/10.1007/s11914-023-00858-8
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