Background
Methods
Clinical data and grouping
Diagnostic criteria
The judging criteria for risk factors
Exclusion criteria
CAG and PCI methods
Perioperative medication during PCI
Success criteria of PCI
Statistical analyses
Results
Comparative analysis of age and risk factors between the two groups
Age (years old) | < 30 | 30–39 | 40–44 | mean ± standard deviation |
---|---|---|---|---|
ACS group, n (%) | 12 (2.89) | 90 (21.69) | 313 (75.24) | 40.77 ± 4.02 |
Control group, n (%) | 14 (3.37) | 90 (21.69) | 311 (74.94) | 40.57 ± 4.01 |
ACS group | Control group | X2 value | P value | |
---|---|---|---|---|
Overweight n (%) | 266 (64.10) | 69 (16.63) | 194.250 | 0.000 |
Hypertension n (%) | 207 (49.88) | 46 (11.08) | 147.378 | 0.000 |
Hyperlipidemia n (%) | 169 (40.72) | 13 (3.13) | 171.27 | 0.000 |
Diabetes n (%) | 97 (23.37) | 17 (4.09) | 65.079 | 0.000 |
Depression or anxiety n (%) | 69 (16.63) | 10 (2.41) | 48.698 | 0.000 |
Gynecological diseases n (%) | 68 (16.39) | 9 (2.17) | 49.813 | 0.000 |
Hyperuricemia n (%) | 62 (14.94) | 27 (6.51) | 15.417 | 0.000 |
Family history of CHD n (%) | 62 (14.94) | 9 (2.17) | 43.264 | 0.000 |
Hyperhomocysteinemia n (%) | 47 (11.33) | 4 (0.96) | 38.628 | 0.000 |
Hypothyroidism n (%) | 40 (9.64) | 4 (0.96) | 31.103 | 0.000 |
Hypercholesterolemia n (%) | 35 (8.43) | 7 (1.69) | 19.662 | 0.000 |
High CRP n (%) | 31 (7.47) | 4 (0.96) | 38.628 | 0.000 |
Anemia n (%) | 33 (7.95) | 15 (3.61) | 7.164 | 0.011 |
Cardiac insufficiency n (%) | 31 (7.47) | 1 (0.24) | 29.253 | 0.000 |
Smoking n (%) | 27 (6.51) | 12 (2.89) | 6.054 | 0.021 |
History of PCI n (%) | 25 (6.02) | 0 (0.00) | 25.776 | 0.000 |
Autoimmune diseases n (%) | 21 (5.06) | 4 (0.96) | 11.919 | 0.001 |
Postmenopausal n (%) | 18 (4.34) | 4 (0.96) | 9.152 | 0.004 |
Oral contraceptive n (%) | 15 (3.61) | 2 (0.48) | 10.149 | 0.002 |
Renal insufficiency n (%) | 10 (2.41) | 0 (0.00) | 10.122 | 0.002 |
Renal artery stenosis n (%) | 4 (0.96) | 0 (0.00) | 4.019 | 0.124 |
The number distribution of combined risk factors in the two groups (see Table 3)
No. of risk factors | ACS group | Control group |
---|---|---|
0, n (%) | 33 (7.95) | 321 (77.35) |
1, n (%) | 88 (21.21) | 72 (17.35) |
2, n (%) | 126 (30.36) | 21 (5.06) |
3, n (%) | 101 (24.34) | 1 (0.24) |
4, n (%) | 41 (9.88) | 0 (0.00) |
5, n (%) | 20 (4.82) | 0 (0.00) |
6, n (%) | 5 (1.20) | 0 (0.00) |
7, n (%) | 1 (0.24) | 0 (0.00) |
Combined risk factors of overweight cases
Combined risk factors | ACS group | Control group |
---|---|---|
0, n (%) | 0 (0.00) | 6 (8.70) |
1, n (%) | 47 (17.67) | 43 (62.32) |
2, n (%) | 84 (31.58) | 19 (27.54) |
3, n (%) | 82 (30.83) | 1 (1.45) |
4, n (%) | 30 (11.28) | 0 (0.00) |
5, n (%) | 18 (6.77) | 0 (0.00) |
6, n (%) | 4 (1.50) | 0 (0.00) |
7, n (%) | 1 (0.38) | 0 (0.00) |
Comparison of blood biomarkers in different group (see Table 5)
Biomarkers | ACS group | Control group | X2 | P value |
---|---|---|---|---|
HB(g/L) | 127.85 ± 15.20 | 129.39 ± 12.10 | 1.613 | 0.107 |
LDL (mmol/L) | 2.64 ± 1.11 | 2.46 ± 0.63 | 2.939 | 0.003 |
HDL (mmol/L) | 1.09 ± 0.26 | 1.24 ± 0.35 | 7.059 | 0.000 |
HDL/LDL | 0.46 ± 0.18 | 0.53 ± 0.19 | 4.892 | 0.000 |
TG (mmol/L) | 1.81 ± 1.57 | 1.38 ± 0.50 | 5.239 | 0.000 |
TC (mmol/L) | 4.36 ± 1.33 | 4.24 ± 0.92 | 1.432 | 0.153 |
TC/HDL | 4.19 ± 1.52 | 3.58 ± 0.93 | 6.978 | 0.000 |
SCr (umol/L) | 63.40 ± 19.32 | 59.22 ± 11.12 | 3.755 | 0.000 |
Uric (umol/L) | 285.30 ± 83.73 | 277.15 ± 66.48 | 1.552 | 0.121 |
CRP (mg/L) | 3.40 ± 5.98 | 1.24 ± 1.46 | 7.124 | 0.000 |
Hcy (ummol/L) | 10.30 ± 6.04 | 8.46 ± 2.45 | 5.732 | 0.000 |
Logistic regression analysis of ACS risk factors
Risk factors | RR | 95%CI | P value |
---|---|---|---|
Hyperlipidemia | 23.940 | 12.209—46.943 | 0.000 |
Homocysteinemia | 15.260 | 5.321—43.763 | 0.000 |
Overweight | 7.403 | 4.950—11.070 | 0.000 |
High CRP | 10.740 | 3.220—35.817 | 0.000 |
Hypertension | 4.384 | 2.799—6.869 | 0.000 |
Hypothyroidism | 9.323 | 2.792—31.133 | 0.000 |
Gynecological disease | 6.609 | 2.588—14.232 | 0.000 |
Depression or anxiety | 5.516 | 2.395—12.705 | 0.000 |
Cardiac insufficiency | 18.692 | 2.254—155.030 | 0.000 |
Hypercholesterolemia | 5.287 | 2.228—12.214 | 0.000 |
Diabetes | 4.125 | 2.138—7.958 | 0.000 |
Oral contraceptive | 11.684 | 2.082—65.581 | 0.005 |
Family history of CHD | 4.043 | 1.657—9.863 | 0.002 |
Autoimmune diseases | 6.023 | 1.595—22.746 | 0.008 |