Skip to main content
Erschienen in: International Journal of Clinical Oncology 5/2011

01.10.2011 | Original Article

The clinical course in pediatric solid tumor patients with focal nodular hyperplasia of the liver

verfasst von: Kiminobu Sugito, Shota Uekusa, Hiroyuki Kawashima, Takeshi Furuya, Kensuke Ohashi, Mikiya Inoue, Taro Ikeda, Tsugumichi Koshinaga, Ryouichi Tomita, Hideo Mugishima, Toshiya Maebayashi

Erschienen in: International Journal of Clinical Oncology | Ausgabe 5/2011

Einloggen, um Zugang zu erhalten

Abstract

Background

Focal nodular hyperplasia (FNH) of the liver is a rare benign lesion that may be related to the vascular and hepatic damage induced by completion of tumor therapy and a reaction to localized vascular abnormality. The aim of this study was to analyze the clinical course in pediatric solid tumor patients with FNH.

Methods

We analyzed thirty-two patients with pediatric solid tumors who received multiagent chemotherapy (15 advanced neuroblastomas, 7 hepatoblastomas, 5 rhabdomyosarcomas, 2 nephroblastomas, 1 rhabdoid tumor of the kidney, 1 clear cell sarcoma of the kidney and 1 pancreatoblastoma). All of them had been previously treated at our hospital, and have been alive for over 3 years without recurrence.

Results

FNH lesions were discovered in three (9.4%) of 32 patients, and were neuroblastoma (NB) stage 4. All 3 patients received induction chemotherapy and high-dose alkylating agents, and developed grade 3 (National Cancer Institute Common Toxicity Criteria; NCI-CTC) liver dysfunction during completion of tumor therapy without veno-occlusive disease. Two of the 3 patients received the same induction chemotherapy and high doses of alkylating agents with total body irradiation for cytoreductive agents prior to peripheral blood cell transplantation. FNH lesions in both female patients who received estrogen replacement therapy after completion of tumor therapy have expanded and are increasing.

Conclusion

FNH appears to be a late complication of iatrogenic disease in NB stage 4 patients. The therapeutic agents for NB stage 4 and estrogen replacement therapy should be considered as risk factors for the development of FNH.
Literatur
1.
Zurück zum Zitat Mathieu D, Vilgrain V, Mahfouz AE et al (1997) Benign liver tumors. Magn Reson Imaging Clin N Am 5:255–288PubMed Mathieu D, Vilgrain V, Mahfouz AE et al (1997) Benign liver tumors. Magn Reson Imaging Clin N Am 5:255–288PubMed
2.
Zurück zum Zitat Bouyn CI, Leclere J, Raimondo G et al (2003) Hepatic focal nodular hyperplasia in children previously treated for a solid tumor. Incidence, risk factors, and outcome. Cancer 97:3107–3113PubMedCrossRef Bouyn CI, Leclere J, Raimondo G et al (2003) Hepatic focal nodular hyperplasia in children previously treated for a solid tumor. Incidence, risk factors, and outcome. Cancer 97:3107–3113PubMedCrossRef
3.
Zurück zum Zitat Joyner BL Jr, Levin TL, Goyal RK et al (2005) Focal nodular hyperplasia of the liver: a sequela of tumor therapy. Pediatr Radiol 35:1234–1239PubMedCrossRef Joyner BL Jr, Levin TL, Goyal RK et al (2005) Focal nodular hyperplasia of the liver: a sequela of tumor therapy. Pediatr Radiol 35:1234–1239PubMedCrossRef
4.
Zurück zum Zitat Citak EC, Karadeniz C, Oguz A et al (2007) Nodular regenerative hyperplasia and focal nodular hyperplasia of the liver mimicking hepatic metastasis in children with solid tumors and a review of literature. Pediatr Hematol Oncol 24:281–289PubMedCrossRef Citak EC, Karadeniz C, Oguz A et al (2007) Nodular regenerative hyperplasia and focal nodular hyperplasia of the liver mimicking hepatic metastasis in children with solid tumors and a review of literature. Pediatr Hematol Oncol 24:281–289PubMedCrossRef
5.
Zurück zum Zitat Sugito K, Kusafuka T, Kawashima H et al (2010) Usefulness of power Doppler ultrasonography and superparamagnetic iron oxide enhanced magnetic resonance imaging for diagnosis of focal nodular hyperplasia of the liver after treatment of neuroblastoma. Pediatr Hematol Oncol 27:250–256PubMedCrossRef Sugito K, Kusafuka T, Kawashima H et al (2010) Usefulness of power Doppler ultrasonography and superparamagnetic iron oxide enhanced magnetic resonance imaging for diagnosis of focal nodular hyperplasia of the liver after treatment of neuroblastoma. Pediatr Hematol Oncol 27:250–256PubMedCrossRef
6.
Zurück zum Zitat Sawaguchi S, Kaneko M, Uchino J et al (1990) Treatment of advanced neuroblastoma with emphasis on intensive induction chemotherapy. A report from the Study Group of Japan. Cancer 66:1879–1887PubMedCrossRef Sawaguchi S, Kaneko M, Uchino J et al (1990) Treatment of advanced neuroblastoma with emphasis on intensive induction chemotherapy. A report from the Study Group of Japan. Cancer 66:1879–1887PubMedCrossRef
7.
Zurück zum Zitat Kaneko M, Tsuchida Y, Uchino J et al (1999) Treatment results of advanced neuroblastoma with the first Japanese study group protocol. Study Group of Japan for Treatment of Advanced Neuroblastoma. J Pediatr Hematol Oncol 21:190–197PubMedCrossRef Kaneko M, Tsuchida Y, Uchino J et al (1999) Treatment results of advanced neuroblastoma with the first Japanese study group protocol. Study Group of Japan for Treatment of Advanced Neuroblastoma. J Pediatr Hematol Oncol 21:190–197PubMedCrossRef
8.
Zurück zum Zitat Sasaki F, Matsunaga T, Iwafuchi M et al (2002) Outcome of hepatoblastoma treated with the JPLT-1 (Japanese Study Group for Pediatric Liver Tumor) Protocol-1: a report from the Japanese Study Group for Pediatric Liver Tumor. J Pediatr Surg 37:851–856PubMedCrossRef Sasaki F, Matsunaga T, Iwafuchi M et al (2002) Outcome of hepatoblastoma treated with the JPLT-1 (Japanese Study Group for Pediatric Liver Tumor) Protocol-1: a report from the Japanese Study Group for Pediatric Liver Tumor. J Pediatr Surg 37:851–856PubMedCrossRef
9.
Zurück zum Zitat Hosoi H, Teramukai S, Matsumoto Y et al (2007) A review of 331 rhabdomyosarcoma cases in patients treated between 1991 and 2002 in Japan. Int J Clin Oncol 12:137–145PubMedCrossRef Hosoi H, Teramukai S, Matsumoto Y et al (2007) A review of 331 rhabdomyosarcoma cases in patients treated between 1991 and 2002 in Japan. Int J Clin Oncol 12:137–145PubMedCrossRef
10.
Zurück zum Zitat Oue T, Fukuzawa M, Okita H et al (2009) Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study-1 (JWiTS-1) protocol: a report from the JWiTS group. Pediatr Surg Int 25:923–929PubMedCrossRef Oue T, Fukuzawa M, Okita H et al (2009) Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study-1 (JWiTS-1) protocol: a report from the JWiTS group. Pediatr Surg Int 25:923–929PubMedCrossRef
11.
Zurück zum Zitat Perilongo G, Shafford E, Maibach R et al (2004) Risk-adapted treatment for childhood hepatoblastoma: final report of the second study of the International Society of Paediatric Oncology-SIOPEL 2. Eur J Cancer 40:411–421PubMedCrossRef Perilongo G, Shafford E, Maibach R et al (2004) Risk-adapted treatment for childhood hepatoblastoma: final report of the second study of the International Society of Paediatric Oncology-SIOPEL 2. Eur J Cancer 40:411–421PubMedCrossRef
12.
Zurück zum Zitat Stocker JT, Ishak KG (1981) Focal nodular hyperplasia of the liver: a study of 21 pediatric cases. Cancer 48:336–345PubMedCrossRef Stocker JT, Ishak KG (1981) Focal nodular hyperplasia of the liver: a study of 21 pediatric cases. Cancer 48:336–345PubMedCrossRef
13.
Zurück zum Zitat Cheon JE, Kim WS, Kim IO et al (1998) Radiological features of focal nodular hyperplasia of the liver in children. Pediatr Radiol 28:878–883PubMedCrossRef Cheon JE, Kim WS, Kim IO et al (1998) Radiological features of focal nodular hyperplasia of the liver in children. Pediatr Radiol 28:878–883PubMedCrossRef
14.
Zurück zum Zitat Nguyen BN, Fléjou JF, Terris B et al (1999) Focal nodular hyperplasia of the liver: a comprehensive pathologic study of 305 lesions and recognition of new histologic forms. Am J Surg Pathol 23:1441–1454PubMedCrossRef Nguyen BN, Fléjou JF, Terris B et al (1999) Focal nodular hyperplasia of the liver: a comprehensive pathologic study of 305 lesions and recognition of new histologic forms. Am J Surg Pathol 23:1441–1454PubMedCrossRef
15.
Zurück zum Zitat Weimann A, Ringe B, Klempnauer J et al (1997) Benign liver tumors: differential diagnosis and indications for surgery. World J Surg 21:983–990PubMedCrossRef Weimann A, Ringe B, Klempnauer J et al (1997) Benign liver tumors: differential diagnosis and indications for surgery. World J Surg 21:983–990PubMedCrossRef
16.
Zurück zum Zitat Cherqui D, Rahmouni A, Charlotte F et al (1995) Management of focal nodular hyperplasia and hepatocellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correlations. Hepatology 22:1674–1681PubMedCrossRef Cherqui D, Rahmouni A, Charlotte F et al (1995) Management of focal nodular hyperplasia and hepatocellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correlations. Hepatology 22:1674–1681PubMedCrossRef
17.
Zurück zum Zitat International Working Party (1995) Terminology of nodular hepatocellular lesions. Hepatology 22:983–993 International Working Party (1995) Terminology of nodular hepatocellular lesions. Hepatology 22:983–993
18.
Zurück zum Zitat Ndimbie OK, Goodman ZD, Chase RL et al (1990) Hemangiomas with localized nodular proliferation of the liver. A suggestion on the pathogenesis of focal nodular hyperplasia. Am J Surg Pathol 14:142–150PubMedCrossRef Ndimbie OK, Goodman ZD, Chase RL et al (1990) Hemangiomas with localized nodular proliferation of the liver. A suggestion on the pathogenesis of focal nodular hyperplasia. Am J Surg Pathol 14:142–150PubMedCrossRef
19.
Zurück zum Zitat Wanless IR, Albrecht S, Bilbao J et al (1989) Multiple focal nodular hyperplasia of the liver associated with vascular malformations of various organs and neoplasia of the brain: a new syndrome. Mod Pathol 2:456–462PubMed Wanless IR, Albrecht S, Bilbao J et al (1989) Multiple focal nodular hyperplasia of the liver associated with vascular malformations of various organs and neoplasia of the brain: a new syndrome. Mod Pathol 2:456–462PubMed
20.
Zurück zum Zitat Horn B, Reiss U, Matthay K et al (2002) Veno-occlusive disease of the liver in children with solid tumors undergoing autologous hematopoietic progenitor cell transplantation: a high incidence in patients with neuroblastoma. Bone Marrow Transplant 29:409–415PubMedCrossRef Horn B, Reiss U, Matthay K et al (2002) Veno-occlusive disease of the liver in children with solid tumors undergoing autologous hematopoietic progenitor cell transplantation: a high incidence in patients with neuroblastoma. Bone Marrow Transplant 29:409–415PubMedCrossRef
21.
Zurück zum Zitat McDonald GB, Sharma P, Matthews DE et al (1984) Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisponsing factors. Hepatology 4:116–122PubMedCrossRef McDonald GB, Sharma P, Matthews DE et al (1984) Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisponsing factors. Hepatology 4:116–122PubMedCrossRef
22.
Zurück zum Zitat Lawrence TS, Robertson JM, Anscher MS et al (1995) Hepatic toxicity resulting from cancer treatment. Int J Radiat Oncol Biol Phys 31:1237–1248PubMedCrossRef Lawrence TS, Robertson JM, Anscher MS et al (1995) Hepatic toxicity resulting from cancer treatment. Int J Radiat Oncol Biol Phys 31:1237–1248PubMedCrossRef
23.
24.
Zurück zum Zitat Scalori A, Tavani A, Gallus S et al (2002) Oral contraceptives and the risk of focal nodular hyperplasia of the liver: a case–control study. Am J Obstet Gynecol 186:195–197PubMedCrossRef Scalori A, Tavani A, Gallus S et al (2002) Oral contraceptives and the risk of focal nodular hyperplasia of the liver: a case–control study. Am J Obstet Gynecol 186:195–197PubMedCrossRef
Metadaten
Titel
The clinical course in pediatric solid tumor patients with focal nodular hyperplasia of the liver
verfasst von
Kiminobu Sugito
Shota Uekusa
Hiroyuki Kawashima
Takeshi Furuya
Kensuke Ohashi
Mikiya Inoue
Taro Ikeda
Tsugumichi Koshinaga
Ryouichi Tomita
Hideo Mugishima
Toshiya Maebayashi
Publikationsdatum
01.10.2011
Verlag
Springer Japan
Erschienen in
International Journal of Clinical Oncology / Ausgabe 5/2011
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI
https://doi.org/10.1007/s10147-011-0210-x

Weitere Artikel der Ausgabe 5/2011

International Journal of Clinical Oncology 5/2011 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.