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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

The clinical significance of incidental intra-abdominal findings on positron emission tomography performed to investigate pulmonary nodules

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Richdeep S Gill, Troy Perry, Jonathan T Abele, Eric LR Bédard, Daniel Schiller
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-25) contains supplementary material, which is available to authorized users.
Eric LR Bédard and Daniel Schiller contributed equally to this work.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

RSG: Participated in study design, data collection and analysis. Writing manuscript and revisions. Approved final version of manuscript.
TP: Participated in study design and data collection. Writing manuscript and revisions. Approved final version of manuscript.
JTA: Creation of figures. Writing and revising manuscript. Approved final version of manuscript.
ELRB: Study design and analysis. Revising manuscript. Approved final version of manuscript.
DS: Study design and analysis. Revising manuscript. Approved final version of manuscript.

Abstract

Background

Lung cancer is a common cause of cancer-related death. Staging typically includes positron emission tomography (PET) scanning, in which18F-fluoro-2-dexoy-D-glucose (FDG) is taken up by cells proportional to metabolic activity, thus aiding in differentiating benign and malignant pulmonary nodules. Uptake of FDG can also occur in the abdomen. The clinical significance of incidental intraabdominal FDG uptake in the setting of pulmonary nodules is not well established. Our objective was to report on the clinical significance of incidental intra-abdominal FDG activity in the setting of lung cancer.

Methods

Fifteen hundred FDG-PET reports for studies performed for lung cancer were retrospectively reviewed for the presence of incidental FDG-positive intraabdominal findings. Patient charts with positive findings were then reviewed and information extracted.

Results

Twenty-five patients (25/1500) demonstrated incidental intraabdominal FDG uptake thought to be significant (1.7%) with a mean patient age of 71 years. Colonic uptake was most common (n = 17) with 9 (52%) being investigated further. Of these 9 cases, a diagnosis of malignancy was made in 3 patients, pre-malignant adenomas in 2 patients, a benign lipoma in 1 patient and no abnormal findings in the remaining patients. 8 patients were not investigated further (3 diagnosed with metastatic lung cancer and 2 were of advanced age) secondary to poor prognosis.

Conclusion

Incidental abdominal findings in the colon on FDG-PET scan for work-up of pulmonary nodules need to be further investigated by colonoscopy.
Zusatzmaterial
Authors’ original file for figure 1
12957_2011_942_MOESM1_ESM.tiff
Authors’ original file for figure 2
12957_2011_942_MOESM2_ESM.tiff
Authors’ original file for figure 3
12957_2011_942_MOESM3_ESM.tiff
Literatur
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