Skip to main content
Erschienen in: European Archives of Oto-Rhino-Laryngology 3/2012

01.03.2012 | Head and Neck

The clinicopathologic differences in papillary thyroid carcinoma with or without co-existing chronic lymphocytic thyroiditis

verfasst von: Yeo-Hoon Yoon, Hak Joon Kim, Jin Woo Lee, Jin Man Kim, Bon Seok Koo

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 3/2012

Einloggen, um Zugang zu erhalten

Abstract

The goal of this study is to determine the clinicopathologic differences in patients with papillary thyroid carcinoma (PTC) with or without chronic lymphocytic thyroiditis (CLT). We reviewed the medical records of 195 consecutive PTC patients who underwent total thyroidectomy and bilateral central lymph node dissection from April 2008 to March 2010. The differences in clinicopathologic factors, such as age, gender, size of primary tumor, perithyroidal invasion, lymphovascular invasion, capsular invasion, and central lymph node (CLN) metastasis, were analyzed in PTC patients with or without CLT. Among 195 patients, 56 (28.7%) had co-existing CLT. Patients with CLT had the following characteristics as compared to patients without CLT: significantly younger, female predominance, smaller tumor size, and lower incidence of capsular invasion (p = 0.038, 0.006, 0.037, and 0.026, respectively). Also, patients with CLT (12.5%) had a significantly lower incidence of CLN metastases than patients without CLT (28.1%; p = 0.025) based on univariate analysis. Moreover, multivariate analysis showed that younger age (p = 0.042, odds ratio = 1.033) and female gender (p = 0.012, odds ratio = 6.865) are independent clinical factors in patients with CLT compared to patients without CLT. CLT was shown to be commonly associated with PTC. Compared to patients with PTC without CLT, patients with CLT were younger with a female predominance, which are the most important and well-known prognostic variables for thyroid cancer mortality.
Literatur
1.
Zurück zum Zitat Davies L, Welch HG (2006) Increasing incidence of thyroid cancer in the US, 1973–2002. JAMA 295:2164–2167PubMedCrossRef Davies L, Welch HG (2006) Increasing incidence of thyroid cancer in the US, 1973–2002. JAMA 295:2164–2167PubMedCrossRef
2.
Zurück zum Zitat Sciuto R, Romano L, Rea S et al (2009) Natural history and clinical outcome of differentiated thyroid carcinoma: a retrospective analysis of 1503 patients treated at a single institution. Ann Oncol 20:1728–1735PubMedCrossRef Sciuto R, Romano L, Rea S et al (2009) Natural history and clinical outcome of differentiated thyroid carcinoma: a retrospective analysis of 1503 patients treated at a single institution. Ann Oncol 20:1728–1735PubMedCrossRef
3.
Zurück zum Zitat Mercante G, Frasoldati A, Pedroni C et al (2009) Prognostic factors affecting neck lymph node recurrence and distant metastasis in papillary microcarcinoma of the thyroid: results of a study in 445 patients. Thyroid 19:707–716PubMedCrossRef Mercante G, Frasoldati A, Pedroni C et al (2009) Prognostic factors affecting neck lymph node recurrence and distant metastasis in papillary microcarcinoma of the thyroid: results of a study in 445 patients. Thyroid 19:707–716PubMedCrossRef
4.
Zurück zum Zitat Baek SK, Jung KY, Kang SM et al (2010) Clinical risk factors associated with cervical lymph node recurrence in papillary thyroid carcinoma. Thyroid 20:147–152PubMedCrossRef Baek SK, Jung KY, Kang SM et al (2010) Clinical risk factors associated with cervical lymph node recurrence in papillary thyroid carcinoma. Thyroid 20:147–152PubMedCrossRef
5.
Zurück zum Zitat Koo BS, Yoon YH, Kim JM et al (2009) Predictive factors of level IIb lymph node metastasis in patients with papillary thyroid carcinoma. Ann Surg Oncol 16:1344–1347PubMedCrossRef Koo BS, Yoon YH, Kim JM et al (2009) Predictive factors of level IIb lymph node metastasis in patients with papillary thyroid carcinoma. Ann Surg Oncol 16:1344–1347PubMedCrossRef
6.
Zurück zum Zitat Dailey ME, Lindsay S, Skahen R (1955) Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland. AMA Arch Surg 70:291–297PubMedCrossRef Dailey ME, Lindsay S, Skahen R (1955) Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland. AMA Arch Surg 70:291–297PubMedCrossRef
7.
Zurück zum Zitat Kim EY, Kim WG, Kim WB et al (2009) Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma. Clin Endocrinol 71:581–586CrossRef Kim EY, Kim WG, Kim WB et al (2009) Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma. Clin Endocrinol 71:581–586CrossRef
8.
Zurück zum Zitat Kebebew E, Treseler PA, Ituarte PH et al (2001) Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg 25:632–637PubMedCrossRef Kebebew E, Treseler PA, Ituarte PH et al (2001) Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg 25:632–637PubMedCrossRef
9.
Zurück zum Zitat Okayasu I, Fujiwara M, Hara Y et al (1995) Association of chronic lymphocytic thyroiditis and thyroid papillary carcinoma. A study of surgical cases among Japanese, and white and African Americans. Cancer 76:2312–2318PubMedCrossRef Okayasu I, Fujiwara M, Hara Y et al (1995) Association of chronic lymphocytic thyroiditis and thyroid papillary carcinoma. A study of surgical cases among Japanese, and white and African Americans. Cancer 76:2312–2318PubMedCrossRef
10.
Zurück zum Zitat Loh KC, Greenspan FS, Dong F et al (1999) Influence of lymphocytic thyroiditis on the prognostic outcome of patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 84:458–463PubMedCrossRef Loh KC, Greenspan FS, Dong F et al (1999) Influence of lymphocytic thyroiditis on the prognostic outcome of patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 84:458–463PubMedCrossRef
11.
Zurück zum Zitat Kashima K, Yokoyama S, Noguchi S et al (1998) Chronic thyroiditis as a favorable prognostic factor in papillary thyroid carcinoma. Thyroid 8:197–202PubMedCrossRef Kashima K, Yokoyama S, Noguchi S et al (1998) Chronic thyroiditis as a favorable prognostic factor in papillary thyroid carcinoma. Thyroid 8:197–202PubMedCrossRef
12.
Zurück zum Zitat Shaha AR, Trivedi H, Carew JF et al (1999) Coexistent Hashimoto’s thyroiditis with papillary thyroid carcinoma: impact on presentation, management, and outcome. Surgery 126:1070–1076PubMedCrossRef Shaha AR, Trivedi H, Carew JF et al (1999) Coexistent Hashimoto’s thyroiditis with papillary thyroid carcinoma: impact on presentation, management, and outcome. Surgery 126:1070–1076PubMedCrossRef
13.
Zurück zum Zitat Repplinger D, Bargren A, Zhang YW et al (2008) Is Hashimoto’s thyroiditis a risk factor for papillary thyroid cancer? J Surg Res 150:49–52PubMedCrossRef Repplinger D, Bargren A, Zhang YW et al (2008) Is Hashimoto’s thyroiditis a risk factor for papillary thyroid cancer? J Surg Res 150:49–52PubMedCrossRef
14.
Zurück zum Zitat Del Rio P, Cataldo S, Sommaruga L et al (2008) The association between papillary carcinoma and chronic lymphocytic thyroiditis: does it modify the prognosis of cancer? Minerva Endocrinol 33:1–5PubMed Del Rio P, Cataldo S, Sommaruga L et al (2008) The association between papillary carcinoma and chronic lymphocytic thyroiditis: does it modify the prognosis of cancer? Minerva Endocrinol 33:1–5PubMed
15.
Zurück zum Zitat Larson SD, Jackson LN, Riall TS et al (2007) Increased incidence of well-differentiated thyroid cancer associated with Hashimoto thyroiditis and the role of the PI3 k/Akt pathway. J Am Coll Surg 204:764–773PubMedCrossRef Larson SD, Jackson LN, Riall TS et al (2007) Increased incidence of well-differentiated thyroid cancer associated with Hashimoto thyroiditis and the role of the PI3 k/Akt pathway. J Am Coll Surg 204:764–773PubMedCrossRef
16.
Zurück zum Zitat Hundahl SA, Fleming ID, Fremgen AM et al (1998) A National Cancer Data Base report on 53, 856 cases of thyroid carcinoma treated in the U.S., 1985–1995. Cancer 83:2638–2648PubMedCrossRef Hundahl SA, Fleming ID, Fremgen AM et al (1998) A National Cancer Data Base report on 53, 856 cases of thyroid carcinoma treated in the U.S., 1985–1995. Cancer 83:2638–2648PubMedCrossRef
17.
Zurück zum Zitat Gilliland FD, Hunt WC, Morris DM et al (1997) Prognostic factors for thyroid carcinoma. A population-based study of 15, 698 cases from the surveillance, epidemiology and end results (SEER) program 1973–1991. Cancer 79:564–573PubMedCrossRef Gilliland FD, Hunt WC, Morris DM et al (1997) Prognostic factors for thyroid carcinoma. A population-based study of 15, 698 cases from the surveillance, epidemiology and end results (SEER) program 1973–1991. Cancer 79:564–573PubMedCrossRef
18.
Zurück zum Zitat Sherman SI, Brierley JD, Sperling M et al (1998) Prospective multicenter study of thyroid carcinoma treatment: initial analysis of staging and outcome. National Thyroid Cancer Treatment Cooperative Study Registry Group. Cancer 83:1012–1021PubMedCrossRef Sherman SI, Brierley JD, Sperling M et al (1998) Prospective multicenter study of thyroid carcinoma treatment: initial analysis of staging and outcome. National Thyroid Cancer Treatment Cooperative Study Registry Group. Cancer 83:1012–1021PubMedCrossRef
19.
Zurück zum Zitat Giordano C, Stassi G, De Maria R et al (1997) Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto’s thyroiditis. Science 275:960–963PubMed Giordano C, Stassi G, De Maria R et al (1997) Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto’s thyroiditis. Science 275:960–963PubMed
20.
Zurück zum Zitat Kimura H, Yamashita S, Namba H et al (1992) Interleukin-1 inhibits human thyroid carcinoma cell growth. J Clin Endocrinol Metab 75:596–602PubMedCrossRef Kimura H, Yamashita S, Namba H et al (1992) Interleukin-1 inhibits human thyroid carcinoma cell growth. J Clin Endocrinol Metab 75:596–602PubMedCrossRef
21.
Zurück zum Zitat Bagnasco M, Venuti D, Paolieri F et al (1989) Phenotypic and functional analysis at the clonal level of infiltrating T lymphocytes in papillary carcinoma of the thyroid: prevalence of cytolytic T cells with natural killer-like or lymphokine-activated killer activity. J Clin Endocrinol Metab 69:832–836PubMedCrossRef Bagnasco M, Venuti D, Paolieri F et al (1989) Phenotypic and functional analysis at the clonal level of infiltrating T lymphocytes in papillary carcinoma of the thyroid: prevalence of cytolytic T cells with natural killer-like or lymphokine-activated killer activity. J Clin Endocrinol Metab 69:832–836PubMedCrossRef
Metadaten
Titel
The clinicopathologic differences in papillary thyroid carcinoma with or without co-existing chronic lymphocytic thyroiditis
verfasst von
Yeo-Hoon Yoon
Hak Joon Kim
Jin Woo Lee
Jin Man Kim
Bon Seok Koo
Publikationsdatum
01.03.2012
Verlag
Springer-Verlag
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 3/2012
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-011-1732-6

Weitere Artikel der Ausgabe 3/2012

European Archives of Oto-Rhino-Laryngology 3/2012 Zur Ausgabe

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.