Skip to main content
Erschienen in: Journal of Medicine and the Person 2/2014

01.08.2014 | Review

The complexity of cancer survivorship: a case for personalized medicine. Report of the 2014 Grandangolo conference

verfasst von: Armando Santoro, Lodovico Balducci

Erschienen in: Journal of Medicine and the Person | Ausgabe 2/2014

Einloggen, um Zugang zu erhalten

Abstract

This article reviews the Grandangolo conference on cancer survivorship and highlights the major findings. These include the improvement in survivorship, and the emergence of survivorship related syndromes, such as new neoplasms, cardiomyopathy, neutorpathy fatigue and memory loss. Emotional disorders may include the Lazarus’ Syndrome and the post-traumatic stress disorder. An open question is whether we should have specialists of survivorship or primary care physicians or oncologists could fulfill this role.
Literatur
1.
Zurück zum Zitat Balducci L’ Aapro M (2014) Complicate and complex: helping the older patient with cancer to exit the labyrinth. J Geriatr Oncol 5:116–118 Balducci L’ Aapro M (2014) Complicate and complex: helping the older patient with cancer to exit the labyrinth. J Geriatr Oncol 5:116–118
2.
Zurück zum Zitat Vissers PA, Thong MS, Power F et al (2013) The impact of comorbidity on health related quality of life among cancer survivors: analysis of data from the PROFILE registry. J Cancer Surv 7:602–613CrossRef Vissers PA, Thong MS, Power F et al (2013) The impact of comorbidity on health related quality of life among cancer survivors: analysis of data from the PROFILE registry. J Cancer Surv 7:602–613CrossRef
3.
Zurück zum Zitat Siegel R, De santis C, Virgo K et al (2012) Cancer treatment and survivorship statistics 2012. CA Cancer J Clin 62:220–241PubMedCrossRef Siegel R, De santis C, Virgo K et al (2012) Cancer treatment and survivorship statistics 2012. CA Cancer J Clin 62:220–241PubMedCrossRef
4.
Zurück zum Zitat Min L, Wenger N, Walling AM et al (2013) When comorbidity, aging, and complexity of primary care meet: development and validation of the geriatric complexity of care index. J Am Geriatr Soc 61:542–550PubMedCentralPubMedCrossRef Min L, Wenger N, Walling AM et al (2013) When comorbidity, aging, and complexity of primary care meet: development and validation of the geriatric complexity of care index. J Am Geriatr Soc 61:542–550PubMedCentralPubMedCrossRef
5.
Zurück zum Zitat Scott IA (2008) Chronic disease management: a primer for physician. Intern Med J 38:427–437PubMedCrossRef Scott IA (2008) Chronic disease management: a primer for physician. Intern Med J 38:427–437PubMedCrossRef
6.
Zurück zum Zitat Campbell LK, Scaduto M, Sharp W et al (2007) A meta-analysis of the neuro-cognitive sequelae of treatment of childhood acute lymphocytic leukemia. Pediatr Blood Cancer 49:65–73PubMedCrossRef Campbell LK, Scaduto M, Sharp W et al (2007) A meta-analysis of the neuro-cognitive sequelae of treatment of childhood acute lymphocytic leukemia. Pediatr Blood Cancer 49:65–73PubMedCrossRef
7.
Zurück zum Zitat Richardson WS, Doster LM (2014) Multimorbidity and comorbidity need to be placed in the context of a framework of risk, responsiveness and vulnerability. J Clin Epidemiol 67:244–246PubMedCrossRef Richardson WS, Doster LM (2014) Multimorbidity and comorbidity need to be placed in the context of a framework of risk, responsiveness and vulnerability. J Clin Epidemiol 67:244–246PubMedCrossRef
8.
Zurück zum Zitat Mills KT, Bellows CF, Hoffman AE et al (2013) Diabetes mellitus and colorectal cancer prognosis: a meta-analysis. Dis Colon Rectum 56:1304–1319PubMedCrossRef Mills KT, Bellows CF, Hoffman AE et al (2013) Diabetes mellitus and colorectal cancer prognosis: a meta-analysis. Dis Colon Rectum 56:1304–1319PubMedCrossRef
9.
Zurück zum Zitat Yerrabothals S, Shaaban H, Capo G et al (2014) The impact of diabetes mellitus on breast cancer outcomes: a single center retrospective study. Pathol Oncol Res 20:209–214CrossRef Yerrabothals S, Shaaban H, Capo G et al (2014) The impact of diabetes mellitus on breast cancer outcomes: a single center retrospective study. Pathol Oncol Res 20:209–214CrossRef
10.
Zurück zum Zitat Peeters BJ, Bazelier MT, Vestergaard P et al (2013) Use of metformin and survival of diabetic women with breast cancer. Curr Drug Saf. 8:357–363PubMedCrossRef Peeters BJ, Bazelier MT, Vestergaard P et al (2013) Use of metformin and survival of diabetic women with breast cancer. Curr Drug Saf. 8:357–363PubMedCrossRef
11.
Zurück zum Zitat Lash TL, Mor W, Wieland D et al (2007) Methodology, design and analytic techniques to address measurement of comorbid diseases. J Gerontol A Biol Sci Clin Sci. 62:281–285CrossRef Lash TL, Mor W, Wieland D et al (2007) Methodology, design and analytic techniques to address measurement of comorbid diseases. J Gerontol A Biol Sci Clin Sci. 62:281–285CrossRef
12.
Zurück zum Zitat Chen RC, Rojce TJ, Extermann M et al (2012) Impact of age and comorbidity on treatment and outcome of elderly cancer patients. Semin Radiat Oncol 22:265–271PubMedCrossRef Chen RC, Rojce TJ, Extermann M et al (2012) Impact of age and comorbidity on treatment and outcome of elderly cancer patients. Semin Radiat Oncol 22:265–271PubMedCrossRef
13.
Zurück zum Zitat Saad A, Mahindra A, Zhang MJ et al (2014) Hematopoietic cell transplant comorbidity index is predictive of survival after autologous hematopoietic stem cell transplantation in multiple myeloma. Biol Blood Bone Marrow Transpl 20:402–408 Saad A, Mahindra A, Zhang MJ et al (2014) Hematopoietic cell transplant comorbidity index is predictive of survival after autologous hematopoietic stem cell transplantation in multiple myeloma. Biol Blood Bone Marrow Transpl 20:402–408
14.
Zurück zum Zitat Yung KC, Piccirillo JF (2008) The incidence and impact of comorbidity diagnosed after the onset of head and neck cancer. Arch Otolaryngol Head Neck Surg 134:1045–1049PubMedCrossRef Yung KC, Piccirillo JF (2008) The incidence and impact of comorbidity diagnosed after the onset of head and neck cancer. Arch Otolaryngol Head Neck Surg 134:1045–1049PubMedCrossRef
15.
Zurück zum Zitat Huang X, Roenthal MB (2014) Transforming specialty practice: the patient-centered medical neighborhood. N Engl J Med 370:1376–1379PubMedCrossRef Huang X, Roenthal MB (2014) Transforming specialty practice: the patient-centered medical neighborhood. N Engl J Med 370:1376–1379PubMedCrossRef
16.
Zurück zum Zitat Balducci L, Goetz-Parten D, Steinmann MA (2013) Polypharmacy and the management of older cancer patients. Ann Oncol 24(Suppl 7):36–40CrossRef Balducci L, Goetz-Parten D, Steinmann MA (2013) Polypharmacy and the management of older cancer patients. Ann Oncol 24(Suppl 7):36–40CrossRef
17.
Zurück zum Zitat Jagsi R, Pottow JA, Griffith KA et al (2014) Long term financial burden of breast cancer. Experiences of a diverse cohort of survivors identified through population based registries. J Clin Oncol (in press) Jagsi R, Pottow JA, Griffith KA et al (2014) Long term financial burden of breast cancer. Experiences of a diverse cohort of survivors identified through population based registries. J Clin Oncol (in press)
18.
Zurück zum Zitat Eisemberg JM (1989) Clinical economics. A guide to economical analysis of medical practice. JAMA 262:2879–2886CrossRef Eisemberg JM (1989) Clinical economics. A guide to economical analysis of medical practice. JAMA 262:2879–2886CrossRef
19.
Zurück zum Zitat Denlinger CS, Carlson RW, Are M et al (2014) Survivorship: introduction and definition. Clinical practice guidelines in oncology. J Natl Compr Cancer Netw 12:34–45 Denlinger CS, Carlson RW, Are M et al (2014) Survivorship: introduction and definition. Clinical practice guidelines in oncology. J Natl Compr Cancer Netw 12:34–45
20.
Zurück zum Zitat Mullan F (1985) Seasons of survival: reflections of a physician with cancer. N Engl J Med 313:270–273PubMedCrossRef Mullan F (1985) Seasons of survival: reflections of a physician with cancer. N Engl J Med 313:270–273PubMedCrossRef
21.
Zurück zum Zitat Khan NF, Rose PW, Evans J (2012) Defining cancer survivorship: a more transparent approach is needed. J Cancer Surv 6:33–36CrossRef Khan NF, Rose PW, Evans J (2012) Defining cancer survivorship: a more transparent approach is needed. J Cancer Surv 6:33–36CrossRef
22.
Zurück zum Zitat Tralongo P, Annunziata MA, Santoro A et al (2013) Beyond semantics: the need to better categorize patients with cancer. J Clin Oncol 31:2637–2638PubMedCrossRef Tralongo P, Annunziata MA, Santoro A et al (2013) Beyond semantics: the need to better categorize patients with cancer. J Clin Oncol 31:2637–2638PubMedCrossRef
23.
Zurück zum Zitat Surbone A, Annunziata MA, Santoro A (2013) Cancer patients and survivors: changing words or changing culture? Ann Oncol 24:2468–2471PubMedCrossRef Surbone A, Annunziata MA, Santoro A (2013) Cancer patients and survivors: changing words or changing culture? Ann Oncol 24:2468–2471PubMedCrossRef
24.
Zurück zum Zitat Miller K, Abraham JH, Rhodes L et al (2013) Use of the word “cure” in oncology. J Oncol Pract 9:136–140CrossRef Miller K, Abraham JH, Rhodes L et al (2013) Use of the word “cure” in oncology. J Oncol Pract 9:136–140CrossRef
25.
Zurück zum Zitat Silva SA, Charon R, Wyer PC (2011) The marriage of evidence and narrative: scientific nurturance within clinical practice. J Eval Clin Pract 17:585–593PubMedCrossRef Silva SA, Charon R, Wyer PC (2011) The marriage of evidence and narrative: scientific nurturance within clinical practice. J Eval Clin Pract 17:585–593PubMedCrossRef
26.
Zurück zum Zitat Kreuter MW, Buskirk TD, Holmes K et al (2008) What makes cancer survivors stories work? An empirical study among African American women. J Cancer Surv 2:33–44CrossRef Kreuter MW, Buskirk TD, Holmes K et al (2008) What makes cancer survivors stories work? An empirical study among African American women. J Cancer Surv 2:33–44CrossRef
27.
Zurück zum Zitat Jones RP, Stättner S, Sutton P et al (2014) Controversies in oncosurgical management of liver-limited stage IV colorectal cancer. Surg Oncol (in press) Jones RP, Stättner S, Sutton P et al (2014) Controversies in oncosurgical management of liver-limited stage IV colorectal cancer. Surg Oncol (in press)
28.
29.
Zurück zum Zitat Denlinger CS, Lacchetti C, Dworkin RH et al (2014) Survivorship pain version 1 2014. J Natl Compr Cancer Netw 12:488–500 Denlinger CS, Lacchetti C, Dworkin RH et al (2014) Survivorship pain version 1 2014. J Natl Compr Cancer Netw 12:488–500
30.
Zurück zum Zitat Pachman DR, Barton DL, Swetz KM et al (2012) Troublesome symptoms in cancer survivors: fatigue, insomnia, neuropathy and pain. J Clin Oncol 30:3687–3696PubMedCrossRef Pachman DR, Barton DL, Swetz KM et al (2012) Troublesome symptoms in cancer survivors: fatigue, insomnia, neuropathy and pain. J Clin Oncol 30:3687–3696PubMedCrossRef
31.
Zurück zum Zitat Karo AE, Jävelä LS, Arola M et al (2013) Cardiovascular mortality of long term survivors of early-onset cancer: a population based study. Int J Cancer 134:664–673CrossRef Karo AE, Jävelä LS, Arola M et al (2013) Cardiovascular mortality of long term survivors of early-onset cancer: a population based study. Int J Cancer 134:664–673CrossRef
32.
Zurück zum Zitat Bober SL, Varela VS (2012) Sexuality in adult cancer survivors: challenges and intervention. J Clin Oncol 30:3712–3719PubMedCrossRef Bober SL, Varela VS (2012) Sexuality in adult cancer survivors: challenges and intervention. J Clin Oncol 30:3712–3719PubMedCrossRef
33.
Zurück zum Zitat Sanoff HK, Deal AM, Krishnamurthy J et al (2014) Effects of cytotoxic chemotherapy on markers of molecular aging in patients with breast cancer. J Natl Cancer Inst 106 (in press) Sanoff HK, Deal AM, Krishnamurthy J et al (2014) Effects of cytotoxic chemotherapy on markers of molecular aging in patients with breast cancer. J Natl Cancer Inst 106 (in press)
34.
Zurück zum Zitat Boffetta P, Kaldor JM (1994) Secondary malignancies following cancer chemotherapy. Acta Oncol 33:591–598PubMedCrossRef Boffetta P, Kaldor JM (1994) Secondary malignancies following cancer chemotherapy. Acta Oncol 33:591–598PubMedCrossRef
35.
Zurück zum Zitat Palm A, Johansson KA (2007) A review of the impact of proton and photon external beam radiotherapy treatment modalities on the dose distribution in field and out of field; implications for long term morbidity of cancer survivors. Acta Oncol 46:462–473PubMedCrossRef Palm A, Johansson KA (2007) A review of the impact of proton and photon external beam radiotherapy treatment modalities on the dose distribution in field and out of field; implications for long term morbidity of cancer survivors. Acta Oncol 46:462–473PubMedCrossRef
36.
Zurück zum Zitat Lee A (1978) The Lazarus syndrome: caring for patients returning from the dead. RN 41:52–64PubMed Lee A (1978) The Lazarus syndrome: caring for patients returning from the dead. RN 41:52–64PubMed
37.
Zurück zum Zitat Godfarb S, Mulhall J, Nelson C et al (2013) Sexual and reproductive health in cancer survivors. Semin Oncol 40:736–744 Godfarb S, Mulhall J, Nelson C et al (2013) Sexual and reproductive health in cancer survivors. Semin Oncol 40:736–744
38.
Zurück zum Zitat Ford JS, Chou JF, Sklar CA (2013) Attendance at a survivorship clinic: impact of knowledge and psychosocial adjustment. J Cancer Surv 7:535–543CrossRef Ford JS, Chou JF, Sklar CA (2013) Attendance at a survivorship clinic: impact of knowledge and psychosocial adjustment. J Cancer Surv 7:535–543CrossRef
39.
Zurück zum Zitat Bruce A, Sheilds L, Molzhan A et al (2014) Stories of liminality: living with life-threatening illnesses. J Holist Nurs 32:35–43PubMedCrossRef Bruce A, Sheilds L, Molzhan A et al (2014) Stories of liminality: living with life-threatening illnesses. J Holist Nurs 32:35–43PubMedCrossRef
40.
Zurück zum Zitat Varela VS, Ng A, Mauch P et al (2013) Post-traumatic stress disorder in survivors of Hodgkin’s lymphoma: prevalence of PTSD and partial PTSD compared with sibling control. Psychooncology 22:434–440PubMedCentralPubMed Varela VS, Ng A, Mauch P et al (2013) Post-traumatic stress disorder in survivors of Hodgkin’s lymphoma: prevalence of PTSD and partial PTSD compared with sibling control. Psychooncology 22:434–440PubMedCentralPubMed
41.
Zurück zum Zitat Temel J, Greer JA, Muzikansky A et al (2010) Early palliative care for patients with metastatic non small cell lung cancer. N Engl J Med 363:733–742PubMedCrossRef Temel J, Greer JA, Muzikansky A et al (2010) Early palliative care for patients with metastatic non small cell lung cancer. N Engl J Med 363:733–742PubMedCrossRef
Metadaten
Titel
The complexity of cancer survivorship: a case for personalized medicine. Report of the 2014 Grandangolo conference
verfasst von
Armando Santoro
Lodovico Balducci
Publikationsdatum
01.08.2014
Verlag
Springer Milan
Erschienen in
Journal of Medicine and the Person / Ausgabe 2/2014
Print ISSN: 2035-9411
Elektronische ISSN: 2036-3877
DOI
https://doi.org/10.1007/s12682-014-0182-5

Weitere Artikel der Ausgabe 2/2014

Journal of Medicine and the Person 2/2014 Zur Ausgabe