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Medical Oncology
Erschienen in: Medical Oncology 3/2017

01.03.2017 | Review Article

The crosstalk between long non-coding RNAs and PI3K in cancer

verfasst von: Leonidas Benetatos, Evangelos Voulgaris, Georgios Vartholomatos

Erschienen in: Medical Oncology | Ausgabe 3/2017

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Abstract

Long non-coding RNAs (lncRNAs) are able to positively or negatively regulate other genes expression in cis or in trans. Their effect can be achieved through RNA–protein, RNA–DNA, or RNA–RNA interactions. They can recruit transcription factors and act as scaffolds or guides for chromatin-modifying enzymes. PI3K kinases transform external stimuli to intracellular signals regulating cell growth, differentiation, proliferation, survival, intracellular trafficking, cytoskeletal changes, cell migration and motility, and metabolism. PI3K is activated in cancer and affects several aspects of oncogenesis. LncRNAs and PI3K have been shown to be interconnected in several different cancer subtypes enhancing aberrant cell proliferation, epithelial-to-mesenchymal transition, migration and invasion, and also cancer cell metabolism. In this review, we have assembled recent data describing the interaction between lncRNAs and PI3K and the results of such interaction.
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Metadaten
Titel
The crosstalk between long non-coding RNAs and PI3K in cancer
verfasst von
Leonidas Benetatos
Evangelos Voulgaris
Georgios Vartholomatos
Publikationsdatum
01.03.2017
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe 3/2017
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-017-0897-2

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