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Erschienen in: Documenta Ophthalmologica 3/2016

16.04.2016 | Original Research Article

The diagnosis and assessment of visual function in Singaporean children with electrophysiology: 10-year results

verfasst von: Anna C. S. Tan, LiYu Chen, Rena Png, Audrey Chia

Erschienen in: Documenta Ophthalmologica | Ausgabe 3/2016

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Abstract

Purpose

To study the clinical use and efficacy of electrophysiology in children.

Methods

This was a retrospective review of all children aged <16 years, who were referred to the Visual Electrophysiology Laboratory at the Singapore National Eye Center between 2003 and 2013.

Results

A total of 586 children, median age 8 years (range 0.15–16), were referred for a variety of reasons including investigation of poor vision (40 %), suspected retinal disease or optic nerve/cortical dysfunction (17 %), nystagmus (13 %) and screening or monitoring of a variety of ocular or neurological conditions (12 %). The number of children with vision 6/15 or worse was 418 (71 %), and 103 (18 %) had vision 6/120 or worse in at least one eye. The most common pathology noted was retinal dystrophy or dysfunction (41 %) or optic nerve/cortical dysfunction (12 %). In 30 %, visual electrophysiology was within normal limits, and in 6 %, a conclusive diagnosis could not be obtained.

Conclusion

Electrophysiology testing played an important role in the assessment of children and added to the clinical management of the patient.
Literatur
1.
Zurück zum Zitat van Genderen M, Riemslag F, Jorritsma F, Hoeben F, Meire F, Stilma J (2006) The key role of electrophysiology in the diagnosis of visually impaired children. Acta Ophthalmol Scand 84:799–806CrossRefPubMed van Genderen M, Riemslag F, Jorritsma F, Hoeben F, Meire F, Stilma J (2006) The key role of electrophysiology in the diagnosis of visually impaired children. Acta Ophthalmol Scand 84:799–806CrossRefPubMed
2.
Zurück zum Zitat Camuglia JE, Greer RM, Welch L, Gole GA (2011) Use of the electroretinogram in a paediatric hospital. Clin Exp Ophthalmol 39:506–512CrossRef Camuglia JE, Greer RM, Welch L, Gole GA (2011) Use of the electroretinogram in a paediatric hospital. Clin Exp Ophthalmol 39:506–512CrossRef
3.
Zurück zum Zitat Parness-Yossifon R, Mets MB (2008) The electroretinogram in children. Curr Opin Ophthalmol 19:398–402CrossRefPubMed Parness-Yossifon R, Mets MB (2008) The electroretinogram in children. Curr Opin Ophthalmol 19:398–402CrossRefPubMed
4.
Zurück zum Zitat Hidajat RR, Goode DH (2001) The clinical value of ophthalmic electrodiagnosis in children. Australas Phys Eng Sci Med 24:172–176CrossRefPubMed Hidajat RR, Goode DH (2001) The clinical value of ophthalmic electrodiagnosis in children. Australas Phys Eng Sci Med 24:172–176CrossRefPubMed
5.
Zurück zum Zitat Bach M, Hawlina M, Holder GE, Marmor MF, Meigen T, Vaegan, Miyake Y (2000) Standard for pattern electroretinography. Int Soc Clin Electrophysiol Vis Doc Ophthalmol 101:11–18 Bach M, Hawlina M, Holder GE, Marmor MF, Meigen T, Vaegan, Miyake Y (2000) Standard for pattern electroretinography. Int Soc Clin Electrophysiol Vis Doc Ophthalmol 101:11–18
6.
Zurück zum Zitat Odom JV, Bach M, Brigell M, Holder GE, McCulloch DL, Tormene AP, Vaegan (2010) ISCEV standard for clinical visual evoked potentials (2009 update). Doc Ophthalmol 120:111–119CrossRefPubMed Odom JV, Bach M, Brigell M, Holder GE, McCulloch DL, Tormene AP, Vaegan (2010) ISCEV standard for clinical visual evoked potentials (2009 update). Doc Ophthalmol 120:111–119CrossRefPubMed
7.
Zurück zum Zitat Hood DC, Bach M, Brigell M, Keating D, Kondo M, Lyons JS, Marmor MF, McCulloch DL, Palmowski-Wolfe AM (2012) ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition). Doc Ophthalmol 124:1–13CrossRefPubMedPubMedCentral Hood DC, Bach M, Brigell M, Keating D, Kondo M, Lyons JS, Marmor MF, McCulloch DL, Palmowski-Wolfe AM (2012) ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition). Doc Ophthalmol 124:1–13CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat McCulloch DL, Marmor MF, Brigell MG, Hamilton R, Holder GE, Tzekov R, Bach M (2015) ISCEV Standard for full-field clinical electroretinography (2015 update). Doc Ophthalmol 130:1–12CrossRefPubMed McCulloch DL, Marmor MF, Brigell MG, Hamilton R, Holder GE, Tzekov R, Bach M (2015) ISCEV Standard for full-field clinical electroretinography (2015 update). Doc Ophthalmol 130:1–12CrossRefPubMed
10.
Zurück zum Zitat Singapore MOH (2015) Health Facts Singapore Singapore MOH (2015) Health Facts Singapore
11.
Zurück zum Zitat Fulton AB, Brecelj J, Lorenz B, Moskowitz A, Thompson D, Westall CA (2006) Pediatric clinical visual electrophysiology: a survey of actual practice. Doc Ophthalmol 113:193–204CrossRefPubMed Fulton AB, Brecelj J, Lorenz B, Moskowitz A, Thompson D, Westall CA (2006) Pediatric clinical visual electrophysiology: a survey of actual practice. Doc Ophthalmol 113:193–204CrossRefPubMed
12.
Zurück zum Zitat Brodie SE (2014) Tips and tricks for successful electroretinography in children. Curr Opin Ophthalmol 25:366–373CrossRefPubMed Brodie SE (2014) Tips and tricks for successful electroretinography in children. Curr Opin Ophthalmol 25:366–373CrossRefPubMed
13.
Zurück zum Zitat Brecelj J, Stirn-Kranjc B (2004) Visual electrophysiological screening in diagnosing infants with congenital nystagmus. Clin Neurophysiol 115:461–470CrossRefPubMed Brecelj J, Stirn-Kranjc B (2004) Visual electrophysiological screening in diagnosing infants with congenital nystagmus. Clin Neurophysiol 115:461–470CrossRefPubMed
14.
Zurück zum Zitat Surachatkumtonekul T, Ruangvaravate N, Sriyakul C (2009) Visual electrophysiology in congenital nystagmus with normal fundus. J Med Assoc Thail 92:224–228 Surachatkumtonekul T, Ruangvaravate N, Sriyakul C (2009) Visual electrophysiology in congenital nystagmus with normal fundus. J Med Assoc Thail 92:224–228
16.
Zurück zum Zitat Harding GF, Robertson K, Spencer EL, Holliday I (2002) Vigabatrin; its effect on the electrophysiology of vision. Doc Ophthalmol 104:213–229CrossRefPubMed Harding GF, Robertson K, Spencer EL, Holliday I (2002) Vigabatrin; its effect on the electrophysiology of vision. Doc Ophthalmol 104:213–229CrossRefPubMed
17.
Zurück zum Zitat Hammoudi DS, Lee SS, Madison A, Mirabella G, Buncic JR, Logan WJ, Snead OC, Westall CA (2005) Reduced visual function associated with infantile spasms in children on vigabatrin therapy. Invest Ophthalmol Vis Sci 46:514–520CrossRefPubMed Hammoudi DS, Lee SS, Madison A, Mirabella G, Buncic JR, Logan WJ, Snead OC, Westall CA (2005) Reduced visual function associated with infantile spasms in children on vigabatrin therapy. Invest Ophthalmol Vis Sci 46:514–520CrossRefPubMed
18.
Zurück zum Zitat Westall CA, Wright T, Cortese F, Kumarappah A, Snead OC, Buncic JR (2014) Vigabatrin retinal toxicity in children with infantile spasms: an observational cohort study. Neurology 83(24):2262–2268CrossRefPubMedPubMedCentral Westall CA, Wright T, Cortese F, Kumarappah A, Snead OC, Buncic JR (2014) Vigabatrin retinal toxicity in children with infantile spasms: an observational cohort study. Neurology 83(24):2262–2268CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Bain KE, Beatty S, Lloyd C (2000) Non-organic visual loss in children. Eye (Lond) 14(Pt 5):770–772CrossRef Bain KE, Beatty S, Lloyd C (2000) Non-organic visual loss in children. Eye (Lond) 14(Pt 5):770–772CrossRef
21.
Zurück zum Zitat Raghunandan A, Buckingham RS (2008) The utility of clinical electrophysiology in a case of nonorganic vision loss. Optometry 79:436–443CrossRefPubMed Raghunandan A, Buckingham RS (2008) The utility of clinical electrophysiology in a case of nonorganic vision loss. Optometry 79:436–443CrossRefPubMed
24.
Zurück zum Zitat Boycott KM, Sauve Y, MacDonald IM (1993) X-linked congenital stationary night blindness. In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Mefford HC, Smith RJH, Stephens K (eds) GeneReviews(R) University of Washington, Seattle University of Washington, Seattle. All rights reserved, Seattle, WA Boycott KM, Sauve Y, MacDonald IM (1993) X-linked congenital stationary night blindness. In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Mefford HC, Smith RJH, Stephens K (eds) GeneReviews(R) University of Washington, Seattle University of Washington, Seattle. All rights reserved, Seattle, WA
25.
Zurück zum Zitat Kim JM, Payne JF, Yan J, Barnes CS (2012) Negative electroretinograms in the pediatric and adult population. Doc Ophthalmol 124:41–48CrossRefPubMed Kim JM, Payne JF, Yan J, Barnes CS (2012) Negative electroretinograms in the pediatric and adult population. Doc Ophthalmol 124:41–48CrossRefPubMed
26.
Zurück zum Zitat Taylor MJ, McCulloch DL (1992) Visual evoked potentials in infants and children. J Clin Neurophysiol 9:357–372CrossRefPubMed Taylor MJ, McCulloch DL (1992) Visual evoked potentials in infants and children. J Clin Neurophysiol 9:357–372CrossRefPubMed
27.
Zurück zum Zitat Andreasson S, Tornqvist K, Ehinger B (1993) Full-field electroretinograms during general anesthesia in normal children compared to examination with topical anesthesia. Acta Ophthalmol (Copenh) 71:491–495CrossRef Andreasson S, Tornqvist K, Ehinger B (1993) Full-field electroretinograms during general anesthesia in normal children compared to examination with topical anesthesia. Acta Ophthalmol (Copenh) 71:491–495CrossRef
28.
Zurück zum Zitat Raitta C, Karhunen U, Seppalainen AM (1982) Changes in the electroretinogram and visual evoked potentials during general anaesthesia using enflurane. Graefes Arch Clin Exp Ophthalmol 218:294–296CrossRefPubMed Raitta C, Karhunen U, Seppalainen AM (1982) Changes in the electroretinogram and visual evoked potentials during general anaesthesia using enflurane. Graefes Arch Clin Exp Ophthalmol 218:294–296CrossRefPubMed
29.
Zurück zum Zitat Chin KC, Taylor MJ, Menzies R, Whyte H (1985) Development of visual evoked potentials in neonates. A study using light emitting diode goggles. Arch Dis Child 60:1166–1168CrossRefPubMedPubMedCentral Chin KC, Taylor MJ, Menzies R, Whyte H (1985) Development of visual evoked potentials in neonates. A study using light emitting diode goggles. Arch Dis Child 60:1166–1168CrossRefPubMedPubMedCentral
30.
31.
Zurück zum Zitat Lenassi E, Likar K, Stirn-Kranjc B, Brecelj J (2008) VEP maturation and visual acuity in infants and preschool children. Doc Ophthalmol 117:111–120CrossRefPubMed Lenassi E, Likar K, Stirn-Kranjc B, Brecelj J (2008) VEP maturation and visual acuity in infants and preschool children. Doc Ophthalmol 117:111–120CrossRefPubMed
Metadaten
Titel
The diagnosis and assessment of visual function in Singaporean children with electrophysiology: 10-year results
verfasst von
Anna C. S. Tan
LiYu Chen
Rena Png
Audrey Chia
Publikationsdatum
16.04.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Documenta Ophthalmologica / Ausgabe 3/2016
Print ISSN: 0012-4486
Elektronische ISSN: 1573-2622
DOI
https://doi.org/10.1007/s10633-016-9539-9

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