nach oben

Neuropsychology Review

Erschienen in:

22.11.2016 | Review

The Differential Effects of Alzheimer's Disease and Lewy Body Pathology on Cognitive Performance: a Meta-analysis

verfasst von: Ashita S. Gurnani, Brandon E. Gavett

Erschienen in: Neuropsychology Review | Ausgabe 1/2017

Einloggen, um Zugang zu erhalten

Abstract

Differential diagnosis of Alzheimer’s disease (AD) from normal aging and other dementia etiologies is imperative for disease specific treatment options and long-term care planning. Neuropathological confirmation is the gold standard for neurodegenerative disease diagnosis, yet most published studies examining the use of neuropsychological tests in the differential diagnosis of dementia rely upon clinical diagnostic outcomes. The present study undertook a meta-analytic review of the literature to identify cognitive tests and domains that allow for the differentiation of individuals with AD pathology from individuals with dementia with Lewy Bodies (DLB) pathology and pathology-free individuals. A comprehensive literature search yielded 14 studies that met the inclusion criteria for the present meta-analysis. Six studies comprised 222 decedents with AD compared to 433 normal controls, and eight studies comprised 431 cases of AD compared to 155 decedents with DLB. Results revealed that the effect of having neuropathologically confirmed AD versus DLB lowered performance in the memory domain, and having DLB decreased performance in the visuospatial domain. No single test differed significantly across the AD and DLB groups. For the AD and pathology free comparison, results indicated that that AD was associated with poorer performance on the memory and language domains. With respect to specific cognitive tests, AD produced lower scores on list learning tests, category fluency, and the Digit Symbol substitution test. The limited number of studies meeting inclusion criteria warrants formulation of guidelines for reporting in clinico-pathological studies; suggested guidelines are provided.

Nur mit Berechtigung zugänglich

Ahmed, S., de Jager, C. A., Haigh, A. M., & Garrard, P. (2013). Semantic processing in connected speech at a uniformly early stage of autopsy-confirmed Alzheimer's disease. Neuropsychology. doi:10.1037/a0031288.PubMed

Albert, M. S., Moss, M. B., Tanzi, R., & Jones, K. (2001). Preclinical prediction of AD using neuropsychological tests. Journal of the International Neuropsychological Society. doi:10.1017/S1355617701755105.PubMed

Albert, Albert, M. S. DeCarli, C. DeKosky, S. De Leon, M. Foster, N. L. Fox, … Khachaturian, Z. (2005). The use of MRI and PET for clinical diagnosis of dementia and investigation of cognitive impairment: A consensus report. In Alzheimer's Association.

Bäckman, L., Jones, S., Berger, A. K., Laukka, E. J., & Small, B. J. (2005). Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis. Neuropsychology. doi:10.1037/0894-4105.19.4.520.PubMed

* Ballard, C., Holmes, C., McKeith, I., Neill, D., O’Brien, J., Cairns, N., et al. (1999). Psychiatric morbidity in dementia with Lewy bodies: a prospective clinical and neuropathological comparative study with Alzheimer’s disease. American Journal of Psychiatry, 156, 1039–1045.

* Beach, T. G., Adler, C. H., Lue, L., Sue, L. I., Bachalakuri, J., Henry-Watson, J., et al. (2009). Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathologica. doi:10.1007/s00401-009-0538.

Beach, T. G., Monsell, S. E., Phillips, L. E., & Kukull, W. (2012). Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer disease centers, 2005–2010. Journal of Neuropathology & Experimental Neurology. doi:10.1097/NEN.0b013e31824b211b.PubMedCentral

* Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C., & Wilson, R. S. (2006). Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology. doi:10.1212/01.wnl.0000219668.47116.e6.

Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P. P., Irwig, L. M., et al. (2003). The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Annals of Internal Medicine, 138, W1–12. doi:10.7326/0003-4819-138-1-200301070-00012-w1.CrossRefPubMed

Caramelli, P., Robitaille, Y., LarocheCholette, A., Nitrini, R., Gauvreau, D., Joanette, Y., & Lecours, A. R. (1998). Structural correlates of cognitive deficits in a selected group of patients with Alzheimer's disease. Cognitive and Behavioral Neurology, 11, 184–190.

Chen, P., Ratcliff, G., Belle, S. H., Cauley, J. A., DeKosky, S. T., & Ganguli, M. (2001). Patterns of cognitive decline in presymptomatic Alzheimer disease: a prospective community study. Archives of General Psychiatry. doi:10.1001/archpsyc.58.9.853.PubMed

Christensen, H., Hadzi-Pavlovic, D., & Jacomb, P. (1991). The psychometric differentiation of dementia from normal aging: A meta-analysis. Psychological Assessment: A Journal of Consulting and Clinical Psychology. doi:10.1037//1040-3590.3.2.147.

Chui, H. C., Zarow, C., Mack, W. J., Ellis, W. G., Zheng, L., Jagust, W. J., et al. (2006). Cognitive impact of subcortical vascular and Alzheimer’s disease pathology. Annals of Neurology. doi:10.1002/ana.21009.PubMedPubMedCentral

Cohen, J. (1988). Statistical power analyses for the behavioral sciences (2nd ed.). New York: Academic Press.

Collerton, D., Burn, D., McKeith, I., & O’Brien, J. (2003). Systematic review and meta-analysis show that dementia with Lewy bodies is a visual-perceptual and attentional-executive dementia. Dementia and Geriatric Cognitive Disorders. doi:10.1159/000072807.PubMed

Davis, D. G., Schmitt, F. A., Wekstein, D. R., & Markesbery, W. R. (1999). Alzheimer neuropathologic alterations in aged cognitively normal subjects. Journal of Neuropathology and Experimental Neurology. doi:10.1097/00005072-199904000-00008.PubMed

Development Core Team, R. (2015). R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing Available from http://www.R-project.org.

Driscoll, I., Resnick, S. M., Troncoso, J. C., An, Y., O'Brien, R., & Zonderman, A. B. (2006). Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly. Annals of Neurology. doi:10.1002/ana.21031.PubMed

Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., et al. (2007). Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria. The Lancet Neurology. doi:10.1016/S1474-4422(07)70178-3.PubMed

Elfgren, C., Brun, A., Gustafson, L., Johanson, A., Minthon, L., Passant, U., & Risberg, J. (1994). Neuropsychological tests as discriminators between dementia of Alzheimer type and frontotemporal dementia. International Journal of Geriatric Psychiatry. doi:10.1002/gps.930090807.

Elias, M., Beiser, A., Wolf, P., Au, R., White, R., & D’Agostino, R. (2000). The preclinical phase of Alzheimer disease: a 22- year prospective study of the Framingham cohort. Archives of Neurology. doi:10.1001/archneur.57.6.808.PubMed

Ferman, T. J., Smith, G. E., Boeve, B. F., Graff-Radford, N. R., Lucas, J. A., Knopman, D. S., et al. (2006). Neuropsychological differentiation of dementia with Lewy bodies from normal aging and Alzheimer's disease. The Clinical Neuropsychologist. doi:10.1080/13854040500376831.PubMed

Field, A. P., & Gillett, R. (2010). How to do a meta-analysis. British Journal of Mathematical and Statistical Psychology. doi:10.1348/000711010X502733.PubMed

Galasko, D., Hansen, L. A., Katzman, R., Wiederholt, W., Masliah, E., Terry, R., et al. (1994). Clinical-neuropathological correlations in Alzheimer's disease and related dementias. Archives of Neurology. doi:10.1001/archneur.1994.00540210060013.PubMed

* Galasko, D., Katzman, R., Salmon, D. P., & Hansen, L. (1996). Clinical and neuropathological findings in Lewy body dementias. Brain and Cognition. doi:10.1006/brcg.1996.0040.

Galvin, J. E., Powlishta, K. K., Wilkins, K., McKeel, D. W., Xiong, C., Grant, E., et al. (2005). Predictors of preclinical Alzheimer disease and dementia: a clinicopathologic study. Archives of Neurology, 62, 758–765.CrossRefPubMed

Galvin, J. E., Boeve, B. F., Duda, J. E., Galasko, D. R., Kaufer, D., Leverenz, J. B., … Lopez, O. L. (2008). Current issues in Lewy body dementia diagnosis, treatment and research. Retrieved from Lewy Body Dementia Association website: http://www.lbda.org/sites/default/files/current_issues.pdf.

Gaugler, J. E., Ascher-Svanum, H., Roth, D. L., Fafowora, T., Siderowf, A., & Beach, T. G. (2013). Characteristics of patients misdiagnosed with Alzheimer’s disease and their medication use: An analysis of the NACC-UDS database. BMC Geriatrics, 13. doi:10.1186/1471-2318-13-137.

* Goldman, W. P., Price, J. L., Storandt, M., Grant, E. A., McKeel, D. W., Rubin, E. H., & Morris, J. C. (2001). Absence of cognitive impairment or decline in preclinical Alzheimer’s disease. Neurology. doi:10.1212/WNL.56.3.361.

* Hamilton, J. M., Salmon, D. P., Galasko, D., Delis, D. C., Hansen, L. A., Masliah, E., et al. (2004). A comparison of episodic memory deficits in neuropathologically-confirmed dementia with Lewy bodies and Alzheimer's disease. Journal of the International Neuropsychological Society. doi:10.1017/S1355617704105043.

Hamilton, J. M., Salmon, D. P., Galasko, D., Raman, R., Emond, J., Hansen, L. A., et al. (2008). Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodies. Neuropsychology. doi:10.1037/a0012949.PubMedCentral

Henry, J. D., Crawford, J. R., & Phillips, L. H. (2004). Verbal fluency performance in dementia of the Alzheimer’s type: a meta-analysis. Neuropsychologia. doi:10.1016/j.neuropsychologia.2004.02.001.

Hirni, D. I., Kivisaari, S. L., Monsch, A. U., & Taylor, K. I. (2016). Distinct neuroanatomical bases of episodic and semantic memory performance in Alzheimer’s disease. Neuropsychologia. doi:10.1016/j.neuropsychologia.2013.01.013.

Hulette, C. M., Welsh-Bohmer, K. A., Murray, M. G., Saunders, A. M., Mash, D. C., & McIntyre, L. M. (1998). Neuropathological and neuropsychological changes in “normal” aging: evidence for preclinical Alzheimer disease in cognitively normal individuals. Journal of Neuropathology and Experimental Neurology. doi:10.1097/00005072-199812000-00009.

Hutchinson, A. D., & Mathais, J. L. (2007). Neuropsychological deficits in frontotemporal dementia and Alzheimer’s disease: a meta-analytic review. Journal of Neurology, Neurosurgery, and Psychiatry. doi:10.1136/jnnp.2006.100669.

Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., et al. (2012). National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease. Alzheimer’s & Dementia, 8, 1–13.

Jacobs, D. M., Sano, M., Dooneief, G., Marder, K., Bell, K. L., & Stern, Y. (1995). Neuropsychological detection and characterization of preclinical Alzheimer's disease. Neurology. doi:10.1212/WNL.45.5.957.

John, S. E., Gurnani, A. S., Bussell, C. A., Saurman, J. L., Griffin, J. W., & Gavett, B. E. (in press). The effectiveness and unique contribution of neuropsychological tests and the δ latent dementia phenotype in the differential diagnosis of dementia in the uniform data set. Neuropsychology.

Johns, E. K., Phillips, N. A., Belleville, S., Goupil, D., Babins, L., Kelner, L., et al. (2009). Executive functions in frontotemporal dementia and Lewy body dementia. Neuropsychology. doi:10.1037/a0016792.PubMed

Johnson, D. K., & Galvin, J. E. (2011). Longitudinal changes in cognition in Parkinson’s disease with and without dementia. Dementia and Geriatric Cognitive Disorders, doi, 1159/000323570.

Johnson, D. K., Morris, J. C., & Galvin, J. E. (2005). Verbal and visuospatial deficits in dementia with Lewy bodies. Neurology. doi:10.1212/01.wnl.0000180964.60708.c2.PubMedCentral

* Johnson, D. K., Storandt, M., Morris, J. C., Langford, Z. D., & Galvin, J. E. (2008). Cognitive profiles in dementia: Alzheimer disease vs healthy brain aging. Neurology. doi:10.1212/01.wnl.0000335972.35970.70.

Johnson, D. K., Storandt, M., Morris, J. C., & Galvin, J. E. (2009). Longitudinal study of the transition from healthy aging to Alzheimer’s disease. Archives of Neurology. doi:10.1001/archneurol.2009.158.PubMedPubMedCentral

Josephs, K. A., Tsuboi, Y., Cookson, N., Watt, H., & Dickson, D. W. (2004). Apolipoprotein E ε4 is a determinant for Alzheimer-type pathologic features in tauopathies, synucleinopathies, and frontotemporal degeneration. Archives of Neurology. doi:10.1001/archneur.61.10.1579.

Kanne, S. M., Balota, D. A., Storandt, M., McKeel, D. W., & Morris, J. C. (1998). Relating anatomy to function in Alzheimer’s disease: neuropsychological profiles predict regional neuropathology 5 years later. Neurology. doi:10.1212/WNL.50.4.979.PubMed

Kazee, A. M., Eskin, T. A., Lapham, L. W., Gabriel, K. R., McDaniel, K. D., & Hamill, R. W. (1993). Clinicopathologic correlates in Alzheimer disease: assessment of clinical and pathologic diagnostic criteria. Alzheimer Disease & Associated Disorders, 7, 152–164.CrossRef

Khachaturian, Z. S. (1985). Diagnosis of Alzheimer’s disease. Archives of Neurology, 42, 1097–1105. doi:10.1001/archneur.1985.04060100083029.CrossRefPubMed

Konstantopoulos, S. (2011). Fixed effects and variance components estimation in three-level meta-analysis. Research Synthesis Methods. doi:10.1002/jrsm.35.PubMed

Kraybill, M. L., Larson, E. B., Tsuang, D. W., Teri, L., McCormick, W. C., Bowen, J. D., et al. (2005). Cognitive differences in dementia patients with autopsy-verified Alzheimer’s disease, Lewy body pathology, or both. Neurology, 64, 2069–2073.CrossRefPubMedPubMedCentral

Lamar, M., Price, C. C., Davis, K. L., Kaplan, E., & Libon, D. J. (2002). Capacity to maintain mental set in dementia. Neuropsychologia. doi:10.1016/S0028-3932(01)00125-7.PubMed

Lezak, M. D., Howieson, D. B., Bigler, E. D., & Tranel, D. (2012). Neuropsychological assessment (5th ed.). New York, NY: Oxford University Press.

Lopez, O. L., Wisniewski, S. R., Becker, J. T., Boller, F., & DeKosky, S. T. (1999). Psychiatric medication and abnormal behavior as predictors of progression in probable Alzheimer disease. Archives of Neurology, 56, 1266–1272.

Mathais, J. L., & Burke, J. (2009). Cognitive functioning in Alzheimer’s and vascular dementia. Neuropsychology. doi:10.1037/a0015384.

McKeith, I. G., Burn, D., O’Brien, J., Perry, R., & Perry, E. (2002). Dementia with Lewy bodies. In K. L. Davis, D. Charney, J. T. Koyle, & C. Nemeroff (Eds.), Neuropsychopharmacology: The fifth generation of progress (pp. 1301–1315). Brentwood, TN: American college of neuropsychophamacology.

McKeith, I. G., Dickson, D. W., Lowe, J. J., Emre, M. M., O'Brien, J. T., Feldman, H. H., et al. (2005). Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology. doi:10.1212/01.wnl.0000187889.17253.b1.

McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack Jr., C. R., Kawas, C. H., et al. (2011). The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia. doi:10.1016/j.jalz.2011.03.005.

Meehl, P. E. (1995). Bootstraps taxometrics: solving the classification problem in psychopathology. American Psychologist. doi:10.1037/0003-066X.50.4.266.PubMed

* Minoshima, S., Foster, N. L., Sima, A. A., Frey, K. A., Albin, R. L., & Kuhl, D. E. (2001). Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Annals of Neurology. doi:10.1002/ana.1133.

Mitchell, A. J. (2009). A meta-analysis of the accuracy of the mini-mental state examination in the detection of dementia and mild cognitive impairment. Journal of Psychiatric Research. doi:10.1016/j.jpsychires.2008.04.014.PubMed

Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine, 6(7), e1000097. doi:10.1371/journal.pmed1000097.CrossRefPubMedPubMedCentral

Mollenhauer, B., Förstl, H., Deuschl, G., Storch, A., Oertel, W., & Trenkwalder, C. (2010). Lewy body and Parkinsonian dementia: common but often misdiagnosed conditions. Deutsches Ärzteblatt International. doi:10.3238/arztebl.2010.0684.PubMedPubMedCentral

Mrak, R. E., & Griffin, W. S. T. (2007). Dementia with Lewy bodies: definition, diagnosis, and pathogenic relationship to Alzheimer’s disease. Neuropsychiatric Disease and Treatment, 3, 619–625.PubMedPubMedCentral

Mungas, D., Beckett, L., Harvey, D., Tomaszewski Farias, S., Reed, B., Carmichael, O., et al. (2010). Heterogeneity of cognitive trajectories in diverse older persons. Psychology and Aging. doi:10.1037/a0019502.PubMedPubMedCentral

Newell, K. L., Hyman, B. T., Growdon, J. H., & Hedley-Whyte, E. T. (1999). Application of the National Institute on Aging (NIA)-Reagan institute criteria for the neuropathological diagnosis of Alzheimer disease. Journal of Neuropathology & Experimental Neurology. doi:10.1097/00005072-199911000-00004.

Palmer, K., Bäckman, L., Winblad, B., & Fratiglioni, L. (2003). Detection of Alzheimer's disease and dementia in the preclinical phase: population based cohort study. British Medical Journal. doi:10.1136/bmj.326.7383.245.

Pinhiero, J. C., & Bates, D. M. (2000). Mixed-effects models in S and S-PLUS. New York: Springer.CrossRef

Price, D. L., Tanzi, R. E., Borchelt, D. R., & Sisodia, S. S. (1998). Alzheimer’s disease: genetic studies and transgenic models. Annual Review of Genetics. doi:10.1146/annurev.genet.32.1.461.

Price, J. L., McKeel, D. W., Buckles, V. D., Roe, C. M., Xiong, C., Grundman, M., et al. (2009). Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiology of Aging. doi:10.1016/j.neurobiolaging.2009.04.002.PubMedCentral

Reed, B. R., Mungas, D. M., Kramer, J. H., Ellis, W., Vinters, H. V., Zarow, C., et al. (2007). Profiles of neuropsychological impairment in autopsy-defined Alzheimer’s disease and cerebrovascular disease. Brain. doi:10.1093/brain/awl385.

* Riley, K. P., Jicha, G. A., Davis, D., Abner, E. L., Cooper, G. E., Stiles, N., et al. (2011). Prediction of preclinical Alzheimer's disease: longitudinal rates of change of cognition. Journal of Alzheimer's Disease. doi:10.3233/JAD-2011-102133.

Rosenthal, R. (1979). The file drawer problem and tolerance for null results. Psychological Bulletin. doi:10.1037/0033-2909.86.3.638.

Rosenthal, R., & DiMatteo, M. R. (2001). Meta-analysis: recent developments in quantitative methods for literature reviews. Annual Review of Psychology. doi:10.1146/annurev.psych.52.1.59.PubMed

Ruscio, J. (2008). A probability-based measure of effect size: robustness to base rates and other factors. Psychological Methods, 13, 19–30. doi:10.1037/1082-989X.13.1.19.CrossRefPubMed

Salmon, D. P. (2000). Disorders of memory in Alzheimer’s disease. In L. S. Cermak (2nd Ed.), Handbook of neuropsychology, Vol. 2: Memory and its disorders (pp.155–195). Amsterdam: Elsevier.

Salmon, D. P., & Bondi, M. W. (2009). Neuropsychological assessment of dementia. Annual Review of Psychology. doi:10.1146/annurev.psych.57.102904.190024.PubMedPubMedCentral

* Scheff, S. W., Price, D. A., Schmitt, F. A., Scheff, M. A., & Mufson, E. J. (2011). Synaptic loss in the inferior temporal gyrus in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease. doi:10.3233/JAD-2011-101782.

* Schmitt, F. A., Davis, D. G., Wekstein, D. R., Smith, C. D., Ashford, J. W., & Markesbery, W. R. (2000). Preclinical. AD revisited: Neuropathology of Cognitively Normal Older Adults. Neurology. doi:10.1212/WNL.55.3.370.

Sloane, P. D., Zimmerman, S., Suchindran, C., Reed, P., Wang, L., Boustani, M., & Sudha, S. (2002). The public health impact of Alzheimer’s disease, 2000-2050: potential implication of treatment advances. Annual Review of Public Health. doi:10.1146/annurev.publhealth.23.100901.140525.PubMed

Storandt, M., Botwinick, J., Danziger, W. L., Berg, L., & Hughes, C. P. (1984). Psychometric differentiation of mild senile dementia of the Alzheimer type. Archives of Neurology. doi:10.1001/archneur.1984.04050170043013.PubMed

Strauss, E., Sherman, E. M. S., & Spreen, O. (2006). A compendium of neuropsychological tests: Administration, norms, and commentary (3rd ed.). New York, NY: Oxford University Press.

Tabert, M. H., Manly, J. J., Liu, X., Pelton, G. H., Rosenblum, S., Jacobs, M., et al. (2006). Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment. Archives of General Psychiatry. doi:10.1001/archpsyc.63.8.916.PubMed

Tierney, M. C., Snow, W. G., Reid, D. W., Zorzitto, M. L., & Fisher, R. H. (1987). Psychometric differentiation of dementia: replication and extension of the findings of Storandt and coworkers. Archives of Neurology. doi:10.1001/archneur.1987.00520190032013.

Tierney, M. C., Szalai, J. P., Snow, W. G., Fisher, R. H., Nores, A., Nadon, G., et al. (1996). Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study. Neurology. doi:10.1212/WNL.46.3.661.

* Tiraboschi, P., & Guerra, U. P. (2010). How to distinguish dementia with Lewy bodies from Alzheimer’s disease? The Open Nuclear Medicine Journal. doi:10.2174/1876388X01002020058.

Tiraboschi, P., Salmon, D. P., Hansen, L. A., Hofstetter, R. C., Thal, L. J., & Corey-Bloom, J. (2006). What best differentiates Lewy body from Alzheimer's disease in early-stage dementia? Brain. doi:10.1093/brain/awh725.PubMed

Tombaugh, T. N., & McIntyre, N. J. (1992). The mini-mental state examination: a comprehensive review. Journal of the American Geriatrics Society. doi:10.1111/j.1532-5415.1992.tb01992.x.PubMed

Varma, A. R., Snowden, J. S., Lloyd, J. J., Talbot, P. R., Mann, D. M. A., & Neary, D. (1999). Evaluation of the NINCDS-ADRDA criteria in the differentiation of Alzheimer’s disease and frontotemporal dementia. Journal of Neurology, Neurosurgery & Psychiatry. doi:10.1136/jnnp.66.2.184.

Viechtbauer, W. (2010). Conducting meta-analyses in R with the metafor package. Journal of Statistical Software, 36, 1–48 Retrieved from http://www.jstatsoft.org/v36/i03.CrossRef

Walker, Z., McKeith, I., Rodda, J., Qassem, T., Tatsch, K., Booij, J., et al. (2012). Comparison of cognitive decline between dementia with Lewy bodies and Alzheimer’s disease: a cohort study. British Medical Journal Open. doi:10.1136/bmjopen-2011-000380.

Wang, B. W., Lu, E., Mackenzie, I. R. A., Assaly, M., Jacova, C., Lee, P. E., et al. (2012). Multiple pathologies are common in Alzheimer patients in clinical trials. The Canadian Journal of Neurological Sciences. doi:10.1017/S0317167100015316.

Welsh, K., Butters, N., Hughes, J., Mohs, R., & Heyman, A. (1991). Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures. Archives of Neurology. doi:10.1001/archneur.1991.00530150046016.PubMed

* Yoshizawa, H., Vonsattel, J. P. G., & Honig, L. S. (2013). Early neuropsychological discriminants for Lewy body disease: an autopsy series. Journal of Neurology, Neurosurgery, and Psychiatry. doi:10.1136/jnnp-2012-304381.

Zakzanis, K. K. (2001). Statistics to tell the truth, the whole truth, and nothing but the truth: formulae, illustrative numerical examples, and heuristic interpretation of effect size analyses for neuropsychological researchers. Archives of Clinical Neuropsychology. doi:10.1016/S0887-6177(00)00076-7.PubMed

Titel: The Differential Effects of Alzheimer's Disease and Lewy Body Pathology on Cognitive Performance: a Meta-analysis
verfasst von: Ashita S. Gurnani
Brandon E. Gavett
Publikationsdatum: 22.11.2016
Verlag: Springer US
Erschienen in: Neuropsychology Review / Ausgabe 1/2017
Print ISSN: 1040-7308
Elektronische ISSN: 1573-6660
DOI: https://doi.org/10.1007/s11065-016-9334-0

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

18.04.2024 | Arterielle Hypertonie | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

The Differential Effects of Alzheimer's Disease and Lewy Body Pathology on Cognitive Performance: a Meta-analysis

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Update Neurologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2017

Wearable Cameras Are Useful Tools to Investigate and Remediate Autobiographical Memory Impairment: A Systematic PRISMA Review

A Meta-Analysis of Working Memory Impairments in Autism Spectrum Disorders

Disrupted Face Processing in Frontotemporal Dementia: A Review of the Clinical and Neuroanatomical Evidence

The Early Presentation of Dementia in People with Down Syndrome: a Systematic Review of Longitudinal Studies

Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Update Neurologie