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28.11.2016 | Urologic Oncology | Ausgabe 5/2017

Annals of Surgical Oncology 5/2017

The Differential Impact of Body Mass Index and the Feature of Metabolic Syndrome on Oncological Outcomes Following Different Surgical Procedures in Japanese Men with Prostate Cancer

Zeitschrift:
Annals of Surgical Oncology > Ausgabe 5/2017
Autoren:
MD, PhD Masaki Shiota, MD, PhD Ario Takeuchi, MD, PhD Masaaki Sugimoto, MD, PhD Eiji Kashiwagi, MD, PhD Takashi Dejima, MD, PhD Keijiro Kiyoshima, MD, PhD Junichi Inokuchi, MD, PhD Katsunori Tatsugami, MD, PhD Akira Yokomizo, MD, PhD Masatoshi Eto

Abstract

Purpose

This study aimed to examine the differential impact of body mass index and the feature of metabolic syndrome (MetS; obesity, hypertension, diabetes mellitus, and dyslipidemia) on biochemical recurrence (BCR) following radical prostatectomy (RP) treatment for prostate cancer using different surgical procedures.

Methods

This study included 283 Japanese patients with clinically localized prostate cancer who were treated with RP between 2008 and 2012. The prognostic significance of overweight and the feature of MetS were analyzed according to surgical procedures.

Results

BCR occurred in 68/283 (24.0%) men. Overweight and the feature of MetS were predictors of BCR in patients who had undergone open RP (ORP), but not in those treated with laparoscopic surgery. Multivariate analyses incorporating preoperative and postoperative risk factors revealed that overweight and the feature of MetS were independent BCR risk factors when treated with ORP.

Conclusions

In Japanese men, overweight and the feature of MetS were associated with worse outcomes following RP, particularly ORP, compared with those following laparoscopic surgery. These results suggest that laparoscopic surgery can overcome the surgical challenges associated with abdominal obesity.

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Zusatzmaterial
Supplementary material 1 (XLSX 12 kb)
10434_2016_5705_MOESM1_ESM.xlsx
Supplementary material 2 (XLSX 12 kb)
10434_2016_5705_MOESM2_ESM.xlsx
Supplementary material 3 (XLSX 12 kb)
10434_2016_5705_MOESM3_ESM.xlsx
Literatur
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