The diffusion MRI signature index is highly correlated with immunohistochemical status and molecular subtype of invasive breast carcinoma
- 08.04.2022
- Breast
Erschienen in:
- Verfasst von
- Mariko Goto
- Denis Le Bihan
- Koji Sakai
- Kei Yamada
- Erschienen in
- European Radiology | Ausgabe 7/2022
Abstract
Objectives
To evaluate the relationship of the signature index (S-index), an advanced diffusion MRI marker, and the immunohistochemical (IHC) status, proliferation rate, and molecular subtype of invasive breast cancers.
Methods
A retrospective study of patients with invasive carcinoma was conducted between 2017 and 2021. All patients underwent dynamic contrast-enhanced MRI and DWI using a 3-T system. For DWI, three b values (0, 200, and 1500 s/mm2) were used to derive the S-index. Three-dimensional ROIs were manually placed over the whole tumor on DWI. Mean and 85th percentile S-index values were compared to the IHC status, proliferation rate, and molecular subtypes of lesions.
Results
The study included 153 patients (mean age, 60 ± 13 years) with 160 invasive carcinomas. S-index values were significantly higher in estrogen receptor–positive (mean, p = .005; 85th percentile, p < .001) and progesterone receptor–positive (mean, p = .003; 85th percentile, p < .001) tumors, and significantly lower in human epidermal growth factor receptor 2 (HER2) – positive tumors (mean, p = .023; 85th percentile, p < .001). Mean and 85th percentile S-index values were significantly different among breast cancer subtypes (mean, p = .015; 85th percentile, p = .002), and the AUC of these values for the prediction of IHC status were 0.64 and 0.66 for HER2, and 0.70 and 0.74 for hormone receptors, respectively.
Conclusions
The DWI S-index showed significantly higher values in invasive carcinomas with immunohistochemical status associated with good prognosis, suggesting its usefulness as a noninvasive imaging biomarker to estimate IHC status and orient treatment.
Key Points
• The signature index, an advanced diffusion MRI marker, showed good discrimination of immunohistochemical status in invasive breast carcinomas.
• The signature index has the potential to differentiate noninvasively invasive breast carcinoma subtypes and appears as an imaging biomarker of prognostic factors and molecular phenotypes
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- Titel
- The diffusion MRI signature index is highly correlated with immunohistochemical status and molecular subtype of invasive breast carcinoma
- Verfasst von
-
Mariko Goto
Denis Le Bihan
Koji Sakai
Kei Yamada
- Publikationsdatum
- 08.04.2022
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
European Radiology / Ausgabe 7/2022
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084 - DOI
- https://doi.org/10.1007/s00330-022-08562-4
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