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10.01.2022 | Original Paper

The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro

verfasst von: Mya Myat Ngwe Tun, Kazufumi Toume, Elizabeth Luvai, Khine Mya Nwe, Shusaku Mizukami, Kenji Hirayama, Katsuko Komatsu, Kouichi Morita

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2022

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Abstract

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in 2019 has led to a global health crisis. Mutations of the SARS-CoV-2 genome have impeded the development of effective therapeutics and vaccines against SARS-CoV-2. Natural products are important for discovering therapeutics to treat the 2019 coronavirus disease (COVID-19). In the present study, we investigated the antiviral activity of herbal drug extracts from Polygala Root, Areca, and Quercus Bark and natural compounds derived from herbal drug such as baicalin and glabridin, with IC₅₀ values of 9.5 µg/ml, 1.2 µg/ml, 5.4 µg/ml, 8.8 µM, and 2.5 µM, respectively, against SARS CoV-2 infection in vitro. Certain herbal drug extracts and natural compounds were found to inhibit viral RNA levels and infectious titers of SARS-CoV-2 in a dose-dependent manner. Furthermore, viral protein analyses showed that herbal drug extracts and natural compounds effectively inhibited SARS-CoV-2 in the various entry treatments. Our study revealed that three herbal drugs are good candidates for further in vivo and clinical studies.

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Titel: The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro
verfasst von: Mya Myat Ngwe Tun
Kazufumi Toume
Elizabeth Luvai
Khine Mya Nwe
Shusaku Mizukami
Kenji Hirayama
Katsuko Komatsu
Kouichi Morita
Publikationsdatum: 10.01.2022
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2022
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-021-01596-w

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