Erschienen in:
18.05.2018 | Glaucoma
The distribution of retinal nerve fiber layer thickness and associations with age, refraction, and axial length: the Gutenberg health study
verfasst von:
Esther M. Hoffmann, Irene Schmidtmann, Angeliki Siouli, Alexander K. Schuster, Manfred E. Beutel, Norbert Pfeiffer, Julia Lamparter
Erschienen in:
Graefe's Archive for Clinical and Experimental Ophthalmology
|
Ausgabe 9/2018
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Abstract
Purpose
To evaluate the distribution of peripapillary retinal nerve fiber layer thickness as measured by optical coherence tomography and its associations with ocular parameters in a population-based setting.
Methods
In the population-based Gutenberg Health Study, 1974 subjects from the Mainz-Bingen region were scheduled for ophthalmologic examinations, including visual acuity, refraction, tonometry, biometry, and measurements of peripapillary retinal nerve fiber layer thickness (pRNFL) by optical coherence tomography (SD-OCT, Spectralis®, Heidelberg Engineering, Germany). The associated factors in the global and sectoral pRNFL data were analyzed using multivariable linear mixed models related to age, sex, and ocular parameters.
Results
Advanced age and longer axial length were associated with a thinner pRNFL, whereas pRNFL thickness was independent of sex, intraocular pressure (IOP), and central corneal thickness (CCT). Spherical equivalent was positively associated with pRNFL thickness, except in the temporal pRNFL sector.
Conclusions
In this large, population-based study, pRNFL thickness decreased with age. Longer eyes had thinner pRNFL thickness. Sex, IOP, and CCT showed no significant association with pRNFL thickness. These data may improve the interpretation of pRNFL data.