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01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

BMC Palliative Care 1/2014

The DOMUS study protocol: a randomized clinical trial of accelerated transition from oncological treatment to specialized palliative care at home

BMC Palliative Care > Ausgabe 1/2014
Mie Nordly, Kirstine Skov Benthien, Hans Von Der Maase, Christoffer Johansen, Marie Kruse, Helle Timm, Eva Soelberg Vadstrup, Geana Paula Kurita, Annika Berglind von Heymann-Horan, Per Sjøgren
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1472-684X-13-44) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

MN, HM, CJ, MK, HT, AH, and PS designed the study and developed the methods; KB, GK, and EV helped to improve the methods. MN, KB, AH, HM, CJ and PS conduct the practical daily activities of the trial. HT, CJ, HM, and PS supervise the study development. PS, CJ, HT, GK, EV supervise the PhDs students and their activities in the study (MN, KB, and AH). MN, HT, CJ, AH and PS drafted the manuscript. All authors read, made suggestions, revised, and approved the final manuscript.



The focus of Specialized Palliative Care (SPC) is to improve care for patients with incurable diseases and their families, which includes the opportunity to make their own choice of place of care and ultimately place of death.
The Danish Palliative Care Trial (DOMUS) aims to investigate whether an accelerated transition process from oncological treatment to continuing SPC at home for patients with incurable cancer results in more patients reaching their preferred place of care and death. The SPC in this trial is enriched with a manualized psychological intervention.


DOMUS is a controlled randomized clinical trial with a balanced parallel-group randomization (1:1). The planned sample size is 340 in- and outpatients treated at the Department of Oncology at Copenhagen University Hospital. Patients are randomly assigned either to: a) standard care plus SPC enriched with a standardized psychological intervention for patients and caregivers at home or b) standard care alone. Inclusion criteria are incurable cancer with no or limited antineoplastic treatment options.


Programs that facilitate transition from hospital treatment to SPC at home for patients with incurable cancer can be a powerful tool to improve patients’ quality of life and support family/caregivers during the disease trajectory. The present study offers a model for achieving optimal delivery of palliative care in the patient’s preferred place of care and attempt to clarify challenges.

Trial registration Identifier: NCT01885637
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