The increase in life expectancy recorded during the last decades has made the role of nursing homes pivotal for the treatment of old patients. Nursing home residents are typically elderly and not autonomous. These patients are often affected by concomitant multiple diseases and treated by several drugs at the same time [
1]. In this setting, the commonly used single disease approach is considered nowadays rather obsolete. This is rooted in handling patients for each single condition in accordance with specific specialist guidelines neglecting the whole clinical picture. On top of this, the concomitant use of multiple drugs, also defined as
Polypharmacy, is associated with poorer outcomes such as prolonged hospital stay, falls, adverse drug reactions, drug-to-drug interactions, nosocomial infections, and mortality [
2,
3]. Furthermore, frailty is defined as a state of increased vulnerability to stressors resulting from a decrease in physiologic reserves [
4]. The most used model to measure frailty is the Frailty Index (FI), proposed by
Rockwood and Mitnitski [
5], which is based on the concept that an aging person becomes frailer (or biologically older) by accumulating functional deficits. The items of FI are 36, encompassing health deficits such as type of diseases, signs, symptoms, and disabilities. …
