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Erschienen in: Sport Sciences for Health 2/2018

14.02.2018 | Original Article

The effect of 12 weeks of aerobic exercise on mitochondrial dynamics in cardiac myocytes of type 2 diabetic rats

verfasst von: Saghi Zafaranieh, Siroos Choobineh, Rahman Soori

Erschienen in: Sport Sciences for Health | Ausgabe 2/2018

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Abstract

Background

Mitochondrial dynamics disorders contribute to the pathogenesis of many diseases involving type 2 diabetes. It appears that exercise training is a strategy for reversing the unbalance between fusion and fission, but, to our understanding, effects of aerobic exercise on this particular issue have not been studied in cardiac myocytes.

Aims

To demonstrate if 12 weeks of aerobic exercise has a significant impact on Dynamin Related Protein 1 (DRP1), Mitofusin2 (MFN2) and Optic Atrophy 1 (OPA1) expressions in cardiac muscle of type 2 diabetic rats.

Methods

10 Wistar rats with an average age of 10 weeks were divided randomly into two groups of five: diabetic control and diabetic exercise. The latter was submitted to a 12-week (5 days a week, 30 min/day) aerobic exercise. 48 h after the last session of exercise, cardiac samples were obtained for genetic experiments. T-test was used for data analysis at p ≤ 0.05.

Results

OPA1 expression was increased significantly (p = 0.03) while MFN2 and DRP1 expressions were elevated insignificantly (p = 0.165, p = 0.19).

Conclusion

This study shows that aerobic training is likely to regulate mitochondrial fission and fusion in cardiac muscle of type 2 diabetic rats. Although more research is necessary.
Fußnoten
1
Prolyl-hydroxylases.
 
2
Body weight.
 
3
Streptozotocin.
 
4
Enzyme-linked immunosorbent assay.
 
5
AMP-activated protein kinase.
 
6
Oxidative phosphorylation.
 
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Metadaten
Titel
The effect of 12 weeks of aerobic exercise on mitochondrial dynamics in cardiac myocytes of type 2 diabetic rats
verfasst von
Saghi Zafaranieh
Siroos Choobineh
Rahman Soori
Publikationsdatum
14.02.2018
Verlag
Springer Milan
Erschienen in
Sport Sciences for Health / Ausgabe 2/2018
Print ISSN: 1824-7490
Elektronische ISSN: 1825-1234
DOI
https://doi.org/10.1007/s11332-018-0430-9

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