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Current Anesthesiology Reports
Erschienen in: Current Anesthesiology Reports 4/2018

01.12.2018 | Cancer Anesthesia (B Riedel and V Gottumukkala, Section Editors)

The Effect of Anaesthetic and Analgesic Technique on Oncological Outcomes

verfasst von: Aislinn Sherwin, Donal J. Buggy

Erschienen in: Current Anesthesiology Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

The purpose of this review is to provide an examination of the recent literature relating to anaesthesia and analgesia for cancer surgery and their potential effects on cancer recurrence and metastasis.

Recent Findings

Opioids continue to have mixed results in terms of their long-term effects on cancer outcomes. While laboratory evidence suggests alterations in immune responses and pro-tumourigenic effects via opioid receptors on cancer cells, clinical evidence is lacking. Regional anaesthesia has the ability to regulate surgical stress response, but retrospective studies provide conflicting results. However, lidocaine appears to have protective functions against cancer and anti-inflammatory properties making it a potentially useful agent perioperatively. An association also exists between the use of non-steroidal anti-inflammatory agents and improved perioperative outcomes; however, prospective clinical studies are required to provide more robust data in this area. Inhalational agents appear to confer increased risk of cancer recurrence in comparison to total intravenous anaesthesia (TIVA). A recent large retrospective trial and in vivo and in vitro evidence point to a beneficial effect of TIVA versus volatiles that should be fully investigated.

Summary

Retrospective analysis provides tenuous links between the techniques used perioperatively and potential cancer recurrence and metastasis. In vitro and in vivo animal studies have furthered research in the area, particularly providing mechanisms on how commonly used agents can affect patient outcomes. However, large prospective randomised control trials are required in this area to further the research on anaesthesia and its effects on cancer recurrence and metastasis.
Literatur
1.
Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G, Bettio M, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer (Oxford, England : 1990). 2018.
2.
Global Burden of Disease Cancer C. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA Oncology. 2017;3(4):524–48.CrossRef
3.
4.
Exadaktylos AK, Buggy DJ, Moriarty DC, Mascha E, Sessler DI. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology. 2006;105(4):660–4.PubMedCrossRef
5.
Buggy DJ, Borgeat A, Cata J, Doherty DG, Doornebal CW, Forget P, et al. Consensus statement from the BJA Workshop on Cancer and Anaesthesia. Br J Anaesth. 2015;114(1):2–3.CrossRefPubMed
6.
Behrenbruch C, Shembrey C, Paquet-Fifield S, Molck C, Cho HJ, Michael M, et al. Surgical stress response and promotion of metastasis in colorectal cancer: a complex and heterogeneous process. Clin Exp Metastasis. 2018;35(4):333–45.CrossRefPubMed
7.
8.
• Lambert AW, Pattabiraman DR, Weinberg RA. Emerging biological principles of metastasis. Cell. 2017;168(4):670–91 Review detailing the cellular and molecular mechanisms of metastasis. A useful article explaining the biology of the process. PubMedPubMedCentralCrossRef
9.
Hiller JG, Perry NJ, Poulogiannis G, Riedel B, Sloan EK. Perioperative events influence cancer recurrence risk after surgery. Nat Rev Clin Oncol. 2018;15(4):205–18.CrossRefPubMed
10.
Wu WK, Sung JJ, Lee CW, Yu J, Cho CH. Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: an update on the molecular mechanisms. Cancer Lett. 2010;295(1):7–16.PubMedCrossRef
11.
Perez-Sayans M, Somoza-Martin JM, Barros-Angueira F, Diz PG, Gandara Rey JM, Garcia-Garcia A. Beta-adrenergic receptors in cancer: therapeutic implications. Oncol Res. 2010;19(1):45–54.PubMedCrossRef
12.
Gupta K, Kshirsagar S, Chang L, Schwartz R, Law PY, Yee D, et al. Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Res. 2002;62(15):4491–8.PubMed
13.
Horowitz M, Neeman E, Sharon E, Ben-Eliyahu S. Exploiting the critical perioperative period to improve long-term cancer outcomes. Nat Rev Clin Oncol. 2015;12(4):213–26.PubMedPubMedCentralCrossRef
14.
Liao D, Johnson RS. Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev. 2007;26(2):281–90.CrossRefPubMed
15.
16.
Huang H, Benzonana LL, Zhao H, Watts HR, Perry NJ, Bevan C, et al. Prostate cancer cell malignancy via modulation of HIF-1alpha pathway with isoflurane and propofol alone and in combination. Br J Cancer. 2014;111(7):1338–49.PubMedPubMedCentralCrossRef
17.
Tavare AN, Perry NJ, Benzonana LL, Takata M, Ma D. Cancer recurrence after surgery: direct and indirect effects of anesthetic agents. Int J Cancer. 2012;130(6):1237–50.CrossRefPubMed
18.
Heaney A, Buggy DJ. Can anaesthetic and analgesic techniques affect cancer recurrence or metastasis? Br J Anaesth. 2012;109(Suppl 1):i17–28.PubMedCrossRef
19.
Koda K, Saito N, Takiguchi N, Oda K, Nunomura M, Nakajima N. Preoperative natural killer cell activity: correlation with distant metastases in curatively research colorectal carcinomas. Int Surg. 1997;82(2):190–3.PubMed
20.
Cata JP, Bauer M, Sokari T, Ramirez MF, Mason D, Plautz G, et al. Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer. J Clin Anesth. 2013;25(4):255–62.PubMedCrossRef
21.
Byrne K, Levins KJ, Buggy DJ. Can anesthetic-analgesic technique during primary cancer surgery affect recurrence or metastasis? Can J Anaesth. 2016;63(2):184–92.PubMedCrossRef
22.
Boland JW, Pockley AG. Influence of opioids on immune function in patients with cancer pain: from bench to bedside. Br J Pharmacol 2017.
23.
Connolly C, Buggy DJ. Opioids and tumour metastasis: does the choice of the anesthetic-analgesic technique influence outcome after cancer surgery? Curr Opin Anaesthesiol. 2016;29(4):468–74.PubMedCrossRef
24.
Franchi S, Moretti S, Castelli M, Lattuada D, Scavullo C, Panerai AE, et al. Mu opioid receptor activation modulates toll like receptor 4 in murine macrophages. Brain Behav Immun. 2012;26(3):480–8.PubMedCrossRef
25.
Xie N, Matigian N, Vithanage T, Gregory K, Nassar ZD, Cabot PJ, et al. Effect of perioperative opioids on cancer-relevant circulating parameters: mu opioid receptor and toll-like receptor 4 activation potential, and proteolytic profile. Clin Cancer Res. 2018;24(10):2319–27.PubMedCrossRef
26.
Hou M, Zhou NB, Li H, Wang BS, Wang XQ, Wang XW, et al. Morphine and ketamine inhibit immune function of gastric cancer patients by increasing percentage of CD4(+)CD25(+)Foxp3(+) regulatory T cells in vitro. J Surg Res. 2016;203(2):306–12.PubMedCrossRef
27.
Desmond F, McCormack J, Mulligan N, Stokes M, Buggy DJ. Effect of anaesthetic technique on immune cell infiltration in breast cancer: a follow-up pilot analysis of a prospective, randomised, investigator-masked study. Anticancer Res. 2015;35(3):1311–9.PubMed
28.
Cui JH, Jiang WW, Liao YJ, Wang QH, Xu M, Li Y. Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia. Medicine. 2017;96(31):e7519.PubMedPubMedCentralCrossRef
29.
Buckley A, McQuaid S, Johnson P, Buggy DJ. Effect of anaesthetic technique on the natural killer cell anti-tumour activity of serum from women undergoing breast cancer surgery: a pilot study. Br J Anaesth. 2014;113(Suppl 1):i56–62.PubMedCrossRef
30.
Ni Eochagain A, Burns D, Riedel B, Sessler DI, Buggy DJ. The effect of anaesthetic technique during primary breast cancer surgery on neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and return to intended oncological therapy. Anaesthesia. 2018;73(5):603–11.PubMedCrossRef
31.
Bakr MA, Amr SA, Mohamed SA, Hamed HB, Abd El-Rahman AM, Mostafa MA, et al. Comparison between the effects of intravenous morphine, tramadol, and ketorolac on stress and immune responses in patients undergoing modified radical mastectomy. Clin J Pain. 2016;32(10):889–97.PubMedCrossRef
32.
Wen Y, Wang M, Yang J, Wang Y, Sun H, Zhao J, et al. A comparison of fentanyl and flurbiprofen axetil on serum VEGF-C, TNF-alpha, and IL-1ss concentrations in women undergoing surgery for breast cancer. Pain Pract. 2015;15(6):530–7.PubMedCrossRef
33.
Kim SY, Kim NK, Baik SH, Min BS, Hur H, Lee J, et al. Effects of postoperative pain management on immune function after laparoscopic resection of colorectal cancer: a randomized study. Medicine. 2016;95(19):e3602.PubMedPubMedCentralCrossRef
34.
Forget P, Collet V, Lavand’homme P, De Kock M. Does analgesia and condition influence immunity after surgery? Effects of fentanyl, ketamine and clonidine on natural killer activity at different ages. Eur J Anaesthesiol. 2010;27(3):233–40.PubMedCrossRef
35.
Wigmore T, Farquhar-Smith P. Opioids and cancer: friend or foe? Curr Opin Support Palliat Care. 2016;10(2):109–18.PubMedCrossRef
36.
Maher DP, White PF. Proposed mechanisms for association between opioid usage and cancer recurrence after surgery. J Clin Anesth. 2016;28:36–40.PubMedCrossRef
37.
Lennon FE, Mirzapoiazova T, Mambetsariev B, Poroyko VA, Salgia R, Moss J, et al. The mu opioid receptor promotes opioid and growth factor-induced proliferation, migration and epithelial mesenchymal transition (EMT) in human lung cancer. PLoS One. 2014;9(3):e91577.PubMedPubMedCentralCrossRef
38.
KJ Levins, S Prendeville, S Conlon, DJ Buggy The effect of anesthetic technique on μ-opioid receptor expression and immune cell infiltration in breast cancer. J Anesth. 2018.
39.
Janku F, Johnson LK, Karp DD, Atkins JT, Singleton PA, Moss J. Treatment with methylnaltrexone is associated with increased survival in patients with advanced cancer. Ann Oncol. 2016;27(11):2032–8.PubMedPubMedCentralCrossRef
40.
Bortsov AV, Millikan RC, Belfer I, Boortz-Marx RL, Arora H, McLean SA. Mu-opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer. Anesthesiology. 2012;116(4):896–902.PubMedCrossRef
41.
Singleton PA, Lingen MW, Fekete MJ, Garcia JG, Moss J. Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: role of receptor transactivation. Microvasc Res. 2006;72(1–2):3–11.CrossRefPubMed
42.
Mathew B, Lennon FE, Siegler J, Mirzapoiazova T, Mambetsariev N, Sammani S, et al. The novel role of the mu opioid receptor in lung cancer progression: a laboratory investigation. Anesth Analg. 2011;112(3):558–67.CrossRefPubMed
43.
Singleton PA, Mirzapoiazova T, Hasina R, Salgia R, Moss J. Increased mu-opioid receptor expression in metastatic lung cancer. Br J Anaesth. 2014;113(Suppl 1):i103–8.PubMedPubMedCentralCrossRef
44.
Connolly C, Madden SF, Buggy DJ, Gallagher HC. Expression of anaesthetic and analgesic drug target genes in excised breast tumour tissue: association with clinical disease recurrence or metastasis. PLoS One. 2017;12(5):e0177105.PubMedPubMedCentralCrossRef
45.
Friesen C, Hormann I, Roscher M, Fichtner I, Alt A, Hilger R, et al. Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma. Cell cycle. 2014;13(10):1560–70.PubMedPubMedCentralCrossRef
46.
Friesen C, Roscher M, Hormann I, Fichtner I, Alt A, Hilger RA, et al. Cell death sensitization of leukemia cells by opioid receptor activation. Oncotarget. 2013;4(5):677–90.PubMedPubMedCentralCrossRef
47.
Lahiff C, Cotter E, Casey R, Doran P, Pidgeon G, Reynolds J, et al. Expression of neuroepithelial transforming gene 1 is enhanced in oesophageal cancer and mediates an invasive tumour cell phenotype. J Exp Clin Cancer Res. 2013;32(1):55.PubMedPubMedCentralCrossRef
48.
Ecimovic P, Murray D, Doran P, McDonald J, Lambert DG, Buggy DJ. Direct effect of morphine on breast cancer cell function in vitro: role of the NET1 gene. Br J Anaesth. 2011;107(6):916–23.CrossRefPubMed
49.
Afsharimani B, Baran J, Watanabe S, Lindner D, Cabot PJ, Parat MO. Morphine and breast tumor metastasis: the role of matrix-degrading enzymes. Clin Exp Metastasis. 2014;31(2):149–58.PubMedCrossRef
50.
Doornebal CW, Vrijland K, Hau CS, Coffelt SB, Ciampricotti M, Jonkers J, et al. Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2(+) breast cancer. Pain. 2015;156(8):1424–32.PubMedCrossRef
51.
Koodie L, Yuan H, Pumper JA, Yu H, Charboneau R, Ramkrishnan S, et al. Morphine inhibits migration of tumor-infiltrating leukocytes and suppresses angiogenesis associated with tumor growth in mice. Am J Pathol. 2014;184(4):1073–84.PubMedPubMedCentralCrossRef
52.
Tai YH, Wu HL, Chang WK, Tsou MY, Chen HH, Chang KY. Intraoperative fentanyl consumption does not impact cancer recurrence or overall survival after curative colorectal cancer resection. Sci Rep. 2017;7(1):10816.PubMedPubMedCentralCrossRef
53.
Oh TK, Kim K, Jheon S, Lee J, Do SH, Hwang JW, et al. Long-term oncologic outcomes for patients undergoing volatile versus intravenous anesthesia for non-small cell lung cancer surgery: a retrospective propensity matching analysis. Cancer Control. 2018;25(1):1073274818775360.PubMedPubMedCentral
54.
Cronin-Fenton DP, Heide-Jorgensen U, Ahern TP, Lash TL, Christiansen PM, Ejlertsen B, et al. Opioids and breast cancer recurrence: a Danish population-based cohort study. Cancer. 2015;121(19):3507–14.PubMedCrossRef
55.
Cata JP, Keerty V, Keerty D, Feng L, Norman PH, Gottumukkala V, et al. A retrospective analysis of the effect of intraoperative opioid dose on cancer recurrence after non-small cell lung cancer resection. Cancer Med. 2014;3(4):900–8.PubMedPubMedCentralCrossRef
56.
Maher DP, Wong W, White PF, McKenna R Jr, Rosner H, Shamloo B, et al. Association of increased postoperative opioid administration with non-small-cell lung cancer recurrence: a retrospective analysis. Br J Anaesth. 2014;113(Suppl 1):i88–94.PubMedCrossRef
57.
Patino MA, Ramirez RE, Perez CA, Feng L, Kataria P, Myers J, et al. The impact of intraoperative opioid use on survival after oral cancer surgery. Oral Oncol. 2017;74:1–7.PubMedCrossRef
58.
Afsharimani B, Doornebal CW, Cabot PJ, Hollmann MW, Parat M. Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasis. Br J Pharmacol. 2015;172(2):251–9.PubMedCrossRef
59.
Chamaraux-Tran TN, Piegeler T. The amide local anesthetic lidocaine in cancer surgery-potential antimetastatic effects and preservation of immune cell function? A narrative review. Front Med. 2017;4:235.CrossRef
60.
Soto G, Naranjo Gonzalez M, Calero F. Intravenous lidocaine infusion. Rev Esp Anestesiol Reanim 2018.
61.
Weibel S, Jokinen J, Pace NL, Schnabel A, Hollmann MW, Hahnenkamp K, et al. Efficacy and safety of intravenous lidocaine for postoperative analgesia and recovery after surgery: a systematic review with trial sequential analysis. Br J Anaesth. 2016;116(6):770–83.PubMedCrossRef
62.
Tikuisis R, Miliauskas P, Samalavicius NE, Zurauskas A, Samalavicius R, Zabulis V. Intravenous lidocaine for post-operative pain relief after hand-assisted laparoscopic colon surgery: a randomized, placebo-controlled clinical trial. Tech Coloproctol. 2014;18(4):373–80.
63.
• Chamaraux-Tran TN, Mathelin C, Aprahamian M, Joshi GP, Tomasetto C, Diemunsch P, et al. Antitumor effects of lidocaine on human breast cancer cells: an in vitro and in vivo experimental trial. Anticancer Res. 2018;38(1):95–105 In vivo and in vitro murine experiment demonstrating a protective effect of lidocaine against breast cancer cells.PubMed
64.
Chang YC, Liu CL, Chen MJ, Hsu YW, Chen SN, Lin CH, et al. Local anesthetics induce apoptosis in human breast tumor cells. Anesth Analg. 2014;118(1):116–24.PubMedCrossRef
65.
Lirk P, Hollmann MW, Fleischer M, Weber NC, Fiegl H. Lidocaine and ropivacaine, but not bupivacaine, demethylate deoxyribonucleic acid in breast cancer cells in vitro. Br J Anaesth. 2014;113(Suppl 1):i32–8.PubMedCrossRef
66.
Dan J, Gong X, Li D, Zhu G, Wang L, Li F. Inhibition of gastric cancer by local anesthetic bupivacaine through multiple mechanisms independent of sodium channel blockade. Biomed Pharmacother. 2018;103:823–8.PubMedCrossRef
67.
Le Gac G, Angenard G, Clement B, Laviolle B, Coulouarn C, Beloeil H. Local anesthetics inhibit the growth of human hepatocellular carcinoma cells. Anesth Analg. 2017;125(5):1600–9.PubMedCrossRef
68.
Wang HW, Wang LY, Jiang L, Tian SM, Zhong TD, Fang XM. Amide-linked local anesthetics induce apoptosis in human non-small cell lung cancer. J Thorac Dis. 2016;8(10):2748–57.PubMedPubMedCentralCrossRef
69.
Piegeler T, Schlapfer M, Dull RO, Schwartz DE, Borgeat A, Minshall RD, et al. Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFalpha-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase. Br J Anaesth. 2015;115(5):784–91.PubMedPubMedCentralCrossRef
70.
Piegeler T, Votta-Velis EG, Liu G, Place AT, Schwartz DE, Beck-Schimmer B, et al. Antimetastatic potential of amide-linked local anesthetics: inhibition of lung adenocarcinoma cell migration and inflammatory Src signaling independent of sodium channel blockade. Anesthesiology. 2012;117(3):548–59.PubMedCrossRef
71.
Johnson MZ, Crowley PD, Foley AG, Xue C, Connolly C, Gallagher HC, et al. Effect of perioperative lidocaine on metastasis after sevoflurane or ketamine-xylazine anaesthesia for breast tumour resection in a murine model. Br J Anaesth. 2018;121(1):76–85.PubMedCrossRef
72.
Hahnenkamp K, Herroeder S, Hollmann MW. Regional anaesthesia, local anaesthetics and the surgical stress response. Best Pract Res Clin Anaesthesiol. 2004;18(3):509–27.PubMedCrossRef
73.
O’Riain SC, Buggy DJ, Kerin MJ, Watson RW, Moriarty DC. Inhibition of the stress response to breast cancer surgery by regional anesthesia and analgesia does not affect vascular endothelial growth factor and prostaglandin E2. Anesth Analg. 2005;100(1):244–9.PubMedCrossRef
74.
Deegan CA, Murray D, Doran P, Moriarty DC, Sessler DI, Mascha E, et al. Anesthetic technique and the cytokine and matrix metalloproteinase response to primary breast cancer surgery. Reg Anesth Pain Med. 2010;35(6):490–5.PubMedCrossRef
75.
Ahlers O, Nachtigall I, Lenze J, Goldmann A, Schulte E, Hohne C, et al. Intraoperative thoracic epidural anaesthesia attenuates stress-induced immunosuppression in patients undergoing major abdominal surgery. Br J Anaesth. 2008;101(6):781–7.PubMedCrossRef
76.
Mo H. The impact of different anesthesia methods on stress reaction and immune function of the patients with gastric cancer during peri-operative period. J Med Assoc Thail. 2015;98(6):568–73.
77.
Terkawi AS, Tsang S, Sessler DI, Terkawi RS, Nunemaker MS, Durieux ME, et al. Improving analgesic efficacy and safety of thoracic paravertebral block for breast surgery: a mixed-effects meta-analysis. Pain Physician. 2015;18(5):E757–80.PubMedCrossRef
78.
Bashandy GM, Abbas DN. Pectoral nerves I and II blocks in multimodal analgesia for breast cancer surgery: a randomized clinical trial. Reg Anesth Pain Med. 2015;40(1):68–74.PubMedCrossRef
79.
Hards M, Harada A, Neville I, Harwell S, Babar M, Ravalia A, et al. The effect of serratus plane block performed under direct vision on postoperative pain in breast surgery. J Clin Anesth. 2016;34:427–31.PubMedCrossRef
80.
Gacio MF, Lousame AM, Pereira S, Castro C, Santos J. Paravertebral block for management of acute postoperative pain and intercostobrachial neuralgia in major breast surgery. Braz J Anesthesiol. 2016;66(5):475–84.PubMedCrossRef
81.
Ris F, Findlay JM, Hompes R, Rashid A, Warwick J, Cunningham C, et al. Addition of transversus abdominis plane block to patient controlled analgesia for laparoscopic high anterior resection improves analgesia, reduces opioid requirement and expedites recovery of bowel function. Ann R Coll Surg Engl. 2014;96(8):579–85.PubMedPubMedCentralCrossRef
82.
Wang Y, Wang L, Chen H, Xu Y, Zheng X, Wang G. The effects of intra- and post-operative anaesthesia and analgesia choice on outcome after gastric cancer resection: a retrospective study. Oncotarget. 2017;8(37):62658–65.PubMedPubMedCentralCrossRef
83.
Cata JP, Gottumukkala V, Thakar D, Keerty D, Gebhardt R, Liu DD. Effects of postoperative epidural analgesia on recurrence-free and overall survival in patients with nonsmall cell lung cancer. J Clin Anesth. 2014;26(1):3–17.PubMedCrossRef
84.
Merquiol F, Montelimard A-S, Nourissat A, Molliex S, Zufferey PJ. Cervical epidural anesthesia is associated with increased cancer-free survival in laryngeal and hypopharyngeal cancer surgery: a retrospective propensity-matched analysis. Reg Anesth Pain Med. 2013;38(5):398–402.PubMedCrossRef
85.
Kovac E, Firoozbakhsh F, Zargar H, Fergany A, Elsharkawy H. Perioperative epidural analgesia is not associated with increased survival from renal cell cancer, but overall survival may be improved: a retrospective chart review L’analgésie péridurale périopératoire n’est pas associée à une augmentation de la survie après un cancer des cellules rénales, mais la survie globale pourrait être améliorée: une analyse de dossiers rétrospective. Can J Anesth. 2017;64(7):754–62.PubMedCrossRef
86.
Wang J, Guo W, Wu Q, Zhang R, Fang J. Impact of combination epidural and general anesthesia on the long-term survival of gastric cancer patients: a retrospective study. Med Sci Monit. 2016;22:2379–85.PubMedPubMedCentralCrossRef
87.
Heinrich S, Janitz K, Merkel S, Klein P, Schmidt J. Short- and long term effects of epidural analgesia on morbidity and mortality of esophageal cancer surgery. Langenbeck’s Arch Surg. 2015;400(1):19–26.CrossRef
88.
Li W, Li Y, Huang Q, Ye S, Rong T. Short and long-term outcomes of epidural or intravenous analgesia after esophagectomy: a propensity-matched cohort study. PLoS One. 2016;11(4):e0154380.PubMedPubMedCentralCrossRef
89.
Tai YH, Chang WK, Wu HL, Chan MY, Chen HH, Chang KY. The effect of epidural analgesia on cancer progression in patients with stage IV colorectal cancer after primary tumor resection: a retrospective cohort study. PloS One. 2018;13(7).
90.
Christopher Doiron R, Jaeger M, Booth CM, Wei X, Robert SD. Is there a measurable association of epidural use at cystectomy and postoperative outcomes? A population-based study. Canadian Urological Association Journal. 2016;10(9–10):321–7.PubMedPubMedCentralCrossRef
91.
Weingarten TN, Taccolini AM, Ahle ST, Dietz KR, Dowd SS, Frank I, et al. Perioperative management and oncological outcomes following radical cystectomy for bladder cancer: a matched retrospective cohort study. Can J Anaesth. 2016;63(5):584–95.PubMedCrossRef
92.
Koumpan Y, Jaeger M, Mizubuti GB, Tanzola R, Jain K, Hosier G, et al. Spinal anesthesia is associated with lower recurrence rates after resection of nonmuscle invasive bladder cancer. J Urol. 2018;199(4):940–6.PubMedCrossRef
93.
Lee BM, Singh Ghotra V, Karam JA, Hernandez M, Pratt G, Cata JP. Regional anesthesia/analgesia and the risk of cancer recurrence and mortality after prostatectomy: a meta-analysis. Pain Manag. 2015;5(5):387–95.PubMedPubMedCentralCrossRef
94.
Kairaluoma P, Mattson J, Heikkila P, Pere P, Leidenius M. Perioperative paravertebral regional anaesthesia and breast cancer recurrence. Anticancer Res. 2016;36(1):415–8.PubMed
95.
Cata JP, Chavez-MacGregor M, Valero V, Black W, Black DM, Goravanchi F, et al. The impact of paravertebral block analgesia on breast cancer survival after surgery. Reg Anesth Pain Med. 2016;41(6):696–703.PubMedCrossRef
96.
Karmakar MK, Samy W, Lee A, Li JW, Chan WC, Chen PP, et al. Survival analysis of patients with breast cancer undergoing a modified radical mastectomy with or without a thoracic paravertebral block: a 5-year follow-up of a randomized controlled trial. Anticancer Res. 2017;37(10):5813–20.PubMed
97.
Finn DM, Ilfeld BM, Unkart JT, Madison SJ, Suresh PJ, Sandhu NPS, et al. Post-mastectomy cancer recurrence with and without a continuous paravertebral block in the immediate postoperative period: a prospective multi-year follow-up pilot study of a randomized, triple-masked, placebo-controlled investigation. J Anesth. 2017;31(3):374–9.PubMedPubMedCentralCrossRef
98.
Macleod LC, Turner RM, 2nd, Lopa S, Hugar LA, Davies BJ, Ben-David B, et al. Effect of multimodal analgesia with paravertebral blocks on biochemical recurrence in men undergoing open radical prostatectomy. Urol Oncol. 2018.
99.
Scavonetto F, Yeoh TY, Umbreit EC, Weingarten TN, Gettman MT, Frank I, et al. Association between neuraxial analgesia, cancer progression, and mortality after radical prostatectomy: a large, retrospective matched cohort study. Br J Anaesth. 2014;113(Suppl 1):i95–102.PubMedCrossRef
100.
• Lee EK, Ahn HJ, Zo JI, Kim K, Jung DM, Park JH. Paravertebral block does not reduce cancer recurrence, but is related to higher overall survival in lung cancer surgery: a retrospective cohort study. Anesth Analg. 2017;125(4):1322–8 Retrospective analysis of patients undergoing open thoracotomy for lung cancer—paravertebral analgesia appeared to have a beneficial association with overall survival. PubMedCrossRef
101.
Call TR, Pace NL, Thorup DB, Maxfield D, Chortkoff B, Christensen J, et al. Factors associated with improved survival after resection of pancreatic adenocarcinoma: a multivariable model. Anesthesiology. 2015;122(2):317–24.PubMedCrossRef
102.
Zimmitti G, Soliz J, Aloia TA, Gottumukkala V, Cata JP, Tzeng CW, et al. Positive impact of epidural analgesia on oncologic outcomes in patients undergoing resection of colorectal liver metastases. Ann Surg Oncol. 2016;23(3):1003–11.PubMedCrossRef
103.
Pei L, Tan G, Wang L, Guo W, Xiao B, Gao X, et al. Comparison of combined general-epidural anesthesia with general anesthesia effects on survival and cancer recurrence: a meta-analysis of retrospective and prospective studies. PLoS One. 2014;9(12):e114667.PubMedPubMedCentralCrossRef
104.
Gurpinar E, Grizzle WE, Piazza GA. NSAIDs inhibit tumorigenesis, but how? Clin Cancer Res. 2014;20(5):1104–13.PubMedCrossRef
105.
Nan H, Hutter CM, Lin Y, Jacobs EJ, Ulrich CM, White E, et al. Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants. JAMA. 2015;313(11):1133–42.PubMedPubMedCentralCrossRef
106.
Zhong S, Chen L, Zhang X, Yu D, Tang J, Zhao J. Aspirin use and risk of breast cancer: systematic review and meta-analysis of observational studies. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2015;24(11):1645–55.CrossRef
107.
Glasner A, Avraham R, Rosenne E, Benish M, Zmora O, Shemer S, et al. Improving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a beta-adrenergic antagonist and a cyclooxygenase-2 inhibitor. J Immunol. 2010;184(5):2449–57.PubMedCrossRef
108.
Forget P, Vandenhende J, Berliere M, Machiels JP, Nussbaum B, Legrand C, et al. Do intraoperative analgesics influence breast cancer recurrence after mastectomy? A retrospective analysis. Anesth Analg. 2010;110(6):1630–5.PubMedCrossRef
109.
Forget P, Bentin C, Machiels JP, Berliere M, Coulie PG, De Kock M. Intraoperative use of ketorolac or diclofenac is associated with improved disease-free survival and overall survival in conservative breast cancer surgery. Br J Anaesth. 2014;113(Suppl 1):i82–7.PubMedCrossRef
110.
Lee BM, Rodriguez A, Mena G, Gottumukkala V, Mehran RJ, Rice DC, et al. Platelet-to-lymphocyte ratio and use of NSAIDs during the perioperative period as prognostic indicators in patients with NSCLC undergoing surgery. Cancer Control. 2016;23(3):284–94.PubMedCrossRef
111.
Choi JE, Villarreal J, Lasala J, Gottumukkala V, Mehran RJ, Rice D, et al. Perioperative neutrophil:lymphocyte ratio and postoperative NSAID use as predictors of survival after lung cancer surgery: a retrospective study. Cancer medicine. 2015;4(6):825–33.PubMedPubMedCentralCrossRef
112.
Forget P, Machiels JP, Coulie PG, Berliere M, Poncelet AJ, Tombal B, et al. Neutrophil:lymphocyte ratio and intraoperative use of ketorolac or diclofenac are prognostic factors in different cohorts of patients undergoing breast, lung, and kidney cancer surgery. Ann Surg Oncol. 2013;20(Suppl 3):S650–60.PubMedCrossRef
113.
Desmedt C, Demicheli R, Fornili M, Bachir I, Duca M, Viglietti G, et al. Potential benefit of intra-operative administration of ketorolac on breast cancer recurrence according to the patient’s body mass index. J Natl Cancer Inst 2018.
114.
Kim R. Anesthetic technique and cancer recurrence in oncologic surgery: unraveling the puzzle. Cancer Metastasis Rev. 2017;36(1):159–77.PubMedCrossRef
115.
Kunst G, Klein AA. Peri-operative anaesthetic myocardial preconditioning and protection - cellular mechanisms and clinical relevance in cardiac anaesthesia. Anaesthesia. 2015;70(4):467–82.PubMedPubMedCentralCrossRef
116.
Benzonana LL, Perry NJ, Watts HR, Yang B, Perry IA, Coombes C, et al. Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro. Anesthesiology. 2013;119(3):593–605.PubMedCrossRef
117.
Luo X, Zhao H, Hennah L, Ning J, Liu J, Tu H, et al. Impact of isoflurane on malignant capability of ovarian cancer in vitro. Br J Anaesth. 2015;114(5):831–9.PubMedCrossRef
118.
Hooijmans CR, Geessink FJ, Ritskes-Hoitinga M, Scheffer GJ. A systematic review of the modifying effect of anaesthetic drugs on metastasis in animal models for cancer. PLoS One. 2016;11(5):e0156152.PubMedPubMedCentralCrossRef
119.
Iwasaki M, Zhao H, Jaffer T, Unwith S, Benzonana L, Lian Q, et al. Volatile anaesthetics enhance the metastasis related cellular signalling including CXCR2 of ovarian cancer cells. Oncotarget. 2016;7(18):26042–56.PubMedPubMedCentralCrossRef
120.
Ash SA, Valchev GI, Looney M, Ni Mhathuna A, Crowley PD, Gallagher HC, et al. Xenon decreases cell migration and secretion of a pro-angiogenesis factor in breast adenocarcinoma cells: comparison with sevoflurane. Br J Anaesth. 2014;113(Suppl 1):i14–21.PubMedCrossRef
121.
Fleischmann E, Marschalek C, Schlemitz K, Dalton JE, Gruenberger T, Herbst F, et al. Nitrous oxide may not increase the risk of cancer recurrence after colorectal surgery: a follow-up of a randomized controlled trial. BMC Anesthesiol. 2009;9:1.PubMedPubMedCentralCrossRef
122.
Markovic-Bozic J, Karpe B, Potocnik I, Jerin A, Vranic A, Novak-Jankovic V. Effect of propofol and sevoflurane on the inflammatory response of patients undergoing craniotomy. BMC Anesthesiol. 2016;16:18.PubMedPubMedCentralCrossRef
123.
Inada T, Hirota K, Shingu K. Intravenous anesthetic propofol suppresses prostaglandin E2 and cysteinyl leukotriene production and reduces edema formation in arachidonic acid-induced ear inflammation. J Immunotoxicol. 2015;12(3):261–5.PubMedCrossRef
124.
Yang N, Liang Y, Yang P, Ji F. Propofol suppresses LPS-induced nuclear accumulation of HIF-1α and tumor aggressiveness in non-small cell lung cancer. Oncol Rep. 2017;37(5):2611–9.PubMedPubMedCentralCrossRef
125.
Cho JS, Lee MH, Kim SI, Park S, Park HS, Oh E, et al. The effects of perioperative anesthesia and analgesia on immune function in patients undergoing breast cancer resection: a prospective randomized study. Int J Med Sci. 2017;14(10):970–6.PubMedPubMedCentralCrossRef
126.
Melamed R, Bar-Yosef S, Shakhar G, Shakhar K, Ben-Eliyahu S. Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures. Anesth Analg. 2003;97(5):1331–9.CrossRefPubMed
127.
He H, Chen J, Xie WP, Cao S, Hu HY, Yang LQ, et al. Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression. Genet Mol Res. 2013;12(2):1907–15.CrossRefPubMed
128.
Wu ZF, Lee MS, Wong CS, Lu CH, Huang YS, Lin KT, et al. Propofol-based total intravenous snesthesia is associated with better survival than desflurane anesthesia in colon cancer surgery. Anesthesiology. 2018.
129.
Ferrell JK, Cattano D, Brown RE, Patel CB, Karni RJ. The effects of anesthesia on the morphoproteomic expression of head and neck squamous cell carcinoma: a pilot study. Transl Res. 2015;166(6):674–82.PubMedCrossRef
130.
Oh CS, Lee J, Yoon TG, Seo EH, Park HJ, Piao L, et al. Effect of equipotent doses of propofol versus sevoflurane anesthesia on regulatory T cells after breast cancer surgery. Anesthesiology. 2018.
131.
Lee JH, Kang SH, Kim Y, Kim HA, Kim BS. Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study. Korean journal of anesthesiology. 2016;69(2):126–32.PubMedPubMedCentralCrossRef
132.
•• Wigmore TJ, Mohammed K, Jhanji S. Long-term survival for patients undergoing volatile versus IV anesthesia for cancer surgery: a retrospective analysis. Anesthesiology. 2016;124(1):69–79 Large retrospective analysis demonstrating a survival trend in those receviing total intravenous anaesthesia versus volatile anaesthesia. PubMedCrossRef
133.
Neeman E, Zmora O, Ben-Eliyahu S. A new approach to reducing postsurgical cancer recurrence: perioperative targeting of catecholamines and prostaglandins. Clin Cancer Res. 2012;18(18):4895–902.PubMedPubMedCentralCrossRef
134.
Watkins JL, Thaker PH, Nick AM, Ramondetta LM, Kumar S, Urbauer DL, et al. Clinical impact of selective and nonselective beta-blockers on survival in patients with ovarian cancer. Cancer. 2015;121(19):3444–51.PubMedCrossRef
135.
Benish M, Bartal I, Goldfarb Y, Levi B, Avraham R, Raz A, et al. Perioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis. Ann Surg Oncol. 2008;15(7):2042–52.PubMedCrossRef
136.
Haldar R, Shaashua L, Lavon H, Lyons YA, Zmora O, Sharon E, et al. Perioperative inhibition of beta-adrenergic and COX2 signaling in a clinical trial in breast cancer patients improves tumor Ki-67 expression, serum cytokine levels, and PBMCs transcriptome. Brain Behav Immun. 2018.
137.
Zhou L, Li Y, Li X, Chen G, Liang H, Wu Y, et al. Propranolol attenuates surgical stress-induced elevation of the regulatory T cell response in patients undergoing radical mastectomy. J Immunol. 2016;196(8):3460–9.PubMedCrossRef
138.
•• Yap A, Lopez-Olivo MA, Dubowitz J, Pratt G, Hiller J, Gottumukkala V, et al. Effect of beta-blockers on cancer recurrence and survival: a meta-analysis of epidemiological and perioperative studies. Br J Anaesth. 2018;121(1):45–57 Recent meta-analysis of studies examining cancer recurrence, disease-free survival and overall survival with use of beta-blockers. PubMedCrossRef
139.
140.
141.
Wetterslev J, Meyhoff CS, Jorgensen LN, Gluud C, Lindschou J, Rasmussen LS. The effects of high perioperative inspiratory oxygen fraction for adult surgical patients. The Cochrane database of systematic reviews. 2015(6):Cd008884.
142.
• Crowley PD, Stuttgen V, O’Carroll E, Ash SA, Buggy DJ, Gallagher HC. Exposure to 60% oxygen promotes migration and upregulates angiogenesis factor secretion in breast cancer cells. Medical gas research. 2017;7(4):226–35 In vitro analysis of effects of high concentration of oxygen on breast cancer cell’s ability to migrate and secrete angiogenesis factors. PubMedCrossRef
143.
Meyhoff CS, Jorgensen LN, Wetterslev J, Siersma VD, Rasmussen LS. Risk of new or recurrent cancer after a high perioperative inspiratory oxygen fraction during abdominal surgery. Br J Anaesth. 2014;113(Suppl 1):i74–81.PubMedCrossRef
144.
Freeman J, Buggy DJ. Modelling the effects of perioperative interventions on cancer outcome: lessons from dexmedetomidine. Br J Anaesth. 2018;120(1):15–7.PubMedCrossRef
145.
Lavon H, Matzner P, Benbenishty A, Sorski L, Rossene E, Haldar R, et al. Dexmedetomidine promotes metastasis in rodent models of breast, lung, and colon cancers. Br J Anaesth. 2018;120(1):188–96.PubMedCrossRef
146.
Cata JP, Singh V, Lee BM, Villarreal J, Mehran JR, Yu J, et al. Intraoperative use of dexmedetomidine is associated with decreased overall survival after lung cancer surgery. J Anaesthesiol Clin Pharmacol. 2017;33(3):317–23.PubMedPubMedCentralCrossRef
147.
Forget P, Berliere M, Poncelet A, De Kock M. Effect of clonidine on oncological outcomes after breast and lung cancer surgery. Br J Anaesth. 2018;121(1):103–4.PubMedCrossRef
148.
Cata JP, Wang H, Gottumukkala V, Reuben J, Sessler DI. Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth. 2013;110(5):690–701.PubMedPubMedCentralCrossRef
149.
Li XX, Meng J, Sun GP, Tang YX, Liang GF, Wang MF, et al. Effects of perioperative blood transfusion on the prognosis in hereditary and sporadic colon cancer. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2015;20(6–7):481–6.CrossRef
150.
Qiu L, Wang DR, Zhang XY, Gao S, Li XX, Sun GP, et al. Impact of perioperative blood transfusion on immune function and prognosis in colorectal cancer patients. Transfus Apher Sci. 2016;54(2):235–41.PubMedCrossRef
151.
Boehm K, Beyer B, Tennstedt P, Schiffmann J, Budaeus L, Haese A, et al. No impact of blood transfusion on oncological outcome after radical prostatectomy in patients with prostate cancer. World J Urol. 2015;33(6):801–6.PubMedCrossRef
152.
Lyu X, Qiao W, Li D, Leng Y. Impact of perioperative blood transfusion on clinical outcomes in patients with colorectal liver metastasis after hepatectomy: a meta-analysis. Oncotarget. 2017;8(25):41740–8.PubMedPubMedCentralCrossRef
153.
Gundisch S, Boeckeler E, Behrends U, Amtmann E, Ehrhardt H, Jeremias I. Glucocorticoids augment survival and proliferation of tumor cells. Anticancer Res. 2012;32(10):4251–61.PubMed
154.
Singh PP, Lemanu DP, Taylor MH, Hill AG. Association between preoperative glucocorticoids and long-term survival and cancer recurrence after colectomy: follow-up analysis of a previous randomized controlled trial. Br J Anaesth. 2014;113(Suppl 1):i68–73.PubMedCrossRef
155.
Yu HC, Luo YX, Peng H, Kang L, Huang MJ, Wang JP. Avoiding perioperative dexamethasone may improve the outcome of patients with rectal cancer. Eur J Surg Oncol. 2015;41(5):667–73.PubMedCrossRef
156.
Huang WW, Zhu WZ, Mu DL, Ji XQ, Nie XL, Li XY, et al. Perioperative management may improve long-term survival in patients after lung cancer surgery: a retrospective cohort study. Anesth Analg. 2018;126(5):1666–74.PubMedPubMedCentralCrossRef
157.
Cata JP, Jones J, Sepesi B, Mehran RJ, Rodriguez-Restrepo A, Lasala J, et al. Lack of association between dexamethasone and long-term survival after non-small cell lung cancer surgery. J Cardiothorac Vasc Anesth. 2016;30(4):930–5.PubMedCrossRef
158.
•• Buggy DJ, Freeman J, Johnson MZ, Leslie K, Riedel B, Sessler DI, et al. Systematic review and consensus definitions for standardised endpoints in perioperative medicine: postoperative cancer outcomes. Br J Anaesth. 2018;121(1):38–44 Consensus guidelines from a number of clinical researchers indicating standardised endpoints to allow pooling and bench-marking of trials in anaesthesia and cancer research. PubMedCrossRef
Metadaten
Titel
The Effect of Anaesthetic and Analgesic Technique on Oncological Outcomes
verfasst von
Aislinn Sherwin
Donal J. Buggy
Publikationsdatum
01.12.2018
Verlag
Springer US
Erschienen in
Current Anesthesiology Reports / Ausgabe 4/2018
Elektronische ISSN: 2167-6275
DOI
https://doi.org/10.1007/s40140-018-0299-9

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