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29.04.2021 | Original Article

The Effect of Combined Guidance of Botulinum Toxin Injection with Ultrasound, Catheter Balloon, and Electromyography on Neurogenic Cricopharyngeal Dysfunction: A Prospective Study

verfasst von: Mengshu Xie, Peishan Zeng, Guifang Wan, Delian An, Zhiming Tang, Chao Li, Xiaomei Wei, Jing Shi, Yaowen Zhang, Zulin Dou, Hongmei Wen

Erschienen in: Dysphagia | Ausgabe 3/2022

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Abstract

Background

Cricopharyngeal botulinum toxin (BTX) injection is one of the treatments for neurogenic cricopharyngeal dysfunction (CPD). We conducted this prospective study to investigate the effect and safety of BTX injection for neurogenic CPD with a novel guidance.

Methods

Twenty-one patients with neurogenic CPD whose symptoms did not reduce after conventional swallowing therapy were included in this study. The impact of BTX injection on the swallowing function of the patients was evaluated.

Key Results

After the injection, the Functional Oral Intake Scale (FOIS) score increased in 17 of 21 patients (80.9%), which ranged from 1 to 3 (P < 0.001). Moreover, there was a significant reduction in the UES opening impairment (P < 0.01), UES residual pressure (P < 0.05), duration of UES relaxation, penetration-aspiration scale score (P < 0.05), secretion (P < 0.05), vallecular residue (P < 0.01), and left (P < 0.05) and right (P < 0.05) pyriform sinus residue. With at least 6 months of follow-up, we found that FOIS continued to increase in patients who showed improvement after the injection (i.e., FOIS 5–7 points), while it remained unchanged in patients without improvement after the injection. There were no side effects reported in this study.

Conclusion & Inferences

BTX injection into the cricopharyngeal muscle guided by ultrasound, catheter balloon, and electromyography possibly has a long-lasting effect that can effectively and safely improve the swallowing function of patients with neurogenic CPD.

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Titel: The Effect of Combined Guidance of Botulinum Toxin Injection with Ultrasound, Catheter Balloon, and Electromyography on Neurogenic Cricopharyngeal Dysfunction: A Prospective Study
verfasst von: Mengshu Xie
Peishan Zeng
Guifang Wan
Delian An
Zhiming Tang
Chao Li
Xiaomei Wei
Jing Shi
Yaowen Zhang
Zulin Dou
Hongmei Wen
Publikationsdatum: 29.04.2021
Verlag: Springer US
Erschienen in: Dysphagia / Ausgabe 3/2022
Print ISSN: 0179-051X
Elektronische ISSN: 1432-0460
DOI: https://doi.org/10.1007/s00455-021-10310-7

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The Effect of Combined Guidance of Botulinum Toxin Injection with Ultrasound, Catheter Balloon, and Electromyography on Neurogenic Cricopharyngeal Dysfunction: A Prospective Study

Abstract

Background

Methods

Key Results

Conclusion & Inferences

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Background

Methods

Key Results

Conclusion & Inferences

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