Introduction
Methods
Study cohort
Mortality
Sociodemographic factors and comorbidities
Statistical analyses
Results
Study sample
Characteristic | AD Cohort N = 70,718 | non-AD Cohort N = 70,718 | P-value |
---|---|---|---|
Sociodemographic factors | |||
Age at beginning of follow-up, mean (SD) | 80.05 (7.1) | 80.02 (7.1) | matched |
Categorized age at beginning of follow-up | 0.429 | ||
< 80 y | 31,971 (45.21) | 32,119 (45.42) | |
≥ 80 y | 38,747 (54.79) | 38,599 (54.58) | |
Sex | matched | ||
Women | 46,116 (65.21) | 46,116 (65.21) | |
Men | 24,602 (34.79) | 24,602 (34.79) | |
Highest occupational social class | < 0.001 | ||
Managerial/ professional | 14,692 (20.78) | 14,929 (21.11) | |
Office worker | 5973 (8.45) | 5888 (8.33) | |
Farming/forestry | 13,439 (19.00) | 13,990 (19.78) | |
Sales/industry/cleaning | 30,148 (42.63) | 27,748 (39.24) | |
Unknown/did not respond | 6466 (9.14) | 8163 (11.54) | |
Comorbidities | |||
Any cardiovascular disease | 35,026 (49.53) | 34,757 (49.15) | 0.153 |
Coronary artery disease | 21,668 (30.64) | 20,006 (28.29) | < 0.001 |
Stroke | 6825 (9.65) | 5833 (8.25) | < 0.001 |
Diabetes | 13,714 (19.39) | 8081 (11.43) | < 0.001 |
Asthma/COPD | 7557 (10.69) | 7646 (10.81) | 0.445 |
History of hip fracture | 3709 (5.24) | 2561 (3.62) | < 0.001 |
Cancer treatment within 5 years of start of follow-up | 16,200 (22.91) | 12,916 (18.26) | < 0.001 |
Any mental or behavioral disorder (exc. dementia) | 41,106 (58.13) | 36,997 (52.32) | < 0.001 |
Follow-up | |||
Duration of follow-up days, mean (min.-max.) | 1787 (7–4016) | 2038 (4–4016) | < 0.001 |
Died during follow-up | 44,585 (63.05) | 26,410 (37.35) | < 0.001 |
Died during 4-y follow-up | 24,277 (34.33) | 15,685 (22.18) | < 0.001 |
Associations between risk factors and survival
AD cohort | Non-AD cohort | ||||
---|---|---|---|---|---|
Category | IR/ 100 Person-years | Median survival time in years (min.-max.) | IR/ 100 Person-years | Median survival time in years (min.-max.) | |
Sociodemographic factors | |||||
Age Category | < 80 y | 9.22 | 5.50 (0.02–11) | 3.47 | 6.33 (0.08–11) |
≥80 y | 16.80 | 4.33 (0.02–11) | 10.22 | 4.84 (0.01–11) | |
Sex | Women | 11.81 | 5 (0.02–11) | 6.36 | 5.61 (0.01–11) |
Men | 15.15 | 4.5 (0.02–11) | 7.35 | 5.33 (0.03–11) | |
SEP | Managerial/professional | 11.33 | 4.93 (0.04–11) | 4.75 | 5.75 (0.08–11) |
Office worker | 11.75 | 4.99 (0.02–11) | 5.64 | 5.67 (0.01–11) | |
Farming/forestry | 13.85 | 4.72 (0.03–11) | 8.21 | 5.33 (0.06–11) | |
Sales/industry/cleaning | 12.99 | 4.78 (0.02–11) | 6.94 | 5.45 (0.02–11) | |
Unknown/ Did not respond | 15.24 | 4.56 (0.04–11) | 7.85 | 5.5 (0.08–11) | |
Comorbidities | |||||
Any cardiovascular disease | No | 11.24 | 5.03 (0.02–11) | 5.11 | 5.83 (0.01–11) |
Yes | 14.75 | 4.58 (0.02–11) | 8.53 | 5.16 (0.03–11) | |
Coronary artery disease | No | 11.66 | 5 (0.02–11) | 5.52 | 5.75 (0.01–11) |
Yes | 16.1 | 4.36 (0.02–11) | 10.23 | 4.89 (0.03–11) | |
Stroke | No | 12.51 | 4.85 (0.02–11) | 6.24 | 5.6 (0.01–11) |
Yes | 16.90 | 4.25 (0.02–11) | 12.96 | 4.54 (0.02–11) | |
Diabetes | No | 12.46 | 4.9 (0.02–11) | 6.32 | 5.6 (0.01–11) |
Yes | 14.82 | 4.43 (0.02–11) | 10.07 | 4.84 (0.03–11) | |
Asthma/COPD | No | 12.63 | 4.84 (0.02–11) | 6.4 | 5.58 (0.02–11) |
yes | 15.2 | 4.43 (0.05–11) | 9.43 | 5 (0.08–11) | |
History of hip fracture | No | 12.63 | 4.84 (0.02–10.91) | 6.65 | 5.58 (0.01–11) |
Yes | 18.49 | 4.08 (0.02–10.91) | 14.88 | 4.25 (0.06–11) | |
Cancer treatment within 5 years of start of follow-up | No | 12.2 | 4.91 (0.02–11) | 5.6 | 5.67 (0.01–11) |
Yes | 16.37 | 4.34 (0.02–11) | 10.93 | 4.9 (0.02–11) | |
Any mental or behavioral disorder (exc. dementia) | No | 12.28 | 4.91 (0.02–11) | 5.60 | 5.75 (0.01–11) |
Yes | 13.33 | 4.75 (0.02–11) | 7.77 | 5.30 (0.02–11) |
AD cohort | Non-AD cohort | |||
---|---|---|---|---|
Unadjusted HR (95% CI) | Adjusted HRa (95% CI) | Unadjusted HR (95% CI) | Adjusted HRa (95% CI) | |
Sociodemographic factors | ||||
Age at baseline, increase per year | 1.07 (1.07–1.07) | 1.07 (1.07–1.07) | 1.11 (1.11–1.11) | 1.12 (1.12–1.12) |
Age Category | ||||
< 80 y | 1.00 | 1.00 | 1.00 | 1.00 |
≥ 80 y | 2.03 (1.99–2.07) | 2.10 (2.06–2.14) | 3.07 (2.99–3.15) | 3.11 (3.02–3.19) |
Gender, Men (vs women) | 1.34 (1.31–1.36) | 1.58 (1.55–1.62) | 1.16 (1.13–1.19) | 1.41 (1.37–1.45) |
Socioeconomic position | ||||
Managerial/professional | 1.00 | 1.00 | 1.00 | 1.00 |
Office worker | 1.03 (0.99–1.08) | 1.09 (1.05–1.14) | 1.19 (1.13–1.26) | 1.12 (1.06–1.18) |
Farming/forestry | 1.23 (1.20–1.27) | 1.05 (1.02–1.08) | 1.73 (1.67–1.80) | 1.29 (1.24–1.34) |
Sales/industry/cleaning | 1.15 (1.12–1.18) | 1.08 (1.05–1.11) | 1.46 (1.41–1.52) | 1.24 (1.19–1.28) |
Unknown/ Did not respond | 1.37 (1.32–1.42) | 1.16 (1.22–1.21) | 1.65 (1.58–1.73) | 0.91 (0.87–0.95) |
Comorbidities (present vs absent) | ||||
Any cardiovascular disease | 1.36 (1.33–1.38) | 1.25 (1.22–1.27) | 1.68 (1.64–1.73) | 1.52 (1.49–1.56) |
Coronary artery disease | 1.45 (1.42–1.48) | 1.26 (1.24–1.29) | 1.88 (1.83–1.93) | 1.57 (1.53–1.61) |
Stroke | 1.42 (1.38–1.46) | 1.30 (1.27–1.34) | 2.12 (2.04–2.2) | 1.79 (1.73–1.86) |
Diabetes | 1.23 (1.21–1.26) | 1.25 (1.22–1.28) | 1.62 (1.56–1.67) | 1.66 (1.61–1.72) |
Asthma/COPD | 1.24 (1.21–1.28) | 1.23 (1.19–1.27) | 1.49 (1.44–1.54) | 1.50 (1.44–1.55) |
History of hip fracture | 1.57 (1.51–1.63) | 1.35 (1.30–1.41) | 2.36 (2.24–2.48) | 1.71 (1.62–1.8) |
Cancer treatment within 5 years of start of follow-up | 1.40 (1.37–1.44) | 1.29 (1.26–1.32) | 1.97 (1.92–2.02) | 1.90 (1.85–1.95) |
Any mental or behavioral disorder (exc. dementia) | 1.09 (1.07–1.11) | 1.11 (1.09–1.13) | 1.39 (1.36–1.43) | 1.41 (1.37–1.44) |
Interaction of covariates and age
AD cohort | Non-AD cohort | |||
---|---|---|---|---|
Comorbidities | < 80 years | ≥80 years | < 80 years | ≥80 years |
Any cardiovascular disease | 1.32 (1.28–1.36) | 1.25 (1.22–1.28) | 1.60 (1.53–1.68) | 1.52 (1.47–1.56) |
Coronary artery disease | 1.36 (1.32–1.41) | 1.28 (1.25–1.31) | 1.78 (1.69–1.87) | 1.59 (1.54–1.64) |
Stroke | 1.45 (1.38–1.52) | 1.25 (1.20–1.30) | 2.27 (2.11–2.44) | 1.74 (1.68–1.82) |
Diabetes | 1.29 (1.24–1.34) | 1.19 (1.16–1.23) | 1.86 (1.75–1.97) | 1.52 (1.46–1.58) |
Asthma/COPD | 1.28 (1.22–1.34) | 1.21 (1.17–1.26) | 1.71 (1.61–1.83) | 1.40 (1.35–1.46) |
History of hip fracture | 1.64 (1.51–1.79) | 1.38 (1.32–1.44) | 2.38 (2.09–2.72) | 1.87 (1.77–1.97) |
Cancer within 5 years of start of follow-up | 1.53 (1.48–1.58) | 1.23 (1.19–1.27) | 2.94 (2.81–3.09) | 1.61 (1.56–1.66) |
Any mental or behavioral disorder (exc. dementia) | 1.11 (1.07–1.14) | 1.11 (1.09–1.39) | 1.40 (1.33–1.46) | 1.42 (1.38–1.46) |