Background
Methods
Participants
Inclusion and exclusion criteria
CRRT procedure
Data collection
Measurement of plasma NGAL
Calculation
Statistical analysis
Results
Clinical characteristics | Patients with SAKI (n = 42) |
---|---|
Age (year) | 53.2 ± 17.3 |
Male gender (n, %) | 28 (66.7) |
Etiological factors (n, %) | |
Abdominal infection | 18 (42.9) |
Pulmonary infection | 12 (28.6) |
Trauma-related infection | 10 (23.8) |
Urinary tract infection | 2 (4.8) |
Underlying diseases (n, %) | |
Hypertension | 16 (38.1) |
Diabetes | 10 (23.8) |
COPD | 8 (19.0) |
Coronary heart disease | 6 (14.3) |
Biological data | Patients with SAKI (n = 42) |
---|---|
MAP (mm Hg) | 67.2 ± 32.5 |
PaO2/FiO2 | 192 (131, 352) |
SOFA | 10 ± 3 |
APACHE II | 18 (14, 21) |
WBC count (×109/L) | 14.5 (11.3, 18.9) |
Hct (%) | 25.0 ± 5.3 |
PLT (×109/L) | 98 (46, 219) |
CRP (mg/dL) | 146.7 (53.3, 189.9) |
PCT (ng/mL) | 13.21 (3.02, 38.81) |
SCr (μmol/L) | 242 (189, 367) |
BUN (mmol/L) | 12.3 ± 8.4 |
Fibrinogen (g/L) | 5.9 ± 3.2 |
Albumin (g/L) | 28 ± 7.5 |
Lactate (mmol/L) | 5.4 (2.2, 7.6) |
T0 | T2 | T4 | T8 | T12 | |
---|---|---|---|---|---|
Ci (ng/mL) | 879 (733, 1466) | 850 (685, 1525) | 859 (688, 1496) | 847 (689, 1417) | 844 (694, 1405) |
Co (ng/mL) | 867 (697, 1451) | 845 (703, 1332) | 890 (661, 1416) | 834 (689, 1326) | 819 (646, 1415) |
Cuf (ng/mL) | 32.2 (26.7, 40.8) | 30.3 (23.6, 34.9) | 27.7 (24.1, 31.9) | 26.1 (21.2, 30.1) | 24.0 (20.1, 28.0) |
Mi (μg/min) | 107 (94, 183) | 104 (97, 194) | 105 (89, 197) | 105 (91, 182) | 110 (88, 180) |
Mo (μg/min) | 104 (92, 181) | 107 (88, 170) | 109 (85, 182) | 107 (89, 170) | 109 (85, 172) |
Muf (ng/min) | 2189 (1330, 2748) | 1807 (1181, 3363) | 1888 (1309, 2312) | 2048 (1129, 3693) | 1397 (1018, 3471) |
Mtr (ng/min) | 1430 (239, 4914) | 1502 (−2500, 4801) | 3240 (593, 5544) | 3024 (−82, 5360) | 4620 (2540, 6687) |
Mad (ng/min) | −313(−2576, 3470) | −1369 (−5611, −1682) | 1651 (−1494, 3308) | 354 (−2195, 3201) | 2216 (507, 5104) |
SC | 0.21 (0.17, 0.26) | 0.19 (0.16, 0.22) | 0.17 (0.15, 0.21) | 0.16 (0.13, 0.20) | 0.16 (0.12, 0.18) |
Clearance | 2.05 (0.39, 3.57) | 1.45 (−3.15, 4.28) | 3.74 (0.73, 6.09) | 3.56 (−0.45, 5.80) | 4.57 (1.85, 8.94) |